Delivery of siRNA by MRI-visible nanovehicles to overcome drug resistance in MCF-7/ADR human breast cancer cells

Biomaterials

Volumn 35, Issue 35, 2014, Pages 9495-9507

  Lin, Gan ^a   Zhu, Wencheng ^a   Yang, Li ^a   Wu, Jun ^a   Lin, Bingbing ^a   Xu, Ye ^a   Cheng, Zhuzhong ^a   Xia, Chunchao ^b   Gong, Qiyong ^b   Song, Bin ^b   Ai, Hua ^a,b  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Magnetic resonance imaging; Multidrug resistance; P glycoprotein; Small interfering RNAs; Superparamagnetic iron oxide

Indexed keywords

ALKYLATION; CELLS; CHEMOTHERAPY; CONTROLLED DRUG DELIVERY; DISEASES; GLYCOPROTEINS; IRON OXIDES; LIPOSOMES; MAGNETIC NANOPARTICLES; MAGNETIC RESONANCE IMAGING; MAMMALS; NANOCOMPOSITES; RNA; SCANNING; TARGETED DRUG DELIVERY;

ATP BINDING CASSETTE TRANSPORTERS; HUMAN BREAST CANCER CELLS; IRON OXIDE NANOPARTICLE; MULTIDRUG RESISTANCE; P-GLYCOPROTEIN; SMALL INTERFERING RNA; SMALL INTERFERING RNA (SIRNA); SUPERPARAMAGNETIC IRON OXIDES;

CYTOLOGY;

DOXORUBICIN; MULTIDRUG RESISTANCE PROTEIN; NANOCARRIER; NANOCOMPOSITE; POLYETHYLENEIMINE; SMALL INTERFERING RNA; ANTINEOPLASTIC AGENT; MESSENGER RNA; NANOMATERIAL;

AGAR GEL ELECTROPHORESIS; ALKYLATION; ARTICLE; BREAST CANCER CELL LINE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CRITICAL MICELLE CONCENTRATION; CYTOTOXICITY; DOWN REGULATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MCF 7 CELL LINE; MULTIDRUG RESISTANCE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; ANIMAL; BAGG ALBINO MOUSE; CELL SURVIVAL; CHEMISTRY; DRUG RESISTANCE; FEMALE; GENE SILENCING; GENETICS; METABOLISM; MOLECULAR WEIGHT; MOUSE; NUDE MOUSE;

MUS;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL SURVIVAL; DOWN-REGULATION; DOXORUBICIN; DRUG DELIVERY SYSTEMS; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE SILENCING; HUMANS; MAGNETIC RESONANCE IMAGING; MCF-7 CELLS; MICE; MICE, INBRED BALB C; MICE, NUDE; MOLECULAR WEIGHT; NANOSTRUCTURES; P-GLYCOPROTEIN; POLYETHYLENEIMINE; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84923875235     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.07.049     Document Type: Article

References (53)

1. Gottesman M.M. Mechanisms of cancer drug resistance. Annu Rev Med 2002, 53:615-627.
2. Szakács G., Paterson J.K., Ludwig J.A., Booth-Genthe C., Gottesman M.M. Targeting multidrug resistance in cancer. Nat Rev Drug Discov 2006, 5(3):219-234.
3. Szakács G., Annereau J.P., Lababidi S., Shankavaram U., Arciello A., Bussey K.J., et al. Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells. Cancer Cell 2004, 6(2):129-137.
4. Dean M., Fojo T., Bates S. Tumour stem cells and drug resistance. Nat Rev Cancer 2005, 5(4):275-284.
5. Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998, 391(6669):806-811.
6. Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001, 411(6836):494-498.
7. de Fougerolles A., Vornlocher H.P., Maraganore J., Lieberman J. Interfering with disease: a progress report on siRNA-based therapeutics. Nat Rev Drug Discov 2007, 6(6):443-453.
8. Navarro G., Sawant R.R., Biswas S., Essex S., Tros de Ilarduya C., Torchilin V.P. P-glycoprotein silencing with siRNA delivered by DOPE-modified PEI overcomes doxorubicin resistance in breast cancer cells. Nanomedicine (Lond) 2012, 7(1):65-78.
9. Tekedereli I., Alpay S.N., Akar U., Yuca E., Ayugo-Rodriguez C., Han H.D., et al. Therapeutic silencing of Bcl-2 by systemically administered siRNA nanotherapeutics inhibits tumor growth by autophagy and apoptosis and enhances the efficacy of chemotherapy in orthotopic xenograft models of ER (-) and ER (+) breast cancer. Mol Ther Nucleic Acids 2013, 2:e121.
10. Deng Z.J., Morton S.W., Ben-Akiva E., Dreaden E.C., Shopsowitz K.E., Hammond P.T. Layer-by-layer nanoparticles for systemic codelivery of an anticancer drug and siRNA for potential triple-negative breast cancer treatment. ACS Nano 2013, 7(11):9571-9584.
11. Jokerst J.V., Gambhir S.S. Molecular imaging with theranostic nanoparticles. Acc Chem Res 2011, 44(10):1050-1060.
12. Willmann J.K., van Bruggen N., Dinkelborg L.M., Gambhir S.S. Molecular imaging in drug development. Nat Rev Drug Discov 2008, 7(7):591-607.
13. Lammers T., Aime S., Hennink W.E., Storm G., Kiessling F. Theranostic nanomedicine. Acc Chem Res 2011, 44(10):1029-1038.
14. Smith B.R., Johnson G.A., Groman E.V., Linney E. Magnetic resonance microscopy of mouse embryos. Proc Natl Acad Sci U S A 1994, 91(9):3530-3533.
15. Weissleder R., Mahmood U. Molecular imaging. Radiology 2001, 219(2):316-333.
16. Xie J., Liu G., Eden H.S., Ai H., Chen X. Surface-engineered magnetic nanoparticle platforms for cancer imaging and therapy. Acc Chem Res 2011, 44(10):883-892.
17. Swierczewska M., Liu G., Lee S., Chen X. High-sensitivity nanosensors for biomarker detection. Chem Soc Rev 2012, 41(7):2641-2655.
18. Liu G., Xie J., Zhang F., Wang Z., Luo K., Zhu L., et al. N-Alkyl-PEI-functionalized iron oxide nanoclusters for efficient siRNA delivery. Small 2011, 7(19):2742-2749.
19. Gao L., Xie L., Long X., Wang Z., He C.Y., Chen Z.Y., et al. Efficacy of MRI visible iron oxide nanoparticles in delivering minicircle DNA into liver via intrabiliary infusion. Biomaterials 2013, 34(14):3688-3696.
20. Thomas M., Klibanov A.M. Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells. Proc Natl Acad Sci U S A 2002, 99(23):14640-14645.
21. Jones M., Leroux J. Polymeric micelles - a new generation of colloidal drug carriers. Eur J Pharm Biopharm 1999, 48(2):101-111.
22. 4 (M= Fe, Co, Mn) nanoparticles. JAm Chem Soc 2004, 126(1):273-279.
23. Han M., Lv Q., Tang X.J., Hu Y.L., Xu D.H., Li F.Z., et al. Overcoming drug resistance of MCF-7/ADR cells by altering intracellular distribution of doxorubicin via MVP knockdown with a novel siRNA polyamidoamine-hyaluronic acid complex. JControl Release 2012, 163(2):136-144.
24. Olvera de la Cruz M., Sanchez I.C. Theory of microphase separation in graft and star copolymers. Macromolecules 1986, 19(10):2501-2508.
25. Kricheldorff H.R., Domschke A. Layer structure. 1. Poly(phenylene-terephthalamide)s derived from mono-, di-, and tetrakis(alkylthio)terephthalic acids. Macromolecules 1994, 27(6):1509-1516.
26. Chen S.A., Ni J.M. Structure/properties of conjugated conductive polymers. 1. Neutral poly(3-alkythiophene)s. Macromolecules 1992, 25(23):6081-6089.
27. Daly W.H., Poché D., Negulescu I. Poly(γ-Alkyl-α, l-glutamate)s, derived from long chain paraffinic alcohols. Prog Polym Sci 1994, 19(1):79-135.
28. Noeding G., Heitz W. Amphiphilic poly(ethyleneimine) based on long-chain alkyl bromides. Macromol Chem Phys 1998, 199(8):1637-1644.
29. Shi H., Zhao Y., Zhang X., Jiang S., Wang D., Han C.C., et al. Phase transition and conformational variation of N-Alkylated branched poly(ethyleneimine) comblike polymer. Macromolecules 2004, 37(26):9933-9940.
30. Liu Y., Fan Y., Liu X.Y., Jiang S.Z., Yuan Y., Chen Y., et al. Amphiphilic hyperbranched copolymers bearing a hyperbranched core and dendritic shell: synthesis, characterization and guest encapsulation performance. Soft Matter 2012, 8(32):8361-8369.
31. Qiu L.Y., Bae Y.H. Self-assembled polyethylenimine-graft-poly(epsilon-caprolactone) micelles as potential dual carriers of genes and anticancer drugs. Biomaterials 2007, 28(28):4132-4142.
32. Souto E.B., Wissing S.A., Barbosa C.M., Müller R.H. Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations. Eur J Pharm Biopharm 2004, 58(1):83-90.
33. Wang Z., Liu G., Sun J., Wu B., Gong Q., Song B., et al. Self-assembly of magnetite nanocrystals with amphiphilic polyethylenimine: structures and applications in magnetic resonance imaging. JNanosci Nanotechnol 2009, 9(1):378-385.
34. Wolfert M.A., Dash P.R., Nazarova O., Oupicky D., Seymour L.W., Smart S., et al. Polyelectrolyte vectors for gene delivery: infuence of cationic polymer on biophysical properties of complexes formed with DNA. Bioconjug Chem 1999, 10(6):993-1004.
35. Doody A.M., Korley J.N., Dang K.P., Zawaneh P.N., Putnam D. Characterizing the structure/function parameter space of hydrocarbon-conjugated branched polyethylenimine for DNA delivery invitro. JControl Release 2006, 116(2):227-237.
36. Moret I., Esteban Peris J., Guillem V.M., Benet M., Revert F., Dasí F., et al. Stability of PEI-DNA and DOTAP-DNA complexes: effect of alkaline pH, heparin and serum. JControl Release 2001, 76(1-2):169-181.
37. Fischer D., Li Y., Ahlemeyer B., Krieglstein J., Kissel T. Invitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis. Biomaterials 2003, 24(7):1121-1131.
38. Hunter A.C. Molecular hurdles in polyfectin design and mechanistic background to polycation induced cytotoxicity. Adv Drug Deliv Rev 2006, 58(14):1523-1531.
39. Miyata K., Nishiyamaa N., Kataoka K. Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artifcial viruses. Chem Soc Rev 2012, 41(7):2562-2574.
40. Pack D.W., Hoffman A.S., Pun S., Stayton P.S. Design and development of polymers for gene delivery. Nat Rev Drug Discov 2005, 4(7):581-593.
41. Liu G., Wang Z., Lu J., Xia C., Gao F., Gong Q., et al. Low molecular weight alkyl-polycation wrapped magnetite nanoparticle clusters as MRI probes for stem cell labeling and invivo imaging. Biomaterials 2011, 32(2):528-537.
42. Neamnark A., Suwantong O., Bahadur R.K., Hsu C.Y., Supaphol P., Uludağ H. Aliphatic lipid substitution on 2 kDa polyethylenimine improves plasmid delivery and transgene expression. Mol Pharm 2009, 6(6):1798-1815.
43. Shim M.S., Kwon Y.J. Acid-responsive linear polyethylenimine for efficient, specific, and biocompatible siRNA delivery. Bioconjug Chem 2009, 20(3):488-499.
44. Song W.J., Du J.Z., Sun T.M., Zhang P.Z., Wang J. Gold nanoparticles capped with polyethyleneimine for enhanced siRNA delivery. Small 2010, 6(2):239-246.
45. Takigawa D.Y., Tirrell D.A. Interactions of synthetic polymers with cell membranes and model membrane systems. Part 6. Disruption of phospholipid packing by branched poly(ethylenimine) derivatives. Macromolecules 1985, 18(3):338-342.
46. Xiong X.B., Uludağ H., Lavasanifar A. Biodegradable amphiphilic poly(ethylene oxide)-block-polyesters with grafted polyamines as supramolecular nanocarriers for efficient siRNA delivery. Biomaterials 2009, 30(2):242-253.
47. Wu H., Hait W.N., Yang J.M. Small interfering RNA-induced suppression of MDR1 (P-glycoprotein) restores sensitivity to multidrug-resistant cancer cells. Cancer Res 2003, 63(7):1515-1519.
48. Stierlé V., Laigle A., Jollès B. Modulation of MDR1 gene expression in multidrug resistant MCF-7 cells by low concentrations of small interfering RNAs. Biochem Pharmacol 2005, 70(10):1424-1430.
49. Abbasi M., Lavasanifar A., Berthiaume L.G., Weinfeld M., Uludağ H. Cationic polymer-mediated small interfering RNA delivery for P-glycoprotein down-regulation in tumor cells. Cancer 2010, 116(23):5544-5554.
50. Medarova Z., Pham W., Farrar C., Petkova V., Moore A. Invivo imaging of siRNA delivery and silencing in tumors. Nat Med 2007, 13(3):372-377.
51. Wang X.Y. Superparamagnetic iron oxide based MRI contrast agents: current status of clinical application. Quant Imaging Med Surg 2011, 1(1):35-40.
52. Langdon S.P. Animal modeling of cancer pathology and studying tumor response to therapy. Curr Drug Targets 2012, 13(12):1535-1547.
53. Abbasi M., Aliabadi H.M., Moase E.H., Lavasanifar A., Kaur K., Lai R., et al. siRNA-mediated down-regulation of P-glycoprotein in a xenograft tumor model in NOD-SCID mice. Pharm Res 2011, 28(10):2516-2529.