Vascular mineralocorticoid receptor and blood pressure regulation

Current Opinion in Pharmacology

Volumn 21, Issue , 2015, Pages 138-144

  Tarjus, Antoine ^a   Amador, Cristian ^a   Michea, Luis ^b   Jaisser, Frédéric ^a  

^a CENTRE DE RECHERCHE DES CORDELIERS   (France)

^b UNIVERSITY OF CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; 15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; EPLERENONE; MINERALOCORTICOID RECEPTOR; PHENYLEPHRINE; SPIRONOLACTONE;

ARTICLE; BLOOD PRESSURE REGULATION; BLOOD VESSEL REACTIVITY; BLOOD VESSEL WALL; BLOOD VOLUME; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; HUMAN; HYPERTENSION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; NEPHRON; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER; SODIUM BALANCE; TRANSGENIC ORGANISM; ANIMAL; BLOOD PRESSURE; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

ANIMALS; BLOOD PRESSURE; ENDOTHELIUM, VASCULAR; HUMANS; MYOCYTES, SMOOTH MUSCLE; RECEPTORS, MINERALOCORTICOID;

EID: 84923860897     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2015.02.004     Document Type: Review

References (53)

1. S. Lewington, R. Clarke, N. Qizilbash, R. Peto, R. Collins, and C. Prospective Studies Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies Lancet 360 2002 1903 1913
2. P.M. Kearney, M. Whelton, K. Reynolds, P. Muntner, P.K. Whelton, and J. He Global burden of hypertension: analysis of worldwide data Lancet 365 2005 217 223
3. T.M. Coffman Under pressure: the search for the essential mechanisms of hypertension Nat Med 17 2011 1402 1409
4. R.L. Wolf, M. Mendlowitz, J. Roboz, G.P. Styan, P. Kornfeld, and A. Weigl Treatment of hypertension with spironolactone. Double-blind study JAMA 198 1966 1143 1149
5. G. Colussi, C. Catena, and L.A. Sechi Spironolactone, eplerenone and the new aldosterone blockers in endocrine and primary hypertension J Hypertens 31 2013 3 15
6. M. Caprio, B.G. Newfell, A. la Sala, W. Baur, A. Fabbri, G. Rosano, M.E. Mendelsohn, and I.Z. Jaffe Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion Circ Res 102 2008 1359 1367
7. I.Z. Jaffe, and M.E. Mendelsohn Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells Circ Res 96 2005 643 650
8. S.P. Kwak, P.D. Patel, R.C. Thompson, H. Akil, and S.J. Watson 5′-Heterogeneity of the mineralocorticoid receptor messenger ribonucleic acid: differential expression and regulation of splice variants within the rat hippocampus Endocrinology 133 1993 2344 2350
9. A. Virdis, M.F. Neves, F. Amiri, E. Viel, R.M. Touyz, and E.L. Schiffrin Spironolactone improves angiotensin-induced vascular changes and oxidative stress Hypertension 40 2002 504 510
10. H. Adel, A. Taye, and M.M. Khalifa Spironolactone improves endothelial dysfunction in streptozotocin-induced diabetic rats Naunyn Schmiedebergs Arch Pharmacol 387 2014 1187 1197
11. A. Schafer, C. Vogt, D. Fraccarollo, J. Widder, U. Flierl, S.K. Hildemann, G. Ertl, and J. Bauersachs Eplerenone improves vascular function and reduces platelet activation in diabetic rats J Physiol Pharmacol 61 2010 45 52
12. N. Schafer, C. Lohmann, S. Winnik, L.J. van Tits, M.X. Miranda, A. Vergopoulos, F. Ruschitzka, J. Nussberger, S. Berger, and T.F. Luscher Endothelial mineralocorticoid receptor activation mediates endothelial dysfunction in diet-induced obesity Eur Heart J 34 2013 3515 3524
13. C.L. Sartorio, D. Fraccarollo, P. Galuppo, M. Leutke, G. Ertl, I. Stefanon, and J. Bauersachs Mineralocorticoid receptor blockade improves vasomotor dysfunction and vascular oxidative stress early after myocardial infarction Hypertension 50 2007 919 925
14. H.V. Joffe, R.Y. Kwong, M.D. Gerhard-Herman, C. Rice, K. Feldman, and G.K. Adler Beneficial effects of eplerenone versus hydrochlorothiazide on coronary circulatory function in patients with diabetes mellitus J Clin Endocrinol Metab 92 2007 2552 2558
15. N. Fujimura, K. Noma, T. Hata, J. Soga, T. Hidaka, N. Idei, Y. Fujii, S. Mikami, T. Maruhashi, and Y. Iwamoto Mineralocorticoid receptor blocker eplerenone improves endothelial function and inhibits Rho-associated kinase activity in patients with hypertension Clin Pharmacol Ther 91 2012 289 297
16. L. Michea, A.M. Delpiano, C. Hitschfeld, L. Lobos, S. Lavandero, and E.T. Marusic Eplerenone blocks nongenomic effects of aldosterone on the Na+/H+ exchanger, intracellular Ca2+ levels, and vasoconstriction in mesenteric resistance vessels Endocrinology 146 2005 973 980
17. P. Lacolley, C. Labat, A. Pujol, C. Delcayre, A. Benetos, and M. Safar Increased carotid wall elastic modulus and fibronectin in aldosterone-salt-treated rats: effects of eplerenone Circulation 106 2002 2848 2853
18. G.F. Mitchell Arterial stiffness and hypertension Hypertension 64 2014 13 18
19. A. Vukusich, S. Kunstmann, C. Varela, D. Gainza, S. Bravo, D. Sepulveda, G. Cavada, L. Michea, and E.T. Marusic A randomized, double-blind, placebo-controlled trial of spironolactone on carotid intima-media thickness in nondiabetic hemodialysis patients Clin J Am Soc Nephrol 5 2010 1380 1387
20. I.R. Preston, K.D. Sagliani, R.R. Warburton, N.S. Hill, B.L. Fanburg, and I.Z. Jaffe Mineralocorticoid receptor antagonism attenuates experimental pulmonary hypertension Am J Physiol Lung Cell Mol Physiol 304 2013 L678 L688
21. B.A. Maron, Y.Y. Zhang, K. White, S.Y. Chan, D.E. Handy, C.E. Mahoney, J. Loscalzo, and J.A. Leopold Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension Circulation 126 2012 963 974
22. B.A. Maron, A.B. Waxman, A.R. Opotowsky, H. Gillies, C. Blair, R. Aghamohammadzadeh, J. Loscalzo, and J.A. Leopold Effectiveness of spironolactone plus ambrisentan for treatment of pulmonary arterial hypertension (from the [ARIES] study 1 and 2 trials) Am J Cardiol 112 2013 720 725
23. R. Garg, A.D. Rao, M. Baimas-George, S. Hurwitz, C. Foster, R.V. Shah, M. Jerosch-Herold, R.Y. Kwong, M.F. Di Carli, and G.K. Adler Mineralocorticoid receptor blockade improves coronary microvascular function in individuals with type 2 diabetes Diabetes 64 2015 236 242
24. C.S. Rigsby, D.M. Pollock, and A.M. Dorrance Spironolactone improves structure and increases tone in the cerebral vasculature of male spontaneously hypertensive stroke-prone rats Microvasc Res 73 2007 198 205
25. C.S. Rigsby, A. Ergul, V. Portik Dobos, D.M. Pollock, and A.M. Dorrance Effects of spironolactone on cerebral vessel structure in rats with sustained hypertension Am J Hypertens 24 2011 708 715
26. K. Sanchez-Pozos, J. Barrera-Chimal, J. Garzon-Muvdi, R. Perez-Villalva, R. Rodriguez-Romo, C. Cruz, G. Gamba, and N.A. Bobadilla Recovery from ischemic acute kidney injury by spironolactone administration Nephrol Dial Transplant 27 2012 3160 3169
27. M. Lombes, M.E. Oblin, J.M. Gasc, E.E. Baulieu, N. Farman, and J.P. Bonvalet Immunohistochemical and biochemical evidence for a cardiovascular mineralocorticoid receptor Circ Res 71 1992 503 510
28. F.A. DeLano, and G.W. Schmid-Schonbein Enhancement of glucocorticoid and mineralocorticoid receptor density in the microcirculation of the spontaneously hypertensive rat Microcirculation 11 2004 69 78
29. A. Nguyen Dinh Cat, V. Griol-Charhbili, L. Loufrani, C. Labat, L. Benjamin, N. Farman, P. Lacolley, D. Henrion, and F. Jaisser The endothelial mineralocorticoid receptor regulates vasoconstrictor tone and blood pressure FASEB J 24 2010 2454 2463
30. A.J. Rickard, J. Morgan, S. Chrissobolis, A.A. Miller, C.G. Sobey, and M.J. Young Endothelial cell mineralocorticoid receptors regulate deoxycorticosterone/salt-mediated cardiac remodeling and vascular reactivity but not blood pressure Hypertension 63 2014 1033 1040
31. Y. Jeong, D.F. Chaupin, K. Matsushita, M. Yamakuchi, S.J. Cameron, C.N. Morrell, and C.J. Lowenstein Aldosterone activates endothelial exocytosis Proc Natl Acad Sci U S A 106 2009 3782 3787
32. J.A. Leopold, A. Dam, B.A. Maron, A.W. Scribner, R. Liao, D.E. Handy, R.C. Stanton, B. Pitt, and J. Loscalzo Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity Nat Med 13 2007 189 197
33. T. Thum, K. Schmitter, F. Fleissner, V. Wiebking, B. Dietrich, J.D. Widder, V. Jazbutyte, S. Hahner, G. Ertl, and J. Bauersachs Impairment of endothelial progenitor cell function and vascularization capacity by aldosterone in mice and humans Eur Heart J 32 2011 1275 1286
34. M. Zhao, I. Celerier, E. Bousquet, J.C. Jeanny, L. Jonet, M. Savoldelli, O. Offret, A. Curan, N. Farman, and F. Jaisser Mineralocorticoid receptor is involved in rat and human ocular chorioretinopathy J Clin Invest 122 2012 2672 2679
35. K. Kusche-Vihrog, K. Sobczak, N. Bangel, M. Wilhelmi, V. Nechyporuk-Zloy, A. Schwab, H. Schillers, and H. Oberleithner Aldosterone and amiloride alter ENaC abundance in vascular endothelium Pflugers Arch 455 2008 849 857
36. D.G. Warnock, K. Kusche-Vihrog, A. Tarjus, S. Sheng, H. Oberleithner, T.R. Kleyman, and F. Jaisser Blood pressure and amiloride-sensitive sodium channels in vascular and renal cells Nat Rev Nephrol 10 2014 146 157
37. P. Jeggle, C. Callies, A. Tarjus, C. Fassot, J. Fels, H. Oberleithner, F. Jaisser, and K. Kusche-Vihrog Epithelial sodium channel stiffens the vascular endothelium in vitro and in Liddle mice Hypertension 61 2013 1053 1059
38. F.R. Perez, F. Venegas, M. Gonzalez, S. Andres, C. Vallejos, G. Riquelme, J. Sierralta, and L. Michea Endothelial epithelial sodium channel inhibition activates endothelial nitric oxide synthase via phosphoinositide 3-kinase/Akt in small-diameter mesenteric arteries Hypertension 53 2009 1000 1007
39. S. Sickinger, H. Maier, S. Konig, N. Vallant, M. Kofler, P. Schumpp, H. Schwelberger, M. Hermann, P. Obrist, and S. Schneeberger Lipocalin-2 as mediator of chemokine expression and granulocyte infiltration during ischemia and reperfusion Transpl Int 26 2013 761 769
40. A.W. Krug, L. Allenhofer, R. Monticone, G. Spinetti, M. Gekle, M. Wang, and E.G. Lakatta Elevated mineralocorticoid receptor activity in aged rat vascular smooth muscle cells promotes a proinflammatory phenotype via extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase and epidermal growth factor receptor-dependent pathways Hypertension 55 2010 1476 1483
41. A. McCurley, P.W. Pires, S.B. Bender, M. Aronovitz, M.J. Zhao, D. Metzger, P. Chambon, M.A. Hill, A.M. Dorrance, and M.E. Mendelsohn Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors Nat Med 18 2012 1429 1433
42. G. Galmiche, A. Pizard, A. Gueret, S. El Moghrabi, A. Ouvrard-Pascaud, S. Berger, P. Challande, I.Z. Jaffe, C. Labat, and P. Lacolley Smooth muscle cell mineralocorticoid receptors are mandatory for aldosterone-salt to induce vascular stiffness Hypertension 63 2014 520 526
43. A. Tarjus, E. Belozertseva, H. Louis, S. El Moghrabi, C. Labat, P. Lacolley, F. Jaisser, and G. Galmiche Role of smooth muscle cell mineralocorticoid receptor in vascular tone Pflugers Arch 2014
44. H.A. Drummond betaENaC is a molecular component of a VSMC mechanotransducer that contributes to renal blood flow regulation, protection from renal injury, and hypertension Front Physiol 3 2012 341
45. A. Kiyosue, D. Nagata, M. Myojo, T. Sato, M. Takahashi, H. Satonaka, R. Nagai, and Y. Hirata Aldosterone-induced osteopontin gene transcription in vascular smooth muscle cells involves glucocorticoid response element Hypertens Res 34 2011 1283 1287
46. C.J. Zhu, Q.Q. Wang, J.L. Zhou, H.Z. Liu, F. Hua, H.Z. Yang, and Z.W. Hu The mineralocorticoid receptor-p38MAPK-NFkappaB or ERK-Sp1 signal pathways mediate aldosterone-stimulated inflammatory and profibrotic responses in rat vascular smooth muscle cells Acta Pharmacol Sin 33 2012 873 878
47. L. Calvier, M. Miana, P. Reboul, V. Cachofeiro, E. Martinez-Martinez, R.A. de Boer, F. Poirier, P. Lacolley, F. Zannad, and P. Rossignol Galectin-3 mediates aldosterone-induced vascular fibrosis Arterioscler Thromb Vasc Biol 33 2013 67 75
48. C. Latouche, S. El Moghrabi, S. Messaoudi, A. Nguyen Dinh Cat, I. Hernandez-Diaz, D. Alvarez de la Rosa, C. Perret, N. Lopez Andres, P. Rossignol, and F. Zannad Neutrophil gelatinase-associated lipocalin is a novel mineralocorticoid target in the cardiovascular system Hypertension 59 2012 966 972
49. J. Voelkl, I. Alesutan, C.B. Leibrock, L. Quintanilla-Martinez, V. Kuhn, M. Feger, S. Mia, M.S. Ahmed, K.P. Rosenblatt, and O.M. Kuro Spironolactone ameliorates PIT1-dependent vascular osteoinduction in klotho-hypomorphic mice J Clin Invest 123 2013 812 822
50. P.J. Fuller, Y. Yao, J. Yang, and M.J. Young Mechanisms of ligand specificity of the mineralocorticoid receptor J Endocrinol 213 2012 15 24
51. K. Barrett Mueller, Q. Lu, N.N. Mohammad, V. Luu, A. McCurley, G.H. Williams, G.K. Adler, R.H. Karas, and I.Z. Jaffe Estrogen receptor inhibits mineralocorticoid receptor transcriptional regulatory function Endocrinology 155 2014 4461 4472
52. A.J. Rickard, J. Morgan, G. Tesch, J.W. Funder, P.J. Fuller, and M.J. Young Deletion of mineralocorticoid receptors from macrophages protects against deoxycorticosterone/salt-induced cardiac fibrosis and increased blood pressure Hypertension 54 2009 537 543
53. M.G. Usher, S.Z. Duan, C.Y. Ivaschenko, R.A. Frieler, S. Berger, G. Schutz, C.N. Lumeng, and R.M. Mortensen Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice J Clin Invest 120 2010 3350 3364