Acetaldehyde, not ethanol, impairs myelin formation and viability in primary mouse oligodendrocytes

Alcoholism: Clinical and Experimental Research

Volumn 39, Issue 3, 2015, Pages 455-462

  Coutts, David J C ^a   Harrison, Neil L ^a  

^a Columbia University ^*  (United States)

Author keywords

Acetaldehyde; Ethanol; Myelination; Oligodendrocyte; White Matter

Indexed keywords

ACETALDEHYDE; ALCOHOL; MYELIN PROTEIN;

ANIMAL CELL; ARTICLE; CELL COUNT; CELL CULTURE; CELL DIFFERENTIATION; CELL SURVIVAL; CELL VIABILITY; COMPARATIVE STUDY; DRINKING BEHAVIOR; IMMUNOCYTOCHEMISTRY; LONG TERM EXPOSURE; MOUSE; MYELIN SHEATH; MYELINATION; NONHUMAN; OLIGODENDROGLIA; PRIMARY CELL; PRIORITY JOURNAL; WHITE MATTER; ANIMAL; C57BL MOUSE; DRUG EFFECTS; PATHOLOGY;

ACETALDEHYDE; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; ETHANOL; MICE; MICE, INBRED C57BL; MYELIN SHEATH; OLIGODENDROGLIA;

EID: 84923847563     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/acer.12642     Document Type: Article

References (42)

1. Alfonso-Loeches S, Guerri C (2011) Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain. Crit Rev Clin Lab Sci 48:19-47.
2. Alfonso-Loeches S, Pascual M, Gómez-Pinedo U, Pascual-Lucas M, Renau-Piqueras J, Guerri C (2012) Toll-like receptor 4 participates in the myelin disruptions associated with chronic alcohol abuse. Glia 60:948-964.
3. Aragon CMG, Abitbol M, Amit Z (1991) Ethanol-induced CTA mediated by acetaldehyde through central catecholamine activity. Psychopharmacology 103:74-77.
4. Aspberg A, Tottmar O (1994) Ethanol-induced increase in catalase activity in reaggregation cultures of rat brain cells is due to increased oligodendrocyte differentiation. Alcohol Clin Exp Res 18:620-624.
5. Bass T, Volpe JJ (1989) Ethanol in clinically relevant concentrations enhances expression of oligodendroglial differentiation but has no effect on astrocytic differentiation or DNA synthesis in primary cultures. Dev Neurosci 11:52-64.
6. Bichenkov E, Ellingson JS (2000) Effects of transient ethanol exposure on the incorporation of [3H]ethanolamine into plasmalogen in the differentiating CG-4 oligodendrocyte cell line. Biochem Pharmacol 60:1703-1711.
7. Correa M, Salamone JD, Segovia KN, Pardo M, Longoni R, Spina L, Peana AT, Vinci S, Acquas E (2012) Piecing together the puzzle of acetaldehyde as a neuroactive agent. Neurosci Biobehav Rev 36:404-430.
8. Creeley CE, Dikranian KT, Johnson SA, Farber NB, Olney JW (2013) Alcohol-induced apoptosis of oligodendrocytes in the fetal macaque brain. Acta Neuropathol Commun 1:1-11.
9. Davies DL, Ross TM (1991) Long-term ethanol-exposure markedly changes the cellular composition of cerebral glial cultures. Dev Brain Res 62:151-158.
10. de la Monte SM (1988) Disproportionate atrophy of cerebral white matter in chronic alcoholics. Arch Neurol 45:990-992.
11. Elofson J, Gongvatana W, Carey KB (2013) Alcohol use and cerebral white matter compromise in adolescence. Addict Behav 38:2295-2305.
12. Fernández-Gamba A, Leal MC, Maarouf CL, Richter-Landsberg C, Wu T, Morelli L, Roher AE, Castaño EM (2012) Collapsin response mediator protein-2 phosphorylation promotes the reversible retraction of oligodendrocyte processes in response to non-lethal oxidative stress. J Neurochem 121:985-995.
13. Fields RD (2008) White matter in learning, cognition and psychiatric disorders. Trends Neurosci 31:361-370.
14. Hagemeier K, Lürbke A, Hucke S, Albrecht S, Preisner A, Klassen E, Hoffmann E, Cui Q-L, Antel JJ, Brück W, Klotz L, Kuhlmann T (2013) Puma, but not noxa is essential for oligodendroglial cell death. Glia 61:1712-1723.
15. Hamby-Mason R, Chen JJ, Schenker S, Perez A, Henderson GI (1997) Catalase mediates acetaldehyde formation from ethanol in fetal and neonatal rat brain. Alcohol Clin Exp Res 21:1063-1072.
16. Harper C, Kril J (1985) Brain atrophy in chronic alcoholic patients: a quantitative pathological study. J Neurol Neurosurg Psychiatry 48:211-217.
17. Harper C, Matsumoto I, Pfefferbaum A, Adalsteinsson E, Sullivan EV, Lewohl J, Dodd P, Taylor M, Fein G, Landman B (2005) The pathophysiology of "brain shrinkage" in alcoholics - structural and molecular changes and clinical implications. Alcohol Clin Exp Res 29:1106-1115.
18. Heffernan T (2008) The impact of excessive alcohol use on prospective memory: a brief review. Curr Drug Abuse Rev 1:36-41.
19. Hipólito L, Sánchez MJ, Polache A, Granero L (2007) Brain metabolism of ethanol and alcoholism: an update. Curr Drug Metab 8:716-727.
20. Huang JK, Jarjour AA, Oumesmar BN, Kerninon C, Williams A, Krezel W, Kagechika H, Bauer J, Zhao C, Evercooren AB-V, Chambon P, Ffrench-Constant C, Franklin RJM (2011) Retinoid X receptor gamma signaling accelerates CNS remyelination. Nat Neurosci 14: 45-53.
21. Jamal M, Ameno K, Uekita I, Kumihashi M, Wang W, Ijiri I (2007) Catalase mediates acetaldehyde formation in the striatum of free-moving rats. Neurotoxicology 28:1245-1248.
22. Korbo L (1999) Glial cell loss in the hippocampus of alcoholics. Alcohol Clin Exp Res 23:164-168.
23. Kril JJ, Halliday GM, Svoboda MD, Cartwright H (1997) The cerebral cortex is damaged in chronic alcoholics. Neuroscience 79:983-998.
24. Lamarche F, Gonthier B, Signorini N, Eysseric H, Barret L (2004) Impact of ethanol and acetaldehyde on DNA and cell viability of cultured neurones. Cell Biol Toxicol 20:361-374.
25. Lewohl JM, Wang L, Miles MF, Zhang L, Dodd PR, Harris RA (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. Alcohol Clin Exp Res 24:1873-1882.
26. Liu J, Lewohl JM, Dodd PR, Randall PK, Harris RA, Mayfield RD (2004) Gene expression profiling of individual cases reveals consistent transcriptional changes in alcoholic human brain. J Neurochem 90:1050-1058.
27. March SM, Abate P (2013) Acetaldehyde involvement in ethanol's postabsortive effects during early ontogeny. Front Behav Neurosci 7:70.
28. Nave K-A (2010) Myelination and the trophic support of long axons. Nat Rev Neurosci 11:275-283.
29. Pfefferbaum A, Sullivan EV, Mathalon DH, Shear PK, Rosenbloom MJ, Lim KO (1995) Longitudinal changes in magnetic resonance imaging brain volumes in abstinent and relapsed alcoholics. Alcohol Clin Exp Res 19:1177-1191.
30. Phillips D, Krueger S, Rydquist J (1991) Short- and long-term effects of combined pre- and postnatal ethanol exposure (three trimester equivalency) on the development of myelin and axons in rat optic nerve. Int J Dev Neurosci 9:631-647.
31. Quertemont E, Grant KA, Correa M, Arizzi MN, Salamone JD, Tambour S, Aragon CMG, McBride WJ, Rodd ZA, Goldstein A, Zaffaroni A, Li T-K, Pisano M, Diana M (2005) The role of acetaldehyde in the central effects of ethanol. Alcohol Clin Exp Res 29:221-234.
32. Rodríguez FD, Simonsson P, Alling C (1992) A method for maintaining constant ethanol concentrations in cell culture media. Alcohol 27:309-313.
33. Šarc L, Lipnik-Štangelj M (2009) Comparison of ethanol and acetaldehyde toxicity in rat astrocytes in primary culture. Arch Ind Hyg Toxicol 60:297-305.
34. Smolen TN, Smolen A (1989) Blood and brain ethanol concentrations during absorption and distribution in long-sleep and short-sleep mice. Alcohol 6:33-38.
35. Sokolov BP (2007) Oligodendroglial abnormalities in schizophrenia, mood disorders and substance abuse. Comorbidity, shared traits, or molecular phenocopies? Int J Neuropsychopharmacol 10:547-555.
36. Tabakoff B, Anderson RA, Ritzmann RF (1976) Brain acetaldehyde after ethanol administration. Biochem Pharmacol 25:1305-1309.
37. Tong M, Longato L, Nguyen Q-G, Chen WC, Spaisman A, de la Monte SM (2011) Acetaldehyde-mediated neurotoxicity: relevance to fetal alcohol spectrum disorders. Oxid Med Cell Longev 2011: Article ID 213286, doi: 10.1155/2011/213286.
38. Urso T, Gavaler JS, Van Thiel DH (1981) Blood ethanol levels in sober alcohol users seen in an emergency room. Life Sci 28:1053-1056.
39. Vargas WM, Bengston L, Gilpin NW, Whitcomb BW, Richardson HN (2014) Alcohol binge drinking during adolescence or dependence during adulthood reduces prefrontal myelin in male rats. J Neurosci 34:14777-14782.
40. Young KM, Psachoulia K, Tripathi RB, Dunn S-J, Cossell L, Attwell D, Tohyama K, Richardson WD (2013) Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodeling. Neuron 77:873-885.
41. Zahr NM, Mayer D, Rohlfing T, Hasak MP, Hsu O, Vinco S, Orduna J, Luong R, Sullivan EV, Pfefferbaum A (2010) Brain injury and recovery following binge ethanol: evidence from in vivo magnetic resonance spectroscopy. Biol Psychiatry 67:846-854.
42. Zimatkin SM (1991) Histochemical study of aldehyde dehydrogenase in the rat CNS. J Neurochem 56:1-11.