Addition of histamine to subcutaneously injected Plasmodium berghei sporozoites increases the parasite liver load and could facilitate whole-parasite vaccination

Malaria Journal

Volumn 14, Issue 1, 2015, Pages

  Pfeil, Johannes ^a,b   Heine, Jan F ^a   Mueller, Ann Kristin ^a,b  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b German Centre for Infectious Diseases (DZIF)   (Germany)

Author keywords

Chemoprophylaxis with sporozoites; Heparin; Histamine; Malaria vaccine; Sporozoite; SPZ; Whole parasite immunization

Indexed keywords

HISTAMINE; MALARIA VACCINE; PROTECTIVE AGENT; SPOROZOITE VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFICACY; IN VIVO STUDY; LIMIT OF QUANTITATION; LIVER FUNCTION; MALARIA; MOUSE; NONHUMAN; PARASITE LOAD; PLASMODIUM BERGHEI; PLASMODIUM BERGHEI INFECTION; REAL TIME POLYMERASE CHAIN REACTION; SPOROZOITE; SURVIVAL TIME; TREATMENT OUTCOME; VACCINATION; ANIMAL; C57BL MOUSE; CHEMISTRY; DRUG EFFECTS; IMMUNOLOGY; LIVER; MORTALITY; PARASITOLOGY;

ANIMALS; HISTAMINE; LIVER; MALARIA; MALARIA VACCINES; MICE, INBRED C57BL; PARASITE LOAD; PLASMODIUM BERGHEI; SPOROZOITES;

EID: 84924169987     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/s12936-015-0552-3     Document Type: Article

References (26)

1. Nussenzweig RS, Vanderberg J, Most H, Orton C. Protective immunity produced by the injection of X-irradiated sporozoites of Plasmodium berghei. Nature. 1967;216:160-2.
2. Clyde DF, Most H, McCarthy VC, Vanderberg JP. Immunization of man against sporozite-induced falciparum malaria. Am J Med Sci. 1973;266:169-77.
3. Hoffman SL, Goh LM, Luke TC, Schneider I, Le TP, Doolan DL, et al. Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites. J Infect Dis. 2002;185:1155-64.
4. Beaudoin RL, Strome CP, Mitchell F, Tubergen TA. Plasmodium berghei: immunization of mice against the ANKA strain using the unaltered sporozoite as an antigen. Exp Parasitol. 1977;42:1-5.
5. Roestenberg M, McCall M, Hopman J, Wiersma J, Luty AJ, van Gemert GJ, et al. Protection against a malaria challenge by sporozoite inoculation. N Engl J Med. 2009;361:468-77.
6. Mueller AK, Labaied M, Kappe SH, Matuschewski K. Genetically modified Plasmodium parasites as a protective experimental malaria vaccine. Nature. 2005;433:164-7.
7. Hoffman SL, Billingsley PF, James E, Richman A, Loyevsky M, Li T, et al. Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria. Hum Vaccin. 2010;6:97-106.
8. Epstein JE, Tewari K, Lyke KE, Sim BK, Billingsley PF, Laurens MB, et al. Live attenuated malaria vaccine designed to protect through hepatic CD8 (+) T cell immunity. Science. 2011;334:475-80.
9. Seder RA, Chang LJ, Enama ME, Zephir KL, Sarwar UN, Gordon IJ, et al. Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine. Science. 2013;341:1359-65.
10. Nganou-Makamdop K, Ploemen I, Behet M, van Gemert GJ, Hermsen C, Roestenberg M, et al. Reduced Plasmodium berghei sporozoite liver load associates with low protective efficacy after intradermal immunization. Parasite Immunol. 2012;34:562-9.
11. Champagne DE. The role of salivary vasodilators in bloodfeeding and parasite transmission. Parasitol Today. 1994;10:430-3.
12. Stark KR, James AA. Anticoagulants in vector arthropods. Parasitol Today. 1996;12:430-7.
13. Lewis MD, Pfeil J, Mueller AK. Continuous oral chloroquine as a novel route for Plasmodium prophylaxis and cure in experimental murine models. BMC Res Notes. 2011;4:262.
14. Janse CJ, Franke-Fayard B, Mair GR, Ramesar J, Thiel C, Engelmann S, et al. High efficiency transfection of Plasmodium berghei facilitates novel selection procedures. Mol Biochem Parasitol. 2006;145:60-70.
15. Ploemen IH, Prudencio M, Douradinha BG, Ramesar J, Fonager J, van Gemert GJ, et al. Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging. PLoS One. 2009;4:e7881.
16. Carroll RW, Wainwright MS, Kim KY, Kidambi T, Gomez ND, Taylor T, et al. A rapid murine coma and behavior scale for quantitative assessment of murine cerebral malaria. PLoS One. 2010;5:e13124.
17. Ploemen IH, Chakravarty S, van Gemert GJ, Annoura T, Khan SM, Janse CJ, et al. Plasmodium liver load following parenteral sporozoite administration in rodents. Vaccine. 2013;31:3410-6.
18. O'Day SJ, Agarwala SS, Naredi P, Kass CL, Gehlsen KR, Glaspy J. Treatment with histamine dihydrochloride and interleukin-2 in patients with advanced metastatic malignant melanoma: a detailed safety analysis. Melanoma Res. 2003;13:307-11.
19. Donskov F, von der Maase H, Henriksson R, Stiemer U, Wersall P, Nellemann H, et al. Outpatient treatment with subcutaneous histamine dihydrochloride in combination with interleukin-2 and interferon-alpha in patients with metastatic renal cell carcinoma: results of an open single-armed multicentre phase II study. Ann Oncol. 2002;13:441-9.
20. Karavodin L, Jensen R, Sarno M, Gehlsen K. Toxicology and toxicokinetics of acute and subchronic administration of histamine dihydrochloride in rats. Drug Chem Toxicol. 2003;26:35-49.
21. Yamauchi LM, Coppi A, Snounou G, Sinnis P. Plasmodium sporozoites trickle out of the injection site. Cell Microbiol. 2007;9:1215-22.
22. Voza T, Kebaier C, Vanderberg JP. Intradermal immunization of mice with radiation-attenuated sporozoites of Plasmodium yoelii induces effective protective immunity. Malar J. 2010;9:362.
23. Chakravarty S, Cockburn IA, Kuk S, Overstreet MG, Sacci JB, Zavala F. CD8+ T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes. Nat Med. 2007;13:1035-41.
24. Martin RK, Saleem SJ, Folgosa L, Zellner HB, Damle SR, Nguyen GK, et al. Mast cell histamine promotes the immunoregulatory activity of myeloid-derived suppressor cells. J Leukoc Biol. 2014;96:151-9.
25. Norman JJ, Arya JM, McClain MA, Frew PM, Meltzer MI, Prausnitz MR. Microneedle patches: usability and acceptability for self-vaccination against influenza. Vaccine. 2014;32:1856-62.
26. Belnoue E, Costa FT, Frankenberg T, Vigario AM, Voza T, Leroy N, et al. Protective T cell immunity against malaria liver stage after vaccination with live sporozoites under chloroquine treatment. J Immunol. 2004;172:2487-95.