What is the impact of SOCS3, IL-35 and IL17 in immune pathogenesis of recurrent pregnancy loss?

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 28, Issue 3, 2015, Pages 324-328

  Ozkan, Zehra Sema ^a   Deveci, Derya ^b   Simsek, Mehmet ^a   Ilhan, Fulya ^a   Risvanli, Ali ^a   Sapmaz, Ekrem ^a  

^a FIRAT UNIVERSITY   (Turkey)

^b FIRAT UNIVERSITY   (Turkey)

Author keywords

IL 17; IL 35; Recurrent pregnancy loss; SOCS3; T helper

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 35; INTERLEUKIN 4; INTERLEUKIN 6; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; INTERLEUKIN DERIVATIVE; INTERLEUKIN-35, HUMAN; SOCS3 PROTEIN, HUMAN; SUPPRESSOR OF CYTOKINE SIGNALING;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNOPATHOGENESIS; MAJOR CLINICAL STUDY; MATERNAL PLASMA; MEDICAL HISTORY; MENSTRUAL CYCLE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; RECURRENCE RISK; RECURRENT ABORTION; RISK ASSESSMENT; TH1 TH2 BALANCE; BLOOD; CASE CONTROL STUDY; PREGNANCY; PROCEDURES;

ABORTION, HABITUAL; ADULT; CASE-CONTROL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INTERLEUKIN-17; INTERLEUKINS; PREGNANCY; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

EID: 84923365531     PISSN: 14767058     EISSN: 14764954     Source Type: Journal    
DOI: 10.3109/14767058.2014.916676     Document Type: Article

References (41)

1. Witkin SS, Linhares IM, Bongiovanni AM, et al. Unique alterations in infection-induced immune activation during pregnancy. BJOG 2011;118:145-53
2. Hunt JS, Petroff MG, McIntire RH, Ober C. HLA-G and immune tolerance in pregnancy. FASEB J 2005;19:681-93
3. Laird SM, Tuckerman EM, Cork BA, et al. A review of immune cells and molecules in women with recurrent miscarriage. Hum Reprod Update 2003;9:163-74
4. Tilburgs T, Roelen DL, van der Mast BJ, et al. Evidence for a selective migration of fetus-specific CD4+CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancy. J Immunol 2008;180:5737-45
5. Hogge WA, Byrnes AL, Lanasa MC, Surti U. The clinical use of karyotyping spontaneous abortions. Am J Obstet Gynecol 2003; 189:397-400
6. Christiansen OB, Nielsen HS, Kolte AM. Future directions of failed implantation and recurrent miscarriage research. Reprod Biomed Online 2006;13:71-83
7. Heuser C, Dalton J, Macpherson C, et al. Idiopathic recurrent pregnancy loss recurs at similar gestational ages. Am J Obstet Gynecol 2010;203:343.e1-5
8. Lee SK, Na BJ, Kim JY, et al. Determination of clinical cellular immune markers in women with recurrent pregnancy loss. Am J Reprod Immunol 2013;70:398-411
9. Hill JA, Polgar K, Anderson DJ. T-helper 1-type immunity to trophoblast in women with recurrent spontaneous abortion. JAMA 1995;273:1933-6
10. Peck A, Mellins ED. Plasticity of T-cell phenotype and function: the T helper type 17 example. Immunology 2009;129:147-53
11. Crome SQ, Wang AY, Levings MK. Translational mini-review series on Th17 cells: function and regulation of human T helper 17 cells in health and disease. Clin Exp Immunol 2010;159:109-19
12. Whitehead GS, Wilson RH, Nakano K, et al. IL-35 production by inducible costimulator (ICOS)-positive regulatory T cells reverses established IL-17-dependent allergic airways disease. J Allergy Clin Immunol 2012;129:207-15
13. Niedbala W, Wei XQ, Cai B, et al. IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells. Eur J Immunol 2007;37:3021-9
14. Saito S, Nakashima A, Shima T, Ito M. Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy. Am J Reprod Immunol 2010;63:601-10
15. Challis JR, Lockwood CJ, Myatt L, et al. Inflammation and pregnancy. Reprod Sci 2009;16:206-15
16. Sykes L, MacIntyre DA, Yap XJ, et al. The Th1:Th2 dichotomy of pregnancy and preterm labour. Mediators Inflamm 2012;2012: 967629
17. Cemgil Arikan D, Aral M, Coskun A, Ozer A. Plasma IL-4, IL-8, IL-12, interferon-c and CRP levels in pregnant women with preeclampsia, and their relation with severity of disease and fetal birth weight. J Matern Fetal Neonatal Med 2012;25:1569-73
18. Toldi G, Rigó Jr J, Stenczer B, et al. Increased prevalence of IL-17-producing peripheral blood lymphocytes in pre-eclampsia. Am J Reprod Immunol 2011;66:223-9
19. Wang WJ, Hao CF, Yi Lin, et al. Increased prevalence of T helper 17 (Th17) cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion patients. J Reprod Immunol 2010; 84:164-70
20. Abell K, Watson CJ. The Jak/Stat pathway: a novel way to regulate PI3K activity. Cell Cycle 2005;4:897-900
21. Carow B, Reuschl AK, Gavier-Widén D, et al. Critical and ?ndependent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis. PLoS Pathog 2013;9: e1003442
22. Raghupathy R, Makhseed M, Azizieh F, et al. Cytokine production by maternal lymphocytes during normal human pregnancy and in unexplained recurrent spontaneous abortion. Hum Reprod 2000;15: 713-18
23. Giannubilo SR, Landi B, Pozzi V, et al. The involvement of inflammatory cytokines in the pathogenesis of recurrent miscarriage. Cytokine 2012;58:50-6
24. Wegmann TG, Lin H, Guilbert L, Mosmann TR. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?. Immunol Today 1993;14: 353-6
25. Kwak-Kim JY, Chung-Bang HS, Ng SC, et al. Increased T helper 1 cytokine responses by circulating T cells are present in women with recurrent pregnancy losses and in infertile women with multiple implantation failures after IVF. Hum Reprod 2003;18:767-73
26. Kaur A, Kaur A. Recurrent pregnancy loss: TNF-A and IL-10 polymorphisms. J Hum Reprod Sci 2011;4:91-4
27. Palmirotta R, La Farina F, Ferroni P, et al. TNFA gene promoter polymorphisms and susceptibility to recurrent pregnancy loss in Italian women. Reprod Sci 2010;17:659-66
28. Liang P, Mo M, Li GG, et al. Comprehensive analysis of peripheral blood lymphocytes in 76 women with recurrent miscarriage before and after lymphocyte immunotherapy. Am J Reprod Immunol 2012; 68:164-74
29. Calleja-Agius J, Jauniaux E, Pizzey AR, Muttukrishna S. Investigation of systemic inflammatory response in first trimester pregnancy failure. Hum Reprod 2012;27:349-57
30. Fischer A. Human immunodeficiency: connecting STAT3, Th17 and human mucosal immunity. Immunol Cell Biol 2008;86:549-51
31. Liu YS, Wu L, Tong XH, et al. Study on the relationship between Th17 cells and unexplained recurrent spontaneous abortion. Am J Reprod Immunol 2011;65:503-11
32. Harrington LE, Hatton RD, Mangan PR, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005;6:1123-32
33. Naundorf S, Schröder M, Hö flich C, et al. IL-10 interferes directly with TCR-induced IFN-gamma but not IL-17 production in memory T cells. Eur J Immunol 2009;39:1066-77
34. Collison LW, Workman CJ, Kuo TT, et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 2007;450: 566-9
35. Bettini M, Castellaw AH, Lennon GP, et al. Prevention of autoimmune diabetes by ectopic pancreatic b-cell expression of interleukin-35. Diabetes 2012;61:1519-26
36. Xu X, Wang Q, Deng B, et al. Monocyte chemoattractant protein-1 secreted by decidual stromal cells inhibits NK cells cytotoxicity by up-regulating expression of SOCS3. PLoS One 2012;7:e41869
37. Braunschweig A, Poehlmann TG, Busch S, et al. Signal transducer and activator of transcription 3 (STAT3) and Suppressor of Cytokine Signaling (SOCS3) balance controls cytotoxicity and IL-10 expression in decidual-like natural killer cell line NK-92. Am J Reprod Immunol 2011;66:329-35
38. Wang Y, Lewis DF, Gu Y, et al. Elevated maternal soluble Gp130 and IL-6 levels and reduced Gp130 and SOCS-3 expressions in women complicated with preeclampsia. Hypertension 2011;57: 336-42
39. Kuzmicki M, Telejko B, Wawrusiewicz-Kurylonek N, et al. The expression of suppressor of cytokine signaling 1 and 3 in fat and placental tissue from women with gestational diabetes. Gynecol Endocrinol 2012;28:841-4
40. Zhang LJ, Li MY. Expression of suppressor of cytokine signaling 3 and its significance in human placenta with pregnant intrahepatic cholestasis. Zhonghua Fu Chan Ke Za Zhi 2010;45:406-10
41. Cao LQ, Qu GD, Wang DM. Expression profiles of IL-10, TNF-A, and SOCS3 in placenta of pregnant women with intrahepatic cholestasis. Zhonghua Gan Zang Bing Za Zhi 2012;20:935-8