Amyloid β oligomers induce interleukin-1β production in primary microglia in a cathepsin B- and reactive oxygen species-dependent manner

Biochemical and Biophysical Research Communications

Volumn 458, Issue 3, 2015, Pages 561-567

  Taneo, Jun ^a   Adachi, Takumi ^a   Yoshida, Aiko ^a   Takayasu, Kunio ^a   Takahara, Kazuhiko ^a,b   Inaba, Kayo ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

AFM; Amyloid ; Fibrils; IL 1 ; Microglia; Oligomers

Indexed keywords

ACETYLCYSTEINE; AMYLOID; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; CATHEPSIN B; CATHEPSIN B INHIBITOR; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MONOMER; N (3 PROPYLCARBAMOYLOXIRANE 2 CARBONYL)ISOLEUCYLPROLINE; OLIGOMER; PROTEIN AGGREGATE; REACTIVE OXYGEN METABOLITE; AMYLOID BETA-PROTEIN (1-42); CROSS LINKING REAGENT; DIPEPTIDE; N-(3-PROPYLCARBAMOYLOXIRANE-2-CARBONYL)-ISOLEUCYL-PROLINE; PEPTIDE FRAGMENT;

ANIMAL CELL; ARTICLE; ATOMIC FORCE MICROSCOPY; CONTROLLED STUDY; CROSS LINKING; CYTOKINE PRODUCTION; CYTOPLASM; ENDOSOME; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MICROGLIA; MICROSCOPY; MOUSE; NONHUMAN; PHAGOLYSOSOME; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN ELECTROPHORESIS; PROTEIN MULTIMERIZATION; PROTEIN SECRETION; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CHEMISTRY; DRUG EFFECTS; IMMUNOLOGY; ULTRASTRUCTURE;

ACETYLCYSTEINE; AMYLOID BETA-PEPTIDES; ANIMALS; CATHEPSIN B; CROSS-LINKING REAGENTS; DIPEPTIDES; INTERLEUKIN-1BETA; MICE; MICE, INBRED BALB C; MICROGLIA; PEPTIDE FRAGMENTS; REACTIVE OXYGEN SPECIES;

EID: 84924078522     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.02.006     Document Type: Article

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