Synthesis and biochemical evaluation of δ 2-isoxazoline derivatives as DNA methyltransferase 1 inhibitors

Journal of Medicinal Chemistry

Volumn 54, Issue 21, 2011, Pages 7663-7677

  Castellano, Sabrina ^a   Kuck, Dirk ^b   Viviano, Monica ^a   Yoo, Jakyung ^c   López Vallejo, Fabian ^c   Conti, Paola ^d   Tamborini, Lucia ^d   Pinto, Andrea ^d   Medina Franco, José L ^c   Sbardella, Gianluca ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b GERMAN CANCER RESEARCH CENTER   (Germany)

^c TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

^d UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 ISOXAZOLINE DERIVATIVE; 5 (N,N DIMETHYLAMINOMETHYL) 3 (4 NITROPHENYL) 4,5 DIHYDROISOXAZOLE; DNA METHYLTRANSFERASE INHIBITOR; PROCAINAMIDE; PROCAINE; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; COLON CARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; IC 50; IN VITRO STUDY;

ANTINEOPLASTIC AGENTS; BINDING SITES; BINDING, COMPETITIVE; CELL PROLIFERATION; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DRUG SCREENING ASSAYS, ANTITUMOR; HCT116 CELLS; HUMANS; ISOXAZOLES; MODELS, MOLECULAR; PROTEIN BINDING; RECOMBINANT PROTEINS; S-ADENOSYLMETHIONINE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80455173681     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2010404     Document Type: Article

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