메뉴 건너뛰기




Volumn 21, Issue 3, 2015, Pages 271-279

Inhibition of G Protein-Coupled Receptor 81 (GPR81) Protects Against Ischemic Brain Injury

Author keywords

Cerebral ischemia; G protein coupled receptor 81; Lactates; Neuroprotection

Indexed keywords

3 HYDROXYBUTYRIC ACID; ADENOSINE TRIPHOSPHATE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 81; MITOGEN ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; ALPHA-RESORCYLIC ACID; CENTRAL NERVOUS SYSTEM AGENTS; G PROTEIN-COUPLED RECEPTOR 81, MOUSE; GLUCOSE; GPR81 PROTEIN, RAT; HYDROXYBENZOIC ACID DERIVATIVE; LACTIC ACID; NEUROPROTECTIVE AGENT; RESORCINOL DERIVATIVE;

EID: 84923991730     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12362     Document Type: Article
Times cited : (72)

References (41)
  • 1
    • 0025368999 scopus 로고
    • Relationship between plasma glucose, brain lactate, and intracellular ph during cerebral ischemia in gerbils
    • Combs DJ, Dempsey RJ, Maley M, Donaldson D, Smith C. Relationship between plasma glucose, brain lactate, and intracellular ph during cerebral ischemia in gerbils. Stroke 1990;21:936-942.
    • (1990) Stroke , vol.21 , pp. 936-942
    • Combs, D.J.1    Dempsey, R.J.2    Maley, M.3    Donaldson, D.4    Smith, C.5
  • 2
    • 71249103087 scopus 로고    scopus 로고
    • Cell-cell and intracellular lactate shuttles
    • Brooks GA. Cell-cell and intracellular lactate shuttles. J Physiol 2009;587:5591-5600.
    • (2009) J Physiol , vol.587 , pp. 5591-5600
    • Brooks, G.A.1
  • 3
    • 59149094602 scopus 로고    scopus 로고
    • Lactate inhibits lipolysis in fat cells through activation of an orphan g-protein-coupled receptor, gpr81
    • Liu C, Wu J, Zhu J, et al. Lactate inhibits lipolysis in fat cells through activation of an orphan g-protein-coupled receptor, gpr81. J Biol Chem 2009;284:2811-2822.
    • (2009) J Biol Chem , vol.284 , pp. 2811-2822
    • Liu, C.1    Wu, J.2    Zhu, J.3
  • 4
    • 56249083891 scopus 로고    scopus 로고
    • Role of gpr81 in lactate-mediated reduction of adipose lipolysis
    • Cai TQ, Ren N, Jin L, et al. Role of gpr81 in lactate-mediated reduction of adipose lipolysis. Biochem Biophys Res Commun 2008;377:987-991.
    • (2008) Biochem Biophys Res Commun , vol.377 , pp. 987-991
    • Cai, T.Q.1    Ren, N.2    Jin, L.3
  • 5
    • 84861851015 scopus 로고    scopus 로고
    • Is lactate a volume transmitter of metabolic states of the brain?
    • Bergersen LH, Gjedde A. Is lactate a volume transmitter of metabolic states of the brain? Front Neuroenergetics 2012;4:5.
    • (2012) Front Neuroenergetics , vol.4 , pp. 5
    • Bergersen, L.H.1    Gjedde, A.2
  • 6
    • 84929046195 scopus 로고    scopus 로고
    • Lactate receptor sites link neurotransmission, neurovascular coupling, and brain energy metabolism
    • Lauritzen KH, Morland C, Puchades M, et al. Lactate receptor sites link neurotransmission, neurovascular coupling, and brain energy metabolism. Cereb Cortex 2014;24:2784-2795.
    • (2014) Cereb Cortex , vol.24 , pp. 2784-2795
    • Lauritzen, K.H.1    Morland, C.2    Puchades, M.3
  • 7
    • 77950361981 scopus 로고    scopus 로고
    • Adipose tissue lipolysis revisited (again!): Lactate involvement in insulin antilipolytic action
    • Langin D. Adipose tissue lipolysis revisited (again!): Lactate involvement in insulin antilipolytic action. Cell Metab 2010;11:242-243.
    • (2010) Cell Metab , vol.11 , pp. 242-243
    • Langin, D.1
  • 8
    • 77950261397 scopus 로고    scopus 로고
    • An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through gpr81
    • Ahmed K, Tunaru S, Tang C, et al. An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through gpr81. Cell Metab 2010;11:311-319.
    • (2010) Cell Metab , vol.11 , pp. 311-319
    • Ahmed, K.1    Tunaru, S.2    Tang, C.3
  • 9
    • 0029100904 scopus 로고
    • Effects of intermittent reperfusion on brain phi, rcbf, and nadh during rabbit focal cerebral ischemia
    • Regli L, Anderson RE, Meyer FB. Effects of intermittent reperfusion on brain phi, rcbf, and nadh during rabbit focal cerebral ischemia. Stroke 1995;26:1444-1451.
    • (1995) Stroke , vol.26 , pp. 1444-1451
    • Regli, L.1    Anderson, R.E.2    Meyer, F.B.3
  • 10
    • 84892745179 scopus 로고    scopus 로고
    • Optogenetic countering of glial acidosis suppresses glial glutamate release and ischemic brain damage
    • Beppu K, Sasaki T, Tanaka KF, et al. Optogenetic countering of glial acidosis suppresses glial glutamate release and ischemic brain damage. Neuron 2014;81:314-320.
    • (2014) Neuron , vol.81 , pp. 314-320
    • Beppu, K.1    Sasaki, T.2    Tanaka, K.F.3
  • 11
    • 77953133213 scopus 로고    scopus 로고
    • Acid-sensing ion channels in acidosis-induced injury of human brain neurons
    • Li M, Inoue K, Branigan D, et al. Acid-sensing ion channels in acidosis-induced injury of human brain neurons. J Cereb Blood Flow Metab 2010;30:1247-1260.
    • (2010) J Cereb Blood Flow Metab , vol.30 , pp. 1247-1260
    • Li, M.1    Inoue, K.2    Branigan, D.3
  • 12
    • 33845897638 scopus 로고    scopus 로고
    • Prolonged activation of asic1a and the time window for neuroprotection in cerebral ischaemia
    • Pignataro G, Simon RP, Xiong ZG. Prolonged activation of asic1a and the time window for neuroprotection in cerebral ischaemia. Brain 2007;130:151-158.
    • (2007) Brain , vol.130 , pp. 151-158
    • Pignataro, G.1    Simon, R.P.2    Xiong, Z.G.3
  • 13
    • 79960024474 scopus 로고    scopus 로고
    • Heteromeric acid-sensing ion channels (asics) composed of asic2b and asic1a display novel channel properties and contribute to acidosis-induced neuronal death
    • Sherwood TW, Lee KG, Gormley MG, Askwith CC. Heteromeric acid-sensing ion channels (asics) composed of asic2b and asic1a display novel channel properties and contribute to acidosis-induced neuronal death. J Neurosci 2011;31:9723-9734.
    • (2011) J Neurosci , vol.31 , pp. 9723-9734
    • Sherwood, T.W.1    Lee, K.G.2    Gormley, M.G.3    Askwith, C.C.4
  • 14
    • 4544230902 scopus 로고    scopus 로고
    • Neuroprotection in ischemia: Blocking calcium-permeable acid-sensing ion channels
    • Xiong ZG, Zhu XM, Chu XP, et al. Neuroprotection in ischemia: Blocking calcium-permeable acid-sensing ion channels. Cell 2004;118:687-698.
    • (2004) Cell , vol.118 , pp. 687-698
    • Xiong, Z.G.1    Zhu, X.M.2    Chu, X.P.3
  • 15
    • 35548957889 scopus 로고    scopus 로고
    • Astrocyte metabolism and signaling during brain ischemia
    • Rossi DJ, Brady JD, Mohr C. Astrocyte metabolism and signaling during brain ischemia. Nat Neurosci 2007;10:1377-1386.
    • (2007) Nat Neurosci , vol.10 , pp. 1377-1386
    • Rossi, D.J.1    Brady, J.D.2    Mohr, C.3
  • 16
    • 84874397791 scopus 로고    scopus 로고
    • Intracellular lactate signaling cascade in atrial remodeling of mitral valvular patients with atrial fibrillation
    • Xu J, Xu X, Si L, et al. Intracellular lactate signaling cascade in atrial remodeling of mitral valvular patients with atrial fibrillation. J Cardiothorac Surg 2013;8:34.
    • (2013) J Cardiothorac Surg , vol.8 , pp. 34
    • Xu, J.1    Xu, X.2    Si, L.3
  • 17
    • 20144367962 scopus 로고    scopus 로고
    • Lactate induces tumour necrosis factor-alpha, interleukin-6 and interleukin-1beta release in microglial- and astroglial-enriched primary cultures
    • Andersson AK, Ronnback L, Hansson E. Lactate induces tumour necrosis factor-alpha, interleukin-6 and interleukin-1beta release in microglial- and astroglial-enriched primary cultures. J Neurochem 2005;93:1327-1333.
    • (2005) J Neurochem , vol.93 , pp. 1327-1333
    • Andersson, A.K.1    Ronnback, L.2    Hansson, E.3
  • 19
    • 0027742942 scopus 로고
    • Brain acidosis induced by hypercarbic ventilation attenuates focal ischemic injury
    • Simon RP, Niro M, Gwinn R. Brain acidosis induced by hypercarbic ventilation attenuates focal ischemic injury. J Pharmacol Exp Ther 1993;267:1428-1431.
    • (1993) J Pharmacol Exp Ther , vol.267 , pp. 1428-1431
    • Simon, R.P.1    Niro, M.2    Gwinn, R.3
  • 21
    • 84868686002 scopus 로고    scopus 로고
    • New evidence of neuroprotection by lactate after transient focal cerebral ischaemia: Extended benefit after intracerebroventricular injection and efficacy of intravenous administration
    • Berthet C, Castillo X, Magistretti PJ, Hirt L. New evidence of neuroprotection by lactate after transient focal cerebral ischaemia: Extended benefit after intracerebroventricular injection and efficacy of intravenous administration. Cerebrovasc Dis 2012;34:329-335.
    • (2012) Cerebrovasc Dis , vol.34 , pp. 329-335
    • Berthet, C.1    Castillo, X.2    Magistretti, P.J.3    Hirt, L.4
  • 22
    • 79960407068 scopus 로고    scopus 로고
    • Monocarboxylate transporter 2 and stroke severity in a rodent model of sleep apnea
    • Wang Y, Guo SZ, Bonen A, et al. Monocarboxylate transporter 2 and stroke severity in a rodent model of sleep apnea. J Neurosci 2011;31:10241-10248.
    • (2011) J Neurosci , vol.31 , pp. 10241-10248
    • Wang, Y.1    Guo, S.Z.2    Bonen, A.3
  • 23
    • 84864322389 scopus 로고    scopus 로고
    • Acidic preconditioning protects against ischemia-induced brain injury
    • Zhang CH, Fan YY, Wang XF, et al. Acidic preconditioning protects against ischemia-induced brain injury. Neurosci Lett 2012;523:3-8.
    • (2012) Neurosci Lett , vol.523 , pp. 3-8
    • Zhang, C.H.1    Fan, Y.Y.2    Wang, X.F.3
  • 24
    • 84895074765 scopus 로고    scopus 로고
    • A novel neuroprotective strategy for ischemic stroke: Transient mild acidosis treatment by co inhalation at reperfusion
    • Fan YY, Shen Z, He P, et al. A novel neuroprotective strategy for ischemic stroke: Transient mild acidosis treatment by co inhalation at reperfusion. J Cereb Blood Flow Metab 2014;34:275-283.
    • (2014) J Cereb Blood Flow Metab , vol.34 , pp. 275-283
    • Fan, Y.Y.1    Shen, Z.2    He, P.3
  • 25
    • 78650876625 scopus 로고    scopus 로고
    • Activation of the central histaminergic system is involved in hypoxia-induced stroke tolerance in adult mice
    • Fan YY, Hu WW, Dai HB, et al. Activation of the central histaminergic system is involved in hypoxia-induced stroke tolerance in adult mice. J Cereb Blood Flow Metab 2011;31:305-314.
    • (2011) J Cereb Blood Flow Metab , vol.31 , pp. 305-314
    • Fan, Y.Y.1    Hu, W.W.2    Dai, H.B.3
  • 26
    • 84871394209 scopus 로고    scopus 로고
    • Transient lack of glucose but not o2 is involved in ischemic postconditioning-induced neuroprotection
    • Fan YY, Zhang XN, He P, et al. Transient lack of glucose but not o2 is involved in ischemic postconditioning-induced neuroprotection. CNS Neurosci Ther 2013;19:30-37.
    • (2013) CNS Neurosci Ther , vol.19 , pp. 30-37
    • Fan, Y.Y.1    Zhang, X.N.2    He, P.3
  • 27
    • 34548695678 scopus 로고    scopus 로고
    • Quantitative colocalization analysis of multicolor confocal immunofluorescence microscopy images: Pushing pixels to explore biological phenomena
    • Zinchuk V, Zinchuk O, Okada T. Quantitative colocalization analysis of multicolor confocal immunofluorescence microscopy images: Pushing pixels to explore biological phenomena. Acta Histochem Cytochem 2007;40:101-111.
    • (2007) Acta Histochem Cytochem , vol.40 , pp. 101-111
    • Zinchuk, V.1    Zinchuk, O.2    Okada, T.3
  • 29
    • 84861559049 scopus 로고    scopus 로고
    • 3,5-dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes
    • Liu C, Kuei C, Zhu J, et al. 3, 5-dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes. J Pharmacol Exp Ther 2012;341:794-801.
    • (2012) J Pharmacol Exp Ther , vol.341 , pp. 794-801
    • Liu, C.1    Kuei, C.2    Zhu, J.3
  • 30
    • 85027955324 scopus 로고    scopus 로고
    • Mitochondrial dysfunction as a mediator of hippocampal apoptosis in a model of hepatic encephalopathy
    • Bustamante J, Lores-Arnaiz S, Tallis S, et al. Mitochondrial dysfunction as a mediator of hippocampal apoptosis in a model of hepatic encephalopathy. Mol Cell Biochem 2011;354:231-240.
    • (2011) Mol Cell Biochem , vol.354 , pp. 231-240
    • Bustamante, J.1    Lores-Arnaiz, S.2    Tallis, S.3
  • 31
    • 79956257759 scopus 로고    scopus 로고
    • Protective effects of d-3-hydroxybutyrate and propionate during hypoglycemic coma: Clinical and biochemical insights from infant rats
    • Schutz PW, Struys EA, Sinclair G, Stockler S. Protective effects of d-3-hydroxybutyrate and propionate during hypoglycemic coma: Clinical and biochemical insights from infant rats. Mol Genet Metab 2011;103:179-184.
    • (2011) Mol Genet Metab , vol.103 , pp. 179-184
    • Schutz, P.W.1    Struys, E.A.2    Sinclair, G.3    Stockler, S.4
  • 32
    • 33846910806 scopus 로고    scopus 로고
    • Is lactate food for neurons? Comparison of monocarboxylate transporter subtypes in brain and muscle
    • Bergersen LH. Is lactate food for neurons? Comparison of monocarboxylate transporter subtypes in brain and muscle. Neuroscience 2007;145:11-19.
    • (2007) Neuroscience , vol.145 , pp. 11-19
    • Bergersen, L.H.1
  • 33
    • 0037423066 scopus 로고    scopus 로고
    • Cooperative expression of survival p-ERK and p-Akt signals in rat brain neurons after transient MCAO
    • Li F, Omori N, Jin G, et al. Cooperative expression of survival p-ERK and p-Akt signals in rat brain neurons after transient MCAO. Brain Res 2003;962:21-26.
    • (2003) Brain Res , vol.962 , pp. 21-26
    • Li, F.1    Omori, N.2    Jin, G.3
  • 34
    • 0019815904 scopus 로고
    • Brain lactic acidosis and ischemic cell damage: 1. Biochemistry and neurophysiology
    • Rehncrona S, Rosen I, Siesjo BK. Brain lactic acidosis and ischemic cell damage: 1. Biochemistry and neurophysiology. J Cereb Blood Flow Metab 1981;1:297-311.
    • (1981) J Cereb Blood Flow Metab , vol.1 , pp. 297-311
    • Rehncrona, S.1    Rosen, I.2    Siesjo, B.K.3
  • 35
    • 23144443656 scopus 로고    scopus 로고
    • Relationship between cerebral blood flow and oxygen metabolism, and extracellular glucose and lactate concentrations during middle cerebral artery occlusion and reperfusion: A microdialysis and positron emission tomography study in nonhuman primates
    • Frykholm P, Hillered L, Langstrom B, Persson L, Valtysson J, Enblad P. Relationship between cerebral blood flow and oxygen metabolism, and extracellular glucose and lactate concentrations during middle cerebral artery occlusion and reperfusion: A microdialysis and positron emission tomography study in nonhuman primates. J Neurosurg 2005;102:1076-1084.
    • (2005) J Neurosurg , vol.102 , pp. 1076-1084
    • Frykholm, P.1    Hillered, L.2    Langstrom, B.3    Persson, L.4    Valtysson, J.5    Enblad, P.6
  • 36
    • 0036673386 scopus 로고    scopus 로고
    • Lactate, glucose and energy metabolism in the ischemic brain (review)
    • Schurr A. Lactate, glucose and energy metabolism in the ischemic brain (review). Int J Mol Med 2002;10:131-136.
    • (2002) Int J Mol Med , vol.10 , pp. 131-136
    • Schurr, A.1
  • 37
  • 38
    • 0029312416 scopus 로고
    • Hypoglycemia prevents increase in lactic acidosis during reperfusion after temporary cerebral ischemia in rats
    • Sappey-Marinier D, Chileuitt L, Weiner MW, Faden AI, Weinstein PR. Hypoglycemia prevents increase in lactic acidosis during reperfusion after temporary cerebral ischemia in rats. NMR Biomed 1995;8:171-178.
    • (1995) NMR Biomed , vol.8 , pp. 171-178
    • Sappey-Marinier, D.1    Chileuitt, L.2    Weiner, M.W.3    Faden, A.I.4    Weinstein, P.R.5
  • 39
    • 77957593752 scopus 로고    scopus 로고
    • Neurons and neuronal stem cells survive in glucose-free lactate and in high glucose cell culture medium during normoxia and anoxia
    • Wohnsland S, Burgers HF, Kuschinsky W, Maurer MH. Neurons and neuronal stem cells survive in glucose-free lactate and in high glucose cell culture medium during normoxia and anoxia. Neurochem Res 2010;35:1635-1642.
    • (2010) Neurochem Res , vol.35 , pp. 1635-1642
    • Wohnsland, S.1    Burgers, H.F.2    Kuschinsky, W.3    Maurer, M.H.4
  • 40
    • 84906876273 scopus 로고    scopus 로고
    • The collective therapeutic potential of cerebral ketone metabolism in traumatic brain injury
    • [Epub ahead of print]
    • Prins M, Matsumoto J. The collective therapeutic potential of cerebral ketone metabolism in traumatic brain injury. J Lipid Res. DOI: 10.1194/jlr.R046706. [Epub ahead of print]
    • J Lipid Res
    • Prins, M.1    Matsumoto, J.2
  • 41
    • 71849093751 scopus 로고    scopus 로고
    • Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia
    • Niizuma K, Yoshioka H, Chen H, et al. Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia. Biochim Biophys Acta 2010;1802:92-99.
    • (2010) Biochim Biophys Acta , vol.1802 , pp. 92-99
    • Niizuma, K.1    Yoshioka, H.2    Chen, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.