Using ancient protein kinases to unravel a modern cancer drug's mechanism

Science

Volumn 347, Issue 6224, 2015, Pages 882-886

  Wilson, C ^a   Agafonov, R V ^a   Hoemberger, M ^a   Kutter, S ^a   Zorba, A ^a   Halpin, J ^a   Buosi, V ^a   Otten, R ^a   Waterman, D ^a   Theobald, D L ^a   Kern, D ^a  

^a BRANDEIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABELSON KINASE; IMATINIB; PROTEIN TYROSINE KINASE; ANTINEOPLASTIC AGENT; BENZAMIDE DERIVATIVE; PIPERAZINE DERIVATIVE; PROTEIN BINDING; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE;

BIOENERGETICS; CANCER; COMMON ANCESTRY; DRUG; ENZYME; MUTATION; PROTEIN; REACTION KINETICS; STEADY-STATE EQUILIBRIUM;

BINDING AFFINITY; BINDING KINETICS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; DRUG BINDING; DRUG MECHANISM; HUMAN; HYDROGEN BOND; LAST COMMON ANCESTOR; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; REVIEW; STEADY STATE; X RAY; CHEMISTRY; CLASSIFICATION; DRUG RESISTANCE; ENTROPY; GENETICS; MOLECULAR EVOLUTION; MUTATION; PHYLOGENY; PROTEIN SECONDARY STRUCTURE;

ANTINEOPLASTIC AGENTS; BENZAMIDES; DRUG RESISTANCE, NEOPLASM; ENTROPY; EVOLUTION, MOLECULAR; HUMANS; IMATINIB MESYLATE; MUTATION; ONCOGENE PROTEINS V-ABL; PHYLOGENY; PIPERAZINES; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, SECONDARY; PYRIMIDINES; SRC-FAMILY KINASES;

EID: 84923348238     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaa1823     Document Type: Review

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