Generation and optimization of human antagonistic antibodies against TIMP-1 as potential therapeutic agents in fibrotic diseases

Human Antibodies

Volumn 15, Issue 4, 2006, Pages 115-124

  Brocks, Bodo ^a   Kraft, Sabine ^a,d   Zahn, Stefan ^a,e   Noll, Sabine ^a,f   Pan, Clark ^b,c,g   Schauer, Michael ^b,c   Krebs, Barbara ^a  

^a MORPHOSYS AG   (Germany)

^b BAYER PHARMA AG   (Germany)

^c BAYER CORPORATION   (United States)

^d ROCHE DIAGNOSTICS GMBH   (Germany)

^e NOVO NORDISK A S   (Denmark)

^f DCS Innovative Diagnostik Systeme   (Germany)

^g GENZYME CORPORATION   (United States)

Author keywords

Affinity optimization; Antagonist; Fibrosis; HuCAL; Human antibody; Phage display; TIMP

Indexed keywords

BLOCKING ANTIBODY; COLLAGENASE 3; IMMUNOGLOBULIN F(AB) FRAGMENT; INTERSTITIAL COLLAGENASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 1 ANTIBODY; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TISSUE INHIBITOR OF METALLOPROTEINASE 4; UNCLASSIFIED DRUG;

ANTIBODY AFFINITY; ANTIBODY ISOLATION; ANTIBODY LIBRARY; ANTIBODY PRODUCTION; ARTICLE; COMBINATORIAL LIBRARY; CONTROLLED STUDY; DRUG POTENCY; FIBROSIS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION;

EID: 34547558586     PISSN: 10932607     EISSN: None     Source Type: Journal    
DOI: 10.3233/hab-2006-15401     Document Type: Article

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