-
1
-
-
39849109338
-
Autophagy fights disease through cellular self-digestion
-
Mizushima, N., Levine, B., Cuervo, A. M. & Klionsky, D. J. Autophagy fights disease through cellular self-digestion. Nature 451, 1069-1075 (2008
-
(2008)
Nature
, vol.451
, pp. 1069-1075
-
-
Mizushima, N.1
Levine, B.2
Cuervo, A.M.3
Klionsky, D.J.4
-
2
-
-
84875892111
-
Autophagy as a stress-response and quality-control mechanism: Implications for cell injury and human disease
-
Murrow, L. & Debnath, J. Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease. Annu. Rev. Pathol. 8, 105-137 (2013
-
(2013)
Annu. Rev. Pathol
, vol.8
, pp. 105-137
-
-
Murrow, L.1
Debnath, J.2
-
3
-
-
0034707036
-
A ubiquitin-like system mediates protein lipidation
-
Ichimura, Y., et al. A ubiquitin-like system mediates protein lipidation. Nature 408, 488-492 (2000
-
(2000)
Nature
, vol.408
, pp. 488-492
-
-
Ichimura, Y.1
-
4
-
-
0032563798
-
A protein conjugation system essential for autophagy
-
Mizushima, N., et al. A protein conjugation system essential for autophagy. Nature 395, 395-398 (1998
-
(1998)
Nature
, vol.395
, pp. 395-398
-
-
Mizushima, N.1
-
5
-
-
0035286734
-
Molecular dissection of autophagy: Two ubiquitin-like systems
-
Ohsumi, Y. Molecular dissection of autophagy: two ubiquitin-like systems. Nat. Rev. Mol. Cell Biol. 2, 211-216 (2001
-
(2001)
Nat. Rev. Mol. Cell Biol
, vol.2
, pp. 211-216
-
-
Ohsumi, Y.1
-
6
-
-
0141960205
-
The mouse apg10 homologue, an e2-like enzyme for apg12p conjugation, facilitates map-lc3 modification
-
Nemoto, T., et al. The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification. J. Biol. Chem. 278, 39517-39526 (2003
-
(2003)
J. Biol. Chem
, vol.278
, pp. 39517-39526
-
-
Nemoto, T.1
-
7
-
-
0032898636
-
Apg7p/cvt2p: A novel protein-Activating enzyme essential for autophagy
-
Tanida, I., et al. Apg7p/Cvt2p: a novel protein-Activating enzyme essential for autophagy. Mol. Biol. Cell 10, 1367-1379 (1999
-
(1999)
Mol. Biol. Cell
, vol.10
, pp. 1367-1379
-
-
Tanida, I.1
-
8
-
-
0037134443
-
Human apg3p/aut1p homologue is an authentic e2 enzyme for multiple substrates, gate-16, gabarap, and map-lc3, and facilitates the conjugation of hapg12p to hapg5p
-
Tanida, I., Tanida-Miyake, E., Komatsu, M., Ueno, T. & Kominami, E. Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p. J. Biol. Chem. 277, 13739-13744 (2002
-
(2002)
J. Biol. Chem
, vol.277
, pp. 13739-13744
-
-
Tanida, I.1
Tanida-Miyake, E.2
Komatsu, M.3
Ueno, T.4
Kominami, E.5
-
9
-
-
84883655855
-
Hidden behind autophagy: The unconventional roles of atg proteins
-
Bestebroer, J., V'kovski, P., Mauthe, M. & Reggiori, F. Hidden behind autophagy: the unconventional roles of ATG proteins. Traffic 14, 1029-1041 (2013
-
(2013)
Traffic
, vol.14
, pp. 1029-1041
-
-
Bestebroer, J.1
V'kovski, P.2
Mauthe, M.3
Reggiori, F.4
-
10
-
-
84873407151
-
Non-Autophagic roles of autophagy-related proteins
-
Subramani, S. & Malhotra, V. Non-Autophagic roles of autophagy-related proteins. EMBO Rep. 14, 143-151 (2013
-
(2013)
EMBO Rep
, vol.14
, pp. 143-151
-
-
Subramani, S.1
Malhotra, V.2
-
11
-
-
77955637249
-
Atg12 conjugation to atg3 regulates mitochondrial homeostasis and cell death
-
Radoshevich, L., et al. ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. Cell 142, 590-600 (2010
-
(2010)
Cell
, vol.142
, pp. 590-600
-
-
Radoshevich, L.1
-
12
-
-
63649086486
-
The escrt machinery in endosomal sorting of ubiquitylated membrane proteins
-
Raiborg, C. & Stenmark, H. The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins. Nature 458, 445-452 (2009
-
(2009)
Nature
, vol.458
, pp. 445-452
-
-
Raiborg, C.1
Stenmark, H.2
-
13
-
-
35948983328
-
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease
-
Filimonenko, M., et al. Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease. J. Cell Biol. 179, 485-500 (2007
-
(2007)
J. Cell Biol
, vol.179
, pp. 485-500
-
-
Filimonenko, M.1
-
14
-
-
34548492271
-
Escrt-iii dysfunction causes autophagosome accumulation and neurodegeneration
-
Lee, J-A., Beigneux, A., Ahmad, S. T., Young, S. G. & Gao, F-B. ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration. Curr. Biol. 17, 1561-1567 (2007
-
(2007)
Curr. Biol
, vol.17
, pp. 1561-1567
-
-
Lee, J.-A.1
Beigneux, A.2
Ahmad, S.T.3
Young, S.G.4
Gao, F.-B.5
-
15
-
-
35348869859
-
Escrts and fab1 regulate distinct steps of autophagy
-
Rusten, T. E., et al. ESCRTs and Fab1 regulate distinct steps of autophagy. Curr. Biol. 17, 1817-1825 (2007
-
(2007)
Curr. Biol
, vol.17
, pp. 1817-1825
-
-
Rusten, T.E.1
-
16
-
-
34548077575
-
Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-Tagged lc3
-
Kimura, S., Noda, T & Yoshimori, T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-Tagged LC3. Autophagy 3, 452-460 (2007
-
(2007)
Autophagy
, vol.3
, pp. 452-460
-
-
Kimura, S.1
Noda, T.2
Yoshimori, T.3
-
17
-
-
84863206297
-
Syndecan-syntenin-Alix regulates the biogenesis of exosomes
-
Baietti, M. F., et al. Syndecan-syntenin-ALIX regulates the biogenesis of exosomes. Nat. Cell Biol. 14, 677-685 (2012
-
(2012)
Nat. Cell Biol
, vol.14
, pp. 677-685
-
-
Baietti, M.F.1
-
18
-
-
0141643096
-
The alg-2-interacting protein alix associates with chmp4b, a human homologue of yeast snf7 that is involved in multivesicular body sorting
-
Katoh, K., et al. The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting. J. Biol. Chem. 278, 39104-39113 (2003
-
(2003)
J. Biol. Chem
, vol.278
, pp. 39104-39113
-
-
Katoh, K.1
-
19
-
-
9144273746
-
Role of lbpa and alix in multivesicular liposome formation and endosome organization
-
Matsuo, H., et al. Role of LBPA and Alix in multivesicular liposome formation and endosome organization. Science 303, 531-534 (2004
-
(2004)
Science
, vol.303
, pp. 531-534
-
-
Matsuo, H.1
-
20
-
-
22844435415
-
Tsg101 and alix interact with murine leukemia virus gag and cooperate with nedd4 ubiquitin ligases during budding
-
Segura-Morales, C., et al. Tsg101 and Alix interact with murine leukemia virus Gag and cooperate with Nedd4 ubiquitin ligases during budding. J. Biol. Chem. 280, 27004-27012 (2005
-
(2005)
J. Biol. Chem
, vol.280
, pp. 27004-27012
-
-
Segura-Morales, C.1
-
21
-
-
0141844660
-
Aip 1/alix is a binding partner for hiv-1 p6 and eiav p9 functioning in virus budding
-
Strack, B., Calistri, A., Craig, S., Popova, E. & Göttlinger, H. G. AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. Cell 114, 689-699 (2003
-
(2003)
Cell
, vol.114
, pp. 689-699
-
-
Strack, B.1
Calistri, A.2
Craig, S.3
Popova, E.4
Göttlinger, H.G.5
-
22
-
-
10744233294
-
The protein network of hiv budding
-
Von Schwedler, U. K., et al. The protein network of HIV budding. Cell 114, 701-713 (2003
-
(2003)
Cell
, vol.114
, pp. 701-713
-
-
Von Schwedler, U.K.1
-
23
-
-
80052293740
-
Activation of the retroviral budding factor alix
-
Zhai, Q., et al. Activation of the retroviral budding factor ALIX. J. Virol. 85, 9222-9226 (2011
-
(2011)
J. Virol
, vol.85
, pp. 9222-9226
-
-
Zhai, Q.1
-
24
-
-
50949107286
-
The hiv-1 p6/eiav p9 docking site in alix is autoinhibited as revealed by a conformation-sensitive anti-Alix monoclonal antibody
-
Zhou, X., et al. The HIV-1 p6/EIAV p9 docking site in Alix is autoinhibited as revealed by a conformation-sensitive anti-Alix monoclonal antibody. Biochem. J. 414, 215-220 (2008
-
(2008)
Biochem. J.
, vol.414
, pp. 215-220
-
-
Zhou, X.1
-
25
-
-
21644443846
-
Alix regulates cortical actin and the spatial distribution of endosomes
-
Cabezas, A., Bache, K. G., Brech, A. & Stenmark, H. Alix regulates cortical actin and the spatial distribution of endosomes. J. Cell Sci. 118, 2625-2635 (2005
-
(2005)
J. Cell Sci
, vol.118
, pp. 2625-2635
-
-
Cabezas, A.1
Bache, K.G.2
Brech, A.3
Stenmark, H.4
-
26
-
-
33845944620
-
Involvement of the conserved adaptor protein alix in actin cytoskeleton assembly
-
Pan, S., et al. Involvement of the conserved adaptor protein Alix in actin cytoskeleton assembly. J. Biol. Chem. 281, 34640-34650 (2006
-
(2006)
J. Biol. Chem
, vol.281
, pp. 34640-34650
-
-
Pan, S.1
-
27
-
-
33646171781
-
Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class i is independent of mammalian escrtii
-
Bowers, K., et al. Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII. J. Biol. Chem. 281, 5094-5105 (2006
-
(2006)
J. Biol. Chem
, vol.281
, pp. 5094-5105
-
-
Bowers, K.1
-
28
-
-
3142630225
-
Exosomes: Endosomal-derived vesicles shipping extracellular messages
-
Fevrier, B. & Raposo, G. Exosomes: endosomal-derived vesicles shipping extracellular messages. Curr. Opin. Cell Biol. 16, 415-421 (2004
-
(2004)
Curr. Opin. Cell Biol
, vol.16
, pp. 415-421
-
-
Fevrier, B.1
Raposo, G.2
-
29
-
-
0036676445
-
Exosomes: Composition, biogenesis and function
-
Théry, C., Zitvogel, L. & Amigorena, S. Exosomes: composition, biogenesis and function. Nat. Rev. Immunol. 2, 569-579 (2002
-
(2002)
Nat. Rev. Immunol
, vol.2
, pp. 569-579
-
-
Théry, C.1
Zitvogel, L.2
Amigorena, S.3
-
30
-
-
79959211941
-
Host factors involved in retroviral budding and release
-
Martin-Serrano, J. & Neil, S. J. Host factors involved in retroviral budding and release. Nat. Rev. Microbiol. 9, 519-531 (2011
-
(2011)
Nat. Rev. Microbiol
, vol.9
, pp. 519-531
-
-
Martin-Serrano, J.1
Neil, S.J.2
-
31
-
-
78651423598
-
Microautophagy of cytosolic proteins by late endosomes
-
Sahu, R., et al. Microautophagy of cytosolic proteins by late endosomes. Dev. Cell 20, 131-139 (2011
-
(2011)
Dev. Cell
, vol.20
, pp. 131-139
-
-
Sahu, R.1
-
32
-
-
50149120573
-
Alix differs from escrt proteins in the control of autophagy
-
Petiot, A., et al. Alix differs from ESCRT proteins in the control of autophagy. Biochem. Biophys. Res. Commun. 375, 63-68 (2008
-
(2008)
Biochem. Biophys. Res. Commun
, vol.375
, pp. 63-68
-
-
Petiot, A.1
-
33
-
-
0032555641
-
Isolation and characterization of rat liver amphisomes-evidence for fusion of autophagosomes with both early and late endosomes
-
Berg, T. O., Fengsrud, M., Stromhaug, P. E., Berg, T. & Seglen, P. O. Isolation and characterization of rat liver amphisomes-Evidence for fusion of autophagosomes with both early and late endosomes. J. Biol. Chem. 273, 21883-21892 (1998
-
(1998)
J. Biol. Chem
, vol.273
, pp. 21883-21892
-
-
Berg, T.O.1
Fengsrud, M.2
Stromhaug, P.E.3
Berg, T.4
Seglen, P.O.5
-
34
-
-
38149044992
-
Induction of autophagy promotes fusion of multivesicular bodies with autophagic vacuoles in k562 cells
-
Fader, C. M., Sanchez, D., Furlan, M. & Colombo, M. I. Induction of autophagy promotes fusion of multivesicular bodies with autophagic vacuoles in k562 cells. Traffic 9, 230-250 (2008
-
(2008)
Traffic
, vol.9
, pp. 230-250
-
-
Fader, C.M.1
Sanchez, D.2
Furlan, M.3
Colombo, M.I.4
-
35
-
-
79960774898
-
Autophagosome precursor maturation requires homotypic fusion
-
Moreau, K., Ravikumar, B., Renna, M., Puri, C. & Rubinsztein, D. C. Autophagosome precursor maturation requires homotypic fusion. Cell 146, 303-317 (2011
-
(2011)
Cell
, vol.146
, pp. 303-317
-
-
Moreau, K.1
Ravikumar, B.2
Renna, M.3
Puri, C.4
Rubinsztein, D.C.5
-
36
-
-
79960798816
-
Snare proteins are required for macroautophagy
-
Nair, U., et al. SNARE proteins are required for macroautophagy. Cell 146, 290-302 (2011
-
(2011)
Cell
, vol.146
, pp. 290-302
-
-
Nair, U.1
-
37
-
-
84870880174
-
The hairpin-Type tail-Anchored snare syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes
-
Itakura, E., Kishi-Itakura, C. & Mizushima, N. The hairpin-Type tail-Anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell 151, 1256-1269 (2012
-
(2012)
Cell
, vol.151
, pp. 1256-1269
-
-
Itakura, E.1
Kishi-Itakura, C.2
Mizushima, N.3
-
38
-
-
84886294903
-
Syntaxin 13, a genetic modifier of mutant chmp2b in frontotemporal dementia, is required for autophagosome maturation
-
Lu, Y., Zhang, Z., Sun, D., Sweeney, S. T. & Gao, F-B. Syntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal dementia, is required for autophagosome maturation. Mol. Cell 52, 264-271 (2013
-
(2013)
Mol. Cell
, vol.52
, pp. 264-271
-
-
Lu, Y.1
Zhang, Z.2
Sun, D.3
Sweeney, S.T.4
Gao, F.-B.5
-
39
-
-
3242877218
-
Rab7 is required for the normal progression of the autophagic pathway in mammalian cells
-
Gutierrez, M. G., Munafó, D. B., Berón, W. & Colombo, M. I. Rab7 is required for the normal progression of the autophagic pathway in mammalian cells. J. Cell Sci. 117, 2687-2697 (2004
-
(2004)
J. Cell Sci
, vol.117
, pp. 2687-2697
-
-
Gutierrez, M.G.1
Munafó, D.B.2
Berón, W.3
Colombo, M.I.4
-
40
-
-
7244255989
-
Role for rab7 in maturation of late autophagic vacuoles
-
Jäger, S., et al. Role for Rab7 in maturation of late autophagic vacuoles. J. Cell Sci. 117, 4837-4848 (2004
-
(2004)
J. Cell Sci
, vol.117
, pp. 4837-4848
-
-
Jäger, S.1
-
41
-
-
79959346132
-
Distinct autophagosomallysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest
-
Ganley, I. G., Wong, P-M., Gammoh, N. & Jiang, X. Distinct autophagosomallysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest. Mol. Cell 42, 731-743 (2011
-
(2011)
Mol. Cell
, vol.42
, pp. 731-743
-
-
Ganley, I.G.1
Wong, P.-M.2
Gammoh, N.3
Jiang, X.4
-
42
-
-
77649337122
-
Hdac6 controls autophagosome maturation essential for ubiquitinselective quality-control autophagy
-
Lee, J. Y., et al. HDAC6 controls autophagosome maturation essential for ubiquitinselective quality-control autophagy. EMBO J. 29, 969-980 (2010
-
(2010)
EMBO J.
, vol.29
, pp. 969-980
-
-
Lee, J.Y.1
-
43
-
-
84893055506
-
The nutrient-responsive transcription factor tfe3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris
-
Martina, J. A., et al. The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris. Sci. Signal. 7, ra9 (2014
-
(2014)
Sci. Signal
, vol.7
, pp. ra9
-
-
Martina, J.A.1
-
44
-
-
80955177196
-
Tfeb links autophagy to lysosomal biogenesis
-
Settembre, C., et al. TFEB links autophagy to lysosomal biogenesis. Science 332, 1429-1433 (2011
-
(2011)
Science
, vol.332
, pp. 1429-1433
-
-
Settembre, C.1
-
45
-
-
84899844485
-
Lipidation of the lc3/gabarap family of autophagy proteins relies on a membrane-curvature-sensing domain in atg3
-
Nath, S., et al. Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3. Nat. Cell Biol. 16, 415-424 (2014
-
(2014)
Nat. Cell Biol
, vol.16
, pp. 415-424
-
-
Nath, S.1
-
46
-
-
81055157988
-
Exosome secretion: Molecular mechanisms and roles in immune responses
-
Bobrie, A., Colombo, M., Raposo, G. & Théry, C. Exosome secretion: molecular mechanisms and roles in immune responses. Traffic 12, 1659-1668 (2011
-
(2011)
Traffic
, vol.12
, pp. 1659-1668
-
-
Bobrie, A.1
Colombo, M.2
Raposo, G.3
Théry, C.4
-
47
-
-
77149155386
-
Unconventional secretion of acb1 is mediated by autophagosomes
-
Duran, J. M., Anjard, C., Stefan, C., Loomis, W. F. & Malhotra, V. Unconventional secretion of Acb1 is mediated by autophagosomes. J. Cell Biol. 188, 527-536 (2010
-
(2010)
J. Cell Biol
, vol.188
, pp. 527-536
-
-
Duran, J.M.1
Anjard, C.2
Stefan, C.3
Loomis, W.F.4
Malhotra, V.5
-
48
-
-
79960308079
-
Autophagy deregulation in neurodegenerative diseases-recent advances and future perspectives
-
Cheung, Z. H. & Ip, N. Y. Autophagy deregulation in neurodegenerative diseases-recent advances and future perspectives. J. Neurochem. 118, 317-325 (2011
-
(2011)
J. Neurochem
, vol.118
, pp. 317-325
-
-
Cheung, Z.H.1
Ip, N.Y.2
-
49
-
-
11444267601
-
Endosome function and dysfunction in alzheimer's disease and other neurodegenerative diseases
-
Nixon, R. A. Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases. Neurobiol. Aging 26, 373-382 (2005
-
(2005)
Neurobiol. Aging
, vol.26
, pp. 373-382
-
-
Nixon, R.A.1
-
50
-
-
41449109334
-
Induction of autophagy during extracellular matrix detachment promotes cell survival
-
Fung, C., Lock, R., Gao, S., Salas, E. & Debnath, J. Induction of autophagy during extracellular matrix detachment promotes cell survival. Mol. Biol. Cell 19, 797-806 (2008
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 797-806
-
-
Fung, C.1
Lock, R.2
Gao, S.3
Salas, E.4
Debnath, J.5
-
51
-
-
10744224318
-
Visualization of retroviral replication in living cells reveals budding into multivesicular bodies
-
Sherer, N. M., et al. Visualization of retroviral replication in living cells reveals budding into multivesicular bodies. Traffic 4, 785-801 (2003
-
(2003)
Traffic
, vol.4
, pp. 785-801
-
-
Sherer, N.M.1
-
52
-
-
54949088988
-
Midbody targeting of the escrt machinery by a noncanonical coiled coil in cep55
-
Lee, H. H., Elia, N., Ghirlando, R., Lippincott-Schwartz, J. & Hurley, J. H. Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55. Science 322, 576-580 (2008
-
(2008)
Science
, vol.322
, pp. 576-580
-
-
Lee, H.H.1
Elia, N.2
Ghirlando, R.3
Lippincott-Schwartz, J.4
Hurley, J.H.5
-
53
-
-
43249109372
-
Isolation and characterization of exosomes from cell culture supernatants and biological fluids
-
3.22.21-23.22.29
-
Théry, C., Amigorena, S., Raposo, G. & Clayton, A. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr. Protoc. Cell Biol. 30, 3.22.21-23.22.29 (2006).\
-
(2006)
Curr. Protoc. Cell Biol
, vol.30
-
-
Théry, C.1
Amigorena, S.2
Raposo, G.3
Clayton, A.4
|