Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis

Nature Communications

Volumn 5, Issue , 2014, Pages

  Baschieri, Francesco ^a,b   Confalonieri, Stefano ^c,d   Bertalot, Giovanni ^c   Di Fiore, Pier Paolo ^c,d,e   Dietmaier, Wolfgang ^f   Leist, Marcel ^a   Crespo, Piero ^g   MacAra, Ian G ^h   Farhan, Hesso ^a,b  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b UNIVERSITY OF KONSTANZ   (Switzerland)

^c EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^d FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^e UNIVERSITY OF MILAN   (Italy)

^f UNIVERSITY OF REGENSBURG   (Germany)

^g UNIVERSITY OF CANTABRIA   (Spain)

^h VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GOLGI MATRIX PROTEIN 130; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PROTEIN; PROTEIN CDC42; RAS PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; UVOMORULIN; AUTOANTIGEN; CADHERIN; CDH1 PROTEIN, HUMAN; GOLGIN SUBFAMILY A MEMBER 2; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 3; RASGRF1 PROTEIN, HUMAN; RASGRF2 PROTEIN, HUMAN; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR;

CANCER; CELL ORGANELLE; GENE EXPRESSION; INHIBITION; METABOLISM; POLARIZATION; SIGNALING; TUMOR;

ARTICLE; BREAST CANCER; CACO 2 CELL LINE; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CELL DIFFERENTIATION; CELL MIGRATION; CELL MOTILITY; CELL POLARITY; CELL SURFACE; COLON CANCER; CONTROLLED STUDY; EMBRYO; ENDOPLASMIC RETICULUM; ENDOSOME; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE SILENCING; GOLGI COMPLEX; HELA CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TISSUE MICROARRAY; GENE EXPRESSION REGULATION; GENETICS; MCF 7 CELL LINE; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

MAMMALIA;

AUTOANTIGENS; CADHERINS; CARCINOGENESIS; CDC42 GTP-BINDING PROTEIN; CELL LINE, TUMOR; CELL POLARITY; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; MAP KINASE SIGNALING SYSTEM; MCF-7 CELLS; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 3; RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS; RAS-GRF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS; SIGNAL TRANSDUCTION;

EID: 84923250091     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms5839     Document Type: Article

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