Balancing the stability and drug release of polymer micelles by the coordination of dual-sensitive cleavable bonds in cross-linked core

Acta Biomaterialia

Volumn 11, Issue 1, 2015, Pages 126-136

  Deng, Hongzhang ^a,c   Zhang, Yumin ^b   Wang, Xue ^a   Zhang, Jianhua ^a   Cao, Yan ^a   Liu, Jinjian ^b   Liu, Jianfeng ^b   Deng, Liandong ^a   Dong, Anjie ^a,c  

^a TIANJIN UNIVERSITY   (China)

^b INSTITUTE OF RADIATION MEDICINE   (China)

^c SynBio Research Platform   (China)

Author keywords

Core cross linked micelles; Drug delivery; pH response; Reduction sensitivity

Indexed keywords

BIOCOMPATIBILITY; BLOOD; CONJUGATED POLYMERS; CONTROLLED DRUG DELIVERY; COVALENT BONDS; CROSSLINKING; DRUG PRODUCTS; ENZYME ACTIVITY; PH SENSORS; POLYETHYLENE GLYCOLS; REDUCTION; STABILITY; STRUCTURAL OPTIMIZATION; SULFUR COMPOUNDS; TARGETED DRUG DELIVERY; TUMORS;

% REDUCTIONS; BLOOD CIRCULATION; CORE CROSS-LINKED MICELLES; DISULPHIDE BONDS; DOXORUBICIN; DRUG RELEASE; NANOCARRIERS; PH RESPONSE; POLYMER MICELLES; REDUCTION SENSITIVITY;

MICELLES;

BENZALDEHYDE; BENZOIC IMINE; COPOLYMER; CYSTAMINE; DOXORUBICIN; GLUTATHIONE; HYDROGEN PEROXIDE; IMINE; MACROGOL; POLYCAPROLACTONE; POLYMETHACRYLIC ACID; THIOL GROUP; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; BIODEGRADABLE PLASTIC; DELAYED RELEASE FORMULATION; DRUG CARRIER; MICELLE; NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCOMPATIBILITY; CELL VIABILITY; CIRCULATION; CONTROLLED STUDY; CRITICAL MICELLE CONCENTRATION; CROSS LINKING; CYTOTOXICITY; DILUTION; DISPERSION; DISULFIDE BOND; DRUG DELIVERY SYSTEM; DRUG RELEASE; ESTERIFICATION; FLUORESCENCE; HEPG2 CELL LINE; HUMAN; HUMAN CELL; HYDROPHILICITY; IN VITRO STUDY; LIVER CANCER; MALE; MICELLE; MOUSE; NONHUMAN; PARTICLE SIZE; PH; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; TISSUE DISTRIBUTION; CHEMISTRY; DELAYED RELEASE FORMULATION; MATERIALS TESTING; PHARMACOLOGY;

ANTIBIOTICS, ANTINEOPLASTIC; BIODEGRADABLE PLASTICS; DELAYED-ACTION PREPARATIONS; DOXORUBICIN; DRUG CARRIERS; HEP G2 CELLS; HUMANS; HYDROGEN PEROXIDE; MATERIALS TESTING; MICELLES; NANOPARTICLES;

EID: 84923999222     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2014.09.047     Document Type: Article

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