Organic cation transporter/solute carrier family 22a is involved in drug transfer into milk in mice

Journal of Pharmaceutical Sciences

Volumn 103, Issue 10, 2014, Pages 3342-3348

  Ito, Naoki ^a   Ito, Kousei ^b   Ikebuchi, Yuki ^a   Kito, Tomoko ^c   Miyata, Hiroshi ^a   Toyoda, Y U ^a   Takada, Tappei ^a   Hisaka, Akihiro ^a   Honma, Masashi ^a   Oka, Akira ^a   Kusuhara, Hiroyuki ^c   Suzuki, Hiroshi ^a  

^a UNIVERSITY OF TOKYO HOSPITAL   (Japan)

^b CHIBA UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Disposition; Drug transfer into milk; Lactation; Mammary transport secretion; Organic cation transporter solute carrier 22a; Pediatric

Indexed keywords

ACICLOVIR; BREAST CANCER RESISTANCE PROTEIN; CIMETIDINE; CLINDAMYCIN; MESSENGER RNA; METFORMIN; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; ORGANIC CATION TRANSPORTER 3; TERBUTALINE; VERAPAMIL; ABC TRANSPORTER; ABCG2 PROTEIN, MOUSE; DRUG; ORGANIC CATION TRANSPORTER; PRIMER DNA;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BINDING; DRUG ELIMINATION; DRUG MILK LEVEL; DRUG UPTAKE; EMBRYO; FEMALE; GESTATIONAL AGE; HEK293 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; LACTATION; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; MILK TO PLASMA CONCENTRATION RATIO; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; BLOOD; GENETICS; KNOCKOUT MOUSE; MALE; METABOLISM; MILK; NUCLEOTIDE SEQUENCE; PHARMACOKINETICS; PHYSIOLOGY;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BASE SEQUENCE; DNA PRIMERS; FEMALE; MALE; MICE; MICE, KNOCKOUT; MILK; ORGANIC CATION TRANSPORT PROTEINS; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS;

EID: 84923381327     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24138     Document Type: Article

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