Inhibition of prostaglandin E2 synthesis in abdominal aortic aneurysms: Implications for smooth muscle cell viability, inflammatory processes, and the expansion of abdominal aortic aneurysms

Circulation

Volumn 100, Issue 1, 1999, Pages 48-54

  Walton, Lesley J ^c   Franklin, Ian J ^c   Bayston, Trevor ^c   Brown, Louise C ^c   Greenhalgh, Roger M ^c   Taylor, Graham W ^a   Powell, Janet T ^b  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b CHARING CROSS HOSPITAL   (United Kingdom)

^c NONE

Author keywords

Aneurysm; Aorta; Cyclooxygenase; Indomethacin; Prostaglandins

Indexed keywords

INDOMETACIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MEFENAMIC ACID; PROSTAGLANDIN E2; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; ISOENZYME; MEMBRANE PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; PTGS2 PROTEIN, HUMAN;

ABDOMINAL AORTA ANEURYSM; AGED; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DNA SYNTHESIS; DRUG EFFECT; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERCHOLESTEROLEMIA; HYPERTENSION; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RISK FACTOR; SMOKING; SMOOTH MUSCLE FIBER; ADOLESCENT; BIOSYNTHESIS; CELL CULTURE; CELL DIVISION; COHORT ANALYSIS; CULTURE MEDIUM; DISEASE COURSE; DNA REPLICATION; ENZYMOLOGY; INFANT; MACROPHAGE; METABOLISM; MIDDLE AGED; PATHOLOGY; SECRETION; TUNICA MEDIA; VASCULAR SMOOTH MUSCLE;

ADOLESCENT; AGED; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AORTIC ANEURYSM, ABDOMINAL; APOPTOSIS; CELL DIVISION; CELLS, CULTURED; CHEMOKINE CCL2; COHORT STUDIES; CULTURE MEDIA, CONDITIONED; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; DISEASE PROGRESSION; DNA REPLICATION; FEMALE; HUMANS; INDOMETHACIN; INFANT; INFLAMMATION; INTERLEUKIN-6; ISOENZYMES; MACROPHAGES; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MUSCLE, SMOOTH, VASCULAR; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; TUNICA MEDIA;

EID: 0033529170     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.100.1.48     Document Type: Article

References (23)

1. Campa JS, Greenhalgh RM, Powell JT. Elastin degradation in abdominal aortic aneurysms. Atherosclerosis. 1987;65:13-21.
2. MacSweeney STR, Powell JT, Greenhalgh RM. Pathogenesis of abdominal aortic aneurysm. Br J Surg. 1994;81:935-941.
3. Lopez-Candales A, Holmes DR, Liao S, Scott MJ, Wickline SA, Thompson RW. Decreased vascular smooth muscle density in medial degeneration of human abdominal aortic aneurysms. Am J Pathol. 1997; 150:993-1007.
4. Freestone T, Turner RJ, Coady A, Higman DJ, Greenhalgh RM, Powell JT. Inflammation and matrix metalloproteinases in the enlarging abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol. 1995;15: 1145-1151.
5. Thompson RW, Holmes DR, Mertens RA, Liao S, Botney MD, Mecham RP, Welgus HG, Parks WC. Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms: an elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages. J Clin Invest. 1995;96:318-326.
6. McMillan WD, Tamarina NA, Cipollone M, Johnson DA, Parker MA, Pearce WH. Size matters: the relationship between MMP-9 expression and aortic diameter. Circulation. 1997;96:2228-2232.
7. Newman KM, Jean-Claude J, Li H, Ramey WG, Tilson MD. Cytokines that activate proteolysis are increased in abdominal aortic aneurysms. Circulation. 1994;90(suppl II):II-224-II-227.
8. Juvonen J, Surcel H-M, Satta J, Teppo AM, Bloigu A, Syrjala H, Airaksinen J, Leinonen M, Saikku PT, Juvonen T. Elevated circulating levels of inflammatory cytokines in patients with abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol. 1997;17:2843-2847.
9. Shah PK. Inflammation, metalloproteinases and increased proteolysis: an emerging pathological paradigm in aortic aneurysm. Circulation. 1997; 96:2115-2117.
10. Unemorei EN, Hibbs MS, Amento EP. Constitutive expression of a 92-kD gelatinase by rheumatoid synovial fibroblasts and its induction in normal human fibroblasts by inflammatory cytokines. J Clin Invest, 1991;88:1656-1662.
11. Diaz A, Munoz E, Johnston R, Korn JH, Jiminez SA. Regulation of human lung fibroblast alpha 1(I) procollagen gene expression by tumor necrosis factor α, interleukin-1β and prostaglandin E2. J Biol Chem. 1993;268:10364-10371.
12. Holmes DR, Wester W, Thompson RW, Reilly JM. Prostaglandin E2 synthesis and cyclooxygenase expression in abdominal aortic aneurysms. J Vasc Surg. 1997;25:810-815.
13. Collin J, Walton J, Araujo L, Lindsell D. Oxford screening programme for abdominal aortic aneurysm in men aged 65 to 74 years. Lancet. 1988;2:613-615.
14. Scott RAP, Ashton HA, Kay DN. Abdominal aortic aneurysm in 4237 screened patients: prevalence, development and management over 6 years. Br J Surg. 1991;78:1122-1125.
15. Wilson KA, Woodburn KR, Ruckley CV, Fowkes FGR. Expansion rates of abdominal aortic aneurysm: current limitations in evaluation. Eur J Vasc Endovasc Surg. 1997;13:521-526.
16. UK Small Aneurysm Trial Participants. Mortality results for randomised controlled trial of early elective surgery or ultrasonographic surveillance for small abdominal aortic aneurysms. Lancet. 1998;352:1649-1655.
17. Shores J, Berger KR, Murphy EA, Pyeritz RE. Progression of aortic dilatation and the benefit of long-term β-adrenergic blockade in Marfan's syndrome. N Engl J Med. 1994;330:1335-1341.
18. UK Small Aneurysm Trial Participants. The UK Small Aneurysm Trial: design, methods and progress. Eur J Vasc Endovasc Surg. 1995;9:42-48.
19. Geng Y-J, Wu Q, Muszynski M, Hansson GK, Libby P. Apoptosis of vascular smooth muscle cells induced by in vitro stimulation with interferon-γ, tumor necrosis factor-α and interleukin-1β. Arterioscler Thromb Vasc Biol. 1996;16:19-27.
20. Kramer HJ, Stevens J, Seeger W. Analysis of 2-, and 3-series prostanoids by post-HPLC ELISA. Anal Biochem. 1993;214:535-543.
21. Coleman RA, Smith WL, Narumiya S. Classification of prostanoid receptors: properties, distribution and structure of the receptors and their subtypes. Pharmacol Rev. 1994;46:205-229.
22. Cryer B, Feldman M. Cyclooxygenase 1 and cyclooxygenase 2 selectivity of widely used nonsteroidal anti-inflammatory drugs. Am J Med. 1998; 104:413-421.
23. Jiang C, Ting AT, Seed B. PPAR-γ agonists inhibit production of monocyte inflammatory cytokines. Nature. 1998;391:82-86.