Decreased miR-146 expression in peripheral blood mononuclear cells is correlated with ongoing islet autoimmunity in type 1 diabetes patients

Journal of Diabetes

Volumn 7, Issue 2, 2015, Pages 158-165

  Yang, Minglan ^a   Ye, Lei ^a   Wang, Bokai ^a   Gao, Jie ^a   Liu, Ruixin ^b   Hong, Jie ^a,b   Wang, Weiqing ^a,b   Gu, Weiqiong ^a   Ning, Guang ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b Shanghai E Institute for Model Organisms   (China)

Author keywords

MiR 146; Peripheral blood mononuclear cells; Type 1 diabetes mellitus

Indexed keywords

B CELL CLL LYMPHOMA 11A; GLUCOSE; GLUTAMATE DECARBOXYLASE ANTIBODY; INSULIN; MESSENGER RNA; MICRORNA; MICRORNA 146; MICRORNA 146A; NUMB HOMOLOG; PROTEIN; SYNTAXIN 3; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; MIRN146 MICRORNA, HUMAN;

ADOLESCENT; ADULT; ANTIBODY TITER; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; BLOOD GLUCOSE MONITORING; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE DURATION; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; MALE; PATIENT; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; RNA ANALYSIS; TREATMENT DURATION; UPREGULATION; BLOOD; CASE CONTROL STUDY; COMPARATIVE STUDY; DIABETES MELLITUS, TYPE 1; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENETICS; METABOLISM; MONONUCLEAR CELL; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; YOUNG ADULT;

ADOLESCENT; ADULT; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 1; FEMALE; GENE EXPRESSION PROFILING; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MICRORNAS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; YOUNG ADULT;

EID: 84924104577     PISSN: 17530393     EISSN: 17530407     Source Type: Journal    
DOI: 10.1111/1753-0407.12163     Document Type: Article

References (31)

1. Lorenzen J, Kumarswamy R, Dangwal S, Thum T. MicroRNAs in diabetes and diabetes-associated complications. RNA Biol. 2012; 9: 820-827.
2. Lehuen A, Diana J, Zaccone P, Cooke A. Immune cell crosstalk in type 1 diabetes. Nat Rev Immunol. 2010; 10: 501-513.
3. Zhou L, He H, Mi JX etal. MicroRNA genes. Ann N Y Acad Sci. 2008; 1150: 72-75.
4. Hezova R, Slaby O, Faltejskova P etal. MicroRNA-342, microRNA-191 and microRNA-510 are differentially expressed in T regulatory cells of type 1 diabetic patients. Cell Immunol. 2010; 260: 70-74.
5. Roggli E, Britan A, Gattesco S etal. Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells. Diabetes. 2010; 59: 978-986.
6. Sebastiani G, Grieco FA, Spagnuolo I etal. Increased expression of microRNA miR-326 in type 1 diabetic patients with ongoing islet autoimmunity. Diabetes Metab Res Rev. 2011; 27: 862-866.
7. Xu G, Shi C, Ji C etal. Expression of microRNA-26b, an obesity-related microRNA, is regulated by free fatty acids, glucose, dexamethasone and growth hormone in human adipocytes. Mol Med Rep. 2014; 10: 223-228.
8. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2011; 34 (Suppl. 1): S62-69.
9. Argyropoulos C, Wang K, McClarty S etal. Urinary microRNA profiling in the nephropathy of type 1 diabetes. PLoS ONE. 2013; 8: e54662.
10. Nielsen LB, Wang C, Sorensen K etal. Circulating levels of microRNA from children with newly diagnosed type 1 diabetes and healthy controls: Evidence that miR-25 associates to residual beta-cell function and glycaemic control during disease progression. Exp Diabetes Res. 2012; 2012: 896362.
11. Collares CV, Evangelista AF, Xavier DJ etal. Identifying common and specific microRNAs expressed in peripheral blood mononuclear cell of type 1, type 2, and gestational diabetes mellitus patients. BMC Res Notes. 2013; 6: 491.
12. Yang L, Boldin MP, Yu Y etal. miR-146a controls the resolution of T cell responses in mice. J Exp Med. 2012; 209: 1655-1670.
13. Tang Y, Luo X, Cui H etal. MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins. Arthritis Rheum. 2009; 60: 1065-1075.
14. Perry MM, Moschos SA, Williams AE etal. Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells. J Immunol. 2008; 180: 5689-5698.
15. Zhao JL, Rao DS, Boldin MP etal. NF-kappaB dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignancies. Proc Natl Acad Sci USA. 2011; 108: 9184-9189.
16. Lu LF, Boldin MP, Chaudhry A etal. Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell. 2010; 142: 914-929.
17. Pauley KM, Satoh M, Chan AL etal. Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Res Ther. 2008; 10: R101.
18. Taganov KD, Boldin MP, Chang KJ, Baltimore D. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA. 2006; 103: 12-481.
19. Sonkoly E, Pivarcsi A. MicroRNAs in inflammation. Int Rev Immunol. 2009; 28: 535-561.
20. Namjou B, Choi CB, Harley IT etal. Evaluation of TRAF6 in a large multiancestral lupus cohort. Arthritis Rheum. 2012; 64: 1960-1969.
21. Luty WH, Rodeberg D, Parness J, Vyas YM. Antiparallel segregation of notch components in the immunological synapse directs reciprocal signaling in allogeneic Th:DC conjugates. J Immunol. 2007; 179: 819-829.
22. Ferrandi C, Richard F, Tavano P etal. Characterization of immune cell subsets during the active phase of multiple sclerosis reveals disease and c-Jun N-terminal kinase pathway biomarkers. Mult Scler. 2011; 17: 43-56.
23. Pattu V, Qu B, Schwarz EC etal. SNARE protein expression and localization in human cytotoxic T lymphocytes. Eur J Immunol. 2012; 42: 470-475.
24. Sankaran VG, Xu J, Ragoczy T etal. Developmental and species-divergent globin switching are driven by BCL11A. Nature. 2009; 460: 1093-1097.
25. Pelayo R, Hirose J, Huang J etal. Derivation of 2 categories of plasmacytoid dendritic cells in murine bone marrow. Blood. 2005; 105: 4407-4415.
26. Salas-Perez F, Codner E, Valencia E etal. MicroRNAs miR-21a and miR-93 are down regulated in peripheral blood mononuclear cells (PBMC) from patients with type 1 diabetes. Immunobiology. 2013; 218: 733-737.
27. Boettler T, Pagni PP, Jaffe R etal. The clinical and immunological significance of GAD-specific autoantibody and T-cell responses in type 1 diabetes. J Autoimmun. 2013; 44: 40-48.
28. Zimmet P. Antibodies to glutamic acid decarboxylase in the prediction of insulin dependency. Diabetes Res Clin Pract. 1996; 34 (Suppl.): S125-131.
29. Bingley PJ, Bonifacio E, Williams AJ etal. Prediction of IDDM in the general population: Strategies based on combinations of autoantibody markers. Diabetes. 1997; 46: 1701-1710.
30. Knip M, Siljander H. Autoimmune mechanisms in type 1 diabetes. Autoimmun Rev. 2008; 7: 550-557.
31. Suzuki R, Shimada A, Maruyama T etal. T-cell function in anti-GAD65(+)diabetes with residual beta-cell function. J Autoimmun. 2003; 20: 83-90.