Nutrient stress alters the glycosylation status of LGR5 resulting in reduced protein stability and membrane localisation in colorectal tumour cells: Implications for targeting cancer stem cells

British Journal of Cancer

Volumn 112, Issue 4, 2015, Pages 714-719

  Morgan, R G ^a   Molnar E ^b   Jones, R F ^a   Collard, T J ^a   Lane, J D ^c   Greenhough, A ^a   Paraskeva, C ^a   Williams, A C ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b School of Physiology and Pharmacology   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

colorectal cancer; glycosylation; LGR5; microenvironment; nutrient stress; stem cell

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GLUCOSE; LEUCINE RICH REPEAT CONTAINING G PROTEIN COUPLED RECEPTOR 5; N ACETYL BETA GLUCOSAMINIDASE; TUNICAMYCIN; UNCLASSIFIED DRUG; LGR5 PROTEIN, HUMAN;

ARTICLE; CANCER STEM CELL; CELL STRESS; CELL SURFACE; CELLULAR DISTRIBUTION; COLORECTAL TUMOR; CONFOCAL LASER MICROSCOPY; CONFOCAL MICROSCOPY; FLOW CYTOMETRY; GOLGI COMPLEX; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NUTRIENT; NUTRIENT STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN PROCESSING; PROTEIN STABILITY; REAL TIME POLYMERASE CHAIN REACTION; TUMOR MICROENVIRONMENT; ADENOMA; CELL MEMBRANE; COLORECTAL NEOPLASMS; DEFICIENCY; FOOD; GENETICS; GLYCOSYLATION; METABOLISM; PHYSIOLOGICAL STRESS; PHYSIOLOGY; PROTEIN TRANSPORT; TUMOR CELL CULTURE;

ADENOMA; CELL MEMBRANE; COLORECTAL NEOPLASMS; FOOD; GLUCOSE; GLYCOSYLATION; HUMANS; NEOPLASTIC STEM CELLS; PROTEIN STABILITY; PROTEIN TRANSPORT; RECEPTORS, G-PROTEIN-COUPLED; STRESS, PHYSIOLOGICAL; TUMOR CELLS, CULTURED; TUMOR MICROENVIRONMENT;

EID: 84923572548     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2015.4     Document Type: Article

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