Synergistic effects of zinc oxide nanoparticles and fatty acids on toxicity to caco-2 cells

International Journal of Toxicology

Volumn 34, Issue 1, 2015, Pages 67-76

  Cao, Yi ^a   Roursgaard, Martin ^a   Kermanizadeh, Ali ^a   Loft, Steffen ^a   Møller, Peter ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Caco 2 cells; fatty acid; lysosomal destabilization; mitochondrial ROS; zinc oxide nanoparticle

Indexed keywords

FATTY ACID; OLEIC ACID; PALMITIC ACID; REACTIVE OXYGEN METABOLITE; ZINC OXIDE NANOPARTICLE; METAL NANOPARTICLE; ZINC OXIDE;

ARTICLE; CACO 2 CELL LINE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; EXPOSURE; FILTRATION; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; LYSOSOME; POROSITY; SUSPENSION; CELL SURVIVAL; DRUG EFFECTS; METABOLISM; MITOCHONDRION;

CACO-2 CELLS; CELL SURVIVAL; HUMANS; LYSOSOMES; METAL NANOPARTICLES; MITOCHONDRIA; OLEIC ACID; PALMITIC ACID; REACTIVE OXYGEN SPECIES; ZINC OXIDE;

EID: 84923516564     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1177/1091581814560032     Document Type: Article

References (28)

1. Shi LE, Li ZH, Zheng W, Zhao YF, Jin YF, Tang ZX. Synthesis, antibacterial activity, antibacterial mechanism and food applications of ZnO nanoparticles: a review. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014 ; 31 (2). 173-186
2. Abbott Chalew T, Schwab K. Toxicity of commercially available engineered nanoparticles to Caco-2 and SW480 human intestinal epithelial cells. Cell Biol Toxicol. 2013 ; 29 (2). 101-116
3. Gerloff K, Albrecht C, Boots AW, Forster I, Schins RPF. Cytotoxicity and oxidative DNA damage by nanoparticles in human intestinal Caco-2 cells. Nanotoxicology. 2009 ; 3 (4). 355-364
4. Moos PJ, Olszewski K, Honeggar M, et al. Responses of human cells to ZnO nanoparticles: a gene transcription study. Metallomics. 2011 ; 3 (11). 1199-1211
5. De Angelis I, Barone F, Zijno A, et al. Comparative study of ZnO and TiO2 nanoparticles: physicochemical characterisation and toxicological effects on human colon carcinoma cells. Nanotoxicology. 2013 ; 7 (8). 1361-1372
6. Kang T, Guan R, Chen X, Song Y, Jiang H, Zhao J. In vitro toxicity of different-sized ZnO nanoparticles in Caco-2 cells. Nanoscale Res Lett. 2013 ; 8 (1). 496-498
7. Mahler GJ, Esch MB, Tako E, et al. Oral exposure to polystyrene nanoparticles affects iron absorption. Nat Nano. 2012 ; 7 (4). 264-271
8. Bateman PA, Jackson KG, Maitin V, Yaqoob P, Williams CM. Differences in cell morphology, lipid and apo B secretory capacity in caco-2 cells following long term treatment with saturated and monounsaturated fatty acids. Biochim Biophys Acta. 2007 ; 1771 (4). 475-485
9. Jackson K, Bateman P, Yaqoob P, Williams C. Impact of saturated, polyunsaturated and monounsaturated fatty acid-rich micelles on lipoprotein synthesis and secretion in caco-2 cells. Lipids. 2009 ; 44 (12). 1081-1089
10. Ulluwishewa D, Anderson RC, McNabb WC, Moughan PJ, Wells JM, Roy NC. Regulation of tight junction permeability by intestinal bacteria and dietary components. J Nutr. 2011 ; 141 (5). 769-776
11. Vandebriel RJ, De Jong WH. A review of mammalian toxicity of ZnO nanoparticles. Nanotechnol Sci Appl. 2012 ; 5: 61-71
12. Sambuy Y, Angelis I, Ranaldi G, Scarino ML, Stammati A, Zucco F. The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics. Cell Biol Toxicol. 2005 ; 21 (1). 1-26
13. Kermanizadeh A, Pojana G, Gaiser BK, et al. In vitro assessment of engineered nanomaterials using a hepatocyte cell line: cytotoxicity, pro-inflammatory cytokines and functional markers. Nanotoxicology. 2013 ; 7 (3). 301-313
14. Walkey CD, Chan WCW. Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment. Chem Soc Rev. 2012 ; 41 (7). 2780-2799
15. Xu M, Li J, Iwai H, et al. Formation of nano-bio-complex as nanomaterials dispersed in a biological solution for understanding nanobiological interactions. Sci Rep. 2012 ; 2: 406
16. Nano JL, Nobili C, Girard-Pipau F, Rampal P. Effects of fatty acids on the growth of Caco-2 cells. Prostaglandins Leukot Essent Fatty Acids. 2003 ; 69 (4). 207-215
17. Klein SG, Serchi T, Hoffmann L, Blomeke B, Gutleb AC. An improved 3D tetraculture system mimicking the cellular organisation at the alveolar barrier to study the potential toxic effects of particles on the lung. Part Fibre Toxicol. 2013 ; 10 (1). 31
18. Valdiglesias V, Costa C, Kilic G, et al. Neuronal cytotoxicity and genotoxicity induced by zinc oxide nanoparticles. Environ Int. 2013 ; 55: 92-100
19. Xu M, Li J, Hanagata N, Su H, Chen H, Fujita D. Challenge to assess the toxic contribution of metal cation released from nanomaterials for nanotoxicology - the case of ZnO nanoparticles. Nanoscale. 2013 ; 5 (11). 4763-4769
20. Sharma V, Anderson D, Dhawan A. Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2). Apoptosis. 2012 ; 17 (8). 852-870
21. Moos PJ, Chung K, Woessner D, Honeggar M, Cutler NS, Veranth JM. ZnO particulate matter requires cell contact for toxicity in human colon cancer cells. Chem Res Toxicol. 2010 ; 23 (4). 733-739
22. Shen C, James SA, de Jonge MD, Turney TW, Wright PF, Feltis BN. Relating cytotoxicity, zinc ions, and reactive oxygen in ZnO nanoparticle-exposed human immune cells. Toxicol Sci. 2013 ; 136 (1). 120-130
23. Gao D, Pararasa C, Dunston CR, Bailey CJ, Griffiths HR. Palmitate promotes monocyte atherogenicity via de novo ceramide synthesis. Free Radic Biol Med. 2012 ; 53 (4). 796-806
24. Yuzefovych L, Wilson G, Rachek L. Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress. Am J Physiol Endocrinol Metab. 2010 ; 299 (6). E1096 - E1105
25. Stern ST, Adiseshaiah PP, Crist RM. Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity. Part Fibre Toxicol. 2012 ; 9 ( 20 ):
26. Cho WS, Duffin R, Howie SE, et al. Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes. Part Fibre Toxicol. 2011 ; 8 ( 27 ):
27. Boya P, Kroemer G. Lysosomal membrane permeabilization in cell death. Oncogene. 2008 ; 27 (50). 6434-6451
28. Feldstein AE, Werneburg NW, Li Z, Bronk SF, Gores GJ. Bax inhibition protects against free fatty acid-induced lysosomal permeabilization. Am J Physiol Gastrointest Liver Physiol. 2006 ; 290 (6). G1339 - G1346