Chemotherapy enhances metastasis formation via VEGFR-1-expressing endothelial cells

Cancer Research

Volumn 71, Issue 22, 2011, Pages 6976-6985

  Daenen, Laura G M ^a   Roodhart, Jeanine M L ^a   Van Amersfoort, Miranda ^a   Dehnad, Mantre ^a   Roessingh, Wijnand ^a   Ulfman, Laurien H ^a   Derksen, Patrick W B ^a   Voest, Emile E ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; PACLITAXEL; VASCULOTROPIN RECEPTOR 1;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER CHEMOTHERAPY; CELL ADHESION; CELL COUNT; CELL HOMING; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFICACY; ENDOTHELIUM CELL; IMMUNE RESPONSE; LUNG METASTASIS; METASTASIS POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; RECEPTOR BLOCKING; UPREGULATION;

ANIMALS; ANTIGENS, CD31; CELL ADHESION; CERCOPITHECUS AETHIOPS; COS CELLS; ENDOTHELIAL CELLS; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NEOPLASMS, EXPERIMENTAL; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 81155126054     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-11-0627     Document Type: Article

References (34)

1. El Sharouni SY, Kal HB, Battermann JJ. Accelerated regrowth of nonsmall- cell lung tumours after induction chemotherapy. Br J Cancer 2003;89:2184-9. (Pubitemid 38167997)
2. Bourhis J, Wilson G, Wibault P, Janot F, Bosq J, Armand JP, et al. Rapid tumor cell proliferation after induction chemotherapy in oropharyngeal cancer. Laryngoscope 1994;104:468-72. (Pubitemid 24118245)
3. Roodhart JM, Langenberg MH, Vermaat JS, Lolkema MP, Baars A, Giles RH, et al. Late release of circulating endothelial cells and endothelial progenitor cells after chemotherapy predicts response and survival in cancer patients. Neoplasia 2010;12: 87-94.
4. Shaked Y, Henke E, Roodhart JM, Mancuso P, Langenberg MH, Colleoni M, et al. Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents. Cancer Cell 2008;14:263-73.
5. Kerbel RS, Ebos JM. Peering into the aftermath: the inhospitable host? Nat Med 2010;16:1084-5.
6. Smakman N, Martens A, Kranenburg O, Borel R, I. Validation of bioluminescence imaging of colorectal liver metastases in the mouse. J Surg Res 2004;122:225-30. (Pubitemid 39535947)
7. Gimeno R, Weijer K, Voordouw A, Uittenbogaart CH, Legrand N, Alves NL, et al. Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- gammac-/- mice: functional inactivation of p53 in developing T cells. Blood 2004;104: 3886-93. (Pubitemid 39620134)
8. Dull T, Zufferey R, Kelly M, Mandel RJ, Nguyen M, Trono D, et al. A third-generation lentivirus vector with a conditional packaging system. J Virol 1998;72:8463-71. (Pubitemid 28471781)
9. Derin D, Soydinc HO, Guney N, Tas F, Camlica H, Duranyildiz D, et al. Serum levels of apoptosis biomarkers, survivin and TNF-alpha in nonsmall cell lung cancer. Lung Cancer 2008;59:240-5. (Pubitemid 351173407)
10. Jia Z, Wang N, Aoyagi T, Wang H, Liu H, Yang T. Amelioration of cisplatin nephrotoxicity by genetic or pharmacologic blockade of prostaglandin synthesis. Kidney Int 2011;79:77-88.
11. Ramesh G, Reeves WB. TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity. J Clin Invest 2002;110:835-42.
12. Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 2005;438:820-7. (Pubitemid 41753060)
13. Kerber M, Reiss Y, Wickersheim A, Jugold M, Kiessling F, Heil M, et al. Flt-1 signaling in macrophages promotes glioma growth in vivo. Cancer Res 2008;68:7342-51.
14. Muramatsu M, Yamamoto S, Osawa T, Shibuya M. Vascular endothelial growth factor receptor-1 signaling promotes mobilization of macrophage lineage cells from bone marrow and stimulates solid tumor growth. Cancer Res 2010;70:8211-21.
15. Jin DK, Shido K, Kopp HG, Petit I, Shmelkov SV, Young LM, et al. Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4 +hemangiocytes. Nat Med 2006;12: 557-67.
16. Lee YJ, Karl DL, Maduekwe UN, Rothrock C, Ryeom S, D'Amore PA, et al. Differential effects of VEGFR-1 and VEGFR-2 inhibition on tumor metastases based on host organ environment. Cancer Res 2010;70: 8357-67.
17. Withers HR, Milas L. Influence of preirradiation of lung on development of artificial pulmonary metastases of fibrosarcoma in mice. Cancer Res 1973;33:1931-6.
18. de Ruiter J, Smink T, van Putten LM. Studies on the enhancement by cyclophosphamide (NSC-26271) of artificial lung metastasis after labeled cell inoculation. Cancer Treat Rep 1976;60:465-70.
19. Carmel RJ, Brown JM. The effect of cyclophosphamide and other drugs on the incidence of pulmonary metastases in mice. Cancer Res 1977;37:145-51. (Pubitemid 8009289)
20. Yamauchi K, Yang M, Hayashi K, Jiang P, Yamamoto N, Tsuchiya H, et al. Induction of cancer metastasis by cyclophosphamide pretreatment of host mice: an opposite effect of chemotherapy. Cancer Res 2008;68:516-20. (Pubitemid 351380079)
21. Hanna N, Fidler IJ. Expression of metastatic potential of allogenic and xenogeneic neoplasms in young nude mice. Cancer Res 1981;41: 438-44. (Pubitemid 11179377)
22. Hanna N, Burton RC. Definitive evidence that natural killer (NK) cells inhibit experimental tumor metastases in vivo. J Immunol 1981;127: 1754-8. (Pubitemid 11023139)
23. Hunt BJ, Jurd KM. Endothelial cell activation. A central pathophysiological process. BMJ 1998;316:1328-9.
24. De Vos FY, Willemse PH, de Vries EG, Gietema JA. Endothelial cell effects of cytotoxics: balance between desired and unwanted effects. Cancer Treat Rev 2004;30:495-513. (Pubitemid 39157851)
25. Vidal F, Aragones J, Alfranca A, de Landazuri MO. Up-regulation of vascular endothelial growth factor receptor Flt-1 after endothelial denudation: role of transcription factor Egr-1. Blood 2000;95:3387-95. (Pubitemid 30428468)
26. Fan F, Gray MJ, Dallas NA, Yang AD, Van BG, Camp ER, et al. Effect of chemotherapeutic stress on induction of vascular endothelial growth factor family members and receptors in human colorectal cancer cells. Mol Cancer Ther 2008;7:3064-70.
27. Tsuchida R, Das B, Yeger H, Koren G, Shibuya M, Thorner PS, et al. Cisplatin treatment increases survival and expansion of a highly tumorigenic side-population fraction by upregulating VEGF/Flt1 autocrine signaling. Oncogene 2008;27:3923-34. (Pubitemid 351913641)
28. Ellis LM, Hicklin DJ. VEGF-targeted therapy: mechanisms of antitumour activity. Nat Rev Cancer 2008;8:579-91.
29. Fischer C, Mazzone M, Jonckx B, Carmeliet P. FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy? Nat Rev Cancer 2008;8:942-56.
30. Hiratsuka S, Nakamura K, Iwai S, Murakami M, Itoh T, Kijima H, et al. MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis. Cancer Cell 2002;2:289-300. (Pubitemid 41043963)
31. Ko JS, Rayman P, Ireland J, Swaidani S, Li G, Bunting KD, et al. Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrained. Cancer Res 2010;70:3526-36.
32. Zhang D, Hedlund EM, Lim S, Chen F, Zhang Y, Sun B, et al. Antiangiogenic agents significantly improve survival in tumor-bearing mice by increasing tolerance to chemotherapy-induced toxicity. Proc Natl Acad Sci U S A 2011;108:4117-22.
33. Sakamoto KM. Su-11248 Sugen. Curr Opin Investig Drugs 2004;5: 1329-39. (Pubitemid 40074975)
34. Ebos JM, Lee CR, Cruz-Munoz W, Bjarnason GA, Christensen JG, Kerbel RS. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 2009;15:232-9.