Resveratrol inhibits proliferation in human colorectal carcinoma cells by inducing G1/S-phase cell cycle arrest and apoptosis through caspase/cyclin-CDK pathways

Molecular Medicine Reports

Volumn 10, Issue 4, 2014, Pages 1697-1702

  Liu, Bin ^a   Zhou, Zhongyou ^a   Zhou, Wei ^a   Liu, Jie ^a   Zhang, Qingyu ^a   Xia, Juan ^a   Liu, Juntao ^a   Chen, Nianping ^a   Li, Mingyi ^a   Zhu, Runzhi ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cell cycle arrest; HCT116, caco 2; Resveratrol

Indexed keywords

CASPASE; CASPASE 7; CASPASE 9; CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLINE; LIPOCORTIN 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROPIDIUM IODIDE; PROTEIN P21; RESVERATROL; ANTINEOPLASTIC AGENT; CDK2 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; STILBENE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CACO 2 CELL LINE; COLORECTAL CARCINOMA; CONTROLLED STUDY; DRUG MECHANISM; G1 PHASE CELL CYCLE CHECKPOINT; HCT116 CELL LINE; HUMAN; HUMAN CELL; MTT ASSAY; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; STAINING; WESTERN BLOTTING; CELL PROLIFERATION; DRUG EFFECTS; METABOLISM; S PHASE CELL CYCLE CHECKPOINT;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CACO-2 CELLS; CASPASE 7; CASPASE 9; CASPASES; CELL PROLIFERATION; CYCLIN D1; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; G1 PHASE CELL CYCLE CHECKPOINTS; HCT116 CELLS; HUMANS; POLY(ADP-RIBOSE) POLYMERASES; PROLIFERATING CELL NUCLEAR ANTIGEN; S PHASE CELL CYCLE CHECKPOINTS; STILBENES;

EID: 84924219724     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2406     Document Type: Article

References (28)

1. Fulda S: Resveratrol and derivatives for the prevention and treatment of cancer. Drug Discov Today 15: 757-765, 2010.
2. Calabrese EJ, Mattson MP and Calabrese V: Dose response biology: the case of resveratrol. Hum Exp Toxicol 29: 1034-1037, 2010.
3. Park SJ, Ahmad F, Philp A, et al: Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell 148: 421-433, 2012.
4. Szekeres T, Fritzer-Szekeres M, Saiko P and Jäger W: Resveratrol and resveratrol analogues - structure-activity relationship. Pharm Res 27: 1042-1048, 2010.
5. Szekeres T, Saiko P, Fritzer-Szekeres M, Djavan B and Jäger W: Chemopreventive effects of resveratrol and resveratrol derivatives. Ann NY Acad Sci 1215: 89-95, 2011.
6. Athar M, Back JH, Kopelovich L, Bickers DR and Kim AL: Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms. Arch Biochem Biophys 486: 95-102, 2009.
7. Tennen RI, Michishita-Kioi E and Chua KF: Finding a target for resveratrol. Cell 148: 387-389, 2012.
8. Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin 60: 277-300, 2010.
9. Siegel RL, Jemal A and Ward EM: Increase in incidence of colorectal cancer among young men and women in the United States. Cancer Epidemiol Biomarkers Prev 18: 1695-1698, 2009.
10. De la Rosa L, Alvarez-Parrilla E and González-Aguilar GA: Fruit and vegetable phytochemicals: Chemistry, nutritional value and stability. Phenolic Compounds: Chemistry and Occurrence in Fruits and Vegetables, Wiley-Blackwell, EUA 53-88, 2010.
11. Agarwal S, Arya V and Zhang L: Review of P-gp Inhibition data in recently approved new drug applications: utility of the proposed [I(1) ]/IC(50) and [I(2) ]/IC(50) criteria in the P-gp decision tree. J Clin Pharmacol 53: 228-233, 2013.
12. Nutakul W, Sobers HS, Qiu P, et al: Inhibitory effects of resveratrol and pterostilbene on human colon cancer cells: a side-by-side comparison. J Agric Food Chem 59: 10964-10970, 2011.
13. Piotrowska H, Kucinska M and Murias M: Biological activity of piceatannol: leaving the shadow of resveratrol. Mutat Res 750: 60-82, 2012.
14. de Athayde Moncorvo Collado A, Corbalán N, Homolya L, Morero R and Minahk C: Resveratrol modulates ATPase activity of liposome-reconstituted ABCG1. FEBS Lett 587: 2359-2363, 2013.
15. Um JH, Park SJ, Kang H, et al: AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes 59: 554-563, 2010.
16. Yasuda Y, Saito M, Yamamura T, Yaguchi T and Nishizaki T: Extracellular adenosine induces apoptosis in Caco-2 human colonic cancer cells by activating caspase-9/-3 via A(2a) adenosine receptors. J Gastroenterol 44: 56-65, 2009.
17. Allan LA and Clarke PR: Apoptosis and autophagy: Regulation of caspase-9 by phosphorylation. FEBS J 276: 6063-6073, 2009.
18. Boucher D, Blais V and Denault JB: Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis. Proc Natl Acad Sci USA 109: 5669-5674, 2012.
19. Rodríguez-Berriguete G, Galvis L, Fraile B, et al: Immunoreactivity to caspase-3, caspase-7, caspase-8, and caspase-9 forms is frequently lost in human prostate tumors. Hum Pathol 43: 229-237, 2012.
20. Peralta-Leal A, Rodríguez-Vargas JM, Aguilar-Quesada R, et al: PARP inhibitors: new partners in the therapy of cancer and inflammatory diseases. Free Radic Biol Med 47: 13-26, 2009.
21. Galluzzi L, Vitale I, Abrams JM, et al: Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 19: 107-120, 2012.
22. Langelier M-F and Pascal JM: PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis. Curr Opin Struct Biol 23: 134-143, 2013.
23. Yang L, Zhang HW, Hu R, et al: Wogonin induces G1 phase arrest through inhibiting Cdk4 and cyclin D1 concomitant with an elevation in p21Cip1 in human cervical carcinoma HeLa cells. Biochem Cell Biol 87: 933-942, 2009.
24. Kim MY: Nitric oxide triggers apoptosis in A375 human melanoma cells treated with capsaicin and resveratrol. Mol Med Rep 5: 585-591, 2012.
25. Majumdar AP, Banerjee S, Nautiyal J, et al: Curcumin synergizes with resveratrol to inhibit colon cancer. Nutr Cancer 61: 544-553, 2009.
26. Soria G and Gottifredi V: PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule? DNA Repair (Amst) 9: 358-364, 2010.
27. Beckerman R, Donner AJ, Mattia M, et al: A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint. Genes Dev 23: 1364-1377, 2009.
28. Adon AM, Zeng X, Harrison MK, et al: Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells. Mol Cell Biol 30: 694-710, 2010.