Eradication of carbapenem-resistant Enterobacteriaceae gastrointestinal colonization with nonabsorbable oral antibiotic treatment: A prospective controlled trial

American Journal of Infection Control

Volumn 41, Issue 12, 2013, Pages 1167-1172

  Oren, Ilana ^a,b   Sprecher, Hannah ^c   Finkelstein, Renato ^a,b   Hadad, Salim ^d   Neuberger, Ami ^a   Hussein, Keatam ^a   Raz Pasteur, Ayelet ^a   Lavi, Noa ^e   Saad, Elias ^e   Henig, Israel ^e   Horowitz, Netanel ^e   Avivi, Irit ^b,e   Benyamini, Noam ^e   Fineman, Riva ^e   Ofran, Yishai ^b,e   Haddad, Nuhad ^e   Rowe, Jacob M ^b,e   Zuckerman, Tsila ^b,e  

^a Infectious Diseases Unit   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^c Clinical Microbiology Laboratory   (Israel)

^d Pharmacy Services   (Israel)

^e Depts Hematol Bone Marrow T   (Israel)

Author keywords

Colistin; Gentamicin; Rectal carriage; SDD

Indexed keywords

ANTIBIOTIC AGENT; CARBAPENEM; COLISTIN; GENTAMICIN; TIGECYCLINE;

ABSENCE OF SIDE EFFECTS; ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL COLONIZATION; BACTERIUM ISOLATE; CARBAPENEM RESISTANT ENTEROBACTERIACEAE GASTROINTESINAL COLONIZATION; CONTROLLED STUDY; ENTEROBACTERIACEAE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL;

COLISTIN; GENTAMICIN; RECTAL CARRIAGE; SDD;

ADMINISTRATION, ORAL; ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BETA-LACTAM RESISTANCE; CARRIER STATE; ENTEROBACTERIACEAE INFECTIONS; FECES; FEMALE; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84888416637     PISSN: 01966553     EISSN: 15273296     Source Type: Journal    
DOI: 10.1016/j.ajic.2013.04.018     Document Type: Article

References (31)

1. L.M. Deshpande, R.N. Jones, T.R. Fritsche, and H.S. Sader Occurrence and characterization of carbapenemase-producing Enterobacteriaceae: report from the SENTRY Antimicrobial Surveillance Program (2000-2004) Microb Drug Resist 12 2006 223 230
2. P. Nordmann, G. Cuzon, and T. Naas The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria Lancet Infect Dis 9 2009 228 236
3. Z. Samra, O. Ofir, Y. Lishtzinsky, L. Madar-Shapiro, and J. Bishara Outbreak of carbapenem-resistant Klebsiella pneumoniae producing KPC-3 in a tertiary medical centre in Israel Int J Antimicrob Agents 30 2007 525 529
4. A. Leavitt, S. Navon-Venezia, I. Chmelnitsky, M.J. Schwaber, and Y. Carmeli Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital Antimicrob Agents Chemother 51 2007 3026 3029
5. K. Hussein, H. Sprecher, T. Mashiach, I. Oren, I. Kassis, and R. Finkelstein Carbapenem resistance among Klebsiella pneumoniae isolates: risk factors, molecular characteristics, and susceptibility patterns Infect Control Hosp Epidemiol 30 2009 666 671
6. M.E. Falagas, D.E. Karageorgopoulos, and P. Nordmann Therapeutic options for infections with Enterobacteriaceae producing carbapenem-hydrolyzing enzymes Future Microbiol 6 2011 653 666
7. D.M. Livermore, M. Warner, S. Mushtaq, M. Dumith, J. Zhang, and N. Woodford What remains against carbapenem-resistant Enterobacteriaceae? Evaluation of chloramphenicol, ciprofloxacin, colistin, fosfomycin, minocycline, nitrofurantoin, temocillin and tigecycline Int J Antimicrob Agents 37 2011 415 419
8. A. Borer, L. Saidel-Odes, K. Riesenberg, S. Eskira, N. Peled, and R. Nativ Attributable mortality rate for carbapenem-resistant Klebsiella pneumoniae bacteremia Infect Control Hosp Epidemiol 30 2009 972 976
9. Guidance for control of infections with carbapenem-resistant or carbapenemase-producing Enterobacteriaceae in acute care facilities MMWR Morb Mortal Wkly Rep 58 2009 256 260
10. G. Troche, L.M. Joly, M. Guibert, and J. Zazzo Detection and treatment of antibiotic-resistant bacterial carriage in a surgical intensive care unit: a 6-year prospective survey Infect Control Hosp Epidemiol 26 2005 161 165
11. D.L. Paterson, N. Singh, J.D. Rihs, C. Squier, B.L. Rihs, and R.R. Muder Control of an outbreak of infection due to extended-spectrum β-lactamase-producing Escherichia coli in a liver transplantation unit Clin Infect Dis 33 2001 126 128
12. E. de Jonge, M.J. Schultz, L. Spanjaard, P.M. Bossuyt, M.B. Vroom, and J. Dankert Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial Lancet 362 2003 1011 1016
13. C. Brun-Buisson, P. Legrand, A. Rauss, C. Richard, F. Montravers, and M. Besbes Intestinal decontamination for control of nosocomial multiresistant gram-negative bacilli: study of an outbreak in an intensive care unit Ann Intern Med 110 1989 873 881
14. M.E. Taylor, and B.A. Oppenheim Selective decontamination of the gastrointestinal tract as an infection control measure J Hosp Infect 17 1991 271 278
15. T. Zuckerman, N. Benyamini, H. Sprecher, R. Fineman, R. Finkelstein, and J.M. Rowe SCT in patients with carbapenem-resistant Klebsiella pneumoniae: a single center experience with oral gentamicin for the eradication of carrier state Bone Marrow Transplant 46 2011 1226 1230
16. T. Kotlovsky, R. Shalginov, L. Austin, and H. Sprecher Rapid detection of bla(KPC)-positive Klebsiella pneumoniae in a clinical setting Eur J Clin Microbiol Infect Dis 28 2009 309 311
17. Clinical and Laboratory Standards Institute Performance standards for antimicrobial susceptibility testing; 20th informational supplement. CLSI document M100-S20 2010 Clinical and Laboratory Standards Institute Wayne [PA]
18. European Committee on Antimicrobial Susceptibility Testing. Clinical breakpoint tables v. 1.3, 2011. Available from: http://www.eucast.org/ clinicalbreakpoints/. Accessed January 5, 2011.
19. E.M. Rudnic, and J.D. Schwartz Oral solid dosage forms. In: Gennaro JP Remington: the science and practice of pharmacy 2000 Lippincott Williams and Wilkins Baltimore [MD] 858 893
20. S. Bratu, D. Landman, R. Haag, R. Recco, A. Eramo, and M. Alam Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City: a new threat to our antibiotic armamentarium Arch Intern Med 165 2005 1430 1435
21. D. Ben-David, Y. Maor, N. Keller, G. Regev-Yochay, I. Tal, and D. Shachar Potential role of active surveillance in the control of a hospital-wide outbreak of carbapenem-resistant Klebsiella pneumoniae infection Infect Control Hosp Epidemiol 31 2010 620 626
22. G. Patel, S. Huprikar, S.H. Factor, S.G. Jenkins, and D.P. Calfee Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies Infect Control Hosp Epidemiol 29 2008 1099 1106
23. M.J. Schwaber, S. Klarfeld-Lidji, S. Navon-Venezia, D. Schwartz, A. Leavitt, and Y. Carmeli Predictors of carbapenem-resistant Klebsiella pneumoniae acquisition among hospitalized adults and effect of acquisition on mortality Antimicrob Agents Chemother 52 2008 1028 1033
24. G.L. Daikos, P. Petrikkos, M. Psichogiou, C. Kosmidis, E. Vryonis, and A. Skoutelis Prospective observational study of the impact of VIM-1 metallo-β-lactamase on the outcome of patients with Klebsiella pneumoniae bloodstream infections Antimicrob Agents Chemother 53 2009 1868 1873
25. M. Souli, I. Galani, A. Antoniadou, E. Papadomichelakis, G. Poulakou, and T. Panagea An outbreak of infection due to β-lactamase Klebsiella pneumoniae carbapenemase 2-producing K pneumoniae in a Greek University Hospital: molecular characterization, epidemiology, and outcomes Clin Infect Dis 50 2010 364 373
26. M.J. Schwaber, B. Lev, A. Israeli, E. Solter, G. Smollan, and B. Rubinovitch Containment of a country-wide outbreak of carbapenem-resistant Klebsiella pneumoniae in Israeli hospitals via a nationally implemented intervention Clin Infect Dis 52 2011 848 855
27. N. Gupta, B.M. Limbago, J.B. Patel, and A.J. Kallen Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention Clin Infect Dis 53 2011 60 67
28. L. Silvestri, S. Kerr, and A. Gullo Prevention of infection using selective decontamination of the digestive tract H.K.F. Saene, L. Silversti, M.A. de la Cal, Infection control in the intensive care unit 2nd ed. 2005 Springer Milan 297 312
29. L. Saidel-Odes, H. Polachek, N. Peled, K. Riesenberg, F. Schlaeffer, and Y. Trabelsi A randomized, double-blind, placebo-controlled trial of selective digestive decontamination using oral gentamicin and oral polymyxin E for eradication of carbapenem-resistant Klebsiella pneumoniae carriage Infect Control Hosp Epidemiol 33 2012 14 19
30. F. Perez, M.J. Pultz, A. Endimiani, R.A. Bonomo, and C.J. Donskey Effect of antibiotic treatment on establishment and elimination of intestinal colonization by KPC-producing Klebsiella pneumoniae in mice Antimicrob Agents Chemother 55 2011 2585 2589
31. F.S. Zimmerman, M.V. Assous, T. Bdolah-Abram, T. Lachish, A.M. Yinnon, and Y. Wiener-Well Duration of carriage of carbapenem-resistant Enterobacteriaceae following hospital discharge Am J Infect Control 41 2013 190 194