The new 4-O-methylhonokiol analog GS12021 inhibits inflammation and macrophage chemotaxis: Role of AMP-activated protein kinase α activation

PLoS ONE

Volumn 10, Issue 2, 2015, Pages

  Kim, Sora ^a   Ka, Sun O ^b   Lee, Youngyi ^a   Park, Byung Hyun ^b   Fei, Xiang ^c   Jung, Jae Kyung ^d   Seo, Seung Yong ^c   Bae, Eun Ju ^a  

^a Woosuk University   (South Korea)

^b Chonbuk National University   (South Korea)

^c Gachon University   (South Korea)

^d Chungbuk National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

3',5 DIALLYL 4' METHOXY[1,1' BIPHENYL] 2 YLMORPHOLINE 4 CARBOXYLATE; ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; HONOKIOL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; SIRTUIN 1; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; 4-O-METHYLHONOKIOL; ADENYLATE KINASE; BIPHENYL DERIVATIVE; GS12021; LIGNAN; MORPHOLINE DERIVATIVE;

ADIPOCYTE; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL LINE; CELL MIGRATION; CELL VIABILITY; CHEMOTAXIS; CONTROLLED STUDY; CYTOLYSIS; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENETIC TRANSFECTION; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; RAW264.7 CELL LINE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA ISOLATION; WESTERN BLOTTING; ANIMAL; CHEMICALLY INDUCED; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; METABOLISM;

ADENYLATE KINASE; ANIMALS; BIPHENYL COMPOUNDS; CELL LINE; CHEMOTAXIS; CYCLOOXYGENASE 2; ENZYME ACTIVATION; INFLAMMATION; LIGNANS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MORPHOLINES; NITRIC OXIDE SYNTHASE TYPE II;

EID: 84923786147     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0117120     Document Type: Article

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