Dysregulation of escherichia coli α-hemolysin expression alters the course of acute and persistent urinary tract infection

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 8, 2015, Pages E871-E880

  Nagamatsu, Kanna ^a   Hannan, Thomas J ^a   Guest, Randi L ^b   Kostakioti, Maria ^a,e   Hadjifrangiskou, Maria ^a,c   Binkley, Jana ^a   Dodson, Karen ^a   Raivio, Tracy L ^b   Hultgren, Scott J ^a,d  

^a Department of Molecular Microbiology ^*  (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e MONSANTO COMPANY   (United States)

Author keywords

Microbial pathogenesis; Persistent colonization; Urinary tract infection; Uropathogenic E. coli

Indexed keywords

ALPHA HEMOLYSIN; CASPASE 11; CASPASE 4; CRYOPYRIN; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LACTATE DEHYDROGENASE; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PROTEIN; PROTEIN CPXR; PROTEIN CXPRA; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; CARRIER PROTEIN; CPXR PROTEIN, BACTERIA; ESCHERICHIA COLI PROTEIN; HEMOLYSIN; HLYA PROTEIN, E COLI; INFLAMMASOME; NLRP3 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL LOAD; BACTERIAL VIRULENCE; CELL DEATH; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOTOXICITY; FEMALE; GENE DELETION; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY CELL; MICROBIAL COMMUNITY; MOUSE; NEUTROPHIL; NONHUMAN; PERSISTENT INFECTION; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FOLDING; REGULATORY MECHANISM; REPORTER GENE; SIGNAL TRANSDUCTION; URINARY TRACT INFECTION; UROPATHOGENIC ESCHERICHIA COLI; UROTHELIUM; ACUTE DISEASE; ANIMAL; APOPTOSIS; BACTERIAL COUNT; BIOLOGICAL MODEL; BLADDER; CHRONIC DISEASE; DISEASE COURSE; ENZYME ACTIVATION; ESCHERICHIA COLI INFECTION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MICROBIOLOGY; PATHOGENICITY; PATHOLOGY; PHYSIOLOGY; SECRETION (PROCESS); VIRULENCE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MURINAE;

ACUTE DISEASE; ANIMALS; APOPTOSIS; BACTERIAL PROTEINS; CARRIER PROTEINS; CASPASE 1; CHRONIC DISEASE; COLONY COUNT, MICROBIAL; DISEASE PROGRESSION; ENZYME ACTIVATION; ESCHERICHIA COLI INFECTIONS; ESCHERICHIA COLI PROTEINS; FEMALE; GENE EXPRESSION REGULATION, BACTERIAL; HEMOLYSIN PROTEINS; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; MICE; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; URINARY BLADDER; URINARY TRACT INFECTIONS; UROPATHOGENIC ESCHERICHIA COLI; VIRULENCE;

EID: 84923676032     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1500374112     Document Type: Article

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