The prognostic implications of macrophages expressing proliferating cell nuclear antigen in breast cancer depend on immune context

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Campbell, Michael J ^a   Wolf, Denise ^a   Mukhtar, Rita A ^a   Tandon, Vickram ^a   Yau, Christina ^a   Au, Alfred ^a   Baehner, Frederick ^a   Van'T Veer, Laura ^a,c   Berry, Donald ^b   Esserman, Laura J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c Agendia NV   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; HORMONE RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TUMOR MARKER;

ADULT; ANTIGEN EXPRESSION; ARTICLE; BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER GRADING; CANCER PATIENT; CANCER PROGNOSIS; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; PHENOTYPE; RECURRENCE FREE SURVIVAL; TUMOR ASSOCIATED LEUKOCYTE; TUMOR BIOPSY; TUMOR MICROENVIRONMENT; BREAST TUMOR; IMMUNOLOGY; KAPLAN MEIER METHOD; MACROPHAGE; METABOLISM; PATHOLOGY; PROGNOSIS;

BREAST NEOPLASMS; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; MACROPHAGES; PROGNOSIS; PROLIFERATING CELL NUCLEAR ANTIGEN; TUMOR MARKERS, BIOLOGICAL;

EID: 84923546419     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0079114     Document Type: Article

References (27)

1. Mantovani A, Sica A (2010) Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr Opin Immunol 22: 231-237. doi: 10.1016/j.coi.2010.01.009. PubMed: 20144856.
2. Mantovani A, Sozzani S, Locati M, Allavena P, Sica A (2002) Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 23: 549-555. doi:10.1016/S1471-4906(02)02302-5. PubMed: 12401408.
3. Ostrand-Rosenberg S (2008) Immune surveillance: a balance between protumor and antitumor immunity. Curr Opin Genet Dev 18: 11-18. doi: 10.1016/j.gde.2007.12.007. PubMed: 18308558.
4. Lamagna C, Aurrand-Lions M, Imhof BA (2006) Dual role of macrophages in tumor growth and angiogenesis. J Leukoc Biol 80: 705-713. doi:10.1189/jlb.1105656. PubMed: 16864600.
5. Leek RD, Harris AL (2002) Tumor-associated macrophages in breast cancer. J Mammary Gland Biol Neoplasia 7: 177-189. doi:10.1023/A: 1020304003704. PubMed: 12463738.
6. Leek RD, Lewis CE, Whitehouse R, Greenall M, Clarke J et al. (1996) Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Res 56: 4625-4629. PubMed: 8840975.
7. Volodko N, Reiner A, Rudas M, Jakesz R (1998) Tumour-associated macrophages in breast cancer and their prognostic correlations. Breast 7: 99-105. doi:10.1016/S0960-9776(98)90065-0.
8. Campbell MJ, Tonlaar NY, Garwood ER, Huo D, Moore DH et al. (2011) Proliferating macrophages associated with high grade, hormone receptor negative breast cancer and poor clinical outcome. Breast Cancer Res Treat 128: 703-711. doi:10.1007/s10549-010-1154-y. PubMed: 20842526.
9. Mukhtar RA, Moore AP, Nseyo O, Baehner FL, Au A et al. (2011) Elevated PCNA+ tumor-associated macrophages in breast cancer are associated with early recurrence and non-Caucasian ethnicity. Breast Cancer Res Treat 130: 635-644. doi:10.1007/s10549-011-1646-4. PubMed: 21717106.
10. Esserman LJ, Berry DA, Cheang MC, Yau C, Perou CM et al. (2011) Chemotherapy response and recurrence-free survival in neoadjuvant breast cancer depends on biomarker profiles: results from the I-SPY 1 TRIAL. (CALGB 150007/150012; ACRIN 6657). Breast cancer research and treatment
11. Esserman LJ, Berry DA, Cheang MC, Yau C, Perou CM et al. (2012) Chemotherapy response and recurrence-free survival in neoadjuvant breast cancer depends on biomarker profiles: results from the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657). Breast Cancer Res Treat 132: 1049-1062. doi:10.1007/s10549-011-1895-2. PubMed: 22198468.
12. Esserman LJ, Berry DA, DeMichele A, Carey L, Davis SE et al. (2012) Pathologic complete response predicts recurrence-free survival more effectively by cancer subset: results from the I-SPY 1 TRIAL-CALGB 150007/150012, ACRIN 6657. J Clin Oncol Off J American Society Of Clinical Oncology 30: 3242-3249. doi:10.1200/JCO.2011.39.2779. PubMed: 22649152.
13. Berry D (2012) Multiplicities in cancer research: ubiquitous and necessary evils. J Natl Cancer Inst 104: 1124-1132. doi:10.1093/jnci/djs352. PubMed: 22859849.
14. Hatzis C, Pusztai L, Valero V, Booser DJ, Esserman L et al. (2011) A genomic predictor of response and survival following taxane-anthracycline chemotherapy for invasive breast cancer. J Am Med Assoc 305: 1873-1881. doi:10.1001/jama.2011.593.
15. Shaykhiev R, Krause A, Salit J, Strulovici-Barel Y, Harvey BG et al. (2009) Smoking-dependent reprogramming of alveolar macrophage polarization: implication for pathogenesis of chronic obstructive pulmonary disease. J Immunol 183: 2867-2883. doi:10.4049/jimmunol. 0900473. PubMed: 19635926.
16. Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M et al. (2004) Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 5: R80. doi:10.1186/gb-2004-5-10-r80. PubMed: 15461798.
17. Falini B, Flenghi L, Pileri S, Gambacorta M, Bigerna B et al. (1993) PG-M1: a new monoclonal antibody directed against a fixative-resistant epitope on the macrophage-restricted form of the CD68 molecule. Am J Pathol 142: 1359-1372. PubMed: 7684194.
18. Gottfried E, Kunz-Schughart LA, Weber A, Rehli M, Peuker A et al. (2008) Expression of CD68 in non-myeloid cell types. Scand J Immunol 67: 453-463. doi:10.1111/j.1365-3083.2008.02091.x. PubMed: 18405323.
19. Egeblad M, Ewald AJ, Askautrud HA, Truitt ML, Welm BE et al. (2008) Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy. Dis Models Mechanisms 1: 155-167; discussion: 10.1242/dmm.000596. PubMed: 19048079.
20. Movahedi K, Laoui D, Gysemans C, Baeten M, Stangé G et al. (2010) Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. Cancer Res 70: 5728-5739. doi:10.1158/1538-7445.AM10-5728. PubMed: 20570887.
21. Baxevanis CN, Dedoussis GV, Papadopoulos NG, Missitzis I, Stathopoulos GP et al. (1994) Tumor specific cytolysis by tumor infiltrating lymphocytes in breast cancer. Cancer 74: 1275-1282. doi: 10.1002/1097-0142(19940815)74:4. PubMed: 7914469.
22. Guo X, Fan Y, Lang R, Gu F, Chen L et al. (2008) Tumor infiltrating lymphocytes differ in invasive micropapillary carcinoma and medullary carcinoma of breast. Mod Pathol Off J United States Canadian Academy Of Pathology, Inc 21: 1101-1107. doi:10.1038/modpathol. 2008.72. PubMed: 18469794.
23. Leong PP, Mohammad R, Ibrahim N, Ithnin H, Abdullah M et al. (2006) Phenotyping of lymphocytes expressing regulatory and effector markers in infiltrating ductal carcinoma of the breast. Immunol Lett 102: 229-236. doi:10.1016/j.imlet.2005.09.006. PubMed: 16246429.
24. Mahmoud SM, Paish EC, Powe DG, Macmillan RD, Grainge MJ et al. (2011) Tumor-infiltrating CD8+ lymphocytes predict clinical outcome in breast cancer. J Clin Oncol Off J American Society Of Clinical Oncology 29: 1949-1955. doi:10.1200/JCO.2010.30.5037. PubMed: 21483002.
25. Denardo DG, Brennan DJ, Rexhepaj E, Ruffell B, Shiao SL et al. (2011) Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy. Cancer Discov 1: 54-67. doi:10.1158/2159-8274.CD-10-0028 PubMed: 22039576.
26. van't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA et al. (2002) Gene expression profiling predicts clinical outcome of breast cancer. Nature 415: 530-536. doi:10.1038/415530a. PubMed: 11823860.
27. Campbell MJ, Zhu J, Yau C, Mukhtar R, Nseyo O et al. (2010) Expression of genes associated with the innate immune system and response to neoadjuvant chemotherapy in breast cancer. 33rd Annual San Antonio Breast Cancer Symposium TX.: San Antonio.