Sedative and analgesic effects of intravenous xylazine and tramadol on horses

Journal of Veterinary Science

Volumn 12, Issue 3, 2011, Pages 281-286

  Seo, Jong Pil ^a   Son, Won Gyun ^a   Gang, Sujin ^a   Lee, Inhyung ^a  

^a Seoul National University   (South Korea)

Author keywords

Analgesia; Horse; Sedation; Tramadol; Xylazine

Indexed keywords

HYPNOTIC SEDATIVE AGENT; NARCOTIC ANALGESIC AGENT; TRAMADOL; XYLAZINE;

ANIMAL; ARTICLE; BLOOD PRESSURE; BREATHING RATE; DRUG COMBINATION; FEMALE; HEART RATE; HORSE; MALE; PHYSIOLOGY;

ANALGESICS, OPIOID; ANIMALS; BLOOD PRESSURE; DRUG THERAPY, COMBINATION; FEMALE; HEART RATE; HORSES; HYPNOTICS AND SEDATIVES; MALE; RESPIRATORY RATE; TRAMADOL; XYLAZINE;

EQUIDAE;

EID: 80052093286     PISSN: 1229845X     EISSN: None     Source Type: Journal    
DOI: 10.4142/jvs.2011.12.3.281     Document Type: Article

References (20)

1. Bryant CE, England GC, Clarke KW. Comparison of the sedative effects of medetomidine and xylazine in horses. Vet Rec 1991, 129, 421-423.
2. Carregaro AB, Luna SPL, Mataqueiro MI, de Queiroz-Neto A. Effects of buprenorphine on nociception and spontaneous locomotor activity in horses. Am J Vet Res 2007, 68, 246-250.
3. DeRossi R, Jorge TP, Ossuna MR, Carneiro RPB, Alves OD, Zanenga NF. Sedation and pain management with intravenous romifidine-butorphanol in standing horses. J Equine Vet Sci 2009, 29, 75-81.
4. Dhanjal JK, Wilson DV, Robinson E, Tobin TT, Dirokulu L. Intravenous tramadol: effects, nociceptive properties, and pharmacokinetics in horses. Vet Anaesth Analg 2009, 36, 581-590.
5. England GCW, Clarke KW. Alpha2 adrenoceptor agonists in the horse-a review. Br Vet J 1996, 152, 641-657.
6. England GC, Clarke KW, Goossens L. A comparison of the sedative effects of three alpha 2-adrenoceptor agonists (romifidine, detomidine and xylazine) in the horse. J Vet Pharmacol Ther 1992, 15, 194-201.
7. García-Quetglas E, Azanza JR, Sádaba B, Muñoz MJ, Gil I, Campanero MA. Pharmacokinetics of tramadol enantiomers and their respective phase I metabolites in relation to CYP2D6 phenotype. Pharmacol Res 2007, 55, 122-130.
8. Giorgi M, Soldani G, Manera C, Ferrarini PL, Sgorbini M, Saccomanni G. Pharmacokinetics of tramadol and its metabolites M1, M2 and M5 in horses following intravenous, immediate release (fasted/fed) and sustained release single dose administration. J Equine Vet Sci 2007, 27, 481-488.
9. Kerr DD, Jones EW, Huggins K, Edwards WC. Sedative and other effects of xylazine given intravenously to horses. Am J Vet Res 1972, 33, 525-532.
10. LeBlanc PH. Chemical restraint for surgery in the standing horse. Vet Clin North Am Equine Pract 1991, 7, 521-533.
11. Mastrocinque S, Fantoni DT. A comparison of preoperative tramadol and morphine for the control of early postoperative pain in canine ovariohysterectomy. Vet Anaesth Analg 2003, 30, 220-228.
12. Moens Y, Lanz F, Doherr MG, Schatzmann U. A comparison of the antinociceptive effects of xylazine, detomidine and romifidine on experimental pain in horses. Vet Anaesth Analg 2003, 30, 183-190.
13. Natalini CC, Robinson EP. Effects of epidural opioid analgesics on heart rate, arterial blood pressure, respiratory rate, body temperature, and behavior in horses. Vet Ther 2003, 4, 364-375.
14. Natalini CC, Robinson EP. Evaluation of the analgesic effects of epidurally administered morphine, alfentanil, butorphanol, tramadol, and U50488H in horses. Am J Vet Res 2000, 61, 1579-1586.
15. Pypendop BH, Siao KT, Ilkiw JE. Effects of tramadol hydrochloride on the thermal threshold in cats. Am J Vet Res 2009, 70, 1465-1470.
16. Raffa RB, Friderichs E, Reimann W, Shank RP, Codd EE, Vaught JL. Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic. J Pharmacol Exp Ther 1992, 260, 275-285.
17. Rohrbach H, Korpivaara T, Schatzmann U, Spadavecchia C. Comparison of the effects of the alpha-2 agonists detomidine, romifidine and xylazine on nociceptive withdrawal reflex and temporal summation in horses. Vet Anaesth Analg 2009, 36, 384-395.
18. Scott LJ, Perry CM. Tramadol: a review of its use in perioperative pain. Drugs 2000, 60, 139-176.
19. Shilo Y, Britzi M, Eytan B, Lifschitz T, Soback S, Steinman A. Pharmacokinetics of tramadol in horses after intravenous, intramuscular and oral administration. J Vet Pharmacol Ther 2008, 31, 60-65.
20. Yamashita K, Tsubakishita S, Futaok S, Ueda I, Hamaguchi H, Seno T, Katoh S, Izumisawa Y, Kotani T, Muir WW. Cardiovascular effects of medetomidine, detomidine and xylazine in horses. J Vet Med Sci 2000, 62, 1025-1032.