메뉴 건너뛰기




Volumn 8, Issue 4, 2014, Pages 407-413

Role of osteocytes in multiple myeloma bone disease

Author keywords

Apoptosis; Osteoclasts; Osteocytes; Receptor activator of nuclear factor kappa b ligand; Sclerostin

Indexed keywords

CYTOKINE; OSTEOCLAST DIFFERENTIATION FACTOR; TNFSF11 PROTEIN, HUMAN;

EID: 84924259117     PISSN: 17514258     EISSN: 17514266     Source Type: Journal    
DOI: 10.1097/SPC.0000000000000090     Document Type: Review
Times cited : (55)

References (65)
  • 1
    • 62549117773 scopus 로고    scopus 로고
    • Pathogenesis of myeloma bone disease
    • Roodman GD. Pathogenesis of myeloma bone disease. Leukemia 2009; 23:435-441.
    • (2009) Leukemia , vol.23 , pp. 435-441
    • Roodman, G.D.1
  • 2
    • 1542330894 scopus 로고    scopus 로고
    • Pathogenesis of myeloma bone disease
    • Roodman GD. Pathogenesis of myeloma bone disease. Blood Cells Mol Dis 2004; 32:290-292.
    • (2004) Blood Cells Mol Dis , vol.32 , pp. 290-292
    • Roodman, G.D.1
  • 3
    • 84893790538 scopus 로고    scopus 로고
    • Relationship between initial clinical presentation and the molecular cytogenetic classification of myeloma
    • Greenberg AJ, Rajkumar SV, Therneau TM, et al. Relationship between initial clinical presentation and the molecular cytogenetic classification of myeloma. Leukemia 2014; 28:398-403.
    • (2014) Leukemia , vol.28 , pp. 398-403
    • Greenberg, A.J.1    Rajkumar, S.V.2    Therneau, T.M.3
  • 4
    • 84902064432 scopus 로고    scopus 로고
    • Bone modeling and remodeling
    • Burr D, Allen M, editors., 1st edn San Diego, United States: Elsevier
    • Allen MR, Burr DB. Bone modeling and remodeling. In: Burr D, Allen M, editors. Basic and Applied Bone Biology, 1st edn San Diego, United States: Elsevier; 2014. pp. 75-90.
    • (2014) Basic and Applied Bone Biology , pp. 75-90
    • Allen, M.R.1    Burr, D.B.2
  • 5
    • 0034874481 scopus 로고    scopus 로고
    • Cancellous bone remodeling occurs in specialized compartments lined by cells expressing osteoblastic markers
    • Hauge EM, Qvesel D, Eriksen EF, et al. Cancellous bone remodeling occurs in specialized compartments lined by cells expressing osteoblastic markers. J Bone Miner Res 2001; 16:1575-1582.
    • (2001) J Bone Miner Res , vol.16 , pp. 1575-1582
    • Hauge, E.M.1    Qvesel, D.2    Eriksen, E.F.3
  • 7
    • 58249109354 scopus 로고    scopus 로고
    • A physical mechanism for coupling bone resorption and formation in adult human bone
    • Andersen TL, Sondergaard TE, Skorzynska KE, et al. A physical mechanism for coupling bone resorption and formation in adult human bone. Am J Pathol 2009; 174:239-247.
    • (2009) Am J Pathol , vol.174 , pp. 239-247
    • Andersen, T.L.1    Sondergaard, T.E.2    Skorzynska, K.E.3
  • 8
    • 84893813155 scopus 로고    scopus 로고
    • Osteocyte-driven bone remodeling
    • Bellido T. Osteocyte-driven bone remodeling. Calcif Tissue Int 2013; 94:25- 34.
    • (2013) Calcif Tissue Int , vol.94 , pp. 25-34
    • Bellido, T.1
  • 9
    • 79251493453 scopus 로고    scopus 로고
    • The amazing osteocyte
    • Bonewald LF. The amazing osteocyte. J Bone Miner Res 2011; 26:229- 238.
    • (2011) J Bone Miner Res , vol.26 , pp. 229-238
    • Bonewald, L.F.1
  • 10
    • 27744461726 scopus 로고    scopus 로고
    • Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation
    • Poole KE, Van Bezooijen RL, Loveridge N, et al. Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation. FASEB J 2005; 19:1842-1844.
    • (2005) FASEB J , vol.19 , pp. 1842-1844
    • Poole, K.E.1    Van, B.R.L.2    Loveridge, N.3
  • 11
    • 80053938104 scopus 로고    scopus 로고
    • Evidence for osteocyte regulation of bone homeostasis through RANKL expression
    • Nakashima T, Hayashi M, Fukunaga T, et al. Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med 2011; 17:1231- 1234.
    • (2011) Nat Med , vol.17 , pp. 1231-1234
    • Nakashima, T.1    Hayashi, M.2    Fukunaga, T.3
  • 12
    • 80053978532 scopus 로고    scopus 로고
    • Matrix-embedded cells control osteoclast formation
    • Xiong J, Onal M, Jilka RL, et al. Matrix-embedded cells control osteoclast formation. Nat Med 2011; 17:1235-1241.
    • (2011) Nat Med , vol.17 , pp. 1235-1241
    • Xiong, J.1    Onal, M.2    Jilka, R.L.3
  • 13
    • 34249657953 scopus 로고    scopus 로고
    • Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction
    • Tatsumi S, Ishii K, Amizuka N, et al. Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. CellMetab 2007; 5:464- 475.
    • (2007) CellMetab , vol.5 , pp. 464-475
    • Tatsumi, S.1    Ishii, K.2    Amizuka, N.3
  • 14
    • 33645334941 scopus 로고    scopus 로고
    • Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss
    • Aguirre JI, Plotkin LI, Stewart SA, et al. Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss. J Bone Min Res 2006; 21:605-615.
    • (2006) J Bone Min Res , vol.21 , pp. 605-615
    • Aguirre, J.I.1    Plotkin, L.I.2    Stewart, S.A.3
  • 15
    • 84856156566 scopus 로고    scopus 로고
    • Osteocyte apoptosis induces bone resorption and impairs the skeletal response to weightlessness
    • Bellido T. Osteocyte apoptosis induces bone resorption and impairs the skeletal response to weightlessness. BoneKEy-Osteovision 2007; 4:252- 256.
    • (2007) BoneKEy-Osteovision , vol.4 , pp. 252-256
    • Bellido, T.1
  • 16
    • 77956030798 scopus 로고    scopus 로고
    • Targeting the bone microenvironment in multiple myeloma
    • Roodman GD. Targeting the bone microenvironment in multiple myeloma. J Bone Miner Metab 2010; 28:244-250.
    • (2010) J Bone Miner Metab , vol.28 , pp. 244-250
    • Roodman, G.D.1
  • 17
    • 75149120560 scopus 로고    scopus 로고
    • Myeloma cell-induced disruption of bone remodelling compartments leads to osteolytic lesions and generation of osteoclast-myeloma hybrid cells
    • Andersen TL, Soe K, Sondergaard TE, et al. Myeloma cell-induced disruption of bone remodelling compartments leads to osteolytic lesions and generation of osteoclast-myeloma hybrid cells. Br J Haematol 2010; 148:551-561.
    • (2010) Br J Haematol , vol.148 , pp. 551-561
    • Andersen, T.L.1    Soe, K.2    Sondergaard, T.E.3
  • 18
    • 0026690115 scopus 로고
    • Abnormal bone remodelling in patients with myelomatosis and normal biochemical indices of bone resorption
    • Taube T, Beneton MNC, McCloskey EV, et al. Abnormal bone remodelling in patients with myelomatosis and normal biochemical indices of bone resorption. Eur J Haematol 1992; 49:192-198.
    • (1992) Eur J Haematol , vol.49 , pp. 192-198
    • Taube, T.1    Beneton, M.N.C.2    McCloskey, E.V.3
  • 19
    • 0029011394 scopus 로고
    • Excessive bone resorption in human plasmacytomas: Direct induction by tumour cells in vivo
    • Bataille R, Chappard D, Basle M. Excessive bone resorption in human plasmacytomas: direct induction by tumour cells in vivo. Br J Haematol 1995; 90:721-724.
    • (1995) Br J Haematol , vol.90 , pp. 721-724
    • Bataille, R.1    Chappard, D.2    Basle, M.3
  • 20
    • 0038345395 scopus 로고    scopus 로고
    • Upregulation of osteoblast apoptosis by malignant plasma cells: A role in myeloma bone disease
    • Silvestris F, Cafforio P, Tucci M, et al. Upregulation of osteoblast apoptosis by malignant plasma cells: A role in myeloma bone disease. Br J Haematol 2003; 122:39-52.
    • (2003) Br J Haematol , vol.122 , pp. 39-52
    • Silvestris, F.1    Cafforio, P.2    Tucci, M.3
  • 21
    • 33745494534 scopus 로고    scopus 로고
    • A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: A potential role in the development of lytic bone disease and tumor progression in multiple myeloma
    • Gunn WG, Conley A, Deininger L, et al. A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: A potential role in the development of lytic bone disease and tumor progression in multiple myeloma. Stem Cells 2006; 24:986-991.
    • (2006) Stem Cells , vol.24 , pp. 986-991
    • Gunn, W.G.1    Conley, A.2    Deininger, L.3
  • 22
    • 0037926821 scopus 로고    scopus 로고
    • AML-1A and AML-1B regulation of MIP-1alpha expression in multiple myeloma
    • Choi SJ, Oba T, Callander NS, et al. AML-1A and AML-1B regulation of MIP-1alpha expression in multiple myeloma. Blood 2003; 101:3778-3783.
    • (2003) Blood , vol.101 , pp. 3778-3783
    • Choi, S.J.1    Oba, T.2    Callander, N.S.3
  • 23
    • 84898456500 scopus 로고    scopus 로고
    • Bone marrow monocyte/macrophage derived activin a mediates the osteoclastogenic effect of IL-3 in multiple myeloma
    • Silbermann R, Bolzoni M, Storti P, et al. Bone marrow monocyte/macrophage derived activin a mediates the osteoclastogenic effect of IL-3 in multiple myeloma. Leukemia 2014; 28:951-954.
    • (2014) Leukemia , vol.28 , pp. 951-954
    • Silbermann, R.1    Bolzoni, M.2    Storti, P.3
  • 24
    • 28544437394 scopus 로고    scopus 로고
    • The role of immune cells and inflammatory cytokines in Paget's disease and multiple myeloma
    • Ehrlich LA, Roodman GD. The role of immune cells and inflammatory cytokines in Paget's disease and multiple myeloma. Immunol Rev 2005; 208:252-266.
    • (2005) Immunol Rev , vol.208 , pp. 252-266
    • Ehrlich, L.A.1    Roodman, G.D.2
  • 25
    • 23744498205 scopus 로고    scopus 로고
    • Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation
    • Giuliani N, Colla S, Morandi F, et al. Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation. Blood 2005; 106:2472-2483.
    • (2005) Blood , vol.106 , pp. 2472-2483
    • Giuliani, N.1    Colla, S.2    Morandi, F.3
  • 26
    • 4143082697 scopus 로고    scopus 로고
    • New insight in the mechanism of osteoclast activation and formation in multiple myeloma: Focus on the receptor activator of NF-kappaB ligand [RANKL]
    • Giuliani N, Colla S, Rizzoli V. New insight in the mechanism of osteoclast activation and formation in multiple myeloma: focus on the receptor activator of NF-kappaB ligand [RANKL]. Exp Hematol 2004; 32:685-691.
    • (2004) Exp Hematol , vol.32 , pp. 685-691
    • Giuliani, N.1    Colla, S.2    Rizzoli, V.3
  • 27
    • 84895927112 scopus 로고    scopus 로고
    • Apoptotic osteocytes and the control of targeted bone resorption
    • Plotkin LI. Apoptotic osteocytes and the control of targeted bone resorption. Curr Osteoporos Rep 2014; 12:121-126.
    • (2014) Curr Osteoporos Rep , vol.12 , pp. 121-126
    • Plotkin, L.I.1
  • 28
    • 65549087003 scopus 로고    scopus 로고
    • Osteocyte apoptosis controls activation of intracortical resorption in response to bone fatigue
    • Cardoso L, Herman BC, Verborgt O, et al. Osteocyte apoptosis controls activation of intracortical resorption in response to bone fatigue. J Bone Miner Res 2009; 24:597-605.
    • (2009) J Bone Miner Res , vol.24 , pp. 597-605
    • Cardoso, L.1    Herman, B.C.2    Verborgt, O.3
  • 29
    • 23044449180 scopus 로고    scopus 로고
    • Microdamage and apoptosis
    • Noble B. Microdamage and apoptosis. Eur J Morphol 2005; 42:91-98.
    • (2005) Eur J Morphol , vol.42 , pp. 91-98
    • Noble, B.1
  • 30
    • 26044479780 scopus 로고    scopus 로고
    • Microcracks in cortical bone: How do they affect bone biology?
    • O'Brien FJ, Brennan O, Kennedy OD, et al. Microcracks in cortical bone: How do they affect bone biology? Curr Osteoporos Rep 2005; 3:39-45.
    • (2005) Curr Osteoporos Rep , vol.3 , pp. 39-45
    • O'Brien, F.J.1    Brennan, O.2    Kennedy, O.D.3
  • 31
    • 84859360993 scopus 로고    scopus 로고
    • Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations
    • Kennedy OD, Herman BC, Laudier DM, et al. Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations. Bone 2012; 50:1115-1122.
    • (2012) Bone , vol.50 , pp. 1115-1122
    • Kennedy, O.D.1    Herman, B.C.2    Laudier, D.M.3
  • 32
    • 79251544283 scopus 로고    scopus 로고
    • Effects of estrogen deficiency and bisphosphonate therapy on osteocyte viability and microdamage accumulation in an ovine model of osteoporosis
    • Brennan O, Kennedy OD, Lee TC, et al. Effects of estrogen deficiency and bisphosphonate therapy on osteocyte viability and microdamage accumulation in an ovine model of osteoporosis. J Orthop Res 2011; 29:419- 424.
    • (2011) J Orthop Res , vol.29 , pp. 419-424
    • Brennan, O.1    Kennedy, O.D.2    Lee, T.C.3
  • 33
    • 84862003148 scopus 로고    scopus 로고
    • Increased osteocyte death in multiple myeloma patients: Role in myeloma-induced osteoclast formation
    • Giuliani N, Ferretti M, Bolzoni M, et al. Increased osteocyte death in multiple myeloma patients: role in myeloma-induced osteoclast formation. Leukemia 2012; 26:1391-1401.
    • (2012) Leukemia , vol.26 , pp. 1391-1401
    • Giuliani, N.1    Ferretti, M.2    Bolzoni, M.3
  • 34
    • 84860390133 scopus 로고    scopus 로고
    • Apoptotic osteocytes regulate osteoclast precursor recruitment and differentiation in vitro
    • Al-Dujaili SA, Lau E, Al-Dujaili H, et al. Apoptotic osteocytes regulate osteoclast precursor recruitment and differentiation in vitro. J Cell Biochem 2011; 112:2412-2423.
    • (2011) J Cell Biochem , vol.112 , pp. 2412-2423
    • Al-Dujaili, S.A.1    Lau, E.2    Al-Dujaili, H.3
  • 35
    • 84856160446 scopus 로고    scopus 로고
    • Cell autonomous requirement of connexin 43 for osteocyte survival: Consequences for endocortical resorption and periosteal bone formation
    • Bivi N, Condon KW, Allen MR, et al. Cell autonomous requirement of connexin 43 for osteocyte survival: consequences for endocortical resorption and periosteal bone formation. J Bone Min Res 2012; 27:374-389.
    • (2012) J Bone Min Res , vol.27 , pp. 374-389
    • Bivi, N.1    Condon, K.W.2    Allen, M.R.3
  • 36
    • 41649087543 scopus 로고    scopus 로고
    • Metastases and multiple myeloma generate distinct transcriptional footprints in osteocytes in vivo
    • Eisenberger S, Ackermann K, Voggenreiter G, et al. Metastases and multiple myeloma generate distinct transcriptional footprints in osteocytes in vivo. J Pathol 2008; 214:617-626.
    • (2008) J Pathol , vol.214 , pp. 617-626
    • Eisenberger, S.1    Ackermann, K.2    Voggenreiter, G.3
  • 37
    • 79958764505 scopus 로고    scopus 로고
    • Novel actions of bisphosphonates in bone: Preservation of osteoblast and osteocyte viability
    • Bellido T, Plotkin LI. Novel actions of bisphosphonates in bone: preservation of osteoblast and osteocyte viability. Bone 2011; 49:50-55.
    • (2011) Bone , vol.49 , pp. 50-55
    • Bellido, T.1    Plotkin, L.I.2
  • 38
    • 0033611467 scopus 로고    scopus 로고
    • OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
    • Kong YY, Yoshida H, Sarosi I, et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 1999; 397:315-323.
    • (1999) Nature , vol.397 , pp. 315-323
    • Kong, Y.Y.1    Yoshida, H.2    Sarosi, I.3
  • 39
    • 0025332897 scopus 로고
    • The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene
    • Yoshida H, Hayashi S-I, Kunisada T, et al. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature 1990; 345:442-444.
    • (1990) Nature , vol.345 , pp. 442-444
    • Yoshida, H.1    Hayashi, S.-I.2    Kunisada, T.3
  • 40
    • 84874040170 scopus 로고    scopus 로고
    • Osteocyte control of osteoclastogenesis
    • O'Brien CA, Nakashima T, Takayanagi H. Osteocyte control of osteoclastogenesis. Bone 2013; 54:258-263.
    • (2013) Bone , vol.54 , pp. 258-263
    • O'Brien, C.A.1    Nakashima, T.2    Takayanagi, H.3
  • 41
    • 0035949510 scopus 로고    scopus 로고
    • Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression
    • Pearse RN, Sordillo EM, Yaccoby S, et al. Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression. Proc Natl Acad Sci U S A 2001; 98:11581-11586.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 11581-11586
    • Pearse, R.N.1    Sordillo, E.M.2    Yaccoby, S.3
  • 42
    • 0035895083 scopus 로고    scopus 로고
    • Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment
    • Giuliani N, Bataille R, Mancini C, et al. Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment. Blood 2001; 98:3527-3533.
    • (2001) Blood , vol.98 , pp. 3527-3533
    • Giuliani, N.1    Bataille, R.2    Mancini, C.3
  • 43
    • 84872505990 scopus 로고    scopus 로고
    • RANKL expression, function, and therapeutic targeting in multiple myeloma and chronic lymphocytic leukemia
    • Schmiedel BJ, Scheible CA, Nuebling T, et al. RANKL expression, function, and therapeutic targeting in multiple myeloma and chronic lymphocytic leukemia. Cancer Res 2013; 73:683-694.
    • (2013) Cancer Res , vol.73 , pp. 683-694
    • Schmiedel, B.J.1    Scheible, C.A.2    Nuebling, T.3
  • 44
    • 72549108623 scopus 로고    scopus 로고
    • Serum levels of total-RANKL in multiple myeloma
    • Jakob C, Goerke A, Terpos E, et al. Serum levels of total-RANKL in multiple myeloma. Clin Lymphoma Myeloma 2009; 9:430-435.
    • (2009) Clin Lymphoma Myeloma , vol.9 , pp. 430-435
    • Jakob, C.1    Goerke, A.2    Terpos, E.3
  • 45
    • 0037303260 scopus 로고    scopus 로고
    • RANK-Fc: A therapeutic antagonist for RANK-L in myeloma
    • Sordillo EM, Pearse RN. RANK-Fc: A therapeutic antagonist for RANK-L in myeloma. Cancer 2003; 97 (Suppl 3):802-812.
    • (2003) Cancer , vol.97 , pp. 802-812
    • Sordillo, E.M.1    Pearse, R.N.2
  • 46
    • 70349488703 scopus 로고    scopus 로고
    • An open-label, phase 2 trial of denosumab in the treatment of relapsed or plateau-phase multiple myeloma
    • Vij R, Horvath N, Spencer A, et al. An open-label, phase 2 trial of denosumab in the treatment of relapsed or plateau-phase multiple myeloma. Am J Hematol 2009; 84:650-656.
    • (2009) Am J Hematol , vol.84 , pp. 650-656
    • Vij, R.1    Horvath, N.2    Spencer, A.3
  • 47
    • 0141482103 scopus 로고    scopus 로고
    • Receptor activator of nuclear factorkappaB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo
    • Farrugia AN, Atkins GJ, To LB, et al. Receptor activator of nuclear factorkappaB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo. Cancer Res 2003; 63:5438-5445.
    • (2003) Cancer Res , vol.63 , pp. 5438-5445
    • Farrugia, A.N.1    Atkins, G.J.2    To, L.B.3
  • 48
    • 0034284054 scopus 로고    scopus 로고
    • -Cell contact between marrow stromalcells andmyelomacells viaVCAM-1andalpha[4]beta[1]-integrin enhances production of osteoclast-stimulating activity
    • Cell
    • Michigami T, Shimizu N, Williams PJ, et al. Cell-cell contact between marrow stromalcells andmyelomacells viaVCAM-1andalpha[4]beta[1]-integrin enhances production of osteoclast-stimulating activity. Blood 2000; 96:1953-1960.
    • (2000) Blood , vol.96 , pp. 1953-1960
    • Michigami, T.1    Shimizu, N.2    Williams, P.J.3
  • 49
    • 0037114636 scopus 로고    scopus 로고
    • Human myeloma cells stimulate the receptor activator of nuclear factor-kappa Bligand [RANKL] in T lymphocytes: A potential role in multiple myeloma bone disease
    • Giuliani N, Colla S, Sala R, et al. Human myeloma cells stimulate the receptor activator of nuclear factor-kappa Bligand [RANKL] in T lymphocytes: A potential role in multiple myeloma bone disease. Blood 2002; 100:4615-4621.
    • (2002) Blood , vol.100 , pp. 4615-4621
    • Giuliani, N.1    Colla, S.2    Sala, R.3
  • 50
    • 84928129492 scopus 로고    scopus 로고
    • Direct cell-to-cell interactions between osteocytes and multiple myeloma [MM] cells upregulate Sost and downregulate OPG expression in osteocytes: Evidence for osteocytic contributions to MM-induced bone disease
    • Delgado-Calle J, Bellido T, Roodman GD. Direct cell-to-cell interactions between osteocytes and multiple myeloma [MM] cells upregulate Sost and downregulate OPG expression in osteocytes: evidence for osteocytic contributions to MM-induced bone disease. Blood 2013; 122:3140.
    • (2013) Blood , vol.122 , pp. 3140
    • Delgado-Calle, J.1    Bellido, T.2    Roodman, G.D.3
  • 51
    • 84895925109 scopus 로고    scopus 로고
    • Developments in sclerostin biology: Regulation of gene expression, mechanisms of action, and physiological functions
    • Weivoda MM, Oursler MJ. Developments in sclerostin biology: regulation of gene expression, mechanisms of action, and physiological functions. Curr Osteoporos Rep 2014; 12:107-114.
    • (2014) Curr Osteoporos Rep , vol.12 , pp. 107-114
    • Weivoda, M.M.1    Oursler, M.J.2
  • 52
    • 12144286871 scopus 로고    scopus 로고
    • Sclerostin is an osteocyteexpressed negative regulator of bone formation, but not a classical BMP antagonist
    • Van Bezooijen RL, Roelen BA, Visser A, et al. Sclerostin is an osteocyteexpressed negative regulator of bone formation, but not a classical BMP antagonist. J Exp Med 2004; 199:805-814.
    • (2004) J Exp Med , vol.199 , pp. 805-814
    • Van, B.R.L.1    Roelen, B.A.2    Visser, A.3
  • 53
    • 5344234448 scopus 로고    scopus 로고
    • Sclerostin promotes the apoptosis of human osteoblastic cells: A novel regulation of bone formation
    • Sutherland MK, Geoghegan JC, Yu C, et al. Sclerostin promotes the apoptosis of human osteoblastic cells: A novel regulation of bone formation. Bone 2004; 35:828-835.
    • (2004) Bone , vol.35 , pp. 828-835
    • Sutherland, M.K.1    Geoghegan, J.C.2    Yu, C.3
  • 54
    • 21244480924 scopus 로고    scopus 로고
    • Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling
    • Li X, Zhang Y, Kang H, et al. Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling. J Biol Chem 2005; 280:19883-19887.
    • (2005) J Biol Chem , vol.280 , pp. 19883-19887
    • Li, X.1    Zhang, Y.2    Kang, H.3
  • 55
    • 9144265626 scopus 로고    scopus 로고
    • Patients with Van Buchem disease, an osteosclerotic genetic disease, have elevated bone formation markers, higher bone density, and greater derived polar moment of inertia than normal
    • Wergedal JE, Veskovic K, Hellan M, et al. Patients with Van Buchem disease, an osteosclerotic genetic disease, have elevated bone formation markers, higher bone density, and greater derived polar moment of inertia than normal. J Clin Endocrinol Metab 2003; 88:5778-5783.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 5778-5783
    • Wergedal, J.E.1    Veskovic, K.2    Hellan, M.3
  • 56
    • 18244403197 scopus 로고    scopus 로고
    • Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease
    • Balemans W, Patel N, Ebeling M, et al. Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease. J Med Genet 2002; 39:91-97.
    • (2002) J Med Genet , vol.39 , pp. 91-97
    • Balemans, W.1    Patel, N.2    Ebeling, M.3
  • 57
    • 85085227717 scopus 로고    scopus 로고
    • Mice lacking sclerostin have increased bone formation and bone strength
    • Li X, Niu Q-T, Sun N, et al. Mice lacking sclerostin have increased bone formation and bone strength. Calcif Tissue Int 2007; 80:S24; Suppl 1.
    • (2007) Calcif Tissue Int , vol.80 , pp. S24
    • Li, X.1    Niu, Q.-T.2    Sun, N.3
  • 58
    • 84868290353 scopus 로고    scopus 로고
    • Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases
    • Ke HZ, Richards WG, Li X, et al. Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases. Endocr Rev 2012; 33:747-783.
    • (2012) Endocr Rev , vol.33 , pp. 747-783
    • Ke, H.Z.1    Richards, W.G.2    Li, X.3
  • 59
    • 84864144433 scopus 로고    scopus 로고
    • Elevated circulating sclerostin correlates with advanced disease features and abnormal bone remodeling in symptomatic myeloma: Reduction postbortezomib monotherapy
    • Terpos E, Christoulas D, Katodritou E, et al. Elevated circulating sclerostin correlates with advanced disease features and abnormal bone remodeling in symptomatic myeloma: reduction postbortezomib monotherapy. Int J Cancer 2012; 131:1466-1471.
    • (2012) Int J Cancer , vol.131 , pp. 1466-1471
    • Terpos, E.1    Christoulas, D.2    Katodritou, E.3
  • 60
    • 81255210568 scopus 로고    scopus 로고
    • Sclerostin is overexpressed by plasma cells from multiple myeloma patients
    • Brunetti G, Oranger A, Mori G, et al. Sclerostin is overexpressed by plasma cells from multiple myeloma patients. Ann N Y Acad Sci 2011; 1237:19-23.
    • (2011) Ann N Y Acad Sci , vol.1237 , pp. 19-23
    • Brunetti, G.1    Oranger, A.2    Mori, G.3
  • 61
    • 84899091262 scopus 로고    scopus 로고
    • Bone marrow plasma macrophage inflammatory protein protein-1 alpha [MIP-1 alpha] and sclerostin in multiple myeloma: Relationship with bone disease and clinical characteristics
    • Wang XT, He YC, Zhou SY, et al. Bone marrow plasma macrophage inflammatory protein protein-1 alpha [MIP-1 alpha] and sclerostin in multiple myeloma: relationship with bone disease and clinical characteristics. Leuk Res 2014; 38:525-531.
    • (2014) Leuk Res , vol.38 , pp. 525-531
    • Wang, X.T.1    He, Y.C.2    Zhou, S.Y.3
  • 62
    • 84864062016 scopus 로고    scopus 로고
    • Myeloma cells suppress osteoblasts through sclerostin secretion
    • Colucci S, Brunetti G, Oranger A, et al. Myeloma cells suppress osteoblasts through sclerostin secretion. Blood Cancer J 2011; 1:e27.
    • (2011) Blood Cancer J , vol.1 , pp. e27
    • Colucci, S.1    Brunetti, G.2    Oranger, A.3
  • 63
    • 84883348503 scopus 로고    scopus 로고
    • Osteogenic inhibition in multiple myeloma
    • Habibi H, Abroun S, Hajifathali A, et al. Osteogenic inhibition in multiple myeloma. Cell J 2013; 15:266-271.
    • (2013) Cell J , vol.15 , pp. 266-271
    • Habibi, H.1    Abroun, S.2    Hajifathali, A.3
  • 64
    • 77954798515 scopus 로고    scopus 로고
    • Thiazolidinediones induce osteocyte apoptosis and increase sclerostin expression
    • Mabilleau G, Mieczkowska A, Edmonds ME. Thiazolidinediones induce osteocyte apoptosis and increase sclerostin expression. Diabet Med 2010; 27:925-932.
    • (2010) Diabet Med , vol.27 , pp. 925-932
    • Mabilleau, G.1    Mieczkowska, A.2    Edmonds, M.E.3
  • 65
    • 80053518269 scopus 로고    scopus 로고
    • Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway
    • Wijenayaka AR, Kogawa M, Lim HP, et al. Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway. PLoS One 2011; 6:e25900.
    • (2011) PLoS One , vol.6 , pp. e25900
    • Wijenayaka, A.R.1    Kogawa, M.2    Lim, H.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.