Critical issues for Klebsiella pneumoniae KPC-carbapenemase producing K. pneumoniae infections: A critical agenda

Future Microbiology

Volumn 10, Issue 2, 2015, Pages 285-296

  De Rosa, Francesco G ^a   Corcione, Silvia ^a   Cavallo, Rossana ^a   Di Perri, Giovanni ^a   Bassetti, Matteo ^b  

^a UNIVERSITY OF TURIN   (Italy)

^b Servicio de Urologia   (Italy)

Author keywords

colistin; epidemiology; infection control; Klebsiella pneumoniae; KPC; KPC Kp; mortality; therapy; tigecycline; treatment

Indexed keywords

CARBAPENEM; CARBAPENEMASE; TIGECYCLINE; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAMASE; CARBAPENEM DERIVATIVE; COLISTIN; MINOCYCLINE;

BACTEREMIA; BACTERIAL COLONIZATION; CARBAPENEM RESISTANT ENTEROBACTERIACEAE; EPIDEMIC; FUNCTIONAL STATUS; GRAFT RECIPIENT; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; INFECTION CONTROL; INTENSIVE CARE UNIT; KLEBSIELLA PNEUMONIAE INFECTION; NONHUMAN; PRIORITY JOURNAL; REVIEW; RISK FACTOR; ANALOGS AND DERIVATIVES; BIOSYNTHESIS; COMPUTER ASSISTED DRUG THERAPY; CROSS INFECTION; DRUG EFFECTS; ENZYMOLOGY; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICROBIOLOGY;

KLEBSIELLA PNEUMONIAE;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; CARBAPENEMS; COLISTIN; CROSS INFECTION; DRUG THERAPY, COMPUTER-ASSISTED; HUMANS; INFECTION CONTROL; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MINOCYCLINE; RISK FACTORS;

EID: 84923186531     PISSN: 17460913     EISSN: 17460921     Source Type: Journal    
DOI: 10.2217/fmb.14.121     Document Type: Review

References (52)

1. Carvalhaes CG, Cayô R, Gales AC. Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae in the intensive care unit: a real challenge to physicians, scientifc community, and society. Shock 39(Suppl. 1), 32-37 (2013).
2. Akova M, Daikos GL, Tzouvelekis L, Carmeli Y. Interventional strategies and current clinical experience with carbapenemase-producing Gram-negative bacteria. Clin. Microbiol. Infect. 18(5), 439-448 (2012).
3. Chen LF, Anderson DJ, Paterson DL. Overview of the epidemiology and the threat of Klebsiella pneumoniae carbapenemases (KPC) resistance. Infect. Drug Resist. 5, 133-141 (2012).
4. European Centre for Disease Prevention and Control. Antimicrobial resistance surveillance in Europe 2012. Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net). ECDC, Stockholm, Sweden (2013).
5. Rapp R P, Urban C. Klebsiella pneumoniae carbapenemases in Enterobacteriaceae: history, evolution, and microbiology concerns. Pharmacotherapy 32(5), 399-407 (2012).
6. Tumbarello M, Viale P, Viscoli C et al. Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy. Clin. Infect. Dis. 55(7), 943-950 (2012).
7. Zarkotou O, Pournaras S, Tselioti P et al. Predictors of mortality in patients with bloodstream infections caused by KPC-producing Klebsiella pneumoniae and impact of appropriate antimicrobial treatment. Clin. Microbiol. Infect. 17(12), 1798-1803 (2011).
8. Qureshi ZA, Paterson DL, Potoski BA et al. Treatment outcome of bacteremia due to KPC-producing Klebsiella pneumoniae: superiority of combination antimicrobial regimens. Antimicrob. Agents Chemother. 56 (4), 2108-2113 (2012).
9. Bilavsky E, Schwaber MJ, Carmeli Y. How to stem the tide of carbapenemase-producing enterobacteriaceae? Proactive versus reactive strategies. Curr. Opin. Infect. Dis. 23, 327-331 (2010).
10. World Health Organization. Antimicrobial resistance: Global Report on Surveillance. www.who.int
11. Giani T, Pini B, Arena F et al. Epidemic diffusion of KPC carbapenemase-producing Klebsiella pneumoniae in Italy: results of the frst countrywide survey, 15 May to 30 June 2011. Euro Surveillance 18(22), pii:20489 (2013).
12. Rocchetti A, Zotti CM, Argentero PA et al. Epidemiology of carbapenemase-producing Klebsiella pneumoniae in a North-West Italian region: report from the regional surveillance system. Presented at: 24th European Congress of Clinical Microbiology and Infectious Diseases. Barcelona, Spain, 10-13 May 2014.
13. Papadimitriou-Olivgeris M, Marangos M, Fligou F et al. KPC-producing Klebsiella pneumoniae enteric colonization acquired during intensive care unit stay: the signifcance of risk factors for its development and its impact on mortality. Diagn. Microbiol. Infect. Dis. 77, 169-173 (2013).
14. Papadimitriou-Olivgeris M, Marangos M, Fligou F et al. Risk factors for KPC-producing Klebsiella pneumoniae enteric colonization upon ICU admission. J. Antimicrob. Chemother. 67, 2976-2981 (2012).
15. Tuon FF, Rocha JL, Toledo P et al. Risk factors for KPC-producing Klebsiella pneumoniae bacteremia. Braz. J. Infect. Dis. 16(5), 416-419 (2012).
16. Feldman N, Adler A, Molshatzki N et al. Gastrointestinal colonization by KPC-producing Klebsiella pneumoniae following hospital discharge: duration of carriage and risk factors for persistent carriage. Clin. Microbiol. Infect. 19 (4), E190-E196 (2013).
17. Tumbarello M, Trecarichi EM, Tumietto F et al. Predictive models for identifcation of hospitalized patients harboring KPC-producing Klebsiella pneumoniae. Antimicrob. Agents Chemother. 58 (6), 3514-3520 (2014).
18. Gagliotti C, Ciccarese V, Sarti M et al. Active surveillance for asymptomatic carriers of carbapenemase-producing Klebsiella pneumoniae in a hospital setting. J. Hosp. Infect. 83(4), 330-332 (2013).
19. Tacconelli E, Cataldo MA, Dancer SJ et al. ESCMID guidelines for the management of the infection control measures to reduce transmission of multidrug-resistant Gram-negative bacteria in hospitalized patients. Clin. Microbiol. Infect. 20(Suppl. 1), 1-55 (2014).
20. Sypsa V, Psichogiou M, Bouzala GA, Hadjihannas L, Hatzakis A, Daikos GL. Transmission dynamics of carbapenemase-producing Klebsiella pneumoniae and anticipated impact of infection control strategies in a surgical unit. PLoS ONE 7(7), e41068 (2012).
21. Munoz-Price LS, De La Cuesta C, Adams S et al. Successful eradication of a monoclonal strain of Klebsiella pneumoniae during a K. pneumoniae carbapenemase-producing K. pneumoniae outbreak in a surgical intensive care unit in Miami, Florida. Infect. Control Hosp. Epidemiol. 31(10), 1074-1077 (2010).
22. Schwaber MJ, Carmeli Y. An ongoing national intervention to contain the spread of carbapenem-resistant enterobacteriaceae. Clin. Infect. Dis. 58(5), 697-703 (2014).
23. Lee GC, Burgess DS. Treatment of Klebsiella pneumoniae carbapenemase (KPC) infections: a review of published case series and case reports. Ann. Clin. Microbiol. Antimicrob. 11, 32 (2012).
24. Daikos GL, Tsaousi S, Tzouvelekis LS et al. Carbapenemase-producing Klebsiella pneumoniae bloodstream infections: lowering mortality by antibiotic combination schemes and the role of carbapenems. Antimicrob. Agents Chemother. 58(4), 2322-2328 (2014).
25. Paul M, Carmeli Y, Durante-Mangoni E et al. Combination therapy for carbapenem-resistant Gram-negative bacteria. J. Antimicrob. Chemother. 69(9), 2305-2309 (2014).
26. Falagas ME, Lourida P, Poulikakos P, Rafailidis PI, Tansarli GS. Antibiotic treatment of infections due to carbapenem-resistant Enterobacteriaceae: systematic evaluation of the available evidence. Antimicrob. Agents Chemother. 58(2), 654-663 (2014).
27. Reygaert WC. Antibiotic optimization in the diffcult-to-treat patient with complicated intra-abdominal or complicated skin and skin structure infections: focus on tigecycline. Ther. Clin. Risk Manag. 6, 419-430 (2010).
28. Weisenberg SA, Morgan DJ, Espinal-Witter R. Clinical outcomes of patients with Klebsiella pneumoniae carbapenemase-producing K. pneumoniae after treatment with imipenem or meropenem. Diagn. Microbiol. Infect. Dis. 64, 233-235 (2009).
29. Daly MW, Riddle DJ, Ledeboer NA. T. igecycline for treatment of pneumonia and empyema caused by carbapenemase-producing Klebsiella pneumoniae. Pharmacotherapy 27, 1052-1057 (2007).
30. Di Carlo P, Pantuso G, Cusimano A et al. Two cases of monomicrobial intraabdominal abscesses due to KPC-3 Klebsiella pneumoniae ST258 clone. BMC Gastroenterol. 11, 103 (2011).
31. Di Carlo P, Gulotta G, Casuccio A et al. KPC-3 Klebsiella pneumoniae ST258 clone infection in postoperative abdominal surgery patients in an intensive care setting: analysis of a case series of 30 patients. BMC Anesthesiol. 13(1), 13 (2013).
32. Balandin Moreno B, Fernández Simón I, Pintado García V et al. Tigecycline therapy for infections due to carbapenemase-producing Klebsiella pneumoniae in critically ill patients. Scand. J. Infect. Dis. 46(3), 175-180 (2014).
33. Bassetti M. Poulakou G. Giamarellou H. Is there a future for tigecycline? Intensive Care Med. 40 (7), 988-997 (2014).
34. Wiskirchen DE, Crandon JL, Nicolau DP. Impact of various conditions on the effcacy of dual carbapenem therapy against KPC-producing Klebsiella pneumoniae. Int. J. Antimicrob. Agents 41(6), 582-585 (2013).
35. Bulik CC, Nicolau DP. Double-carbapenem therapy for carbapenemase-producing Klebsiella pneumoniae. Antimicrob. Agents Chemother. 55(6), 3002-3004 (2011).
36. Ceccarelli G, Falcone M, Giordano A et al. Successful ertapenem-doripenem combination treatment of bacteremic ventilator-associated pneumonia due to colistin-resistant KPC-producing Klebsiella pneumoniae. Antimicrob. Agents Chemother. 57(6), 2900-2901 (2013).
37. Thomson KS. Double-carbapenem therapy not proven to be more active than carbapenem monotherapy against KPC-positive Klebsiella pneumoniae. Antimicrob. Agents Chemother. 56(7), 4037 (2012).
38. Bratu S. Mooty M, Nichani S et al. Emergence of KPC-possessing Klebsiella pneumoniae in Brooklyn, New York: epidemiology and recommendations for detection. Antimicrob. Agents Chemother. 49, 3018-3020 (2005).
39. Anderson KF, Lonsway DR, Rasheed JK et al. Evaluation of methods to identify the Klebsiella pneumoniae carbapenemase in Enterobacteriaceae. J. Clin. Microbiol. 45, 2723-2725 (2007).
40. Lee GC, Burgess DS. Polymyxins and doripenem combination against KPC-producing Klebsiella pneumoniae. J. Clin. Med. Res. 5(2), 97-100 (2013).
41. Gomez E, Sanchez M, Gul Z et al. Polymyxin combination therapy and the use of serum bactericidal titers in the management of KPC-producing Klebsiella pneumoniae infections: a report of 3 cases. Case Rep. Med. 659769 (2011).
42. Zuckerman T, Benyamini N, Sprecher H et al. SCT in patients with carbapenem resistant Klebsiella pneumoniae: a single center experience with oral gentamicin for the eradication of carrier state. Bone Marrow Transpl. 46, 1226-1230 (2011).
43. Oren I, Sprecher H, Finkelstein R et al. Eradication of carbapenem-resistant Enterobacteriaceae gastrointestinal colonization with nonabsorbable oral antibiotic treatment: a prospective controlled trial. Am. J. Infect. Control 41, 1167-1172 (2013).
44. Saidel-Odes L, Polachek H, Peled N et al. A randomized, double-blind, placebo-controlled trial of selective digestive decontamination using oral gentamicin and oral polymyxin E for eradication of carbapenem-resistant Klebsiella pneumoniae carriage. Infect. Control Hosp. Epidemiol. 33, 14-19 (2012).
45. Tascini C, Sbrana F, Flammini S et al. Oral gentamicin gut decontamination for prevention of KPC-producing Klebsiella pneumoniae infections: relevance of concomitant systemic antibiotic therapy. Antimicrob. Agents Chemother. 58(4), 1972-1976 (2014).
46. Lübbert C, Faucheux S, Becker-Rux D et al. Rapid emergence of secondary resistance to gentamicin and colistin following selective digestive decontamination in patients with KPC-2-producing Klebsiella pneumoniae: a single-centre experience. Int. J. Antimicrob. Agents 42(6), 565-570 (2013).
47. Sbrana F, Malacarne P, Viaggi B et al. Carbapenem-sparing antibiotic regimens for infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae in intensive care unit. Clin. Infect. Dis. 56(5), 697-700 (2013).
48. Johnson K, Boucher H W. Editorial commentary: imminent challenges: carbapenem-resistant enterobacteriaceae in transplant recipients and patients with hematologic malignancy. Clin. Infect. Dis. 58(9), 1284-1286 (2014).
49. Satlin MJ, Jenkins SG, Walsh TJ. The global challenge of carbapenem-resistant Enterobacteriaceae in transplant recipients and patients with hematologic malignancies. Clin. Infect. Dis. 58(9), 1274-1278 (2014).
50. Bergamasco MD, Barroso Barbosa M, de Oliveira Garcia D et al. Infection with Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae in solid organ transplantation. Transpl. Infect. Dis. 14(2), 198-205 (2012).
51. Ariza-Heredia EJ, Patel R, Blumberg EA et al. Outcomes of transplantation using organs from a donor infected with Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae. Transpl. Infect. Dis. 14 (3), 229-236 (2012).
52. Lübbert C, Becker-Rux D, Rodloff AC et al. Colonization of liver transplant recipients with KPC-producing Klebsiella pneumoniae is associated with high infection rates and excess mortality: a case-control analysis. Infection 42(2), 309-316 (2014).