Task-based functional connectivity as an indicator of genetic liability to schizophrenia

Schizophrenia Research

Volumn 162, Issue 1-3, 2015, Pages 118-123

  Poppe, Andrew B ^a   Carter, Cameron S ^b,c   Minzenberg, Michael J ^b,c   MacDonald, Angus W ^a,d  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

FMRI; Functional connectivity; Genetic liability; Independent component analysis; Relatives; Schizophrenia

Indexed keywords

ADULT; ARTICLE; CONNECTOME; CONTROLLED STUDY; DEMOGRAPHY; FEMALE; FIRST DEGREE RELATIVE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENETIC SUSCEPTIBILITY; HUMAN; INDEPENDENT COMPONENT ANALYSIS; MAJOR CLINICAL STUDY; MALE; MENTAL PERFORMANCE; MIDDLE FRONTAL GYRUS; NEUROIMAGING; POSTERIOR PARIETAL CORTEX; PRIORITY JOURNAL; RIGHT HEMISPHERE; SCHIZOPHRENIA; TASK BASED FUNCTIONAL CONNECTIVITY; BRAIN; BRAIN MAPPING; FAMILY; GENETIC PREDISPOSITION; GENETICS; MENTAL FUNCTION; NERVE TRACT; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADULT; BRAIN; BRAIN MAPPING; FAMILY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MENTAL PROCESSES; NEURAL PATHWAYS; NEUROPSYCHOLOGICAL TESTS; SCHIZOPHRENIA;

EID: 84923227467     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2014.11.022     Document Type: Article

References (30)

1. Cohen J.D., Servan-Schreiber D. Context, cortex, and dopamine: a connectionist approach to behavior and biology in schizophrenia. Psychol. Rev. 1992, 99(1):45-77.
2. Delawalla Z., Csernansky J.G., Barch D.M. Prefrontal cortex function in nonpsychotic siblings of individuals with schizophrenia. Biol. Psychiatry 2008, 63(5):490-497.
3. Dickinson D., Iannone V.N., Wilk C.M., Gold J.M. General and specific cognitive deficits in schizophrenia. Biol. Psychiatry 2004, 55(8):826-833.
4. First M.B., Spitzer R.L., Williams J.B. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition with Psychotic Screen 2002, Biometrics Research, New York City.
5. Fornito A., Yoon J., Zalesky A., Bullmore E.T., Carter C.S. General and specific functional connectivity disturbances in first-episode schizophrenia during cognitive control performance. Biol. Psychiatry 2011, 70(1):64-72.
6. Gottesman I.I., Gould T.D. The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry 2003, 160(4):636-645.
7. Gottesman I.I., Shields J. Schizophrenia and Genetics; A Twin Study Vantage Point 1972, Academic Press, New York.
8. Harrison P.J., Weinberger D.R. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol. Psychiatry 2005, 10(1):40-68. (image 45).
9. Henderson D., Poppe A.B., Barch D.M., Carter C.S., Gold J.M., Ragland J.D., MacDonald A.W. Optimization of a goal maintenance task for use in clinical applications. Schizophr. Bull. 2012, 38(1):104-113.
10. Jaeger T.F. Categorical data analysis: away from ANOVAs (transformation or not) and towards logit mixed models. J. Mem. Lang. 2008, 59(4):434-446.
11. Jones J.A., Sponheim S.R., MacDonald A.W. The dot pattern expectancy task: reliability and replication of deficits in schizophrenia. Psychol. Assess. 2010, 22(1):131-141.
12. Kim D.I., Manoach D.S., Mathalon D.H., Turner J.A., Mannell M., Brown G.G., Ford J.M., Gollub R.L., White T., Wible C., Belger A., Bockholt H.J., Clark V.P., Lauriello J., O'Leary D., Mueller B.A., Lim K.O., Andreasen N., Potkin S.G., Calhoun V.D. Dysregulation of working memory and default-mode networks in schizophrenia using independent component analysis, an fBIRN and MCIC study. Hum. Brain Mapp. 2009, 30(11):3795-3811.
13. Laird A.R., Fox P.M., Eickhoff S.B., Turner J.A., Ray K.L., McKay D.R., Glahn D.C., Beckmann C.F., Smith S.M., Fox P.T. Behavioral interpretations of intrinsic connectivity networks. J. Cogn. Neurosci. 2011, 23(12):4022-4037.
14. MacDonald A.W. Building a clinically relevant cognitive task: case study of the AX paradigm. Schizophr. Bull. 2008, 34(4):619-628.
15. MacDonald A.W., Pogue-Geile M.F., Johnson M.K., Carter C.S. A specific deficit in context processing in the unaffected siblings of patients with schizophrenia. Arch. Gen. Psychiatry 2003, 60(1):57-65.
16. MacDonald A.W., Carter C.S., Kerns J.G., Ursu S., Barch D.M., Holmes A.J., Stenger V.A., Cohen J.D. Specificity of prefrontal dysfunction and context processing deficits to schizophrenia in never-medicated patients with first-episode psychosis. Am. J. Psychiatry 2005, 162(3):475-484.
17. MacDonald A.W., Becker T.M., Carter C.S. Functional magnetic resonance imaging study of cognitive control in the healthy relatives of schizophrenia patients. Biol. Psychiatry 2006, 60(11):1241-1249.
18. Minzenberg M.J., Laird A.R., Thelen S., Carter C.S., Glahn D.C. Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia. Arch. Gen. Psychiatry 2009, 66(8):811-822.
19. Perlstein W.M., Dixit N.K., Carter C.S., Noll D.C., Cohen J.D. Prefrontal cortex dysfunction mediates deficits in working memory and prepotent responding in schizophrenia. Biol. Psychiatry 2003, 53(1):25-38.
20. Pettersson-Yeo W., Allen P., Benetti S., McGuire P., Mechelli A. Dysconnectivity in schizophrenia: where are we now?. Neurosci. Biobehav. Rev. 2011, 35(5):1110-1124.
21. Rasetti R., Sambataro F., Chen Q., Callicott J.H., Mattay V.S., Weinberger D.R. Altered cortical network dynamics: a potential intermediate phenotype for schizophrenia and association with ZNF804A. Arch. Gen. Psychiatry 2011, 68(12):1207-1217.
22. Repovs G., Csernansky J.G., Barch D.M. Brain network connectivity in individuals with schizophrenia and their siblings. Biol. Psychiatry 2011, 69(10):967-973.
23. Servan-Schreiber D., Cohen J.D., Steingard S. Schizophrenic deficits in the processing of context. A test of a theoretical model. Arch. Gen. Psychiatry 1996, 53(12):1105-1112.
24. Snitz B.E., MacDonald A.W., Carter C.S. Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of putative endophenotypes. Schizophr. Bull. 2006, 32(1):179-194.
25. Tost H., Bilek E., Meyer-Lindenberg A. Brain connectivity in psychiatric imaging genetics. Neuroimage 2012, 62(4):2250-2260.
26. Whalley H.C., Simonotto E., Marshall I., Owens D.G.C., Goddard N.H., Johnstone E.C., Lawrie S.M. Functional disconnectivity in subjects at high genetic risk of schizophrenia. Brain 2005, 128:2097-2108.
27. Wilkinson G.S. WRAT-3: Wide Range Achievement Test Administration Manual 1993, Wide Range, Inc., Wilmington, DE.
28. Woodward N.D., Waldie B., Rogers B., Tibbo P., Seres P., Purdon S.E. Abnormal prefrontal cortical activity and connectivity during response selection in first episode psychosis, chronic schizophrenia, and unaffected siblings of individuals with schizophrenia. Schizophr. Res. 2009, 109(1-3):182-190.
29. Yoon J.H., Minzenberg M.J., Ursu S., Ryan Walter B.S., Wendelken C., Ragland J.D., Carter C.S. Association of dorsolateral prefrontal cortex dysfunction with disrupted coordinated brain activity in schizophrenia: relationship with impaired cognition, behavioral disorganization, and global function. Am. J. Psychiatry 2008, 165(8):1006-1014.
30. Zhou Y., Liang M., Jiang T., Tian L., Liu Y., Liu Z. Functional dysconnectivity of the dorsolateral prefrontal cortex in first-episode schizophrenia using resting-state fMRI. Neurosci. Lett. 2007, 417:297-302.