Decrease in neuroimmune activation by HSV-mediated gene transfer of TNFα soluble receptor alleviates pain in rats with diabetic neuropathy

Brain, Behavior, and Immunity

Volumn 41, Issue 1, 2014, Pages 144-151

  Ortmann, Kathryn L Maier ^a,c   Chattopadhyay, Munmun ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

Diabetic neuropathy; DRG; Gene therapy; Inflammation; Pain behavior; TNF

Indexed keywords

HERPESVIRUS VECTOR; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P55; TUMOR NECROSIS FACTOR ALPHA; RECOMBINANT HUMAN TUMOR NECROSIS FACTOR-BINDING PROTEIN-1; TUMOR NECROSIS FACTOR DECOY RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETIC NEUROPATHY; FOOT; GENE TRANSFER; HERPES SIMPLEX VIRUS; HYPERALGESIA; HYPERGLYCEMIA; IMMUNOREACTIVITY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NERVE FIBER; NERVOUS SYSTEM INFLAMMATION; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; OUTCOME ASSESSMENT; PAIN THRESHOLD; PATHOGENESIS; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SCIATIC NERVE; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; SPINAL GANGLION; STRESS; VIRAL GENE DELIVERY SYSTEM; ADVERSE EFFECTS; ANIMAL; CELL CULTURE; COMPLICATION; DIABETIC NEUROPATHIES; EXPERIMENTAL DIABETES MELLITUS; GENE THERAPY; GENE VECTOR; GENETIC TRANSDUCTION; GENETICS; HEAT; IMMUNOLOGY; INFLAMMATION; METABOLISM; NEURALGIA; PATHOPHYSIOLOGY; POSTERIOR HORN CELL; PRESSURE; PROTEIN PROCESSING; SIMPLEXVIRUS; SINGLE BLIND PROCEDURE; SKIN; SPRAGUE DAWLEY RAT; THERAPEUTIC USE;

ANIMALS; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEUROPATHIES; FOOT; GANGLIA, SPINAL; GENETIC THERAPY; GENETIC VECTORS; HOT TEMPERATURE; HYPERALGESIA; INFLAMMATION; MALE; NEURALGIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PAIN THRESHOLD; POSTERIOR HORN CELLS; PRESSURE; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SCIATIC NERVE; SIMPLEXVIRUS; SINGLE-BLIND METHOD; SKIN; TRANSDUCTION, GENETIC; TUMOR NECROSIS FACTOR DECOY RECEPTORS;

EID: 84924076356     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2014.05.009     Document Type: Article

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