Occurrence and fate of select psychoactive pharmaceuticals and antihypertensives in two wastewater treatment plants in New York State, USA

Science of the Total Environment

Volumn 514, Issue , 2015, Pages 273-280

  Subedi, Bikram ^a   Kannan, Kurunthachalam ^a,b  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Fate; Metabolites; Pharmaceuticals; Psychoactives; Removal efficiency; Sludge; Suspended particulate matter; Wastewater treatment plant

Indexed keywords

BIOMOLECULES; DRUG PRODUCTS; METABOLITES; RECLAMATION; REMOVAL; SEWAGE PUMPING PLANTS; TOXICITY; WATER TREATMENT PLANTS;

FATE; PSYCHOACTIVES; REMOVAL EFFICIENCIES; SLUDGE; SUSPENDED PARTICULATE MATTERS; WASTEWATER TREATMENT PLANTS;

WASTEWATER TREATMENT;

6 N [2 (3,5 DIMETHOXYPHENYL) 2 (2 METHYLPHENYL)ETHYL]ADENOSINE; ALPHA HYDROXY ALPRAZOLAM; ALPRAZOLAM; ANTIDEPRESSANT AGENT; ANTIHYPERTENSIVE AGENT; ANXIOLYTIC AGENT; ARIPIPRAZOLE; ATENOLOL; CARBAMAZEPINE; CITALOPRAM; CLOPIDOGREL; CLOPIDOGREL CARBOXYLIC ACID; DEHYDROARIPIPRAZOLE; DIAZEPAM; DIPHENHYDRAMINE; DRUG METABOLITE; HYPNOTIC SEDATIVE AGENT; LORAZEPAM; NORCITALOPRAM; NORDAZEPAM; NORQUETIAPINE; NORSERTRALINE; NORVERAPAMIL; OXAZEPAM; PROPRANOLOL; PSYCHOTROPIC AGENT; QUETIAPINE; SERTRALINE; UNCLASSIFIED DRUG; VERAPAMIL; WASTE WATER; WATER POLLUTANT;

DRUG; ENVIRONMENTAL FATE; METABOLITE; SLUDGE; WASTE FACILITY; WASTEWATER; WATER TREATMENT;

ARTICLE; BIOREMEDIATION; CHEMICAL MODIFICATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENVIRONMENTAL IMPACT; POLLUTION TRANSPORT; PRIORITY JOURNAL; SLUDGE; SUSPENDED PARTICULATE MATTER; UNITED STATES; WASTE COMPONENT REMOVAL; WASTE WATER MANAGEMENT; WASTE WATER TREATMENT PLANT; WATER ANALYSIS; ANALYSIS; CHEMISTRY; ENVIRONMENTAL MONITORING; SEWAGE; WASTE WATER; WATER POLLUTANT;

NEW YORK [UNITED STATES]; UNITED STATES;

ANTIHYPERTENSIVE AGENTS; ENVIRONMENTAL MONITORING; NEW YORK; PSYCHOTROPIC DRUGS; WASTE DISPOSAL, FLUID; WASTE WATER; WATER POLLUTANTS, CHEMICAL;

EID: 84923250169     PISSN: 00489697     EISSN: 18791026     Source Type: Journal    
DOI: 10.1016/j.scitotenv.2015.01.098     Document Type: Article

References (54)

1. Alonso S.G., Catalá M., Maroto R.R., Gil J.L.R.A., Miguel Á.G.d., Valcárcel Y. Pollution by psychoactive pharmaceuticals in the Rivers of Madrid metropolitan area (Spain). Environ. Int. 2010, 36:195-201.
2. Ashton D., Hilton M., Thomas K.V. Investigating the environmental transport of human pharmaceuticals to streams in the United Kingdom. Sci. Total Environ. 2004, 333(1-3):167-184.
3. Bartelt-Hunt S.L., Snow D.D., Damon T., Shockley J., Hoagland K. The occurrence of illicit and therapeutic pharmaceuticals in wastewater effluent and surface waters in Nebraska. Environ. Pollut. 2009, 157(3):786-791.
4. Behera S.K., Kim H.W., Oh J.E., Park H.S. Occurrence and removal of antibiotics, hormones and several other pharmaceuticals in wastewater treatment plants of the largest industrial city of Korea. Sci. Total Environ. 2011, 409(20):4351-4360.
5. Benotti M.J., Trenholm R.A., Vanderford B.J., Holady J.C., Stanford B.D., Snyder S.A. Pharmaceuticals and endocrine disrupting compounds in U.S. drinking water. Environ. Sci. Technol. 2009, 43(3):597-603.
6. Brodin T., Piovano S., Fick J., Klaminder J., Heynen M., Jonsson M. Ecological effects of pharmaceuticals in aquatic systems-impacts through behavioural alterations. Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci. 2014, 369(1656).
7. Brooks B.W., Turner P.K., Stanley J.K., Weston J.J., Glidewell E.A., Foran C.M., Slattery M., La Point T.W., Huggett D.B. Waterborne and sediment toxicity of fluoxetine to select organisms. Chemosphere 2003, 52(1):135-142.
8. Calisto V., Esteves V.I. Psychiatric pharmaceuticals in the environment. Chemosphere 2009, 77(10):1257-1274.
9. Chari B.P., Halden R.U. Validation of mega composite sampling and nationwide mass inventories for 26 previously unmonitored contaminants in archived biosolids from the U.S National Biosolids Repository. Water Res. 2012, 46(15):4814-4824.
10. Choi K., Kim Y., Park J., Park C.K., Kim M.Y., Kim H.S., Kim P. Seasonal variations of several pharmaceutical residues in surface water and sewage treatment plants of Han River, Korea. Sci. Total Environ. 2008, 402:120-128.
11. Deegan A.M., Shaik B., Nolan K., Urell K., Oelgemoller M., Tobin J.M., rrisey A. Treatment options for wastewater effluents from pharmaceutical companies. Int. J. Environ. Sci. Technol. 2011, 8:649-666.
12. Dolar D., Gros M., Rodriguez-Mozaz S., Moreno J., Comas J., Rodriguez-Roda I., Barcelo D. Removal of emerging contaminants from municipal wastewater with an integrated membrane system, MBR-RO. J. Hazard. Mater. 2012, 239-240:64-69.
13. Du B., Price A.E., Scott W.C., Kristofco L.A., Ramirez A.J., Chambliss C.K., Yelderman J.C., Brooks B.W. Comparison of contaminants of emerging concern removal, discharge, and water quality hazards among centralized and on-site wastewater treatment system effluents receiving common wastewater influent. Sci. Total Environ. 2014, 466-467:976-984.
14. Escher B.I., Bramaz N., Richter M., Lienert J. Comparative ecotoxicological hazard assessment of beta-blockers and their human metabolites using a mode-of-action-based test battery and a QSAR approach. Environ. Sci. Technol. 2006, 40(23):7402-7408.
15. Gallini A., Donohue J.M., Huskamp H.A. Diffusion of antipsychotics in the US And French markets, 1998-2008. Psychiatr. Serv. 2013, 64(7):680-687.
16. Gracia-Lor E., Sancho J.V., Serrano R., Hernandez F. Occurrence and removal of pharmaceuticals in wastewater treatment plants at the Spanish Mediterranean area of Valencia. Chemosphere 2012, 87(5):453-462.
17. Hass U., Duennbier U., Massmann G. Occurrence and distribution of psychoactive compounds and their metabolites in the urban water cycle of Berlin (Germany). Water Res. 2012, 46(18):6013-6022.
18. Hummel D., Loffler D., Fink G., Ternes T.A. Simultaneous determination of psychoactive drugs and their metabolites in aqueous matrices by liquid chromatography mass Spectrometry. Environ. Sci. Technol. 2006, 40(23):7321-7328.
19. IMS Press Release, IMS Health reports U.S. prescription sales grew 5.1 percent in 2009 to $300.3 billion Available online:. http://www.imshealth.com.
20. INCB International Narcotics Control Board. Psychotic Substances 2009 2010, Available online: http://www.incb.org/documents/Psychotropics/technical-publications/2009/Psychotropic_Report_2009.pdf, United Nations, New York.
21. INCB International Narcotics Control Board. Psychotic Substances 2012 2013, United Nations, New York, (Available online:http://www.incb.org/documents/Psychotropics/technical-publications/2012/en/Eng_2012_PUBlication.pdf).
22. Jelic A., Fatone F., Di Fabio S., Petrovic M., Cecchi F., Barcelo D. Tracing pharmaceuticals in a municipal plant for integrated wastewater and organic solid waste treatment. Sci. Total Environ. 2012, 433:352-361.
23. Kim Y., Choi K., Jung J., Park S., Kim P.G., Park J. Aquatic toxicity of acetaminophen, carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea. Environ. Int. 2007, 33(3):370-375.
24. Kinney C.A., Furlong E.T., Kolpin D.W., Burkhardt M.R., Zaugg S.D., Werner S.L., Bossio J.P., Benotti M.J. Bioaccumulation of pharmaceuticals and other anthropogenic waste indicators in earthworms from agricultural soil amended with biosolid or swine manure. Environ. Sci. Technol. 2008, 42(6):1863-1870.
25. Kolpin D.W., Furlong E.T., Meyer M.T., Thurman E.M., Zaugg S.D., Barber L.B., Buxton H.T. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance. Environ. Sci. Technol. 2002, 36(6):1202-1211.
26. Lajeunesse A., Smyth S.A., Barclay K., Sauve S., Gagnon C. Distribution of antidepressant residues in wastewater and biosolids following different treatment processes by municipal wastewater treatment plants in Canada. Water Res. 2012, 46(17):5600-5612.
27. Lopez-Serna R., Perez S., Ginebreda A., Petrovic M., Barcelo D. Fully automated determination of 74 pharmaceuticals in environmental and waste waters by online solid phase extraction-liquid chromatography-electrospray-tandem mass spectrometry. Talanta 2010, 83(2):410-424.
28. Meakins N.C., Bubb J.M., Lester J.N. Fate and behavior of organic micropollutants during wastewater treatment process: a review. Int. J. Environ. Pollut. 1994, 4:27-58.
29. Menken M., Munsat T.L., Toole J.F. The global burden of disease study: implications for neurology. Arch. Neurol. 2000, 57(3):418-420.
30. Metcalfe C.D., Chu S., Judt C., Li H., Oakes K.D., Servos M.R., Andrews D.M. Antidepressants and their metabolites in municipal wastewater, and downstream exposure in an urban watershed. Environ. Toxicol. Chem. 2010, 29(1):79-89.
31. Miao X.S., Yang J.J., Metcalfe C.D. Carbamazepine and its metabolites in wastewater and in biosolids in a municipal wastewater treatment plant. Environ. Sci. Technol. 2005, 39(19):7469-7475.
32. Pedersen J.A., Soliman M., Suffet I.H. Human pharmaceuticals, hormones, and personal care product ingredients in runoff from agricultural fields irrigated with treated wastewater. J. Agric. Food Chem. 2005, 53(5):1625-1632.
33. Petersen K., Heiaas H.H., Tollefsen K.E. Combined effects of pharmaceuticals, personal care products, biocides and organic contaminants on the growth of Skeletonema pseudocostatum. Aquat. Toxicol. 2014, 150:45-54.
34. Petrovic M., Barceló D. Analysis, Fate and Removal of Pharmaceuticals in the Water Cycle 2007, Wilson & Wilson's, Amsterdam, The Netherlands.
35. Peysson W., Vulliet E. Determination of 136 pharmaceuticals and hormones in sewage sludge using quick, easy, cheap, effective, rugged and safe extraction followed by analysis with liquid chromatography-time-of-flight-mass spectrometry. J. Chromatogr. A 2013, 1290:46-61.
36. Radjenovic J., Petrovic M., Barcelo D. Fate and distribution of pharmaceuticals in wastewater and sewage sludge of the conventional activated sludge (CAS) and advanced membrane bioreactor (MBR) treatment. Water Res. 2009, 43(3):831-841.
37. Rosi-Marshall E.J., Snow D., Bartelt-Hunt S.L., Paspalof A., Tank J.L. A review of ecological effects and environmental fate of illicit drugs in aquatic ecosystems. J. Hazard. Mater. 2015, 282:18-25.
38. Ruhoy I.S., Daughton C.G. Beyond the medicine cabinet: an analysis of where and why medications accumulate. Environ. Int. 2008, 34(8):1157-1169.
39. Ryu J., Yoon Y., Oh J. Occurrence of endocrine disrupting compounds and pharmaceuticals in 11 WWTPs in Seoul, Korea. KSCE J. Civ. Eng. 2011, 15(1):57-64.
40. Schultz M.M., Furlong E.T., Kolpin D.W., Werner S.L., Schoenfuss H.L., Barber L.B., Blazer V.S., Norris D.O., Vajda A.M. Antidepressant pharmaceuticals in two U.S. effluent-impacted streams: occurrence and fate in water and sediment, and selective uptake in fish neural tissue. Environ. Sci. Technol. 2010, 44(6):1918-1925.
41. Sheehan J.J., Sliwa J.K., Amatniek J.C., Grinspan A., Canuso C.M. Atypical antipsychotic metabolism and excretion. Curr. Drug Metab. 2010, 11(6):516-525.
42. Sinclair E., Kannan K. Mass loading and fate of perfluoroalkyl surfactants in wastewater treatment plants. Environ. Sci. Technol. 2006, 40(5):1408-1414.
43. Skegg K., Skegg D.C., McDonald B.W. Is there seasonal variation in the prescribing of antidepressants in the community?. J. Epidemiol. Community Health 1986, 40(4):285-288.
44. Subedi B., Kannan K. Mass loading and removal of select illicit drugs in two wastewater treatment plants in New York State and estimation of illicit drug usage in communities through wastewater analysis. Environ. Sci. Technol. 2014, 48(12):6661-6670.
45. Subedi B., Lee S., Moon H.B., Kannan K. Psychoactive pharmaceuticals in sludge and their emission from wastewater treatment facilities in Korea. Environ. Sci. Technol. 2013, 47(23):13321-13329.
46. Sui Q., Huang J., Deng S., Chen W., Yu G. Seasonal variation in the occurrence and removal of pharmaceuticals and personal care products in different biological wastewater treatment processes. Environ. Sci. Technol. 2011, 45(8):3341-3348.
47. Tansella M., Micciolo R. Trends in the prescription of antidepressants in urban and rural general practices. J. Affect. Disord. 1992, 24(2):117-125.
48. Ternes T.A. Occurrence of drugs in German sewage treatment plants and rivers. Water Res. 1998, 32(11):3245-3260.
49. Thomas M.A., Klaper R.D. Psychoactive pharmaceuticals induce fish gene expression profiles associated with human idiopathic autism. PLoS ONE 2012, 7(6):e32917.
50. USEPA Emerging Technologies for Biosolid Management 2006, U.S. Environmental Protection Agency, Washington, DC, (EPA 832-R-06-005).
51. van der Ven K., Keil D., Moens L.N., Hummelen P.V., van Remortel P., Maras M., De Coen W. Effects of the antidepressant mianserin in zebrafish: molecular markers of endocrine disruption. Chemosphere 2006, 65(10):1836-1845.
52. Wick A., Fink G., Joss A., Siegrist H., Ternes T.A. Fate of beta blockers and psycho-active drugs in conventional wastewater treatment. Water Res. 2009, 43(4):1060-1074.
53. Yuan S., Jiang X., Xia X., Zhang H., Zheng S. Detection, occurrence and fate of 22 psychiatric pharmaceuticals in psychiatric hospital and municipal wastewater treatment plants in Beijing, China. Chemosphere 2013, 90:2520-2525.
54. Zhang Y., Geissen S.U., Gal C. Carbamazepine and diclofenac: removal in wastewater treatment plants and occurrence in water bodies. Chemosphere 2008, 73(8):1151-1161.