Cytotoxic effects and oxidative stress response of six PBDE metabolites on human L02 cells

Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering

Volumn 46, Issue 12, 2011, Pages 1320-1327

  Zhong, Yu F ^a   Wang, Liu L ^a   Yin, Ling L ^a   An, Jing ^a   Hou, Mei L ^a   Zheng, Ke W ^a   Zhang, Xin Y ^a   Wu, Ming H ^a   Yu, Zhi Q ^b   Sheng, Guo Y ^b   Fu, Jia M ^b  

^a SHANGHAI UNIVERSITY   (China)

^b GUANGZHOU INSTITUTE OF GEOCHEMISTRY   (China)

Author keywords

apoptosis; cytotoxicity; LDH; oxidative stress response; PBDEs

Indexed keywords

AFTER-TREATMENT; CELL VIABILITY; CYTOTOXIC EFFECTS; DOSE-DEPENDENT MANNER; GLUTATHIONES; LDH; LEAKAGE TESTS; OXIDATIVE STRESS RESPONSE; PBDES; POLYBROMINATED DIPHENYL ETHERS; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE ACTIVITIES;

BIOMOLECULES; CELL DEATH; CELL PROLIFERATION; ETHERS; METABOLISM; METABOLITES; ORGANIC POLLUTANTS; OXIDATIVE STRESS; OXYGEN;

CYTOTOXICITY;

GLUTATHIONE; LACTATE DEHYDROGENASE; POLYBROMINATED DIPHENYL ETHER; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

APOPTOSIS; ARTICLE; CELL LINE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME RELEASE; HUMAN; HUMAN CELL; METABOLITE; OXIDATIVE STRESS;

APOPTOSIS; CELL LINE; CELL SURVIVAL; GLUTATHIONE; HALOGENATED DIPHENYL ETHERS; HUMANS; OXIDATIVE STRESS; POLYBROMINATED BIPHENYLS; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE;

EID: 80053083274     PISSN: 10934529     EISSN: 15324117     Source Type: Journal    
DOI: 10.1080/10934529.2011.602937     Document Type: Article

References (44)

1. Hites, R.A. Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. Environ. Sci. Technol. 2004, 38, 945-956. (Pubitemid 38228706)
2. Darnerud, P.O.; Eriksen, G.S.; Johannesson, T.; Larsen, P.B.; Viluksela, M. Ploybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology. Environ. Health Perspect. 2001, 109(Suppl 1), 49-68. (Pubitemid 32303230)
3. Chen, D.A.; Mai, B.; Song, J.; Sun, Q.; Luo, Y.; Luo, X.; Zeng, E.Y.; Hale, R.C. Polybrominated diphenyl ethers in birds of prey from Northern China. Environ. Sci. Technol. 2007, 41, 1828-1833. (Pubitemid 46449208)
4. de Wit, C.A. An overview of brominated flame retardants in the environment. Chemosphere 2002, 46, 583-624. (Pubitemid 34304081)
5. Gill, U.; Chu, I.; Ryan, J.J.; Feeley, M. Polybrominated diphenyl ethers: human tissue levels and toxicology. Rev. Environ. Contam. Toxicol. 2004, 183, 55-97.
6. Hazrati, S.; Harrad, S. Causes of variability in concentrations of polychlorinated biphenyls and polybrominated diphenyl ethers in indoor air. Environ. Sci. Technol. 2006, 40, 7584-7589. (Pubitemid 46012549)
7. Law, R.J.; Allchin, C.R.; de Boer, J.; Covaci, A.; Herzke, D.; Lepom, P.; Morris, S.; Tronczynski, J.; de Wit, C.A. Levels and trends of brominated flame retardants in the European environment. Chemosphere 2006, 64, 187-208. (Pubitemid 43841888)
8. McDonald, T.A. Polybrominated diphenylether levels among United States residents: daily intake and risk of harm to the developing brain and reproductive organs. Integr. Environ. Assess. Manag. 2005, 1, 343-354.
9. Schecter, A.; Papke, O.; Harris, T.R.; Tung, K.C.; Musumba, A.; Olson, J.; Birnbaum, L. Polybrominated diphenyl ether (PBDE) levels in expanded market basket survey of U.S. food and estimated PBDE dietary intake by age and sex. Environ. Health Perspect. 2006a, 114, 1515-1520. (Pubitemid 44509647)
10. Athanasiadou, M.; Cuadra, S.N.; Marsh, G.; Bergman, A.; Jakobsson, K. Polybrominated diphenyl ethers (PBDEs) and bioaccumulative hydroxylated PBDE metabolites in young humans from Managua, Nicaragua. Environ. Health Perspect. 2008, 116, 400-408. (Pubitemid 351395611)
11. Domingo, J.L.; Martí-Cid, R.; Castell, V.; Llobet, J.M. Human exposure to PBDEs through the diet in Catalonia, Spain: temporal trend. A review of recent literature on dietary PBDE intake. Toxicology 2008, 248, 25-32.
12. Furst, P. Dioxins, polychlorinated biphenyls and other organohalogen compounds in human milk. Mol. Nutr. Food Res. 2006, 50, 922-933. (Pubitemid 44621797)
13. Petreas, M.; She, J.; Brown, F.R.; Winkler, J.; Windham, G.; Rogers, E.; Zhao, G.; Bhatia, R.; Charles, M.J. High body burdens of 2,2-,4,4- tetrabromodiphenyl ether (BDE-47) in California women. Environ. Health Perspect. 2003, 111, 1175-1179. (Pubitemid 36939398)
14. Schecter, A.; Johnson-Welch, S.; Tung, K.C.; Harris, T.R.; Papke, O.; Rosen, R. Polybrominated diphenyl ether (PBDE) levels in livers of U.S. human fetuses and newborns. J. Toxicol. Environ. Health Pt. A 2007, 70, 1-6. (Pubitemid 46019518)
15. Schecter, A.; Papke, O.; Tung, K.C.; Joseph, J.; Harris, T.R.; Dahlgren, J. Polybrominated diphenyl etherflameretardants in the US population: Current levels, temporal trends, and comparison with dioxins, dibenzofurans, and polychlorinated biphenyls. J. Occup. Environ. Med. 2005a, 47, 199-211. (Pubitemid 40365757)
16. Siddiqi, M.A.; Laessig, R.H.; Reed, K.D. Polybrominated diphenyl ethers (PBDEs): new pollutants-old diseases. Clin. Med. Res. 2003, 1, 281-290.
17. Sjodin, A.; Patterson Jr, D.G.; Bergman, A. A review on human exposure to brominated flame retardants-particularly polybrominated diphenyl ethers. Environ. Int. 2003, 29, 829-839. (Pubitemid 37337125)
18. Eriksson, P.; Jakobsson, E.; Fredriksson, A. Brominated flame retardants: a novel class of developmental neurotoxicants in our environment? Environ. Health Perspect. 2001, 109, 903-908. (Pubitemid 32976254)
19. Hallgren, S.; Sinjari, T.; Hakansson, H.; Darnerud, P.O. Effects of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) on thyroid hormone and vitamin A levels in rats and mice. Arch. Toxicol. 2001, 75, 200-208. (Pubitemid 32524349)
20. Kuriyama, S.N.; Talsness, C.E.; Grote, K.; Chahoud, I. Developmental exposure to low-dose PBDE-99: effects on male fertility and neurobehavior in rat offspring. Environ. Health Perspect. 2005, 113, 149-154. (Pubitemid 40326323)
21. Lilienthal, H.; Hack, A.; Roth-Härer, A.; Grande, S.W.,; Talsness, C.E. Effects of developmental exposure to 2,2-,4,4-,5-pentabromodiphenyl ether (PBDE-99) on sex steroids, sexual development, and sexually dimorphic behavior in rats. Environ. Health Perspect. 2006, 114, 194-201. (Pubitemid 43193639)
22. Marsh, G.; Stenutz, R.; Bergman, A. Synthesis of hydroxylated and methoxylated polybrominated diphenyl etherssNatural products and potential polybrominated diphenyl ether metabolites. Eur. J. Org. Chem. 2003, 14, 2566-2576.
23. Reistad, T.; Fonnum, F.; Mariussen, E. Neurotoxicity of the pentabrominated diphenyl ether mixture, DE-71, and hexabromocyclododecane (HBCD) in rat cerebellar granule cells in vitro. Arch. Toxicol. 2006, 80, 785-796. (Pubitemid 44817818)
24. Madia, F.; Giordano, G.; Fattori, V.; Vitalone, A.; Branchi, I.; Capone, F.; Costa, L.G. Differential in vitro neurotoxicity of the flame retardant PBDE-99 and of the PCB Aroclor 1254 in human astrocytoma cells. Toxicol. Lett. 2004, 154, 11-21. (Pubitemid 39314584)
25. Hakk, H.; Letcher, R.J. Metabolism in the toxicokinetics and fate of brominated flame retardants-A review. Environ. Int. 2003, 29, 801-828. (Pubitemid 37337124)
26. Hovander, L.; Malmberg, T.; Athanasiadou, M.; Athanassiadis, I.; Rahm, S.; Bergman, Å .; Wehler, E.K. Identification of hydroxylated PCB metabolites and other phenolic halogenated pollutants in human blood plasma. Arch. Environ. Contam. Toxicol. 2002, 42, 105-117. (Pubitemid 34260160)
27. Marsh, G.; Athanasiadou, M.; Athanassiadis, I.; Sandholm, A. Identification of hydroxylated metabolites in 2,2-,4,4-tetratbromodiphenyl ether exposed rats. Chemosphere 2006, 63, 690-697.
28. Marsh, G.; Athanasiadou, M.; Bergman, A.; Asplind, L. Identification of hydroxylated and methoxylated polybrominated diphenyl ethers in Baltic Sea salmon (Salmo salar) blood. Environ. Sci. Technol. 2004, 38, 10-18. (Pubitemid 38044728)
29. McKinney, M.A.; De Guise, S.; Martineau, D.; Beland, P.; Arukwe, A.; Letcher, R.J. Biotransformation of polybrominated diphenyl ethers and polychlorinated biphenyls in beluga whale (Delphinapterus leucas) and rat mammalian model using an in vitro hepatic microsomal assay. Aquat. Toxicol. 2006, 77, 87-97.
30. Sinkkonen, S.; Rantalainen, A.L.; Paasivirta, J.; Lahtipera, M. Polybrominated methoxy diphenyl ethers (MeO-PBDEs) in fish and guillemots of Baltic Atlantic and Arctic environments. Chemosphere 2004, 56, 767-775. (Pubitemid 38891885)
31. Teuten, E.L.; Xu, L.; Reddy, C.M. Two abundant bioaccumulated halogenated compounds are natural products. Science 2005, 307, 917-920. (Pubitemid 40229226)
32. Valters, K.; Li, H.; Alaee, M.; D'Sa, I.; Marsh, G.; Bergman, A.; Letcher, R.J. Polybrominated diphenyl ethers and hydroxylated and methoxylated brominated and chlorinated analogues in the plasma of fish from the Detroit River. Environ. Sci. Technol. 2005, 39, 5612-5619. (Pubitemid 41098393)
33. Letcher, R.J.; Klasson-Wehler, E.; Bergman, A. Methyl sulfate and hydroxylated metabolites of polychlorinated biphenyls. The Handbook Environ. Chem. 3, 2000, part K.
34. Örn, U.; Klasson-Wehler, E. Metabolism of 2,20,4,40- tetrabromodiphenyl ether in rat and mouse. Xenobiotica. 1998, 28, 199-211. (Pubitemid 28102455)
35. Hamers, T.; Kamstra, J.H.; Sonneveld, E.; Murk, A.J.; Keter, M.H.A.; Andersson, P.L.; Legler, J.; Brouwer, A. In vitro profiling of the endocrine-disrupting potency of brominated flame retardants. Toxicol Sci 2006, 92, 157-173. (Pubitemid 43985800)
36. Canton, R.F.; Sanderson, J.T.; Nijmeijer, S.; Bergman, A.; Letcher, R.J.; van den Berg M. In vitro effects of brominated flame retardants and metabolites on CYP17 catalytic activity: a novel mechanism of action? Toxicol. Appl. Pharmacol. 2006, 216, 274-281. (Pubitemid 44488558)
37. Canton, R.F.; Sanderson, T.; Letcher, R.J.; Bergman, A.; van den Berg, M. Inhibition and induction of aromatase (CYP19) activity by brominated flame retardants in H295R human adrenocortical carcinoma cells. Toxicol. Sci. 2005, 88, 447-455. (Pubitemid 41672152)
38. Song, R.; He, Y.; Murphy, M.B.; Yeung, L.W.; Yu, R.M.; Lam, M.H.; Lam, P.K.; Hecker, M.; Giesy, J.P.; Wu, R.S.; Zhang, W.; Sheng, G.; Fu, J. Effects of fifteen PBDE metabolites, DE71, DE79 and TBBPAon steroidogenesis in theH295R cell line. Chemosphere 2008, 71, 1888-1894.
39. Meerts, I.A.T.M.; van Zanden, J.J.; Luijkis, E.A.C.; van Leeuwen-Bol, I.; Marsh, G.; Jakobsson, E.; Bergman, A.; Brouwer, A. Potent competitive interactions of some polybrominated flame retardants and related compounds with human transthyretin in vitro. Toxicol. Sci. 2000, 56, 95-104. (Pubitemid 30441468)
40. Masella, R.; Di Benedetto, R.; Vari, R.; Filesi, C.; Giovannini, C. Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes. J. Nutr. Biochem. 2005, 16, 577-586. (Pubitemid 41338369)
41. He, P.; He, W.; Wang, A.; Xia, T.; Xu, B.; Zhang, M.; Chen, X. PBDE47-induced oxidative stress, DNA damage and apoptosis in primary cultured rat hippocampal neurons. Neurotoxicology 2008, 29, 124-129.
42. Shao, J.; White, C.C.; Dabrowski, M.J.; Kavanagh, T.J.; Eckert, M.L.; Gallagher, E.P. The role of mitochondrial and oxidative injury in BDE 47 toxicity to human fetal liver hematopoietic stem cells. Toxicol. Sci. 2008, 101, 81-90. (Pubitemid 350239013)
43. An, J.; Li, S.H.; Zhong, Y.F.; Wang, Y.P.; Zhen, K.W.; Zhang, X.Y.; Wang, Y.J.; Wu, M.H.; Yu, Z.Q.; Sheng, G.Y.,; Fu, J.M.; Huang, Y.C. The cytotoxic effects of synthetic 6-hydroxylated and 6-methoxylated polybrominated diphenyl ether 47 (BDE47). Environ. Toxicol. 2010, Apr 12. [Epub ahead of print]
44. Wang, J.; Zhang, J.; Bai, S.; Wang, G.; Mu, L.; Sun, B.; Wang, D.; Kong, Q.; Liu, Y.; Yao, X.; Xu, Y.; Li, H. Simulated microgravity promotes cellular senescence via oxidant stress in rat PC12 cells. Neurochem. Int. 2009, 55(7), 710-716.