The histone methyltransferase Smyd2 is a negative regulator of macrophage activation by suppressing interleukin 6 (IL-6) and tumor necrosis factor α (tnf-α)

Journal of Biological Chemistry

Volumn 290, Issue 9, 2015, Pages 5414-5423

  Xu, Guiliang ^a   Liu, Guilin ^a   Xiong, Sidong ^a   Liu, Haiyan ^a   Chen, Xi ^b,c   Zheng, Biao ^b,c  

^a SOOCHOW UNIVERSITY   (China)

^b EAST CHINA NORMAL UNIVERSITY   (China)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL MEMBRANES; CHEMICAL ACTIVATION; IMMUNOLOGY; MOLECULES; PATHOLOGY; T-CELLS;

CELL DIFFERENTIATION; CELL SURFACE MOLECULES; COSTIMULATORY MOLECULES; EPIGENETIC MODIFICATION; HISTONE METHYLTRANSFERASE; MACROPHAGE ACTIVATION; PRO-INFLAMMATORY CYTOKINES; TUMOR NECROSIS FACTOR ALPHA;

MACROPHAGES;

HISTONE H3; HISTONE METHYLTRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN SMYD2; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; HISTONE; HISTONE LYSINE METHYLTRANSFERASE; LYSINE; SMYD2 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EPIGENETICS; HISTONE METHYLATION; LYMPHOCYTE DIFFERENTIATION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TH17 CELL; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; CELL LINE; CYTOLOGY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENETICS; MACROPHAGE; METABOLISM; METHYLATION; MUTATION; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL LINE; CELLS, CULTURED; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; INTERLEUKIN-6; LYSINE; MACROPHAGE ACTIVATION; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; METHYLATION; MICE, INBRED C57BL; MUTATION; NF-KAPPA B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; T-LYMPHOCYTES, REGULATORY; TH17 CELLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84924059414     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.610345     Document Type: Article

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