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Volumn 13, Issue 12, 2012, Pages 1535-1547

Animal modeling of cancer pathology and studying tumor response to therapy

Author keywords

Canine; Genetically engineered mice; Model; Murine; Preclinical; Transplantable; Xenograft

Indexed keywords

CELECOXIB; CETUXIMAB; CYCLOPHOSPHAMIDE; DOXORUBICIN; EFLORNITHINE; ENDOSTATIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERLOTINIB; ESTROGEN RECEPTOR; FLURBIPROFEN; FLUTAMIDE; GEFITINIB; GEMCITABINE; GENISTEIN; GW 654652; NERATINIB; PERTUZUMAB; PROTEIN P53; RAPAMYCIN; RESVERATROL; RETINOIC ACID; SELENIUM; TAMOXIFEN; TOCERANIB; TOREMIFENE; TRASTUZUMAB; UNCLASSIFIED DRUG;

EID: 84870207027     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/138945012803530152     Document Type: Review
Times cited : (37)

References (148)
  • 1
    • 12944312687 scopus 로고    scopus 로고
    • 50 years of preclinical drug screening: Empirical to target-driven approaches
    • Sugitt M, Bibby MC. 50 years of preclinical drug screening: empirical to target-driven approaches. Clin Cancer Res 2005; 11: 971-981.
    • (2005) Clin Cancer Res , vol.11 , pp. 971-981
    • Sugitt, M.1    Bibby, M.C.2
  • 2
    • 70350034197 scopus 로고    scopus 로고
    • Contemporary preclinical development of anticancer agents - what are the optimal preclinical models?
    • Damia G, D'Incalci M. Contemporary preclinical development of anticancer agents - what are the optimal preclinical models? Eur J Cancer 2009; 45: 2768-2781.
    • (2009) Eur J Cancer , vol.45 , pp. 2768-2781
    • Damia, G.1    D'Incalci, M.2
  • 3
    • 33645734205 scopus 로고    scopus 로고
    • Contributions of Human Tumor Xenografts to Anticancer Drug Development
    • Sausville EA, Burger AM. Contributions of Human Tumor Xenografts to Anticancer Drug Development. Cancer Res 2006; 66: 3351-3354.
    • (2006) Cancer Res , vol.66 , pp. 3351-3354
    • Sausville, E.A.1    Burger, A.M.2
  • 4
    • 33750435151 scopus 로고    scopus 로고
    • Tumor models for efficacy determination
    • Teicher BA. Tumor models for efficacy determination. Mol Cancer Ther 2006; 5: 2435-2443.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2435-2443
    • Teicher, B.A.1
  • 5
    • 0036467484 scopus 로고    scopus 로고
    • Technology advanced cancer modeling in mice
    • Tuveson DA and Jacks T. Technology advanced cancer modeling in mice. Curr Opin Genet Dev 2002; 12(1): 105-110.
    • (2002) Curr Opin Genet Dev , vol.12 , Issue.1 , pp. 105-110
    • Tuveson, D.A.1    Jacks, T.2
  • 6
    • 34247876272 scopus 로고    scopus 로고
    • Murine models to evaluate novel and conventional strategies for cancer
    • Talmadge JE, Singh RK, Fidler IJ, Raz A. Murine models to evaluate novel and conventional strategies for cancer. Am J Pathol 2007; 170: 793-804.
    • (2007) Am J Pathol , vol.170 , pp. 793-804
    • Talmadge, J.E.1    Singh, R.K.2    Fidler, I.J.3    Raz, A.4
  • 7
    • 33748331308 scopus 로고    scopus 로고
    • The mighty mouse: Genetically engineered mouse models in cancer drug development
    • Sharpless NE, DePinho RA. The mighty mouse: genetically engineered mouse models in cancer drug development. Nature Rev Drug Discovery 2006; 5: 741-754.
    • (2006) Nature Rev Drug Discovery , vol.5 , pp. 741-754
    • Sharpless, N.E.1    Depinho, R.A.2
  • 9
    • 77953998205 scopus 로고    scopus 로고
    • Non-germline genetically engineered mouse models for translational cancer research
    • Heyer J, Kwong LN, Lowe SW, Chin L. Non-germline genetically engineered mouse models for translational cancer research. Nature Rev Cancer 2010; 10: 470-480.
    • (2010) Nature Rev Cancer , vol.10 , pp. 470-480
    • Heyer, J.1    Kwong, L.N.2    Lowe, S.W.3    Chin, L.4
  • 10
    • 38549112058 scopus 로고    scopus 로고
    • Translation of new cancer treatments from pet dogs to humans
    • Paoloni M, Khanna C. Translation of new cancer treatments from pet dogs to humans. Nature Reviews Cancer 2008; 8: 147-156.
    • (2008) Nature Reviews Cancer , vol.8 , pp. 147-156
    • Paoloni, M.1    Khanna, C.2
  • 11
    • 1342288971 scopus 로고    scopus 로고
    • Comparative biology of mouse versus human cells: Modelling human cancer in mice
    • Rangarajan A, Weinberg RA. Comparative biology of mouse versus human cells: modelling human cancer in mice. Nature Rev Cancer 2003; 3: 952-959.
    • (2003) Nature Rev Cancer , vol.3 , pp. 952-959
    • Rangarajan, A.1    Weinberg, R.A.2
  • 12
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000: 100: 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 13
    • 1942454409 scopus 로고    scopus 로고
    • Orthotopic models for cancer for preclinical drug evaluation. Advantages and disadvantages
    • Bibby MC. Orthotopic models for cancer for preclinical drug evaluation. Advantages and disadvantages. Eur J Cancer 2004; 40: 852-857.
    • (2004) Eur J Cancer , vol.40 , pp. 852-857
    • Bibby, M.C.1
  • 14
    • 0028087881 scopus 로고
    • Metastatic models of human cancer xenografted in the nude mouse: The importance of orthotopic implantation
    • Kubota T. Metastatic models of human cancer xenografted in the nude mouse: the importance of orthotopic implantation. J Cell Biochem 1994; 56: 4-8.
    • (1994) J Cell Biochem , vol.56 , pp. 4-8
    • Kubota, T.1
  • 15
    • 2042458747 scopus 로고    scopus 로고
    • Relationships between drug activity in NCI preclinical in vitro and in vivo models an early clinical trials
    • Johnson JI, Decker S, Zaharevitz D, et al. Relationships between drug activity in NCI preclinical in vitro and in vivo models an early clinical trials. Br J Cancer 2001; 84: 1424-1431.
    • (2001) Br J Cancer , vol.84 , pp. 1424-1431
    • Johnson, J.I.1    Decker, S.2    Zaharevitz, D.3
  • 16
    • 0141566685 scopus 로고    scopus 로고
    • Clinical predictive value of the in vitro cell line, human xenograft, and mouse allograft preclinical cancer models
    • Voskoglou-Nomikos T, Pater JL, Seymour L. Clinical predictive value of the in vitro cell line, human xenograft, and mouse allograft preclinical cancer models. Clin Cancer Res 2003; 9: 4227-4239.
    • (2003) Clin Cancer Res , vol.9 , pp. 4227-4239
    • Voskoglou-Nomikos, T.1    Pater, J.L.2    Seymour, L.3
  • 17
    • 0023146915 scopus 로고
    • Use of nude mouse xenografts as preclinical drug screens: In vivo activity of established chemotherapeutic agents against melanoma and ovarian carcinoma xenografts
    • Taetle R, Rosen F, Abramson I, Venditti J, Howell S. Use of nude mouse xenografts as preclinical drug screens: in vivo activity of established chemotherapeutic agents against melanoma and ovarian carcinoma xenografts. Cancer Treat Rep 1987; 71: 297-304.
    • (1987) Cancer Treat Rep , vol.71 , pp. 297-304
    • Taetle, R.1    Rosen, F.2    Abramson, I.3    Venditti, J.4    Howell, S.5
  • 20
    • 0020505928 scopus 로고
    • Antitumor efficacy of seventeen anticancer drugs in human breast cancer xenograft (MX-1) transplanted in nude mice
    • Inoue K, Fujiomoto S, Ouawa M. Antitumor efficacy of seventeen anticancer drugs in human breast cancer xenograft (MX-1) transplanted in nude mice. Cancer Chemother Pharmacol 1983; 10: 182-186.
    • (1983) Cancer Chemother Pharmacol , vol.10 , pp. 182-186
    • Inoue, K.1    Fujiomoto, S.2    Ouawa, M.3
  • 21
    • 1942518912 scopus 로고    scopus 로고
    • Clonogenic assay with established human tumor xenografts: Correlation of in vitro to in vivo activity as a basis for anticancer drug discovery
    • Fiebig HH, Maier A, Burger AM. Clonogenic assay with established human tumor xenografts: correlation of in vitro to in vivo activity as a basis for anticancer drug discovery. Eur J Cancer 2004: 40: 802-820.
    • (2004) Eur J Cancer , vol.40 , pp. 802-820
    • Fiebig, H.H.1    Maier, A.2    Burger, A.M.3
  • 22
    • 0022978571 scopus 로고
    • 6-Day subrenal capsule assay (SRCA) as a predictor of the response of advanced cancers to chemotherapy
    • Favre R, Marotia L, Drancourt M, et al. 6-Day subrenal capsule assay (SRCA) as a predictor of the response of advanced cancers to chemotherapy. Eur J Cancer Clin Oncol 1986; 22: 1171-1178.
    • (1986) Eur J Cancer Clin Oncol , vol.22 , pp. 1171-1178
    • Favre, R.1    Marotia, L.2    Drancourt, M.3
  • 23
    • 0019502702 scopus 로고
    • Chemotherapy responsiveness of human tumors as first transplant generation xenografts in the normal mouse: Six-day subrenal capsule assay
    • Bogden AE, Cobb WR, Lepage DJ, Haskell PM, Gulkin TA, Ward A, Kelton DE, Esber HJ. Chemotherapy responsiveness of human tumors as first transplant generation xenografts in the normal mouse: six-day subrenal capsule assay. Cancer 1981; 48: 10-20.
    • (1981) Cancer , vol.48 , pp. 10-20
    • Bogden, A.E.1    Cobb, W.R.2    Lepage, D.J.3    Haskell, P.M.4    Gulkin, T.A.5    Ward, A.6    Kelton, D.E.7    Esber, H.J.8
  • 24
    • 0021021278 scopus 로고
    • Initial clinical trials of the subrenal capsule assay as a predictor of tumor response to chemotherapy
    • Griffin TW, Bogden AE, Reich SD, et al. Initial clinical trials of the subrenal capsule assay as a predictor of tumor response to chemotherapy. Cancer 1983; 52: 2185-2192.
    • (1983) Cancer , vol.52 , pp. 2185-2192
    • Griffin, T.W.1    Bogden, A.E.2    Reich, S.D.3
  • 25
    • 0020431204 scopus 로고
    • Responsiveness of gynaecologic tumors to chemotherapeutic agents in the 6-day subrenal capsule assay
    • Hunter RE, Reich SD, Griffin TW, Bogden AE. Responsiveness of gynaecologic tumors to chemotherapeutic agents in the 6-day subrenal capsule assay. Gynecol Oncol 1982; 14: 298-306.
    • (1982) Gynecol Oncol , vol.14 , pp. 298-306
    • Hunter, R.E.1    Reich, S.D.2    Griffin, T.W.3    Bogden, A.E.4
  • 26
    • 77649178137 scopus 로고    scopus 로고
    • Patient-Derived First Generation Xenografts of Non-Small Cell Lung Cancers: Promising Tools for Predicting Drug Responses for Personalized Chemotherapy
    • Dong X, Guan J, English JC, et al. Patient-Derived First Generation Xenografts of Non-Small Cell Lung Cancers: Promising Tools for Predicting Drug Responses for Personalized Chemotherapy. Clin Cancer Res 2010; 16: 1442-1451.
    • (2010) Clin Cancer Res , vol.16 , pp. 1442-1451
    • Dong, X.1    Guan, J.2    English, J.C.3
  • 27
    • 33746068275 scopus 로고    scopus 로고
    • Establishment in Severe Combined Immunodeficiency Mice of Subrenal Capsule Xenografts and-Transplantable Tumor Lines from a Variety of Primary Human Lung Cancers: Potential Models for Studying Tumor Progression^ Related Changes
    • Cutz J, Guan J, Bayani J, et al. Establishment in Severe Combined Immunodeficiency Mice of Subrenal Capsule Xenografts and-Transplantable Tumor Lines from a Variety of Primary Human Lung Cancers: Potential Models for Studying Tumor Progression^ Related Changes. Clin Cancer Res 2006; 12: 4043-4054.
    • (2006) Clin Cancer Res , vol.12 , pp. 4043-4054
    • Cutz, J.1    Guan, J.2    Bayani, J.3
  • 28
    • 0035120420 scopus 로고    scopus 로고
    • Why drugs fail: Of mice and men revisited
    • Takimoto CH. Why drugs fail: of mice and men revisited. Clin Cancer Res 2001; 7: 229-230.
    • (2001) Clin Cancer Res , vol.7 , pp. 229-230
    • Takimoto, C.H.1
  • 29
    • 0024358188 scopus 로고
    • DNA topoisomerase Itargeted chemotherapy of human colon cancer in xenografts
    • Giovanella BC, Stehlin JS, Wall ME, et al. DNA topoisomerase Itargeted chemotherapy of human colon cancer in xenografts. Science 1989; 246: 146-148.
    • (1989) Science , vol.246 , pp. 146-148
    • Giovanella, B.C.1    Stehlin, J.S.2    Wall, M.E.3
  • 30
    • 0028904703 scopus 로고
    • A Phase I and pharmacokinetic study of a new camptothecin derivative, 9-aminocamptothecin
    • Rubin E, Wood V, Bharti A, et al. A Phase I and pharmacokinetic study of a new camptothecin derivative, 9-aminocamptothecin. Clin Cancer Res 1995; 1: 269-276.
    • (1995) Clin Cancer Res , vol.1 , pp. 269-276
    • Rubin, E.1    Wood, V.2    Bharti, A.3
  • 31
    • 9244231199 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of 9-aminocamptothecin given by 72-hour infusion in adult cancer patients
    • Dahut W, Harold N, Takimoto C, et al. Phase I and pharmacologic study of 9-aminocamptothecin given by 72-hour infusion in adult cancer patients. J Clin Oncol 1996; 14: 1236-1244.
    • (1996) J Clin Oncol , vol.14 , pp. 1236-1244
    • Dahut, W.1    Harold, N.2    Takimoto, C.3
  • 32
    • 0035127478 scopus 로고    scopus 로고
    • Relation between 9-aminocamptothecin systemic exposure and tumor response in human solid tumor xenografts
    • Kirstein MN, Houghton PJ, Cheshire PJ, et al. Relation between 9-aminocamptothecin systemic exposure and tumor response in human solid tumor xenografts. Clin Cancer Res 2001; 7: 358-366.
    • (2001) Clin Cancer Res , vol.7 , pp. 358-366
    • Kirstein, M.N.1    Houghton, P.J.2    Cheshire, P.J.3
  • 33
    • 1942422737 scopus 로고    scopus 로고
    • Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development
    • Peterson JK, Houghton PJ. Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development. Eur Cancer 2004; 40: 837-844.
    • (2004) Eur Cancer , vol.40 , pp. 837-844
    • Peterson, J.K.1    Houghton, P.J.2
  • 34
    • 0028365978 scopus 로고
    • Preclinical phase II studies in human tumor xenografts: A European multicenter followup study
    • Langdon SP, Hendriks HR, Braakhuis BJ, et al. Preclinical phase II studies in human tumor xenografts: a European multicenter followup study. Ann Oncol 1994; 5: 415-422.
    • (1994) Ann Oncol , vol.5 , pp. 415-422
    • Langdon, S.P.1    Hendriks, H.R.2    Braakhuis, B.J.3
  • 35
    • 0026452172 scopus 로고
    • Phase II preclinical drug screening in human tumor xenografts: A first European multicenter collaborative study
    • Boven E, Winograd B, Berger DP, et al. Phase II preclinical drug screening in human tumor xenografts: a first European multicenter collaborative study. Cancer Res 1992; 52: 5940-5947.
    • (1992) Cancer Res , vol.52 , pp. 5940-5947
    • Boven, E.1    Winograd, B.2    Berger, D.P.3
  • 36
    • 33745014556 scopus 로고    scopus 로고
    • Genes regulated by estrogen in breast tumor cells in vitro are similarly regulated in vivo in tumor xenografts and human breast tumors
    • Creighton CJ, Cordero KE, Larios JM, et al. Genes regulated by estrogen in breast tumor cells in vitro are similarly regulated in vivo in tumor xenografts and human breast tumors. Genome Biol 2006; 7: R28.
    • (2006) Genome Biol , vol.7
    • Creighton, C.J.1    Cordero, K.E.2    Larios, J.M.3
  • 37
    • 78149490372 scopus 로고    scopus 로고
    • Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer
    • Taylor KJ, Sims AH, Liang L, et al. Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer. Breast Cancer Res 2010; 12(3): R39.
    • (2010) Breast Cancer Res , vol.12 , Issue.3
    • Taylor, K.J.1    Sims, A.H.2    Liang, L.3
  • 38
    • 34548863946 scopus 로고    scopus 로고
    • Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
    • Herschkowitz JI, Simin K, Weigmans VJ, et al. Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol 2007; 8: R76.
    • (2007) Genome Biol , vol.8
    • Herschkowitz, J.I.1    Simin, K.2    Weigmans, V.J.3
  • 39
    • 2942652871 scopus 로고    scopus 로고
    • Mechanisms of Tamoxifen Resistance: Increased Estrogen Receptor-HER2/neu Cross-Talk in ER/HER2-Positive Breast Cancer
    • Shou J, Massarweh S, Osborne CK, et al. Mechanisms of Tamoxifen Resistance: Increased Estrogen Receptor-HER2/neu Cross-Talk in ER/HER2-Positive Breast Cancer. JNCI 2004; 96: 926-935.
    • (2004) JNCI , vol.96 , pp. 926-935
    • Shou, J.1    Massarweh, S.2    Osborne, C.K.3
  • 40
    • 38849091433 scopus 로고    scopus 로고
    • Tamoxifen Resistance in Breast Tumors Is Driven by Growth Factor Receptor Signaling with Repression of Classic Estrogen Receptor Genomic Function
    • Massarweh S, Osborne CK, Creighton CJ, et al. Tamoxifen Resistance in Breast Tumors Is Driven by Growth Factor Receptor Signaling with Repression of Classic Estrogen Receptor Genomic Function. Cancer Res 2008; 68: 826-833.
    • (2008) Cancer Res , vol.68 , pp. 826-833
    • Massarweh, S.1    Osborne, C.K.2    Creighton, C.J.3
  • 41
    • 54749118927 scopus 로고    scopus 로고
    • Development of resistance to targeted therapies transforms the clinically associated molecular profile subtype of breast tumor xenografts
    • Creighton CJ, Massarweh S, Huang S, et al. Development of resistance to targeted therapies transforms the clinically associated molecular profile subtype of breast tumor xenografts. Cancer Res 2008; 68: 7493-7501.
    • (2008) Cancer Res , vol.68 , pp. 7493-7501
    • Creighton, C.J.1    Massarweh, S.2    Huang, S.3
  • 42
    • 34249739172 scopus 로고    scopus 로고
    • Treatment of human epidermal growth factor receptor 2 overexpressing breast cancer xenografts with multiagent HER-targeted therapy
    • Arpino G, Gutierrez C, Weiss H, et al. Treatment of human epidermal growth factor receptor 2 overexpressing breast cancer xenografts with multiagent HER-targeted therapy. JNCI 2007; 99: 694-705.
    • (2007) JNCI , vol.99 , pp. 694-705
    • Arpino, G.1    Gutierrez, C.2    Weiss, H.3
  • 43
    • 77949903478 scopus 로고    scopus 로고
    • Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy
    • Baselga J, Gelmon KA, Verma S, et al. Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy. J Clin Oncol 2010; 28: 1138-1144.
    • (2010) J Clin Oncol , vol.28 , pp. 1138-1144
    • Baselga, J.1    Gelmon, K.A.2    Verma, S.3
  • 44
    • 73649149433 scopus 로고    scopus 로고
    • Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models
    • Scheuer W, Friess T, Burtscher H, Bossenmaier B, Endl J, Hasmann M. Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models. Cancer Res 2009; 69: 9330-9336.
    • (2009) Cancer Res , vol.69 , pp. 9330-9336
    • Scheuer, W.1    Friess, T.2    Burtscher, H.3    Bossenmaier, B.4    Endl, J.5    Hasmann, M.6
  • 45
  • 46
    • 0022380768 scopus 로고
    • The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
    • Adams JM, Harris AW, Pinkert CA, et al. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 1985; 318: 533-538.
    • (1985) Nature , vol.318 , pp. 533-538
    • Adams, J.M.1    Harris, A.W.2    Pinkert, C.A.3
  • 47
    • 0023022625 scopus 로고
    • The c-myc oncogene perturbs B lymphocyte development in E-mu-myc transgenic mice
    • Langdon WY, Harris AW, Cory S, Adams JM. The c-myc oncogene perturbs B lymphocyte development in E-mu-myc transgenic mice. Cell 1986; 47: 11-18.
    • (1986) Cell , vol.47 , pp. 11-18
    • Langdon, W.Y.1    Harris, A.W.2    Cory, S.3    Adams, J.M.4
  • 48
    • 0023247255 scopus 로고
    • Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice
    • Ornitz DM, Hammer RE, Messing A, Palmiter RD, Brinster RL. Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice. Science 1987; 238: 188-193.
    • (1987) Science , vol.238 , pp. 188-193
    • Ornitz, D.M.1    Hammer, R.E.2    Messing, A.3    Palmiter, R.D.4    Brinster, R.L.5
  • 49
    • 0023666146 scopus 로고
    • Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice
    • Quaife CJ, Pinkert CA, Ornitz DM, Palmiter RD, Brinster RL. Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice. Cell 1987; 48: 1023-1034.
    • (1987) Cell , vol.48 , pp. 1023-1034
    • Quaife, C.J.1    Pinkert, C.A.2    Ornitz, D.M.3    Palmiter, R.D.4    Brinster, R.L.5
  • 50
    • 0022497717 scopus 로고
    • Consequences of widespread deregulation of the c-myc gene in transgenic mice: Multiple neoplasms and normal development
    • Leder A, Pattengale PK, Kuo A, Stewart TA, Leder P. Consequences of widespread deregulation of the c-myc gene in transgenic mice: Multiple neoplasms and normal development. Cell 1986; 45: 485-495.
    • (1986) Cell , vol.45 , pp. 485-495
    • Leder, A.1    Pattengale, P.K.2    Kuo, A.3    Stewart, T.A.4    Leder, P.5
  • 51
    • 0023631608 scopus 로고
    • Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo
    • Sinn E, Muller W, Pattengale P, Tepler I, Wallace R, Leder P. Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo. Cell 1987; 49: 465-475.
    • (1987) Cell , vol.49 , pp. 465-475
    • Sinn, E.1    Muller, W.2    Pattengale, P.3    Tepler, I.4    Wallace, R.5    Leder, P.6
  • 52
    • 0031020561 scopus 로고    scopus 로고
    • Animal models and the molecular pathology of cancer
    • Lovejoy EA, Clarke AR, Harrison DJ. Animal models and the molecular pathology of cancer. J Pathol 1997; 181: 130-135.
    • (1997) J Pathol , vol.181 , pp. 130-135
    • Lovejoy, E.A.1    Clarke, A.R.2    Harrison, D.J.3
  • 54
    • 18444385085 scopus 로고    scopus 로고
    • Survey of Genetically Engineered Mouse Models for Prostate Cancer: Analyzing the Molecular Basis of Prostate Cancer Development, Progression and Metastasis
    • Kaspar S. Survey of Genetically Engineered Mouse Models for Prostate Cancer: Analyzing the Molecular Basis of Prostate Cancer Development, Progression and Metastasis. J Cell Biochem 2005; 94: 279-297.
    • (2005) J Cell Biochem , vol.94 , pp. 279-297
    • Kaspar, S.1
  • 55
    • 77349105286 scopus 로고    scopus 로고
    • Modeling prostate cancer: A perspective on transgenic mouse models
    • Jeet V, Russell PJ and Khatri A. Modeling prostate cancer: a perspective on transgenic mouse models. Cancer Metast Rev 2010; 29: 123-142.
    • (2010) Cancer Metast Rev , vol.29 , pp. 123-142
    • Jeet, V.1    Russell, P.J.2    Khatri, A.3
  • 57
    • 0029832290 scopus 로고    scopus 로고
    • Metastatic prostate cancer in a transgenic mouse
    • Gingrich JR, Barrios RJ, Morton RA, et al. Metastatic prostate cancer in a transgenic mouse. Cancer Res 1996; 56: 4096-4102.
    • (1996) Cancer Res , vol.56 , pp. 4096-4102
    • Gingrich, J.R.1    Barrios, R.J.2    Morton, R.A.3
  • 58
    • 0031883020 scopus 로고    scopus 로고
    • Development, progression, and androgen-dependence of prostate tumors in probasin-large T antigen transgenic mice: A model for prostate cancer
    • Kasper S, Sheppard PC, Yan Y, et al. Development, progression, and androgen-dependence of prostate tumors in probasin-large T antigen transgenic mice: a model for prostate cancer. Lab Invest 1998; 78, 319-333.
    • (1998) Lab Invest , vol.78 , pp. 319-333
    • Kasper, S.1    Sheppard, P.C.2    Yan, Y.3
  • 59
    • 0035266381 scopus 로고    scopus 로고
    • A probasin-large T antigen transgenic mouse line develops prostate adenocarcinoma and neuroendocrine carcinoma with metastatic potential
    • Masumori N, Thomas TZ, Chaurand P, et al. A probasin-large T antigen transgenic mouse line develops prostate adenocarcinoma and neuroendocrine carcinoma with metastatic potential. Cancer Res 2001; 61: 2239-2249.
    • (2001) Cancer Res , vol.61 , pp. 2239-2249
    • Masumori, N.1    Thomas, T.Z.2    Chaurand, P.3
  • 60
    • 2942587152 scopus 로고    scopus 로고
    • Engineered FGF-2 expression induces glandular epithelial hyperplasia in the murine prostatic dorsal lobe
    • Konno-Takahashi N, Takeuchi T, Nishimatsu H, Kamijo T, Tomita K, Schalken JA. Engineered FGF-2 expression induces glandular epithelial hyperplasia in the murine prostatic dorsal lobe. Eur Urol 2004; 46: 126-132.
    • (2004) Eur Urol , vol.46 , pp. 126-132
    • Konno-Takahashi, N.1    Takeuchi, T.2    Nishimatsu, H.3    Kamijo, T.4    Tomita, K.5    Schalken, J.A.6
  • 61
    • 0141731322 scopus 로고    scopus 로고
    • Fibroblast growth factor 2 promotes tumor progression in an autochthonous mouse model of prostate cancer
    • Polnaszek N, Kwabi-Addo B, Peterson LE, Ozen M, Greenberg NM, Ortega S. Fibroblast growth factor 2 promotes tumor progression in an autochthonous mouse model of prostate cancer. Cancer Res 2003; 63: 5754-5760.
    • (2003) Cancer Res , vol.63 , pp. 5754-5760
    • Polnaszek, N.1    Kwabi-Addo, B.2    Peterson, L.E.3    Ozen, M.4    Greenberg, N.M.5    Ortega, S.6
  • 62
    • 0036993587 scopus 로고    scopus 로고
    • Enforced expression of FGF-7 promotes epithelial hyperplasia whereas a dominant negative FGFR2iiib promotes the emergence of neuroendocrine phenotype in prostate glands of transgenic mice
    • Foster BA, Evangelou A, Gingrich JR, Kaplan PJ, DeMayo F, Greenberg NM. Enforced expression of FGF-7 promotes epithelial hyperplasia whereas a dominant negative FGFR2iiib promotes the emergence of neuroendocrine phenotype in prostate glands of transgenic mice. Differentiation 2002; 70: 624-632.
    • (2002) Differentiation , vol.70 , pp. 624-632
    • Foster, B.A.1    Evangelou, A.2    Gingrich, J.R.3    Kaplan, P.J.4    Demayo, F.5    Greenberg, N.M.6
  • 63
    • 0030995015 scopus 로고    scopus 로고
    • Abnormal prostate development in C3(1)-bcl-2 transgenic mice
    • Zhang X, Chen MW, Ng A, et al. Abnormal prostate development in C3(1)-bcl-2 transgenic mice. Prostate 1997; 32: 16-26.
    • (1997) Prostate , vol.32 , pp. 16-26
    • Zhang, X.1    Chen, M.W.2    Ng, A.3
  • 64
    • 0038662735 scopus 로고    scopus 로고
    • Prostate hyperplasia in a transgenic mouse with prostate-specific expression of prolactin
    • Kindblom J, Dillner K, Sahlin L, et al. Prostate hyperplasia in a transgenic mouse with prostate-specific expression of prolactin. Endocrinol 2003; 144: 2269-2278.
    • (2003) Endocrinol , vol.144 , pp. 2269-2278
    • Kindblom, J.1    Dillner, K.2    Sahlin, L.3
  • 66
    • 0033914135 scopus 로고    scopus 로고
    • Epithelial defect in prostates of Stat5a null mice
    • Nevalainen MT, Ahonen TJ, Yamashita H, et al. Epithelial defect in prostates of Stat5a null mice. Lab Invest 2000; 80: 993-1006.
    • (2000) Lab Invest , vol.80 , pp. 993-1006
    • Nevalainen, M.T.1    Ahonen, T.J.2    Yamashita, H.3
  • 67
    • 0035845558 scopus 로고    scopus 로고
    • Prostatic intraepithelial neoplasia in mice expressing an androgen receptor transgene in prostate epithelium
    • Stanbrough M, Leav I, Kwan PW, Bubley GJ, Balk SP. Prostatic intraepithelial neoplasia in mice expressing an androgen receptor transgene in prostate epithelium. Proc Natl Acad Sci USA 2001; 98: 10823-10828.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10823-10828
    • Stanbrough, M.1    Leav, I.2    Kwan, P.W.3    Bubley, G.J.4    Balk, S.P.5
  • 68
    • 2442653901 scopus 로고    scopus 로고
    • Prostatic intraepithelial neoplasia and intestinal metaplasia in prostates of probasin-RAS transgenic mice
    • Scherl A, Li JF, Cardiff RD, Schreiber-Agus N. Prostatic intraepithelial neoplasia and intestinal metaplasia in prostates of probasin-RAS transgenic mice. Prostate 2004; 59: 448-459.
    • (2004) Prostate , vol.59 , pp. 448-459
    • Scherl, A.1    Li, J.F.2    Cardiff, R.D.3    Schreiber-Agus, N.4
  • 69
    • 0036733760 scopus 로고    scopus 로고
    • Fibroblast growth factor 8 isoform B overexpression in prostate epithelium: A new mouse model for prostatic intraepithelial neoplasia
    • Song Z, Wu X, Powell WC, et al. Fibroblast growth factor 8 isoform B overexpression in prostate epithelium: a new mouse model for prostatic intraepithelial neoplasia. Cancer Research 2002; 62: 5096-5105.
    • (2002) Cancer Research , vol.62 , pp. 5096-5105
    • Song, Z.1    Wu, X.2    Powell, W.C.3
  • 70
    • 0345734275 scopus 로고    scopus 로고
    • Inducible prostate intraepithelial neoplasia with reversible hyperplasia in conditional FGFR1-expressing mice
    • Freeman KW, Welm BE, Gangula RD, et al. Inducible prostate intraepithelial neoplasia with reversible hyperplasia in conditional FGFR1-expressing mice. Cancer Research 2003; 63: 8256-8263.
    • (2003) Cancer Research , vol.63 , pp. 8256-8263
    • Freeman, K.W.1    Welm, B.E.2    Gangula, R.D.3
  • 71
    • 0037379776 scopus 로고    scopus 로고
    • Expression of the F-box protein SKP2 induces hyperplasia, dysplasia, and low-grade carcinoma in the mouse prostate
    • Shim EH, Johnson L, Noh HL, et al. Expression of the F-box protein SKP2 induces hyperplasia, dysplasia, and low-grade carcinoma in the mouse prostate. Cancer Res 2003; 63:1583-1588.
    • (2003) Cancer Res , vol.63 , pp. 1583-1588
    • Shim, E.H.1    Johnson, L.2    Noh, H.L.3
  • 72
    • 0038271762 scopus 로고    scopus 로고
    • Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model
    • Majumder PK, Yeh JJ, George DJ, et al. Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model. Proc Natl Acad Sci USA 2003; 100: 7841-7846.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 7841-7846
    • Majumder, P.K.1    Yeh, J.J.2    George, D.J.3
  • 73
    • 33745839267 scopus 로고    scopus 로고
    • Conditional expression of human 15-lipoxygenase-1 in mouse prostate induces prostatic intraepithelial neoplasia: The FLiMP mouse model
    • Kelavkar UP, Parwani AV, Shappell SB, Martin WD. Conditional expression of human 15-lipoxygenase-1 in mouse prostate induces prostatic intraepithelial neoplasia: the FLiMP mouse model. Neoplasia 2006; 8: 510-522.
    • (2006) Neoplasia , vol.8 , pp. 510-522
    • Kelavkar, U.P.1    Parwani, A.V.2    Shappell, S.B.3    Martin, W.D.4
  • 74
    • 0036605972 scopus 로고    scopus 로고
    • Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis
    • Kim MJ, Bhatia-Gaur R, Banach-Petrosky WA, et al. Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis. Cancer Res 2002; 62: 2999-3004.
    • (2002) Cancer Res , vol.62 , pp. 2999-3004
    • Kim, M.J.1    Bhatia-Gaur, R.2    Banach-Petrosky, W.A.3
  • 75
    • 0036174513 scopus 로고    scopus 로고
    • Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia
    • Abdulkadir SA, Magee JA, Peters TJ, et al. Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia. Mol Cell Biol 2002; 22: 1495-1503.
    • (2002) Mol Cell Biol , vol.22 , pp. 1495-1503
    • Abdulkadir, S.A.1    Magee, J.A.2    Peters, T.J.3
  • 77
    • 0141569009 scopus 로고    scopus 로고
    • Myc-driven murine prostate cancer shares molecular features with human prostate tumors
    • Ellwood-Yen K, Graeber TG, Wongvipat J, et al. Myc-driven murine prostate cancer shares molecular features with human prostate tumors. Cancer Cell 2003; 4: 223-238.
    • (2003) Cancer Cell , vol.4 , pp. 223-238
    • Ellwood-Yen, K.1    Graeber, T.G.2    Wongvipat, J.3
  • 78
    • 34047265189 scopus 로고    scopus 로고
    • Inactivation of Apc in the mouse prostate causes prostate carcinoma
    • Bruxvoort KJ, Charbonneau HM, Giambernardi TA, et al. Inactivation of Apc in the mouse prostate causes prostate carcinoma. Cancer Res 2007; 67: 2490-2496.
    • (2007) Cancer Res , vol.67 , pp. 2490-2496
    • Bruxvoort, K.J.1    Charbonneau, H.M.2    Giambernardi, T.A.3
  • 79
    • 10744222860 scopus 로고    scopus 로고
    • Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
    • Wang S, Gao J, Lei Q, et al. Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell 2003; 4: 209-221.
    • (2003) Cancer Cell , vol.4 , pp. 209-221
    • Wang, S.1    Gao, J.2    Lei, Q.3
  • 80
    • 0037022364 scopus 로고    scopus 로고
    • Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice
    • You MJ, Castrillon DH, Bastian BC, et al. Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice. Proc Natl Acad Sci USA 2002; 99: 1455-1460.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 1455-1460
    • You, M.J.1    Castrillon, D.H.2    Bastian, B.C.3
  • 81
    • 23244460597 scopus 로고    scopus 로고
    • Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
    • Chen Z, Trotman LC, Shaffer D, et al. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis; Nature 2005; 436: 725-730.
    • (2005) Nature , vol.436 , pp. 725-730
    • Chen, Z.1    Trotman, L.C.2    Shaffer, D.3
  • 82
    • 33748078111 scopus 로고    scopus 로고
    • Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer
    • Zhou Z, Flesken-Nikitin A, Corney DC, et al. Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer. Cancer Res 2006; 66: 7889-7898.
    • (2006) Cancer Res , vol.66 , pp. 7889-7898
    • Zhou, Z.1    Flesken-Nikitin, A.2    Corney, D.C.3
  • 84
    • 2942724235 scopus 로고    scopus 로고
    • MTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
    • Majumder PK, Febbo PG, Bikoff R, et al. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med 2004; 10: 594-601.
    • (2004) Nat Med , vol.10 , pp. 594-601
    • Majumder, P.K.1    Febbo, P.G.2    Bikoff, R.3
  • 85
    • 0034655083 scopus 로고    scopus 로고
    • E-7869 (Rflurbiprofen) inhibits progression of prostate cancer in the TRAMP mouse
    • Wechter WJ, Leipold DD, Murray ED, et al. E-7869 (Rflurbiprofen) inhibits progression of prostate cancer in the TRAMP mouse. Cancer Res 2000; 60: 2203-2208.
    • (2000) Cancer Res , vol.60 , pp. 2203-2208
    • Wechter, W.J.1    Leipold, D.D.2    Murray, E.D.3
  • 86
    • 2342625403 scopus 로고    scopus 로고
    • Suppression of prostate carcinogenesis by dietary supplementation of celecoxib in transgenic adenocarcinoma of the mouse prostate model
    • Gupta S, Adhami VM, Subbarayan M, et al. Suppression of prostate carcinogenesis by dietary supplementation of celecoxib in transgenic adenocarcinoma of the mouse prostate model. Cancer Res 2004; 64: 3334-3343.
    • (2004) Cancer Res , vol.64 , pp. 3334-3343
    • Gupta, S.1    Adhami, V.M.2    Subbarayan, M.3
  • 88
    • 33947626040 scopus 로고    scopus 로고
    • Genistein chemoprevention of prostate cancer in TRAMP mice
    • Wang J, Eltoum IE, Lamartiniere CA. Genistein chemoprevention of prostate cancer in TRAMP mice. J Carcinog 2007; 6: 3.
    • (2007) J Carcinog , vol.6 , pp. 3
    • Wang, J.1    Eltoum, I.E.2    Lamartiniere, C.A.3
  • 89
    • 0034665334 scopus 로고    scopus 로고
    • Chemoprevention of prostate carcinogenesis by alphadifluoromethylornithine in TRAMP mice
    • Gupta S, Ahmad N, Marengo SR, MacLennan GT, Greenberg NM, Mukhtar H. Chemoprevention of prostate carcinogenesis by alphadifluoromethylornithine in TRAMP mice. Cancer Res 2000; 60: 5125-5133.
    • (2000) Cancer Res , vol.60 , pp. 5125-5133
    • Gupta, S.1    Ahmad, N.2    Marengo, S.R.3    Maclennan, G.T.4    Greenberg, N.M.5    Mukhtar, H.6
  • 90
    • 0033869485 scopus 로고    scopus 로고
    • Efficacious chemoprevention of primary prostate cancer by flutamide in an autochthonous transgenic model
    • Raghow S, Kuliyev E, Steakley M, Greenberg N, Steiner MS. Efficacious chemoprevention of primary prostate cancer by flutamide in an autochthonous transgenic model. Cancer Res 2000; 60: 4093-4097.
    • (2000) Cancer Res , vol.60 , pp. 4093-4097
    • Raghow, S.1    Kuliyev, E.2    Steakley, M.3    Greenberg, N.4    Steiner, M.S.5
  • 91
    • 0036494569 scopus 로고    scopus 로고
    • Toremifene prevents prostate cancer in the transgenic adenocarcinoma of mouse prostate model
    • Raghow S, Hooshdaran MZ, Katiyar S, Steiner MS. Toremifene prevents prostate cancer in the transgenic adenocarcinoma of mouse prostate model. Cancer Res 2002; 62: 1370-1376.
    • (2002) Cancer Res , vol.62 , pp. 1370-1376
    • Raghow, S.1    Hooshdaran, M.Z.2    Katiyar, S.3    Steiner, M.S.4
  • 92
    • 4544361438 scopus 로고    scopus 로고
    • Retinoic acid slows progression and promotes apoptosis of spontaneous prostate cancer
    • Huss WJ, Lai L, Barrios RJ, Hirschi KK, Greenberg NM. Retinoic acid slows progression and promotes apoptosis of spontaneous prostate cancer. Prostate 2004; 61: 142-152.
    • (2004) Prostate , vol.61 , pp. 142-152
    • Huss, W.J.1    Lai, L.2    Barrios, R.J.3    Hirschi, K.K.4    Greenberg, N.M.5
  • 93
    • 0034194329 scopus 로고    scopus 로고
    • Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade
    • Hurwitz AA, Foster BA, Kwon ED, et al. Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade. Cancer Res 2000; 60: 2444-2448.
    • (2000) Cancer Res , vol.60 , pp. 2444-2448
    • Hurwitz, A.A.1    Foster, B.A.2    Kwon, E.D.3
  • 94
    • 2342546870 scopus 로고    scopus 로고
    • Gene-directed enzyme prodrug therapy for prostate cancer in a mouse model that imitates the development of human disease
    • Martiniello-Wilks R, Dane A, Voeks DJ, et al. Gene-directed enzyme prodrug therapy for prostate cancer in a mouse model that imitates the development of human disease. J Gene Med 2004; 6: 43-54.
    • (2004) J Gene Med , vol.6 , pp. 43-54
    • Martiniello-Wilks, R.1    Dane, A.2    Voeks, D.J.3
  • 95
    • 34548268026 scopus 로고    scopus 로고
    • Modelling breast cancer: One size does not fit all
    • Vargo-Gogola T, Rosen JM. Modelling breast cancer: one size does not fit all. Nature Rev Cancer 2007; 7: 659-672.
    • (2007) Nature Rev Cancer , vol.7 , pp. 659-672
    • Vargo-Gogola, T.1    Rosen, J.M.2
  • 96
    • 0034696279 scopus 로고    scopus 로고
    • The mammary pathology of genetically engineered mice: The consensus report and recommendations from the Annapolis meeting
    • Cardiff RD, Anver MR, Gusterson BA, Hennighausen L, Jensen RA, Merino MJ. The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting. Oncogene 2000; 19: 968-988.
    • (2000) Oncogene , vol.19 , pp. 968-988
    • Cardiff, R.D.1    Anver, M.R.2    Gusterson, B.A.3    Hennighausen, L.4    Jensen, R.A.5    Merino, M.J.6
  • 97
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature 2000; 406: 747-752.
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1    Sorlie, T.2    Eisen, M.B.3
  • 98
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Sorlie T, Perou CM, Tibshirani R, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 2001; 98: 10869-10874.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10869-10874
    • Sorlie, T.1    Perou, C.M.2    Tibshirani, R.3
  • 99
    • 59449097165 scopus 로고    scopus 로고
    • Unlocking the power of cross-species genomic analyses: Identification of evolutionarily conserved breast cancer networks and validation of preclinical models
    • Bennett CN, Green JE. Unlocking the power of cross-species genomic analyses: identification of evolutionarily conserved breast cancer networks and validation of preclinical models. Breast Cancer Res 2008; 5: 213.
    • (2008) Breast Cancer Res , vol.5 , pp. 213
    • Bennett, C.N.1    Green, J.E.2
  • 100
    • 33747348485 scopus 로고    scopus 로고
    • Application and potential limitations of animal models used in the development of trastuzumab (herceptin): A case study
    • Pegram M, Ngo D. Application and potential limitations of animal models used in the development of trastuzumab (herceptin): a case study. Drug Delivery Reviews 2006; 58: 723-734.
    • (2006) Drug Delivery Reviews , vol.58 , pp. 723-734
    • Pegram, M.1    Ngo, D.2
  • 101
    • 14644443626 scopus 로고    scopus 로고
    • The promise of genetically engineered mice for cancer prevention studies
    • Green JE, Hudson T. The promise of genetically engineered mice for cancer prevention studies. Nature Rev Cancer 2005; 5: 184-198.
    • (2005) Nature Rev Cancer , vol.5 , pp. 184-198
    • Green, J.E.1    Hudson, T.2
  • 102
    • 35949000084 scopus 로고    scopus 로고
    • The Rexinoid LG100268 prevents the development of preinvasive and invasive estrogen receptor negative tumors in MMTV-erbB2 mice
    • Li Y, Zhang Y, Hill J, et al. The Rexinoid LG100268 prevents the development of preinvasive and invasive estrogen receptor negative tumors in MMTV-erbB2 mice. Clin Cancer Res 2007; 13: 6224-6231.
    • (2007) Clin Cancer Res , vol.13 , pp. 6224-6231
    • Li, Y.1    Zhang, Y.2    Hill, J.3
  • 103
    • 42149183454 scopus 로고    scopus 로고
    • The rexinoid, bexarotene, prevents the development of premalignant lesions in MMTV-erbB2 mice
    • Li Y, Zhang Y, Hill J, et al. The rexinoid, bexarotene, prevents the development of premalignant lesions in MMTV-erbB2 mice. Br J Cancer 2008; 98: 1380-1388.
    • (2008) Br J Cancer , vol.98 , pp. 1380-1388
    • Li, Y.1    Zhang, Y.2    Hill, J.3
  • 104
    • 0342545914 scopus 로고    scopus 로고
    • Tamoxifen chemoprevention of a hormone-independent tumor in the proto-neu transgenic mice model
    • Menard S, Aiello P, Tagliabue E, et al. Tamoxifen chemoprevention of a hormone-independent tumor in the proto-neu transgenic mice model. Cancer Res 2000; 60: 273-275.
    • (2000) Cancer Res , vol.60 , pp. 273-275
    • Menard, S.1    Aiello, P.2    Tagliabue, E.3
  • 105
    • 0035940429 scopus 로고    scopus 로고
    • Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor
    • Rodriguez-Manzaneque JC, Lane TF, Ortega MA, Hynes RO, Lawler J, Iruela-Arispe ML. Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor. Proc Natl Acad Sci USA 2001; 98: 12485-12490.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12485-12490
    • Rodriguez-Manzaneque, J.C.1    Lane, T.F.2    Ortega, M.A.3    Hynes, R.O.4    Lawler, J.5    Iruela-Arispe, M.L.6
  • 106
    • 0035134335 scopus 로고    scopus 로고
    • Systemic gene therapy with antiangiogenic factors inhibits spontaneous breast tumor growth and metastasis in MMTVneu transgenic mice
    • Sacco MG, Catò EM, Ceruti R, et al. Systemic gene therapy with antiangiogenic factors inhibits spontaneous breast tumor growth and metastasis in MMTVneu transgenic mice. GeneTher 2001; 8: 67-70.
    • (2001) GeneTher , vol.8 , pp. 67-70
    • Sacco, M.G.1    Catò, E.M.2    Ceruti, R.3
  • 107
    • 0037882102 scopus 로고    scopus 로고
    • Prevention of HER-2/neu transgenic mammary carcinoma by tamoxifen plus interleukin 12
    • Nanni P, Nicoletti G, De Giovanni C, et al. Prevention of HER-2/neu transgenic mammary carcinoma by tamoxifen plus interleukin 12. Int J Cancer 2003; 105: 384-389.
    • (2003) Int J Cancer , vol.105 , pp. 384-389
    • Nanni, P.1    Nicoletti, G.2    de Giovanni, C.3
  • 108
    • 0141962313 scopus 로고    scopus 로고
    • Combined antiestrogen, antiangiogenic and anti-invasion therapy inhibits primary and metastatic tumor growth in the MMTVneu model of breast cancer
    • Sacco MG, Soldati S, Indraccolo S, et al. Combined antiestrogen, antiangiogenic and anti-invasion therapy inhibits primary and metastatic tumor growth in the MMTVneu model of breast cancer. Gene Ther 2003; 10: 1903-1909.
    • (2003) Gene Ther , vol.10 , pp. 1903-1909
    • Sacco, M.G.1    Soldati, S.2    Indraccolo, S.3
  • 109
    • 0348230978 scopus 로고    scopus 로고
    • Effect of epidermal growth factor receptor inhibitor on development of estrogen receptor-negative mammary tumors
    • Lu C, Speers C, Zhang Y, et al. Effect of epidermal growth factor receptor inhibitor on development of estrogen receptor-negative mammary tumors. J Natl Cancer Inst 2003; 95: 1825-1833.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 1825-1833
    • Lu, C.1    Speers, C.2    Zhang, Y.3
  • 110
    • 0034671471 scopus 로고    scopus 로고
    • Estrogen promotes increased mammary tumor development in C3(1)/SV40 Tag transgenic mice: Paradoxical loss of ERα expression during tumor development
    • Yoshidome K, Shibata M.-A, Couldrey C, Korach KS, Green JE. Estrogen promotes increased mammary tumor development in C3(1)/SV40 Tag transgenic mice: paradoxical loss of ERα expression during tumor development. Cancer Res 2000; 60: 6901-6910.
    • (2000) Cancer Res , vol.60 , pp. 6901-6910
    • Yoshidome, K.1    Shibata, M.-A.2    Couldrey, C.3    Korach, K.S.4    Green, J.E.5
  • 111
    • 14644395916 scopus 로고    scopus 로고
    • Celecoxib delays tumor incidence and multiplicity in the C3(1)/SV40 Large T-antigen transgenic mammary cancer model
    • (abs)
    • Kavanaugh C, Green JE. Celecoxib delays tumor incidence and multiplicity in the C3(1)/SV40 Large T-antigen transgenic mammary cancer model. Proc. Am. Assoc. Cancer Res 2003; 44, R4885 (abs).
    • (2003) Proc. Am. Assoc. Cancer Res , vol.44
    • Kavanaugh, C.1    Green, J.E.2
  • 112
    • 0034662624 scopus 로고    scopus 로고
    • Effect of endostatin on spontaneous tumorigenesis of mammary adenocarcinoma in a transgenic mouse model
    • Yokoyama Y, Green JE, Sukhatme VP, Ramakrishnan S. Effect of endostatin on spontaneous tumorigenesis of mammary adenocarcinoma in a transgenic mouse model. Cancer Res 2000; 60: 4362-4365.
    • (2000) Cancer Res , vol.60 , pp. 4362-4365
    • Yokoyama, Y.1    Green, J.E.2    Sukhatme, V.P.3    Ramakrishnan, S.4
  • 113
    • 13444291201 scopus 로고    scopus 로고
    • Inhibition of VEGF receptors significantly impairs mammary cancer growth in C3(1)/Tag transgenic mice through anti-angiogenic and non-antiangiogenic mechanisms
    • Huh JI, Calvo A, Stafford J, et al. Inhibition of VEGF receptors significantly impairs mammary cancer growth in C3(1)/Tag transgenic mice through anti-angiogenic and non-antiangiogenic mechanisms. Oncogene 2005; 24: 790-800.
    • (2005) Oncogene , vol.24 , pp. 790-800
    • Huh, J.I.1    Calvo, A.2    Stafford, J.3
  • 114
    • 0035886864 scopus 로고    scopus 로고
    • 2-difluoromethylornithine and dehydroepiandrosterone inhibit mammary tumor progression but not mammary or prostate tumor initiation in C3(1)/SV40 T/tantigen transgenic mice
    • Green JE, Shibata MA, Shibata E, et al. 2-difluoromethylornithine and dehydroepiandrosterone inhibit mammary tumor progression but not mammary or prostate tumor initiation in C3(1)/SV40 T/tantigen transgenic mice. Cancer Res 2001; 61: 7449-7455.
    • (2001) Cancer Res , vol.61 , pp. 7449-7455
    • Green, J.E.1    Shibata, M.A.2    Shibata, E.3
  • 115
    • 77953262592 scopus 로고    scopus 로고
    • Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models
    • Singh M, Lima A, Molina R, et al. Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models. Nature Biotech 2010; 28: 565-593.
    • (2010) Nature Biotech , vol.28 , pp. 565-593
    • Singh, M.1    Lima, A.2    Molina, R.3
  • 116
    • 30344470210 scopus 로고    scopus 로고
    • Requirement for CDK4 kinase function in breast cancer
    • Yu Q, Sicinska E, Geng Y, et al. Requirement for CDK4 kinase function in breast cancer. Cancer Cell 2006; 9: 23-32.
    • (2006) Cancer Cell , vol.9 , pp. 23-32
    • Yu, Q.1    Sicinska, E.2    Geng, Y.3
  • 117
    • 30344479175 scopus 로고    scopus 로고
    • Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis
    • Landis MW, Pawlyk BS, Li T, Sicinski P, Hinds PW. Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis. Cancer Cell 2006; 9: 13-22.
    • (2006) Cancer Cell , vol.9 , pp. 13-22
    • Landis, M.W.1    Pawlyk, B.S.2    Li, T.3    Sicinski, P.4    Hinds, P.W.5
  • 118
    • 33744814638 scopus 로고    scopus 로고
    • Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors
    • Politi K, Zakowski MF, Fan P-D, Schonfield EA, Pao W, Varmus HE. Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors. Genes Dev 2006; 20: 1496-1510.
    • (2006) Genes Dev , vol.20 , pp. 1496-1510
    • Politi, K.1    Zakowski, M.F.2    Fan, P.-D.3    Schonfield, E.A.4    Pao, W.5    Varmus, H.E.6
  • 119
    • 33744788136 scopus 로고    scopus 로고
    • The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies
    • Ji H, Li D, Chen L, et al. The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. Cancer Cell 2006; 9: 485-495.
    • (2006) Cancer Cell , vol.9 , pp. 485-495
    • Ji, H.1    Li, D.2    Chen, L.3
  • 120
    • 67149134933 scopus 로고    scopus 로고
    • Breaching the cancer fortress
    • Olson P, Hanahan D. Breaching the cancer fortress. Science 2009; 324: 1400-1401.
    • (2009) Science , vol.324 , pp. 1400-1401
    • Olson, P.1    Hanahan, D.2
  • 121
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
    • Olive KP, Jacobetz MA, Davidson CJ, et al. Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer. Science 2009; 324: 1457-1461.
    • (2009) Science , vol.324 , pp. 1457-1461
    • Olive, K.P.1    Jacobetz, M.A.2    Davidson, C.J.3
  • 122
    • 0036099675 scopus 로고    scopus 로고
    • ErbB2 is essential in the prevention of dilated cardiomyopathy
    • Crone SA, Zhao YY, Fan L, et al. ErbB2 is essential in the prevention of dilated cardiomyopathy. Nature Med 2002; 8: 459-465.
    • (2002) Nature Med , vol.8 , pp. 459-465
    • Crone, S.A.1    Zhao, Y.Y.2    Fan, L.3
  • 123
    • 0029064203 scopus 로고
    • Targeted disruption of mouse EGF receptor: Effect of genetic background on mutant phenotype
    • Threadgill DW, Dlugosz AA, Hansen LA, et al. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 1995; 269: 230-234.
    • (1995) Science , vol.269 , pp. 230-234
    • Threadgill, D.W.1    Dlugosz, A.A.2    Hansen, L.A.3
  • 124
    • 74049163724 scopus 로고    scopus 로고
    • Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas
    • Zhou Y, Rideout WM, Zi T, et al. Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas. Nature Biotech 2010; 28: 71-78.
    • (2010) Nature Biotech , vol.28 , pp. 71-78
    • Zhou, Y.1    Rideout, W.M.2    Zi, T.3
  • 125
    • 34247502075 scopus 로고    scopus 로고
    • Accelerated Preclinical Testing Using Transplanted Tumors from Genetically Engineered Mouse Breast Cancer Models
    • Varticovski L, Hollingshead MG, Robles AI, et al. Accelerated Preclinical Testing Using Transplanted Tumors from Genetically Engineered Mouse Breast Cancer Models. Clin Cancer Res 2007; 13: 2168-2177.
    • (2007) Clin Cancer Res , vol.13 , pp. 2168-2177
    • Varticovski, L.1    Hollingshead, M.G.2    Robles, A.I.3
  • 126
    • 66349136558 scopus 로고    scopus 로고
    • Dissecting genetic requirements of human breast tumorigenesis in a tissue transgenic model of human breast cancer in mice
    • Wu M, Jung L, Cooper AB, et al. Dissecting genetic requirements of human breast tumorigenesis in a tissue transgenic model of human breast cancer in mice. Proc Natl Acad Sci USA 2009; 106: 7022-7027.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 7022-7027
    • Wu, M.1    Jung, L.2    Cooper, A.B.3
  • 127
    • 38549112058 scopus 로고    scopus 로고
    • Translation of new cancer treatments from pet dogs to humans
    • Paolomi M, Khanna C. Translation of new cancer treatments from pet dogs to humans. Nature Rev Cancer 2008; 8: 147-156.
    • (2008) Nature Rev Cancer , vol.8 , pp. 147-156
    • Paolomi, M.1    Khanna, C.2
  • 128
    • 1942518888 scopus 로고    scopus 로고
    • Spontaneous and genetically engineered animal models: Use in preclinical drug development
    • Hansen K, Khanna C. Spontaneous and genetically engineered animal models: use in preclinical drug development. Eur J Cancer 2004; 40: 858-880.
    • (2004) Eur J Cancer , vol.40 , pp. 858-880
    • Hansen, K.1    Khanna, C.2
  • 129
    • 0024563484 scopus 로고
    • Animal modeling and thermal dose
    • Dewhirst MW. Animal modeling and thermal dose. Radiol Clin North Am 1989; 27: 509-518.
    • (1989) Radiol Clin North Am , vol.27 , pp. 509-518
    • Dewhirst, M.W.1
  • 130
    • 0025191304 scopus 로고
    • Canine models of bone marrow transplantation
    • Ladiges WC, Storb R, Thomas ED. Canine models of bone marrow transplantation. Lab Anim Sci 1990; 40: 11-15.
    • (1990) Lab Anim Sci , vol.40 , pp. 11-15
    • Ladiges, W.C.1    Storb, R.2    Thomas, E.D.3
  • 131
    • 0027425879 scopus 로고
    • The role of photodynamic therapy in posterior fossa brain tumors. A preclinical study in a canine glioma model
    • Whelan HT, Schmidt MH, Segura AD, et al. The role of photodynamic therapy in posterior fossa brain tumors. A preclinical study in a canine glioma model. J Neurosurg 1993; 79: 562-568.
    • (1993) J Neurosurg , vol.79 , pp. 562-568
    • Whelan, H.T.1    Schmidt, M.H.2    Segura, A.D.3
  • 132
    • 0032103188 scopus 로고    scopus 로고
    • In vivo tumor transfection with superantigen plus cytokine genes induces tumor regression and prolongs survival in dogs with malignant melanoma
    • Dow SW, Elmslie RE, Willson AP, Roche L, Gorman C, Potter TA. In vivo tumor transfection with superantigen plus cytokine genes induces tumor regression and prolongs survival in dogs with malignant melanoma. J Clin Invest 1998; 101: 2406-2414.
    • (1998) J Clin Invest , vol.101 , pp. 2406-2414
    • Dow, S.W.1    Elmslie, R.E.2    Willson, A.P.3    Roche, L.4    Gorman, C.5    Potter, T.A.6
  • 133
    • 28644447707 scopus 로고    scopus 로고
    • Genome sequence, comparative analysis and haplotype structure of the domestic dog
    • Lindblad-Toh K, Wade CM, Mikkelsen TS, et al. Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature 2005; 438: 803-819.
    • (2005) Nature , vol.438 , pp. 803-819
    • Lindblad-Toh, K.1    Wade, C.M.2    Mikkelsen, T.S.3
  • 134
    • 0142029014 scopus 로고    scopus 로고
    • Genomics. A dog's breakfast?
    • O'Brien SJ, Murphy WJ. Genomics. A dog's breakfast? Science 2003; 301: 1854-1855.
    • (2003) Science , vol.301 , pp. 1854-1855
    • O'Brien, S.J.1    Murphy, W.J.2
  • 135
    • 0141596080 scopus 로고    scopus 로고
    • The dog genome:Survey sequencing and comparative analysis
    • Kirkness EF, Bafna V, Halpern AL, et al. The dog genome:survey sequencing and comparative analysis. Science 2003; 301: 1898-1903.
    • (2003) Science , vol.301 , pp. 1898-1903
    • Kirkness, E.F.1    Bafna, V.2    Halpern, A.L.3
  • 136
    • 0028928375 scopus 로고
    • Efficacy of liposomal muramyl tripeptide (CGP 19835A) in the treatment of relapsed osteosarcoma
    • Kleinerman ES, Gano JB, Johnston DA, Benjamin RS, Jaffe N. Efficacy of liposomal muramyl tripeptide (CGP 19835A) in the treatment of relapsed osteosarcoma. Am J Clin Oncol 1995; 18: 93-99.
    • (1995) Am J Clin Oncol , vol.18 , pp. 93-99
    • Kleinerman, E.S.1    Gano, J.B.2    Johnston, D.A.3    Benjamin, R.S.4    Jaffe, N.5
  • 137
    • 0029125936 scopus 로고
    • Biologic therapy for osteosarcoma using liposomeencapsulated muramyl tripeptide
    • Kleinerman ES. Biologic therapy for osteosarcoma using liposomeencapsulated muramyl tripeptide. Hematol Oncol Clin North Am 1995; 9: 927-938.
    • (1995) Hematol Oncol Clin North Am , vol.9 , pp. 927-938
    • Kleinerman, E.S.1
  • 138
    • 20144380941 scopus 로고    scopus 로고
    • Osteosarcoma: A randomized prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin, doxorubicin, and high dose methotrexate
    • Meyers PA, Schwartz CL, Krailo M, et al. Osteosarcoma: a randomized prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin, doxorubicin, and high dose methotrexate. J Clin Oncol 2005; 23: 2004-2011.
    • (2005) J Clin Oncol , vol.23 , pp. 2004-2011
    • Meyers, P.A.1    Schwartz, C.L.2    Krailo, M.3
  • 139
    • 33645828043 scopus 로고    scopus 로고
    • Liposomal muramyl tripeptide phosphatidylethanolamine: Targeting and activating macrophages for adjuvant treatment of osteosarcoma
    • Nardin A, Lefebvre ML, Labroquère K, Faure O, Abastado JP. Liposomal muramyl tripeptide phosphatidylethanolamine: Targeting and activating macrophages for adjuvant treatment of osteosarcoma. Curr Cancer Drug Targets 2006; 6(2): 123-133.
    • (2006) Curr Cancer Drug Targets , vol.6 , Issue.2 , pp. 123-133
    • Nardin, A.1    Lefebvre, M.L.2    Labroquère, K.3    Faure, O.4    Abastado, J.P.5
  • 140
    • 61749090944 scopus 로고    scopus 로고
    • Prostate cancer in dogs: Comparative and clinical aspects
    • LeRoy BE, Northrup N. Prostate cancer in dogs: comparative and clinical aspects. Vet Journal 2009; 180: 149-162.
    • (2009) Vet Journal , vol.180 , pp. 149-162
    • Leroy, B.E.1    Northrup, N.2
  • 141
    • 0034909010 scopus 로고    scopus 로고
    • Role of canine basal cells in postnatal prostatic development, induction of hyperplasia, and sex hormone-stimulated growth; and the ductal origin of carcinoma
    • Leav I, Schelling KH, Adams JY, Merk FB, Alroy J. Role of canine basal cells in postnatal prostatic development, induction of hyperplasia, and sex hormone-stimulated growth; and the ductal origin of carcinoma. Prostate 2001; 48: 210-224.
    • (2001) Prostate , vol.48 , pp. 210-224
    • Leav, I.1    Schelling, K.H.2    Adams, J.Y.3    Merk, F.B.4    Alroy, J.5
  • 142
    • 0033809969 scopus 로고    scopus 로고
    • Clinical and pathologic aspects of spontaneous canine prostate carcinoma: A retrospective analysis of 76 cases
    • Cornell KK, Bostwick DG, Cooley DM, et al. Clinical and pathologic aspects of spontaneous canine prostate carcinoma: a retrospective analysis of 76 cases. Prostate 2000; 45: 173-183.
    • (2000) Prostate , vol.45 , pp. 173-183
    • Cornell, K.K.1    Bostwick, D.G.2    Cooley, D.M.3
  • 143
    • 0037420025 scopus 로고    scopus 로고
    • Effects of dietary selenium supplementation on DNA damage and apoptosis in canine prostate
    • Waters DJ, Shen S, Cooley DM, et al. Effects of dietary selenium supplementation on DNA damage and apoptosis in canine prostate. JNCI 2003; 95: 237-241.
    • (2003) JNCI , vol.95 , pp. 237-241
    • Waters, D.J.1    Shen, S.2    Cooley, D.M.3
  • 144
    • 0029847895 scopus 로고    scopus 로고
    • Expression of stem cell factor receptor (c-kit) by the malignant mast cells from spontaneous canine mast cell tumours
    • London CA, Kisseberth WC, Galli SJ, et al. Expression of stem cell factor receptor (c-kit) by the malignant mast cells from spontaneous canine mast cell tumours. J Comp Pathol 1996; 115: 399-414.
    • (1996) J Comp Pathol , vol.115 , pp. 399-414
    • London, C.A.1    Kisseberth, W.C.2    Galli, S.J.3
  • 145
    • 0344629819 scopus 로고    scopus 로고
    • Proof of target for SU11654: Inhibition of KIT phosphorylation in canine mast cell tumors
    • Pryer NK, Lee LB, Zadovaskaya R, et al. Proof of target for SU11654: inhibition of KIT phosphorylation in canine mast cell tumors. Clin. Cancer Res 2003; 9: 5729-5734.
    • (2003) Clin. Cancer Res , vol.9 , pp. 5729-5734
    • Pryer, N.K.1    Lee, L.B.2    Zadovaskaya, R.3
  • 146
    • 0025164639 scopus 로고
    • Spontaneous tumors in dogs and cats: Models for the study of cancer biology and treatment
    • MacEwen EG. Spontaneous tumors in dogs and cats: models for the study of cancer biology and treatment. Cancer Metast Rev 1990; 9: 125-136.
    • (1990) Cancer Metast Rev , vol.9 , pp. 125-136
    • Macewen, E.G.1
  • 147
    • 0021811264 scopus 로고
    • Chemotherapy of advanced mammary adenocarcinoma in 14 cats
    • Jeglum KA, DeGuzman E, Young KM. Chemotherapy of advanced mammary adenocarcinoma in 14 cats. J Am Vet Med Assoc 1985; 187: 157-160.
    • (1985) J Am Vet Med Assoc , vol.187 , pp. 157-160
    • Jeglum, K.A.1    Deguzman, E.2    Young, K.M.3
  • 148
    • 33747348485 scopus 로고    scopus 로고
    • Application and potential limitations of animal models used in the development of trastuzumab (herceptin): A case study
    • Pegram M, Ngo D. Application and potential limitations of animal models used in the development of trastuzumab (herceptin): a case study. Drug Delivery Reviews 2006; 58: 723-734.
    • (2006) Drug Delivery Reviews , vol.58 , pp. 723-734
    • Pegram, M.1    Ngo, D.2


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