Suppression of experimental aneurysmal degeneration with chemically modified tetracycline derivatives

Annals of the New York Academy of Sciences

Volumn 800, Issue , 1996, Pages 263-265

  Petrinec, Drazen ^a   Holmes, Dennis R ^a   Liao, Shixiong ^a   Golub, Lorne M ^b   Thompson, Robert W ^a,c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c Section of Vascular Surgery   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; ELASTIN; MATRIX METALLOPROTEINASE; TETRACYCLINE DERIVATIVE;

ABDOMINAL AORTA ANEURYSM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY DIAMETER; ARTERY DILATATION; ARTICLE; CONTROLLED STUDY; MALE; NONHUMAN; PROTEIN DEGRADATION; RAT;

ANIMALIA;

EID: 0030459843     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb33326.x     Document Type: Article

References (5)

1. THOMPSON, R. W., D. R. HOLMES, R. A. MERTENS, S. LIAO, M. D. BOTNEY, R. P. MECHAM, H. G. WELGUS & W. C. PARKS. 1995. Production and localization of 92-kD gelatinase in abdominal aortic aneurysms: An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages. J. Clin. Invest. 96: 318-326.
2. GOLUB, L. M., N. S. RAMAMURTHY, T. F. MCNAMARA, R. A. GREENWALD & B. R. RIFKIN. 1991. Tetracyclines inhibit connective tissue breakdown: New therapeutic implications for an old family of drugs. Crit. Rev. Oral. Biol. Med. 2: 297-322.
3. ANIDJAR, S., J. L. SALZMANN, D. GENTRIC, P. LAGNEAU, J. P. CAMILLERI & J. B. MICHEL. 1990. Elastase induced experimental aneurysms in rats. Circulation 82: 973-981.
4. HALPERN, V. J., G. B. NACKMAN, R. H. GANDHI, E. IRIZARRY, J. V. SCHOLES, W. G. RAMEY & M. D. TILSON. 1994. The elastase infusion model of experimental aortic aneurysms: Synchrony of induction of endogenous proteinases with matrix destruction and inflammatory cell response. J. Vasc. Surg. 20: 51-60.
5. PETRINEC, D., S. LIAO, D. R. HOLMES, J. M. REILLY, W. C. PARKS & R. W. THOMPSON. 1996. Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: Preservation of aortic elastin associated with suppressed production of 92-kD gelatinase. J. Vasc. Surg. 23: 336-346.