Evaluating the translational potential of progesterone treatment following transient cerebral ischaemia in male mice

BMC Neuroscience

Volumn 15, Issue 1, 2014, Pages

  Wong, Raymond ^a   Gibson, Claire L ^b   Kendall, David A ^a   Bath, Philip M W ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Co morbid; Functional; Mini pump; Mouse; Progesterone; Stroke

Indexed keywords

PROGESTERONE; NEUROPROTECTIVE AGENT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL WELLBEING; ARTICLE; BODY MASS; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROPROTECTION; NONHUMAN; OSMOTIC MINIPUMP; OVERALL SURVIVAL; SPATIAL LEARNING; SURVIVAL RATE; T-MAZE TEST; TASK PERFORMANCE; TRANSIENT ISCHEMIC ATTACK; TREATMENT RESPONSE; WORKING MEMORY; AGE; ANIMAL; BRAIN; C57BL MOUSE; CEREBRAL ARTERY DISEASE; CONVALESCENCE; DISEASE MODEL; DRUG EFFECTS; DRUG SCREENING; EVALUATION STUDY; HYPERTENSION; ISCHEMIC ATTACK, TRANSIENT; MAZE TEST; MOTOR ACTIVITY; PATHOLOGY; PATHOPHYSIOLOGY; RANDOMIZATION; SEVERITY OF ILLNESS INDEX; SURVIVAL;

AGE FACTORS; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; HYPERTENSION; INFARCTION, MIDDLE CEREBRAL ARTERY; ISCHEMIC ATTACK, TRANSIENT; MALE; MAZE LEARNING; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; PROGESTERONE; RANDOM ALLOCATION; RECOVERY OF FUNCTION; SEVERITY OF ILLNESS INDEX; SURVIVAL ANALYSIS;

EID: 84923879752     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/s12868-014-0131-5     Document Type: Article

References (51)

1. Adamson JBA, Ebrahim S: Is stroke the most common cause of disability? J Stroke Cerebrovasc Dis 2004, 13:171-177.
2. Wolfe C, Rudd T, Beech R: Stroke Services Research: An overview with recommendations for future research. London: The Stroke Association; 1996.
3. Elijovich L, Chong JY: Current and future use of intravenous thrombolysis for acute ischemic stroke. Curr Atherosclerol Rep 2010, 12:316-321.
4. Alkayed NJ, Murphy SJ, Traystman RJ, Hurn PD: Neuroprotective effects of female gonadal steroids in reproductively senescent female rats. Stroke 2000, 31:161-168.
5. Chen J, Chopp M: Neuroprotective effects of progesterone after transient middle cerebral artery occlusion in rat. J Neurol Sci 1999, 171:24-30.
6. Gibson CL, Constantin D, Prior MJ, Bath PMW, Murphy SP: Progesterone supresses the inflammatory response and nitric oxide synthase-2 expression following cerebral ischemia. Exp Neurol 2005, 193:522-530.
7. Gibson CL, Murphy SP: Progesterone enhances functional recovery after middle cerebral artery occlusion in male mice. J Cereb Blood Flow Metab 2004, 24:805-813.
8. Ishrat T, Sayeed I, Atif F, Stein DG: Effects of progesterone administration on infarct volume and functional deficits following permanent focal cerebral ischemia in rats. Brain Res 2009, 1257:94-101.
9. Jiang N, Chopp M, Stein D, Feit H: Progesterone is neuroprotective after transient middle cerebral artery occlusion in male rats. Brain Res 1996, 735:101-107.
10. Kumon Y, Kim SC, Tompkins P, Stevens A, Sakaki S, Loftus CM: Neuroprotective effect of postischemic administration of progesterone in spontaneously hypertensive rats with focal cerebral ischemia. J Neurosurg 2000, 92:848-852.
11. Murphy SJ, Littleton-Kearney MM, Hurn PD: Progesterone administration during reperfusion, but not preischemia alone, reduces injury in ovariectomized rats. J Cerebral Blood Flow Metab 2002, 22:1181-1188.
12. Sayeed I, Parvez S, Wali B, Siemen D, Stein DG: Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism for better neuroprotective effects of allopregnanolone over progesterone. Brain Res 2009, 1263:165-173.
13. Sayeed I, Wali B, Stein DG: Progesterone inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion. Restor Neurol Neurosci 2007, 25:151-159.
14. Gibson CL, Gray LJ, Bath PMW, Murphy SP: Progesterone for the treatment of experimental brain injury; a systematic review. Brain 2008, 131:318-328.
15. Coomber B, Gibson CL: Sustained levels of progesterone prior to the onset of cerebral ischemia are not beneficial to female mice. Brain Res 2010, 1361:124-132.
16. Parker SM, Hurn PD, Murphy SJ: Progesterone and allopregnanolone as neuroprotectants in ischemic ovariectomized mouse brain. J Cereb Blood Flow Metab 2005, 25:S21-S.
17. Cutler SM, VanLandingham JW, Murphy AZ, Stein DG: Slow-release and injected progesterone treatments enhance acute recovery after traumatic brain injury. Pharmacol Biochem Behav 2006, 84:420-428.
18. Karatepe AG, Gunaydin R, Kaya T, Turkmen G: Comorbidity in patients after stroke: impact on functional outcome. J Rehabil Med 2008, 40:831-835.
19. Feigin VL, Lawes CM, Bennett DA, Anderson CS: Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century. Lancet Neurol 2003, 2:43-53.
20. Herman B, Leyten ACM, Vanluijk JH, Frenken C, Decoul A, Schulte BPM: Epidemiology of stroke in Tilburg, the Netherlands. The population-based stroke incidence register: 2. Incidence, initial clinical picture and medical care, and three-week case fatality. Stroke 1982, 13:629-634.
21. Niessen LW, Barendregt JJ, Bonneux L, Koudstaal PJ: Stroke trends in an aging population. Stroke 1993, 24:931-939.
22. Arboix A, Roig H, Rossich R, Martinez EM, Garcia-Eroles L: Differences between hypertensive and non-hypertensive ischemic stroke. Eur J Neurol 2004, 11:687-692.
23. Goldstein LB, Bushnell CCD, Adams RJ, Appel LJ, Braun LT, Chaturvedi S, Creaqer MA, Culebras A, Eckel RH, Hart RG, Hinchey JA, Howard VJ, Jauch EC, Levine SR, Meschia JF, Moore WS, Nixon JV, Pearson TA: Guidelines for the primary prevention of stroke a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2011, 42:517-584.
24. Rodgers A, MacMahon S, Gamble G, Slattery J, Sandercock P, Warlow C: Blood pressure and risk of stroke in patients with cerebrovascular disease. Br Med J 1996, 313:147.
25. Andersen KK, Andersen ZJ, Olsen TS: Predictors of early and late case-fatality in a nationwide Danish Study of 26,818 patients with first-ever ischemic stroke. Stroke 2011, 42:2806-2812.
26. Heuschmann PU, Kolominsky-Rabas PL, Misselwitz B, Hermanek P, Leffmann C, Janzen RW, Rother J, Buecker-Nott HJ, Berger K: Predictors of in-hospital mortality and attributable risks of death after ischemic stroke - the German Stroke Registers Study Group. Arch Intern Med 2004, 164:1761-1768.
27. Wong R, Ray D, Kendall DA: Progesterone pharmacokinetics in the mouse: implications for potential stroke therapy. J Pharm Pharmacol 2012, 64:1614-1620.
28. Pineiro R, Pendlebury ST, Smith S, Flitney D, Blamire AM, Styles P, Matthews PM: Relating MRI changes to motor deficit after ischemic stroke by segmentation of functional motor pathways. Stroke. 2000, 31:672-679.
29. Gibson CL, Coomber B, Murphy SP: Progesterone is neuroprotective following cerebral ischaemia in reproductively ageing female mice. Brain 2011, 134:2125-2133.
30. Wang J, Jiang C, Liu C, Li X, Chen N, Hao Y: Neuroprotective effects of progesterone following stroke in aged rats. Behav Brain Res 2010, 209:119-122.
31. Jiang C, Wang JP, Li X, Liu CL, Chen NN, Hao YJ: Progesterone exerts neuroprotective effects by inhibiting inflammatory response after stroke. Inflamm Res 2009, 58:619-624.
32. Hayakawa K, Mishima K, Irie K, Hazekawa M, Mishima S, Fujioka M, Orito K, Egashira N, Katsurabayashi S, Takasaki K, Iwasaki K, Fujiwara M: Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism. Neuropharmacology 2008, 55:1280-1286.
33. Longa EZ, Weinstein PR, Carlson S, Cummins R: Reversible middle cerebral-artery occlusion without craniectomy in rats. Stroke 1989, 20:84-91.
34. Clark W, Gunion-Rinker L, Lessov N, Hazel K: Citicoline treatment for experimental intracerebral hemorrhage in mice. Stroke 1998, 29:2136-2139.
35. Gerlai R, Henderson JT, Roder JC, Jia ZP: Multiple behavioral anomalies in GluR2 mutant mice exhibiting enhanced LTP. Behav Brain Res 1998, 95:37-45.
36. Gerlai R, Thibodeaux H, Palmer JT, Campagne MV, Van Bruggen N: Transient focal cerebral ischemia induces sensorimotor deficits in mice. Behav Brain Res 2000, 108:63-71.
37. Ishibashi S, Kuroiwa T, Endo S, Okeda R, Mizusawa H: Neurological dysfunctions versus regional infarction volume after focal ischemia in Mongolian gerbils. Stroke 2003, 34:1501-1506.
38. Itoh J, Ukai M, Kameyama T: U-50,488H, a kappa-opioid receptor agonist, markedly prevents memory dysfunctions induced by transient cerebral-ischemia in mice. Brain Res 1993, 619:223-228.
39. Kadam SD, Mulholland JD, Smith DR, Johnston MV, Comi AM: Chronic brain injury and behavioral impairments in a mouse model of term neonatal strokes. Behav Brain Res 2009, 197:77-83.
40. Matchett GA, Calinisan JB, Matchett GC, Martin RD, Zhang JH: The effect of granulocyte-colony stimulating factor in global cerebral ischemia in rats. Brain Research 2007, 1136:200-207.
41. Carloni S, Perrone S, Buonocore G, Longini M, Proietti F, Balduini W: Melatonin protects from the long-term consequences of a neonatal hypoxic-ischemic brain injury in rats. J Pineal Res 2008, 44:157-164.
42. Zhang L, Schallert T, Zhang ZG, Jiang Q, Arniego P, Li QJ, Lu M, Chopp M: A test for detecting long-term sensorimotor dysfunction in the mouse after focal cerebral ischemia. J Neurosci Methods 2002, 117:207-214.
43. Liu A, Margaill I, Zhang S, Labombarda F, Coqueran B, Delespierre B, Liere P, Marchand-Leroux C, O'Malley BW, Lydon JP, De Nicola AF, Sitruk-Ware R, Mattern C, Plotkine M, Schumacher M, Guennoun R: Progesterone receptors: a key for neuroprotection in experimental stroke. Endocrinology 2012, 153:3747-3757.
44. Murphy SJ, Traystman RJ, Hurn PD: Progesterone exacerbates striatal stroke injury in progesterone deficient female animals. Stroke 2000, 31:1173-1178.
45. Wang RY, Wang PSG, Yang YR: Effect of age in rats following middle cerebral artery occlusion. Gerontology 2003, 49:27-32.
46. Toung TJ, Chen T-Y, Littleton-Kearney MT, Hurn PD, Murphy SJ: Effects of combined estrogen and progresterone on brain infarction in reproductively senescent female rats. J Cereb Blood Flow Metab 2004, 24:1160-1166.
47. Jacob SW, de la Torre JC: Pharmacology of dimethyl sulfoxide in cardiac and CNS damage. Pharmacol Rep 2009, 61:225-235.
48. Bath PMW, Gray LJ, Bath AJG, Buchan AM, Miyata T, Green AR: Effects of NXY-059 in experimental stroke: an individual animal meta-analysis. Br J Pharmacol 2009, 157:1157-1171.
49. Perez AP, Munoz JY, Cortes VB, Velasco PD: Obesity and cardiovascular disease. Public Health Nutr 2007, 10:1156-1163.
50. Goldstein LB, Adams R, Becker K, Furberg CD, Gorelick PB, Hademenos G, Hill M, Howard G, Howard VJ, Jacobs B, Levine SR, Mosca L, Sacco RL, Sherman DG, Wolf PA, del Zoppo GJ: Primary prevention of ischemic stroke: a statement for healthcare professionals from the Stroke Council of the American Heart Association. Circulation 2001, 103:163-182.
51. Appelros P, Stegmayr B, Terent A: Sex differences in stroke epidemiology a systematic review. Stroke 2009, 40:1082-1090.