Far-red-absorbing cationic phthalocyanine photosensitizers: Synthesis and evaluation of the photodynamic anticancer activity and the mode of cell death induction

Journal of Medicinal Chemistry

Volumn 58, Issue 4, 2015, Pages 1736-1749

  Machacek, Miloslav ^a   Cidlina, Antonin ^a   Novakova, Veronika ^a   Svec, Jan ^a   Rudolf, Emil ^b   Miletin, Miroslav ^a   Kučera, Radim ^a   Simunek, Tomas ^a   Zimcik, Petr ^a  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; PHOTOSENSITIZING AGENT; PHTHALOCYANINE; ZINC COMPLEX; ANTINEOPLASTIC AGENT; INDOLE DERIVATIVE; MAGNESIUM; ORGANOMETALLIC COMPOUND; ZINC;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL DEATH; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME ACTIVITY; FLOW CYTOMETRY; HELA CELL LINE; IC50; LYSOSOME; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PHOTOPHYSICAL PROPERTY; PHYSICAL PARAMETERS; 3T3 CELL LINE; ANIMAL; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HCT116 CELL LINE; HUMAN; LIGHT; PHOTOCHEMOTHERAPY; RADIATION ABSORPTION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

3T3 CELLS; ABSORPTION, RADIATION; ANIMALS; ANTINEOPLASTIC AGENTS; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HCT116 CELLS; HELA CELLS; HUMANS; INDOLES; LIGHT; MAGNESIUM; MICE; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; STRUCTURE-ACTIVITY RELATIONSHIP; ZINC;

EID: 84923914198     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5014852     Document Type: Article

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