Synthetic chemically modified mRNA-based delivery of cytoprotective factor promotes early cardiomyocyte survival post-acute myocardial infarction

Molecular Pharmaceutics

Volumn 12, Issue 3, 2015, Pages 991-996

  Huang, Chien Ling ^a   Leblond, Anne Laure ^a   Turner, Elizebeth C ^a   Kumar, Arun Hs ^a   Martin, Kenneth ^a   Whelan, Derek ^a   O'Sullivan, Donnchadh M ^a   Caplice, Noel M ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

cytoprotective; insulin like growth factor 1; modified mRNA; myocardial infarction

Indexed keywords

MESSENGER RNA; MICRORNA; MICRORNA 1; MICRORNA 133; MICRORNA 145; MITOGEN ACTIVATED PROTEIN KINASE; MODIFIED MRNA; PROTEIN KINASE B; SOMATOMEDIN C; UNCLASSIFIED DRUG; GREEN FLUORESCENT PROTEIN; NANOPARTICLE; POLYETHYLENEIMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; ENZYME PHOSPHORYLATION; EXPERIMENTAL MYOCARDIAL INFARCTION; HEART MUSCLE CELL; IN VIVO STUDY; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSIENT TRANSFECTION; ANIMAL; C57BL MOUSE; CARDIAC MUSCLE CELL; CELL LINE; CHEMISTRY; DRUG DELIVERY SYSTEM; GENE TRANSFER; GENETIC TRANSFECTION; GENETICS; METABOLISM; MYOCARDIAL INFARCTION; PATHOLOGY; PHARMACEUTICS;

ANIMALS; BIOPHARMACEUTICS; CELL LINE; CELL SURVIVAL; CYTOPROTECTION; DRUG DELIVERY SYSTEMS; GENE TRANSFER TECHNIQUES; GREEN FLUORESCENT PROTEINS; INSULIN-LIKE GROWTH FACTOR I; MICE; MICE, INBRED C57BL; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; NANOPARTICLES; POLYETHYLENEIMINE; RNA, MESSENGER; TRANSFECTION;

EID: 84923934691     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp5006239     Document Type: Article

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