Skeletal muscle adiposity is associated with physical activity, exercise capacity and fibre shift in COPD

European Respiratory Journal

Volumn 44, Issue 5, 2014, Pages 1188-1198

  Maddocks, Matthew ^a   Shrikrishna, Dinesh ^b   Vitoriano, Simone ^a   Natanek, Samantha A ^b   Tanner, Rebecca J ^b   Hart, Nicholas ^c   Kemp, Paul R ^b   Moxham, John ^a   Polkey, Michael I ^b   Hopkinson, Nicholas S ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

^c GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOSE TISSUE; ADULT; AGED; ARTERIAL CARBON DIOXIDE TENSION; ARTICLE; BODY COMPOSITION; BODY MASS; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; INTRAMUSCULAR FAT; MAJOR CLINICAL STUDY; MALE; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; QUADRICEPS FEMORIS MUSCLE; SKELETAL MUSCLE ADIPOSITY; CASE CONTROL STUDY; CHEMISTRY; EXERCISE; EXERCISE TOLERANCE; MIDDLE AGED; MOTOR ACTIVITY; MUSCLE STRENGTH; OBSERVER VARIATION; PATHOPHYSIOLOGY; PHENOTYPE; PHYSIOLOGY; RADIOGRAPHY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SKELETAL MUSCLE;

BIOLOGICAL MARKER; CARBON MONOXIDE;

ADIPOSE TISSUE; ADIPOSITY; AGED; BIOMARKERS; CARBON MONOXIDE; CASE-CONTROL STUDIES; EXERCISE; EXERCISE TOLERANCE; FEMALE; HUMANS; MALE; MIDDLE AGED; MOTOR ACTIVITY; MUSCLE STRENGTH; MUSCLE, SKELETAL; OBSERVER VARIATION; PHENOTYPE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; QUADRICEPS MUSCLE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84923911725     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00066414     Document Type: Article

References (52)

1. Seymour JM, Spruit M, Hopkinson NS, et al. The prevalence of quadriceps weakness in COPD and the relationship with disease severity. Eur Respir J 2010; 36: 81-88.
2. Kelly JL, Elkin SL, Fluxman J, et al. Breathlessness and skeletal muscle weakness in patients undergoing lung health screening in primary care. COPD 2013; 10: 40-54.
3. Watz H, Waschki B, Boehme C, et al. Extrapulmonary effects of chronic obstructive pulmonary disease on physical activity: a cross-sectional study. Am J Respir Crit Care Med 2008; 177: 743-751.
4. Man WD, Soliman M, Nikoletou D, et al. Non-volitional assessment of skeletal muscle strength in patients with chronic obstructive pulmonary disease. Thorax 2003; 58: 665-669.
5. Gosselink R, Troosters T, Decramer M. Peripheral muscle weakness contributes to exercise limitation in COPD. Am J Respir Crit Care Med 1996; 153: 976-980.
6. Shrikrishna D, Patel M, Tanner RJ, et al. Quadriceps wasting and physical inactivity in patients with COPD. Eur Respir J 2012; 40: 1115-1122.
7. Decramer M, Gosselink R, Troosters T, et al. Muscle weakness is related to utilization of health care resources in COPD patients. Eur Respir J 1997; 10: 417-423.
8. Swallow EB, Reyes D, Hopkinson NS, et al. Quadriceps strength predicts mortality in patients with moderate to severe chronic obstructive pulmonary disease. Thorax 2007; 62: 115-120.
9. Shrikrishna D, Hopkinson NS. Chronic obstructive pulmonary disease: consequences beyond the lung. Clin Med 2012; 12: 71-74.
10. Swallow EB, Gosker HR, Ward KA, et al. A novel technique for nonvolitional assessment of quadriceps muscle endurance in humans. J Appl Physiol 2007; 103: 739-746.
11. Gosker HR, Zeegers MP, Wouters EF, et al. Muscle fibre type shifting in the vastus lateralis of patients with COPD is associated with disease severity: a systematic review and meta-analysis. Thorax 2007; 62: 944-949.
12. van dehn Borst B, Slot IG, Hellwig VA, et al. Loss of quadriceps muscle oxidative phenotype and decreased endurance in patients with mild-to-moderate COPD. J Appl Physiol 2013; 114: 1319-1328.
13. Natanek SA, Gosker HR, Slot IG, et al. Heterogeneity of quadriceps muscle phenotype in chronic obstructive pulmonary disease (COPD); implications for stratified medicine? Muscle Nerve 2013; 48: 488-497.
14. Steiner MC, Roubenoff R, Tal-Singer R, et al. Prospects for the development of effective pharmacotherapy targeted at the skeletal muscles in chronic obstructive pulmonary disease: a translational review. Thorax 2012; 67: 1102-1109.
15. Håggmark T, Jansson E, Svane B. Cross-sectional area of the thigh muscle in man measured by computed tomography. Scand J Clin Lab Invest 1978; 38: 355-360.
16. Borkan GA, Hults DE, Gerzof SG, et al. Age changes in body composition revealed by computed tomography. J Gerontol 1983; 38: 673-677.
17. Goodpaster BH, Kelley DE, Thaete FL, et al. Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content. J Appl Physiol 2000; 89: 104-110.
18. Simoneau JA, Colberg SR, Thaete FL, et al. Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women. FASEB J 1995; 9: 273-278.
19. Goodpaster BH, Thaete FL, Simoneau JA, et al. Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes 1997; 46: 1579-1585.
20. Goodpaster BH, Carlson CL, Visser M, et al. Attenuation of skeletal muscle and strength in the elderly: the Health ABC Study. J Appl Physiol 2001; 90: 2157-2165.
21. Visser M, Kritchevsky SB, Goodpaster BH, et al. Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: the health, aging and body composition study. J Am Geriatr Soc 2002; 50: 897-904.
22. Visser M, Goodpaster BH, Kritchevsky SB, et al. Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons. J Gerontol A Biol Sci Med Sci 2005; 60: 324-333.
23. Lang T, Cauley JA, Tylavsky F, et al. Computed tomographic measurements of thigh muscle cross-sectional area and attenuation coefficient predict hip fracture: the health, aging, and body composition study. J Bone Miner Res 2010; 25: 513-519.
24. Vestbo J, Hurd SS, Agustí AG, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2013; 187: 347-365.
25. Natanek SA, Gosker HR, Slot IG, et al. Pathways associated with reduced quadriceps oxidative fibres and endurance in COPD. Eur Respir J 2013; 41: 1275-1283.
26. Mourtzakis M, Prado CM, Lieffers JR, et al. A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care. Appl Physiol Nutr Metab 2008; 33: 997-1006.
27. Irving BA, Weltman JY, Brock DW, et al. NIH ImageJ and Slice-O-Matic computed tomography imaging software to quantify soft tissue. Obesity 2007; 15: 370-376.
28. Strandberg S, Wretling ML, Wredmark T, et al. Reliability of computed tomography measurements in assessment of thigh muscle cross-sectional area and attenuation. BMC Med Imaging 2010; 10: 18.
29. Pallas O, Corominas J, Gea J. Degeneración mixoide en los mu sculos esqueléticos periféricos de pacientes con EPOC grave. Parte de la miopatía periférica? [Is myxoid degeneration in the peripheral skeletal muscles of patients with severe COPD related to peripheral myopathy?]. Arch Bronconeumol 1999; 35: 143.
30. Koechlin C, Maltais F, Saey D, et al. Hypoxaemia enhances peripheral muscle oxidative stress in chronic obstructive pulmonary disease. Thorax 2005; 60: 834-841.
31. Allaire J, Maltais F, LeBlanc P, et al. Lipofuscin accumulation in the vastus lateralis muscle in patients with chronic obstructive pulmonary disease. Muscle Nerve 2002; 25: 383-389.
32. Remels AH, Schrauwen P, Broekhuizen R, et al. Peroxisome proliferator-activated receptor expression is reduced in skeletal muscle in COPD. Eur Respir J 2007; 30: 245-252.
33. Narkar VA, Downes M, Yu RT, et al. AMPK and PPARd agonists are exercise mimetics. Cell 2008; 134: 405-415.
34. Sala E, Roca J, Marrades RM, et al. Effects of endurance training on skeletal muscle bioenergetics in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999; 159: 1726-1734.
35. Lewis A, Riddoch-Contreras J, Natanek SA, et al. Downregulation of the serum response factor/miR-1 axis in the quadriceps of patients with COPD. Thorax 2012; 67: 26-34.
36. Rutten EP, Grydeland TB, Pillai SG, et al. Quantitative CT: associations between emphysema, airway wall thickness and body composition in COPD. Pulm Med 2011; 2011: 419328.
37. Hopkinson NS, Nickol AH, Payne J, et al. Angiotensin converting enzyme genotype and strength in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2004; 170: 395-399.
38. Blomstrand E, Challiss RA, Cooney GJ, et al. Maximal activities of hexokinase, 6-phosphofructokinase, oxoglutarate dehydrogenase, and carnitine palmitoyltransferase in rat and avian muscles. Biosci Rep 1983; 3: 1149-1153.
39. Wang YX, Zhang CL, Yu RT, et al. Regulation of muscle fiber type and running endurance by PPARd. PLoS Biol 2004; 2: e294.
40. Lillioja S, Young AA, Culter CL, et al. Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man. J Clin Invest 1987; 80: 415-424.
41. Oberbach A, Bossenz Y, Lehmann S, et al. Altered fiber distribution and fiber-specific glycolytic and oxidative enzyme activity in skeletal muscle of patients with type 2 diabetes. Diabetes Care 2006; 29: 895-900.
42. Phillips DI, Caddy S, Ilic V, et al. Intramuscular triglyceride and muscle insulin sensitivity: evidence for a relationship in nondiabetic subjects. Metabolism 1996; 45: 947-950.
43. Hegarty BD, Furler SM, Ye J, et al. The role of intramuscular lipid in insulin resistance. Acta Physiol Scand 2003; 178: 373-383.
44. van den Borst B, Gosker HR, Schols AM. Central fat and peripheral muscle: partners in crime in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2013; 187: 8-13.
45. Roig M, Eng JJ, MacIntyre DL, et al. Deficits in muscle strength, mass, quality and mobility in people with chronic obstructive pulmonary disease. J Cardiopulm Rehabil Prev 2011; 31: 120-124.
46. Mathur S, MacIntyre DL, Forster BB, et al. Preservation of eccentric torque of the knee extensors and flexors in patients with COPD. J Cardiopulm Rehabil Prev 2007; 27: 411-416.
47. Shields GS, Coissi GS, Jimenez-Royo P, et al. Bioenergetic abnormailites and intermuscular fat in chronic obstructive pulmonary disease (COPD)-associated quadricpes weakness. Muscle Nerve 2014 [In press DOI: 10.1002/ mus.24289].
48. Seymour JM, Ward K, Sidhu PS, et al. Ultrasound measurement of rectus femoris cross-sectional area and the relationship with quadriceps strength in COPD. Thorax 2009; 64: 418-423.
49. MacDonald AJ, Greig CA, Baracos V. The advantages and limitations of cross-sectional body composition analysis. Curr Opin Support Palliat Care 2011; 5: 342-349.
50. Hudash G, Albright JP, McAuley E, et al. Cross-sectional thigh components: computerized tomographic assessment. Med Sci Sports Exerc 1985; 17: 417-421.
51. Mitsiopoulos N, Baumgartner R, Heymsfield S, et al. Cadaver validation of skeletal muscle measurement by magnetic resonance imaging and computerized tomography. J Appl Physiol 1998; 85: 115-122.
52. Taaffe DR, Henwood TR, Nalls MA, et al. Alterations in muscle attenuation following detraining and retraining in resistance-trained older adults. Gerontology 2009; 55: 217-223.