Interference of doxycycline pretreatment in a model of abdominal aortic aneurysms

Cardiovascular Pathology

Volumn 24, Issue 2, 2015, Pages 110-120

  Mata, Karina M ^a   Tefé Silva, Cristiane ^a   Floriano, Elaine M ^a   Fernandes, Cleverson R ^a   Rizzi, Elen ^a   Gerlach, Raquel F ^a   Mazzuca, Marc Q ^a   Ramos, Simone G ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Abdominal aortic aneurysm; Doxycycline pretreatment; Inflammatory response; Metalloproteinases 2 and 9

Indexed keywords

DOXYCYCLINE; GELATINASE A; GELATINASE B; ENZYME INHIBITOR;

ABDOMINAL AORTA ANEURYSM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA WALL; ARTICLE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SHAM PROCEDURE; ZYMOGRAPHY; ABDOMINAL AORTA; ANIMAL; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; PATHOLOGY; WISTAR RAT;

ANIMALS; AORTA, ABDOMINAL; AORTIC ANEURYSM, ABDOMINAL; DISEASE MODELS, ANIMAL; DOXYCYCLINE; ENZYME INHIBITORS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; RATS; RATS, WISTAR;

EID: 84923357892     PISSN: 10548807     EISSN: 18791336     Source Type: Journal    
DOI: 10.1016/j.carpath.2014.10.004     Document Type: Article

References (62)

1. RA Sheth, M Maricevich, and U Mahmood In vivo optical molecular imaging of matrix metalloproteinase activity in abdominal aortic aneurysms correlates with treatment effects on growth rate Atherosclerosis 212 2010 181 187
2. S Anidjar, PB Dobrin, M Eichorst, GP Graham, and G Chejfec Correlation of inflammatory infiltrate with the enlargement of experimental aortic aneurysms J Vasc Surg 16 1992 139 147
3. T Freestone, RJ Turner, A Coady, DJ Higman, RM Greenhalgh, and JT Powell Inflammation and matrix metalloproteinases in the enlarging abdominal aortic aneurysm Arterioscler Thromb Vasc Biol 15 1995 1145 1151
4. A Lopez-Candales, DR Holmes, S Liao, MJ Scott, SA Wickline, and RW Thompson Decreased vascular smooth muscle cell density in medial degeneration of human abdominal aortic aneurysms Am J Pathol 150 1997 993 1007
5. PK Shah Inflammation, metalloproteinases, and increased proteolysis: an emerging pathophysiological paradigm in aortic aneurysm Circulation 96 1997 2115 2117
6. K Shimizu, RN Mitchell, and P Libby Inflammation and cellular immune responses in abdominal aortic aneurysms Arterioscler Thromb Vasc Biol 26 2006 987 994
7. Y Bi, H Zhong, K Xu, X Qi, Z Zhang, G Wu, and X Han Novel experimental model of enlarging abdominal aortic aneurysm in rabbits J Vasc Surg 2014 10.1016/j.jvs.2014.02.062
8. KM Mata, PS Prudente, FS Rocha, CM Prado, EM Floriano, J Elias, E Rizzi, RF Gerlach, MA Rossi, and SG Ramos Combining two potential causes of metalloproteinase secretion causes abdominal aortic aneurysms in rats: a new experimental model Int J Exp Pathol 92 2011 26 39
9. D Petrinec, S Liao, DR Holmes, JM Reilly, WC Parks, and RW Thompson Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: preservation of aortic elastin associated with suppressed production of 92 kD gelatinase J Vasc Surg 23 1996 336 346
10. AN Sapadin, and R Fleischmajer Tetracyclines: nonantibiotic properties and their clinical implications J Am Acad Dermatol 54 2006 258 265
11. R Hanemaaijer, H Visser, P Koolwijk, T Sorsa, T Salo, LM Golub, and VW van Hinsbergh Inhibition of MMP synthesis by doxycycline and chemically modified tetracyclines (CMTs) in human endothelial cells Adv Dent Res 12 1998 114 118
12. LM Golub, JM Goodson, HM Lee, AM Vidal, TF McNamara, and NS Ramamurthy Tetracyclines inhibit tissue collagenases. Effects of ingested low-dose and local delivery systems J Periodontol 56 1985 93 97
13. LM Golub, S Ciancio, NS Ramamamurthy, M Leung, and TF McNamara Low-dose doxycycline therapy: effect on gingival and crevicular fluid collagenase activity in humans J Periodontal Res 25 1990 321 330
14. JR O'Dell, CE Haire, W Palmer, W Drymalski, S Wees, K Blakely, M Churchill, PJ Eckhoff, A Weaver, D Doud, N Erikson, F Dietz, R Olson, P Maloley, LW Klassen, and GF Moore Treatment of early rheumatoid arthritis with minocycline or placebo: results of a randomized, double-blind, placebo-controlled trial Arthritis Rheum 40 1997 842 848
15. RW Thompson, and BT Baxter MMP inhibition in abdominal aortic aneurysms. Rationale for a prospective randomized clinical trial Ann N Y Acad Sci 878 1999 159 178
16. JT Bettany, and RG Wolowacz Tetracycline derivatives induce apoptosis selectively in cultured monocytes and macrophages but not in mesenchymal cells Adv Dent Res 12 1998 136 143
17. A Solomon, M Rosenblatt, DQ Li, Z Liu, D Monroy, Z Ji, BL Lokeshwar, and SC Pflugfelder Doxycycline inhibition of interleukin-1 in the corneal epithelium Invest Ophthalmol Vis Sci 41 2000 2544 2557
18. NS Ramamurthy, AT Vernillo, RA Greenwald, HM Lee, T Sorsa, LM Golub, and BR Rifkin Reactive oxygen species activate and tetracyclines inhibit rat osteoblast collagenase J Bone Miner Res 8 1993 1247 1253
19. E Sho, J Chu, M Sho, B Fernandes, D Judd, P Ganesan, H Kimura, and RL Dalman Continuous periaortic infusion improves doxycycline efficacy in experimental aortic aneurysms J Vasc Surg 39 2004 1312 1321
20. AK Prall, GM Longo, WG Mayhan, EA Waltke, B Fleckten, RW Thompson, and BT Baxter Doxycycline in patients with abdominal aortic aneurysms and in mice: comparison of serum levels and effect on aneurysm growth in mice J Vasc Surg 35 2002 923 929
21. MA Bartoli, FE Parodi, J Chu, MB Pagano, D Mao, BT Baxter, C Buckley, TL Ennis, and RW Thompson Localized administration of doxycycline suppresses aortic dilatation in an experimental mouse model of abdominal aortic aneurysm Ann Vasc Surg 20 2006 228 236
22. D Petrinec, DR Holmes, S Liao, LM Golub, and RW Thompson Suppression of experimental aneurysmal degeneration with chemically modified tetracycline derivatives Ann N Y Acad Sci 800 1996 263 265
23. BR Dodd, and RA Spence Doxycycline inhibition of abdominal aortic aneurysm growth: a systematic review of the literature Curr Vasc Pharmacol 9 2011 471 478
24. JA Curci, D Petrinec, S Liao, LM Golub, and RW Thompson Pharmacologic suppression of experimental abdominal aortic aneurysms: acomparison of doxycycline and four chemically modified tetracyclines J Vasc Surg 28 1998 1082 1093
25. DA Guimaraes, E Rizzi, CS Ceron, AM Oliveira, DM Oliveira, MM Castro, CR Tirapelli, RF Gerlach, and JE Tanus-Santos Doxycycline dose-dependently inhibits MMP-2-mediated vascular changes in 2K1C hypertension Basic Clin Pharmacol Toxicol 108 2011 318 325
26. MP Bendeck, M Conte, M Zhang, N Nili, BH Strauss, and SM Farwell Doxycycline modulates smooth muscle cell growth, migration, and matrix remodeling after arterial injury Am J Pathol 160 2002 1089 1095
27. MM Castro, E Rizzi, CM Prado, MA Rossi, JE Tanus-Santos, and RF Gerlach Imbalance between matrix metalloproteinases and tissue inhibitor of metalloproteinases in hypertensive vascular remodeling Matrix Biol 29 2010 194 201
28. RF Gerlach, JA Uzuelli, CD Souza-Tarla, and JE Tanus-Santos Effect of anticoagulants on the determination of plasma matrix metalloproteinase (MMP)-2 and MMP-9 activities Anal Biochem 344 2005 147 149
29. E Rizzi, MM Castro, K Fernandes, F Barbosa, GM Arisi, N Garcia-Cairasco, LM Bendhack, JE Tanus-Santos, and RF Gerlach Evidence of early involvement of matrix metalloproteinase-2 in lead-induced hypertension Arch Toxicol 83 2009 439 449
30. BE Perdue, and HC Standiford Tetracyclines VL Yu, TC Merigan, S L Barriere, Antimicrobial therapy and vaccines 1999 Williams & Wilkins Baltimore 981 995
31. PG Welling, PA Koch, CC Lau, and WA Craig Bioavailability of tetracycline and doxycycline in fasted and nonfasted subjects Antimicrob Agents Chemother 11 1977 462 469
32. K Kurosawa, JS Matsumura, and D Yamanouchi Current status of medical treatment for abdominal aortic aneurysm Circ J 77 2013 2860 2866
33. H Nagase, R Visse, and G Murphy Structure and function of matrix metalloproteinases and TIMPs Cardiovasc Res 69 2006 562 573
34. C Saracini, P Bolli, E Sticchi, G Pratesi, R Pulli, F Sofi, C Pratesi, GF Gensini, R Abbate, and B Giusti Polymorphisms of genes involved in extracellular matrix remodeling and abdominal aortic aneurysm J Vasc Surg 55 2012 171 179
35. A Yamawaki-Ogata, R Hashizume, XM Fu, A Usui, and Y Narita Mesenchymal stem cells for treatment of aortic aneurysms World J Stem Cells 6 2014 278 287
36. DG Hackam, D Thiruchelvam, and DA Redelmeier Angiotensin-converting enzyme inhibitors and aortic rupture: a population-based case-control study Lancet 368 2006 659 665
37. O Schouten, JH van Laanen, E Boersma, R Vidakovic, HH Feringa, M Dunkelgrun, JJ Bax, J Koning, UH van, and D Poldermans Statins are associated with a reduced infrarenal abdominal aortic aneurysm growth Eur J Vasc Endovasc Surg 32 2006 21 26
38. A Yamawaki-Ogata, R Hashizume, M Satake, H Kaneko, S Mizutani, T Moritan, Y Ueda, and Y Narita A doxycycline loaded, controlled-release, biodegradable fiber for the treatment of aortic aneurysms Biomaterials 31 2010 9554 9564
39. BT Baxter, WH Pearce, EA Waltke, FN Littooy, JW Hallett, KC Kent, GR Upchurch, EL Chaikof, JL Mills, B Fleckten, GM Longo, JK Lee, and RW Thompson Prolonged administration of doxycycline in patients with small asymptomatic abdominal aortic aneurysms: report of a prospective (phase II) multicenter study J Vasc Surg 36 2002 1 12
40. LJ Walton, IJ Franklin, T Bayston, LC Brown, RM Greenhalgh, GW Taylor, and JT Powell Inhibition of prostaglandin E2 synthesis in abdominal aortic aneurysms: implications for smooth muscle cell viability, inflammatory processes, and the expansion of abdominal aortic aneurysms Circulation 100 1999 48 54
41. K Yoshimura, H Aoki, Y Ikeda, K Fujii, N Akiyama, A Furutani, Y Hoshii, N Tanaka, R Ricci, T Ishihara, K Esato, K Hamano, and M Matsuzaki Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase Nat Med 11 2005 1330 1338
42. BT Baxter, MC Terrin, and RL Dalman Medical management of small abdominal aortic aneurysms Circulation 117 2008 1883 1889
43. EL Chaikof, DC Brewster, RL Dalman, MS Makaroun, KA Illig, GA Sicard, CH Timaran, GR Upchurch, and FJ Veith The care of patients with an abdominal aortic aneurysm: the Society for Vascular Surgery practice guidelines J Vasc Surg 50 2009 S2 S49
44. A Trollope, JV Moxon, CS Moran, and J Golledge Animal models of abdominal aortic aneurysm and their role in furthering management of human disease Cardiovasc Pathol 20 2011 114 123
45. K Kaito, H Urayama, and G Watanabe Doxycycline treatment in a model of early abdominal aortic aneurysm Surg Today 33 2003 426 433
46. S Lamparter, SH Slight, and KT Weber Doxycycline and tissue repair in rats J Lab Clin Med 139 2002 295 302
47. MD Huffman, JA Curci, G Moore, DB Kerns, BC Starcher, and RW Thompson Functional importance of connective tissue repair during the development of experimental abdominal aortic aneurysms Surgery 128 2000 429 438
48. X Xie, H Lu, JJ Moorleghen, DA Howatt, DL Rateri, LA Cassis, and A Daugherty Doxycycline does not influence established abdominal aortic aneurysms in angiotensin II-infused mice PLoS One 7 2012 e46411
49. E Monk, A Shalita, and DM Siegel Clinical applications of non-antimicrobial tetracyclines in dermatology Pharmacol Res 63 2011 130 145
50. JA Curci, D Mao, DG Bohner, BT Allen, BG Rubin, JM Reilly, GA Sicard, and RW Thompson Preoperative treatment with doxycycline reduces aortic wall expression and activation of matrix metalloproteinases in patients with abdominal aortic aneurysms J Vasc Surg 31 2000 325 342
51. R Pyo, JK Lee, JM Shipley, JA Curci, D Mao, SJ Ziporin, TL Ennis, SD Shapiro, RM Senior, and RW Thompson Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms J Clin Invest 105 2000 1641 1649
52. B Sivaraman, and A Ramamurthi Multifunctional nanoparticles for doxycycline delivery towards localized elastic matrix stabilization and regenerative repair Acta Biomater 9 2013 6511 6525
53. JR Boyle, E McDermott, M Crowther, AD Wills, PR Bell, and MM Thompson Doxycycline inhibits elastin degradation and reduces metalloproteinase activity in a model of aneurysmal disease J Vasc Surg 27 1998 354 361
54. CM Bhamidipati, GS Mehta, G Lu, CW Moehle, C Barbery, PD DiMusto, A Laser, IL Kron, GR Upchurch, and G Ailawadi Development of a novel murine model of aortic aneurysms using peri-adventitial elastase Surgery 152 2012 238 246
55. MW Manning, LA Cassis, and A Daugherty Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms Arterioscler Thromb Vasc Biol 23 2003 483 488
56. JH Lindeman, H Abdul-Hussien, JH van Bockel, R Wolterbeek, and R Kleemann Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm: doxycycline selectively depletes aortic wall neutrophils and cytotoxic T cells Circulation 119 2009 2209 2216
57. H Abdul-Hussien, R Hanemaaijer, JH Verheijen, JH van Bockel, RH Geelkerken, and JH Lindeman Doxycycline therapy for abdominal aneurysm: Improved proteolytic balance through reduced neutrophil content J Vasc Surg 49 2009 741 749
58. E Sho, M Sho, K Hoshina, H Kimura, TK Nakahashi, and RL Dalman Hemodynamic forces regulate mural macrophage infiltration in experimental aortic aneurysms Exp Mol Pathol 76 2004 108 116
59. M Mosorin, J Juvonen, F Biancari, J Satta, HM Surcel, M Leinonen, P Saikku, and T Juvonen Use of doxycycline to decrease the growth rate of abdominal aortic aneurysms: a randomized, double-blind, placebo-controlled pilot study J Vasc Surg 34 2001 606 610
60. F Aziz, and H Kuivaniemi Role of matrix metalloproteinase inhibitors in preventing abdominal aortic aneurysm Ann Vasc Surg 21 2007 392 401
61. CA Meijer, T Stijnen, MN Wasser, JF Hamming, JH van Bockel, and JH Lindeman Doxycycline for stabilization of abdominal aortic aneurysms: a randomized trial Ann Intern Med 159 2013 815 823
62. R Ding, CL McGuinness, KG Burnand, E Sullivan, and A Smith Matrix metalloproteinases in the aneurysm wall of patients treated with low-dose doxycycline Vascular 13 2005 290 297