Development of an ultrasensitive immunoassay using affinity maturated antibodies for the measurement of rodent insulin

Analytical Biochemistry

Volumn 473, Issue , 2015, Pages 72-79

  Imai, Sunao ^a   Naito, Shoichi ^a   Takahashi, Tatsuya ^a   Yamauchi, Akira ^a   Nakamura, Etsuo ^a   Sato, Masaaki ^a   Mitsuda, Yuuichi ^a   Takagi, Hiroyuki ^a   Numata, Yoshito ^a   Fujii, Ikuo ^b   Yamane, Shoji ^a  

^a SHIONOGI AND CO LTD   (Japan)

^b Osaka Prefecture University   (Japan)

Author keywords

Affinity maturation; Monoclonal antibody; Phage display; Rodent insulin; Sandwich enzyme immunoassay

Indexed keywords

CHEMICAL DETECTION; CLINICAL RESEARCH; DIAGNOSIS; ENZYMES; IMMUNOLOGY; MAMMALS; MONOCLONAL ANTIBODIES; PHAGE DISPLAY;

AFFINITY MATURATION; CLINICAL DIAGNOSIS; DRUG DISCOVERY RESEARCHES; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; HOMEOSTASIS MODEL ASSESSMENTS; INSULIN SENSITIVITY; PLASMA INSULIN CONCENTRATION;

INSULIN;

IMMUNOREACTIVE INSULIN; MONOCLONAL ANTIBODY; INSULIN;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY AFFINITY; ARTICLE; CHEMOLUMINESCENCE; ENZYME LINKED IMMUNOSORBENT ASSAY; INSULIN BLOOD LEVEL; LIMIT OF DETECTION; MOUSE; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; RAT; AMINO ACID SEQUENCE; ANIMAL; BLOOD; CHEMISTRY; CYTOLOGY; DIET RESTRICTION; EXPERIMENTAL DIABETES MELLITUS; FEMALE; GENETICS; HYBRIDOMA; IMMUNOLOGY; MOLECULAR GENETICS; PROCEDURES;

MUS; RATTUS; RODENTIA;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES, MONOCLONAL; DIABETES MELLITUS, EXPERIMENTAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FASTING; FEMALE; HYBRIDOMAS; INSULIN; LIMIT OF DETECTION; MICE; MOLECULAR SEQUENCE DATA; RATS;

EID: 84923241397     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2014.12.003     Document Type: Article

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