Randomized trial of glucosamine and chondroitin supplementation on inflammation and oxidative stress biomarkers and plasma proteomics profiles in healthy humans

PLoS ONE

Volumn 10, Issue 2, 2015, Pages

  Navarro, Sandi L ^a   White, Emily ^a   Kantor, Elizabeth D ^b   Zhang, Yuzheng ^a   Rho, Junghyun ^a   Song, Xiaoling ^a   Milne, Ginger L ^c   Lampe, Paul D ^a   Lampe, Johanna W ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; CHONDROITIN SULFATE; GLUCOSAMINE; INTERLEUKIN 6; ISOPROSTANE DERIVATIVE; PLACEBO; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; ANTIINFLAMMATORY AGENT; CHONDROITIN; PLASMA PROTEIN;

ABSENCE OF SIDE EFFECTS; ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG RESPONSE; FEMALE; HUMAN; INFLAMMATION; MALE; OBESITY; OXIDATIVE STRESS; PATIENT COMPLIANCE; PROTEIN BLOOD LEVEL; PROTEOMICS; RANDOMIZED CONTROLLED TRIAL; SUPPLEMENTATION; ADVERSE EFFECTS; BLOOD; DIETARY SUPPLEMENT; DRUG EFFECTS; METABOLISM; MIDDLE AGED; NORMAL HUMAN;

ANIMALIA;

ADULT; ANTI-INFLAMMATORY AGENTS; BIOMARKERS; BLOOD PROTEINS; CHONDROITIN; DIETARY SUPPLEMENTS; FEMALE; GLUCOSAMINE; HEALTHY VOLUNTEERS; HUMANS; MALE; MIDDLE AGED; OVERWEIGHT; OXIDATIVE STRESS;

EID: 84923876483     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0117534     Document Type: Article

References (51)

1. Qato DM, Alexander GC, Conti RM, Johnson M, Schumm P, et al. (2008) Use of prescription and over-the-counter medications and dietary supplements among older adults in the United States. JAMA 300: 2867-2878. doi: 10.1001/jama.2008.892 PMID: 19109115
2. Jordan KM, Arden NK, Doherty M, Bannwarth B, Bijlsma JW, et al. (2003) EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis 62: 1145-1155. PMID: 14644851
3. Zhang W, Moskowitz RW, Nuki G, Abramson S, Altman RD, et al. (2008) OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage 16: 137-162. doi: 10.1016/j.joca.2007.12.013 PMID: 18279766
4. Satia JA, Littman A, Slatore CG, Galanko JA, White E (2009) Associations of herbal and specialty supplements with lung and colorectal cancer risk in the VITamins and Lifestyle study. Cancer Epidemiol Biomarkers Prev 18: 1419-1428. doi: 10.1158/1055-9965.EPI-09-0038 PMID: 19423520
5. Pocobelli G, Kristal AR, Patterson RE, Potter JD, Lampe JW, et al. (2010) Total mortality risk in relation to use of less-common dietary supplements. Am J Clin Nutr 91: 1791-1800. doi: 10.3945/ajcn.2009. 28639 PMID: 20410091
6. Bell GA, Kantor ED, Lampe JW, Shen DD, White E (2012) Use of glucosamine and chondroitin in relation to mortality. Eur J Epidemiol 27: 593-603. doi: 10.1007/s10654-012-9714-6 PMID: 22828954
7. Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420: 860-867. PMID: 12490959
8. Bartsch H, Nair J (2006) Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair. Langenbecks Arch Surg 391: 499-510. PMID: 16909291
9. Tudek B, Speina E (2012) Oxidatively damaged DNA and its repair in colon carcinogenesis. Mutat Res 736: 82-92. doi: 10.1016/j.mrfmmm.2012.04.003 PMID: 22561673
10. Iovu M, Dumais G, du Souich P (2008) Anti-inflammatory activity of chondroitin sulfate. Osteoarthritis Cartilage 16 Suppl 3: S14-18. doi: 10.1016/j.joca.2008.06.008 PMID: 18667340
11. Largo R, Alvarez-Soria MA, Diez-Ortego I, Calvo E, Sanchez-Pernaute O, et al. (2003) Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes. Osteoarthritis Cartilage 11: 290-298. PMID: 12681956
12. Chan PS, Caron JP, OrthMW(2006) Short-term gene expression changes in cartilage explants stimulated with interleukin beta plus glucosamine and chondroitin sulfate. J Rheumatol 33: 1329-1340. PMID: 16821268
13. Bak YK, Lampe JW, Sung MK (2014) Dietary supplementation of glucosamine sulfate attenuates intestinal inflammation in a mouse model of experimental colitis. J Gastroenterol Hepatol 29: 957-963. doi: 10.1111/jgh.12485 PMID: 24325781
14. Kantor ED, Lampe JW, Vaughan TL, Peters U, Rehm CD, et al. (2012) Association between use of specialty dietary supplements and C-reactive protein concentrations. Am J Epidemiol 176: 1002-1013. doi: 10.1093/aje/kws186 PMID: 23139249
15. Kantor ED, Ulrich CM, Owen RW, Schmezer P, Neuhouser ML, et al. (2013) Specialty supplement use and biologic measures of oxidative stress and DNA damage. Cancer Epidemiol Biomarkers Prev 22: 2312-2322. doi: 10.1158/1055-9965.EPI-13-0470 PMID: 23917455
16. Herder C, Schneitler S, Rathmann W, Haastert B, Schneitler H, et al. (2007) Low-grade inflammation, obesity, and insulin resistance in adolescents. J Clin Endocrinol Metab 92: 4569-4574. PMID: 17911172
17. Fenkci S, Rota S, Sabir N, Sermez Y, Guclu A, et al. (2006) Relationship of serum interleukin-6 and tumor necrosis factor alpha levels with abdominal fat distribution evaluated by ultrasonography in overweight or obese postmenopausal women. J Investig Med 54: 455-460. PMID: 17169269
18. Uwe S (2008) Anti-inflammatory interventions of NF-kappaB signaling: potential applications and risks. Biochem Pharmacol 75: 1567-1579. PMID: 18070616
19. Aziz N, Fahey JL, Detels R, Butch AW (2003) Analytical performance of a highly sensitive C-reactive protein-based immunoassay and the effects of laboratory variables on levels of protein in blood. Clin Diagn Lab Immunol 10: 652-657. PMID: 12853400
20. Navarro SL, Brasky TM, Schwarz Y, Song X, Wang CY, et al. (2012) Reliability of serum biomarkers of inflammation from repeated measures in healthy individuals. Cancer Epidemiol Biomarkers Prev 21: 1167-1170. doi: 10.1158/1055-9965.EPI-12-0110 PMID: 22564866
21. Fitzgerald DW, Bezak K, Ocheretina O, Riviere C, Wright TC, et al. (2012) The effect of HIV and HPV coinfection on cervical COX-2 expression and systemic prostaglandin E2 levels. Cancer Prev Res (Phila) 5: 34-40. doi: 10.1158/1940-6207.CAPR-11-0496 PMID: 22135046
22. Milne GL, Gao B, Terry ES, Zackert WE, Sanchez SC (2013) Measurement of F2- isoprostanes and isofurans using gas chromatography-mass spectrometry. Free Radic Biol Med 59: 36-44. doi: 10. 1016/j.freeradbiomed.2012.09.030 PMID: 23044261
23. Loch CM, Ramirez AB, Liu Y, Sather CL, Delrow JJ, et al. (2007) Use of high density antibody arrays to validate and discover cancer serum biomarkers. Mol Oncol 1: 313-320. doi: 10.1016/j.molonc.2007. 08.004 PMID: 19383305
24. Rho JH, Lampe PD (2013) High-throughput screening for native autoantigen-autoantibody complexes using antibody microarrays. J Proteome Res 12: 2311-2320. doi: 10.1021/pr4001674 PMID: 23541305
25. Ramirez AB, Loch CM, Zhang Y, Liu Y, Wang X, et al. (2010) Use of a single-chain antibody library for ovarian cancer biomarker discovery. Mol Cell Proteomics 9: 1449-1460. doi: 10.1074/mcp.M900496-MCP200 PMID: 20467042
26. Li CI, Mirus JE, Zhang Y, Ramirez AB, Ladd JJ, et al. (2012) Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study. Breast Cancer Res Treat 135: 611-618. doi: 10.1007/s10549-012-2204-4 PMID: 22903690
27. Ramirez AB, Lampe PD (2010) Discovery and validation of ovarian cancer biomarkers utilizing high density antibody microarrays. Cancer Biomark 8: 293-307. doi: 10.3233/CBM-2011-0215 PMID: 22045360
28. Smyth GK (2005) Limma: linear models for microarray data. In: Gentleman R, Carey V, Dudoit S, Irizarry R, Huber I.W, editor. Bioinformatics and Computational Biology Solutions Using R and Bioconductor. New York: Springer. pp. 397-420.
29. Smyth GK, Speed T (2003) Normalization of cDNA microarray data. Methods 31: 265-273. PMID: 14597310
30. Kanehisa M, Goto S, Sato Y, Kawashima M, Furumichi M, et al. (2014) Data, information, knowledge and principle: back to metabolism in KEGG. Nucleic Acids Res 42: D199-205. doi: 10.1093/nar/ gkt1076 PMID: 24214961
31. Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, et al. (2000) Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 25: 25-29. PMID: 10802651
32. Pahl HL (1999) Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 18: 6853-6866. PMID: 10602461
33. Largo R, Martinez-Calatrava MJ, Sanchez-Pernaute O, Marcos ME, Moreno-Rubio J, et al. (2009) Effect of a high dose of glucosamine on systemic and tissue inflammation in an experimental model of atherosclerosis aggravated by chronic arthritis. Am J Physiol Heart Circ Physiol 297: H268-276. doi: 10.1152/ajpheart.00142.2009 PMID: 19411287
34. Azuma K, Osaki T, Wakuda T, Tsuka T, Imagawa T, et al. (2012) Suppressive effects of N-acetyl-Dglucosamine on rheumatoid arthritis mouse models. Inflammation 35: 1462-1465. doi: 10.1007/ s10753-012-9459-0 PMID: 22434264
35. Yomogida S, Kojima Y, Tsutsumi-Ishii Y, Hua J, Sakamoto K, et al. (2008) Glucosamine, a naturally occurring amino monosaccharide, suppresses dextran sulfate sodium-induced colitis in rats. Int J Mol Med 22: 317-323. PMID: 18698490
36. Beauchemin N, Arabzadeh A (2013) Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis. Cancer Metastasis Rev 32: 643-671. doi: 10.1007/ s10555-013-9444-6 PMID: 23903773
37. Kantor ED, Lampe JW, Navarro SL, Song X, Milne GL, et al. (2014) Associations between glucosamine and chondroitin supplement use and biomarkers of systemic inflammation. J Altern Complement Med 20: 479-485. doi: 10.1089/acm.2013.0323 PMID: 24738579
38. Yin H, Gao L, Tai HH, Murphey LJ, Porter NA, et al. (2007) Urinary prostaglandin F2alpha is generated from the isoprostane pathway and not the cyclooxygenase in humans. J Biol Chem 282: 329-336. PMID: 17107953
39. Nakamura H, Nishioka K (2002) Effects of glucosamine/chondroitin supplement on osteoarthritis: Involvement of PGE2 and YKL-40. J Rheumatism Joint Surgery 21: 175-184.
40. Nakamura H, Masuko K, Yudoh K, Kato T, Kamada T, et al. (2007) Effects of glucosamine administration on patients with rheumatoid arthritis. Rheumatol Int 27: 213-218. PMID: 16953394
41. Rawlings JS, Rosler KM, Harrison DA (2004) The JAK/STAT signaling pathway. J Cell Sci 117: 1281-1283. PMID: 15020666
42. Cerutti A, Rescigno M (2008) The biology of intestinal immunoglobulin A responses. Immunity 28: 740-750. doi: 10.1016/j.immuni.2008.05.001 PMID: 18549797
43. Muller WA (2011) Mechanisms of leukocyte transendothelial migration. Annu Rev Pathol 6: 323-344. doi: 10.1146/annurev-pathol-011110-130224 PMID: 21073340
44. Kroeze WK, Sheffler DJ, Roth BL (2003) G-protein-coupled receptors at a glance. J Cell Sci 116: 4867-4869. PMID: 14625380
45. Mukhtar E, Adhami VM, Mukhtar H (2014) Targeting microtubules by natural agents for cancer therapy. Mol Cancer Ther 13: 275-284. doi: 10.1158/1535-7163.MCT-13-0791 PMID: 24435445
46. Alberti C (2009) Cytoskeleton structure and dynamic behaviour: quick excursus from basic molecular mechanisms to some implications in cancer chemotherapy. Eur Rev Med Pharmacol Sci 13: 13-21. PMID: 19364082
47. Jordan MA, Wilson L (1998) Microtubules and actin filaments: dynamic targets for cancer chemotherapy. Curr Opin Cell Biol 10: 123-130. PMID: 9484604
48. Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol Cell Proteomics 3: 311-326. PMID: 14718574
49. Zhang Q, Menon R, Deutsch EW, Pitteri SJ, Faca VM, et al. (2008) A mouse plasma peptide atlas as a resource for disease proteomics. Genome Biol 9: R93. doi: 10.1186/gb-2008-9-6-r93 PMID: 18522751
50. Cao R, Zhang Y (2004) SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Mol Cell 15: 57-67. PMID: 15225548
51. Pasini D, Bracken AP, Jensen MR, Lazzerini Denchi E, Helin K (2004) Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J 23: 4061-4071. PMID: 15385962