Epidemic diffusion Of KPC carbapenemase-producing klebsiella pneumoniae in Italy: Results of the first countrywide survey, 15 may to 30 june 2011

Eurosurveillance

Volumn 18, Issue 22, 2013, Pages

  Giani, T ^a   Pini, B ^b   Arena, F ^a   Conte, V ^a   Bracco, S ^b   Migliavacca, R ^c   Pantosti, A ^d   Pagani, L ^c   Luzzaro, F ^b   Rossolini, G M ^a,e,f  

^a UNIVERSITY OF SIENA   (Italy)

^b A MANZONI HOSPITAL   (Italy)

^c UNIVERSITY OF PAVIA   (Italy)

^d ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^e UNIVERSITY OF FLORENCE   (Italy)

^f CAREGGI UNIVERSITY HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAPENEM; CARBAPENEMASE; COLISTIN; ERTAPENEM; GENTAMICIN; IMIPENEM; MEROPENEM; TIGECYCLINE;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM EXAMINATION; BLOODSTREAM INFECTION; CLONAL SPECIES; CROSS-SECTIONAL STUDY; DISK DIFFUSION; DOT HYBRIDIZATION; ENTEROBACTER; ESCHERICHIA COLI; GENETIC VARIABILITY; GENOTYPE; HAFNIA ALVEI; HUMAN; INTENSIVE CARE UNIT; ITALY; KLEBSIELLA PNEUMONIAE INFECTION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR EPIDEMIOLOGY; MULTILOCUS SEQUENCE TYPING; NONHUMAN; POLYMERASE CHAIN REACTION; PULSED FIELD GEL ELECTROPHORESIS; SERRATIA MARCESCENS; SPECTROPHOTOMETRY; SURGICAL WARD; URINE CULTURE; WARD;

EID: 84878469949     PISSN: 1025496X     EISSN: 15607917     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Grundmann H, Livermore DM, Giske CG, Canton R, Rossolini GM, Campos J, et al. Carbapenem-non-susceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts. Euro Surveill. 2010;15(46):pii=19711. Available from: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19711. PMid:21144429.
2. Nordmann P, Dortet L, Poirel L. Carbapenem resistance in Enterobacteriaceae: here is the storm! Trends Mol Med. 2012;18(5):263-72. http://dx.doi.org/10.1016/j.molmed.2012.03.003.PMid:22480775.
3. Hirsch EB, Tam VH. Detection and treatment options for Klebsiella pneumoniae carbapenemases (KPCs): an emerging cause of multidrug-resistant infection. J Antimicrob Chemother. 2010; 65(6):1119-25.http://dx.doi.org/10.1093/jac/dkq108.PMid:20378670.
4. Falagas ME, Karageorgopoulos DE, Nordmann P. Therapeutic options for infections with Enterobacteriaceae producing carbapenem-hydrolyzing enzymes. Future Microbiol 2011;6(6):653-66.http://dx.doi.org/10.2217/fmb.11.49.PMid:21707312.
5. Borer A, Saide-Odes L, Riesenberg K, Eskira S, Peled N, Nativ R, et al. Attributable mortality rate for carbapenem-resistant Klebsiella pneumoniae bacteremia. Infec. Control Hosp Epidemiol. 2009;30(10): 972-6.http://dx.doi.org/10.1086/605922.PMid:19712030.
6. Canton R, Akova M, Carmeli Y, Giske CG, Glupczynski Y, Gniadkowski M, et al. Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe. Clin Microbiol Infect. 2012;18(5):413-31.http://dx.doi.org/10.1111/j.1469-0691.2012.03821.x.PMid:22507109.
7. Nordmann P, Naas T, Poirel L. Global spread of carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis. 2011;17(10):1791-8.http://dx.doi.org/10.3201/eid1710.110655.PMid:22000347. PMCid:3310682.
8. Cornaglia G, Giamarellou H, Rossolini GM. Metallo-β-lactamases: a last frontier for beta-lactams? Lancet Infect Dis. 2011;11(5):381-93.http://dx.doi.org/10.1016/S1473-3099(11)70056-1.
9. Poirel L, Potron A, Nordmann P. OXA-48-like carbapenemases: the phantom menace. J Antimicrob Chemother. 2012;67(7):1597-606.http://dx.doi.org/10.1093/jac/dks121.PMid:22499996.
10. European Centre for Disease Prevention and Control (ECDC). Antimicrobial resistance surveillance in Europe 2011. Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net). Stockholm: ECDC; 2012.Available from: http://www.ecdc.europa.eu/en/publications/Publications/antimicrobial-resistance-surveillance-europe-2011.pdf
11. Luzzaro F, Docquier JD, Colinon C, Endimiani A, Lombardi G, Amicosante G, et al. Emergence in Klebsiella pneumoniae and Enterobacter cloacae clinical isolates of the VIM-4 metallo-beta-lactamase encoded by a conjugative plasmid. Antimicrob Agents Chemother. 2004;48(2):648-50.http://dx.doi.org/10.1128/AAC.48.2.648-650.2004.PMid:14742229. PMCid:321512.
12. Cagnacci S, Gualco L, Roveta S, Mannelli S, Borgianni L, Docquier JD, et al. Bloodstream infections caused by multidrug-resistant Klebsiella pneumoniae producing the carbapenem-hydrolysing VIM-1 metallo-beta-lactamase: first Italian outbreak. J Antimicrob Chemother. 2008;61(2):296-300.http://dx.doi.org/10.1093/jac/dkm471.PMid:18065411.
13. Giani T, D'Andrea MM, Pecile P, Borgianni L, Nicoletti P, Tonelli F, et al. Emergence in Italy of Klebsiella pneumoniae sequence type 258 producing KPC-3 carbapenemase. J Clin Microbiol. 2009;47(11):3793-4.http://dx.doi.org/10.1128/JCM.01773-09.PMid:19759220. PMCid:2772625.
14. Fontana C, Favaro M, Sarmati L, Natoli S, Altieri A, Bossa MC, et al. Emergence of KPC-producing Klebsiella pneumoniae in Italy. BMC Res Notes. 2010;3:40.http://dx.doi.org/10.1186/1756-0500-3-40.PMid:20178590. PMCid:2844393.
15. Mammina C, Palma DM, Bonura C, Anna Plano MR, Monastero R, Sodano C, et al. Outbreak of infection with Klebsiella pneumoniae sequence type 258 producing Klebsiella pneumoniae carbapenemase 3 in an intensive care unit in Italy. J Clin Microbiol. 2010;48(4):1506-7.http://dx.doi.org/10.1128/JCM.00315-10.PMid:20200298. PMCid:2849560.
16. Agodi A, Voulgari E, Barchitta M, Politi L, Koumaki V, Spanakis N, et al. Containment of an outbreak of KPC-3-producing Klebsiella pneumoniae in Italy. J Clin Microbiol. 2011;49(11):3986-9.http://dx.doi.org/10.1128/JCM.01242-11.PMid:21900525. PMCid:3209099.
17. Aschbacher R, Pagani L, Doumith M, Pike R, Woodford N, Spoladore G, et al. Metallo-beta-lactamases among Enterobacteriaceae from routine samples in an Italian tertiary-care hospital and long-term care facilities during 2008. Clin Microbiol Infect. 2011;17(2):181-9.http://dx.doi.org/10.1111/j.1469-0691.2010.03225.x.PMid:20345467.
18. Gaibani P, Ambretti S, Berlingeri A, Cordovana M, Farruggia P, Panico M, et al. Outbreak of NDM-1-producing Enterobacteriaceae in northern Italy, July to August 2011. Euro Surveill. 2011;16(47):pii=20027.Available from: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20027
19. Gaibani P, Ambretti S, Berlingeri A, Gelsomino F, Bielli A, Landini MP, et al. Rapid increase of carbapenemase-producing Klebsiella pneumoniae strains in a large Italian hospital: surveillance period 1 March - 30 September 2010. Euro Surveill. 2011;16(8):pii=19800.Available from: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19800
20. Mezzatesta ML, Gona F, Caio C, Petrolito V, Sciortino D, Sciacca A, et al. Outbreak of KPC-3-producing, and colistin-resistant, Klebsiella pneumoniae infections in two Sicilian hospitals. Clin Microbiol Infect. 2011;17(9):1444-7.PMid:21668577.
21. Mammina C, Bonura C, Aleo A, Fasciana T, Brunelli T, Pesavento G, et al. Sequence type 101 (ST101) as the predominant carbapenem-non-susceptible Klebsiella pneumoniae clone in an acute general hospital in Italy. Int J Antimicrob Agents. 2012; 39(6):543-5.http://dx.doi.org/10.1016/j.ijantimicag.2012.02.012 PMid:22534506.
22. Orsi GB, Bencardino A, Vena A, Carattoli A, Venditti C, Falcone M, et al. Infection-patient risk factors for outer membrane permeability and KPC-producing carbapenem resistant Klebsiella pneumoniae isolation: results of a double case-control study. Infection. 2013; 41(1):61-7.http://dx.doi.org/10.1007/s15010-012-0354-2.PMid:23070604.
23. Richter SN, Frasson I, Franchin E, Bergo C, Lavezzo E, Barzon L, et al. KPC-mediated resistance in Klebsiella pneumoniae in two hospitals in Padua, Italy, June 2009-December 011: massive spreading of a KPC-3-encoding plasmid and involvement of non-intensive care units. Gut Pathog. 2012; 4(1):7.http://dx.doi.org/10.1186/1757-4749-4-7.PMid:22800501. PMCid:3411510.
24. Capone A, Giannella M, Fortini D, Giordano A, Meledandri M, Ballardini M, et al. High rate of colistin resistance among patients with carbapenem-resistant Klebsiella pneumoniae infection accounts for an excess of mortality. Clin Microbiol Infect. 2013;19(1):E23-E30.http://dx.doi.org/10.1111/1469-0691.12070.PMid:23137235.
25. Sisto A, D'Ancona F, Meledandri M, Pantosti A, Rossolini GM, Raglio A, et al. Carbapenem non-susceptible Klebsiella pneumoniae from Micronet network hospitals, Italy, 2009 to 2012. Euro Surveill. 2012;17(33):pii=20247.Available from: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20247.PMid:22913976.
26. The European Committee on Antimicrobial Susceptibility Testing (EUCAST) [Internet]. Breakpoint tables for interpretation of MICs and zone diameters. Version 3.1. 11 Feb 2013.Avaible from: http://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Breakpoint_tables/Breakpoint_table_v_3.1.pdf
27. Clinical Laboratory Standards Institute (CLSI). Methods for dilution antimicrobial susceptibility. Tests for bacteria that grow aerobically; Approved standars. Ninth edition. CLSI document M07-A9. Wayne, PA: CLSI. 2012.
28. Giske CG, Gezelius L, Samuelsen O, Warner M, Sundsfjord A, Woodford N. A sensitive and specific phenotypic assay for detection of metallo-beta-lactamases and KPC in Klebsiella pneumoniae with the use of meropenem disks supplemented with aminophenylboronic acid, dipicolinic acid and cloxacillin. Clin Microbiol Infect. 2011;17(4):552-6.http://dx.doi.org/10.1111/j.1469-0691.2010.03294.x.PMid:20597925.
29. Tsakris A, Poulou A, Pournaras S, Voulgari E, Vrioni G, Themeli-Digalaki K, et al. A simple phenotypic method for the differentiation of metallo-beta-lactamases and class A KPC carbapenemases in Enterobacteriaceae clinical isolates. J Antimicrob Chemother. 2011;65(8):1664-71.http://dx.doi.org/10.1093/jac/dkq210.PMid:20542902.
30. Srinivasan U, Zhang L, France AM, Ghosh D, Shalaby W, Xie J, et al. Probe hybridization array typing: a binary typing method for Escherichia coli. J Clin Microbiol. 2007;45(1):206-14.http://dx.doi.org/10.1128/JCM.01543-06.PMid:17079499. PMCid:1828955.
31. D'Andrea MM, Giani T, D'Arezzo S, Capone A, Petrosillo N, Visca P, et al. Characterization of pABVA01, a plasmid encoding the OXA-24 carbapenemase from Italian isolates of Acinetobacter baumannii. Antimicrob Agents Chemother. 2009;53(8):3528-33.http://dx.doi.org/10.1128/AAC.00178-09.PMid:19487447. PMCid:2715606.
32. D'Andrea MM, Venturelli C, Giani T, Arena F, Conte V, Bresciani P, et al. Persistent carriage and infection by multidrug-resistant Escherichia coli ST405 producing NDM-1 carbapenemase: report on the first Italian cases. J Clin Microbiol. 2011;49(7):2755-8.http://dx.doi.org/10.1128/JCM.00016-11.PMid:21525229. PMCid:3147842.
33. Giani T, Conte V, Di Pilato V, Aschbacher R, Weber C, Larcher C, et al. Escherichia coli from Italy producing OXA-48 carbapenemase encoded by a novel Tn1999 transposon derivative. Antimicrob Agents Chemother. 2012;56(4):2211-3.http://dx.doi.org/10.1128/AAC.00035-12.PMid:22290939. PMCid:3318333.
34. Lee K, Chong Y, Shin HB, Kim YA, Yong D, Yum JH. Modified Hodge and EDTA-disk synergy tests to screen metallo-beta-lactamase-producing strains of Pseudomonas and Acinetobacter species. Clin Microbiol Infect. 2001;7(2):88-91.http://dx.doi.org/10.1046/j.1469-0691.2001.00204.x.PMid:11298149.
35. Lauretti L, Riccio ML, Mazzariol A, Cornaglia G, Amicosante G, Fontana R, et al. Cloning and characterization of blaVIM, a new integron-borne metallo-beta-lactamase gene from a Pseudomonas aeruginosa clinical isolate. Antimicrob Agents Chemother. 1999;43(7):1584-90.PMid:10390207. PMCid:89328.
36. Yuan M, Aucken H, Hall LM, Pitt TL, Livermore DM. Epidemiological typing of Klebsiellae with extended-spectrum beta-lactamases from European intensive care units. J Antimicrob Chemother. 1998;41(5):527-39.http://dx.doi.org/10.1093/jac/41.5.527.PMid:9630406.
37. Van Belkum A, Tassios PT, Dijkshoorn L, Haeggman S, Cookson B, Fry NK, et al. Guidelines for the validation and application of typing methods for use in bacterial epidemiology. Clin Microbiol Infect. 2007;13 Suppl 3:1-46.http://dx.doi.org/10.1111/j.1469-0691.2007.01786.x.PMid:17716294.
38. Diancourt L, Passet V, Verhoef J, Grimont PA, Brisse S. Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates. J Clin Microbiol. 2005;43(8):4178-82.http://dx.doi.org/10.1128/JCM.43.8.4178-4182.2005.PMid:16081970. PMCid:1233940.
39. Institut Pasteur. Klebsiella pneumoniae MLST Database. Paris: Institut Pasteur. [Accessed].Available from: http://www.pasteur.fr/recherche/genopole/PF8/mlst/Kpneumoniae.html
40. Baraniak A, Izdebski R, Herda M, Fiett J, Hryniewicz W, Gniadkowski M, et al. Emergence of Klebsiella pneumoniae ST258 with KPC-2 in Poland. Antimicrob Agents Chemother. 2009; 53(10):4565-7.http://dx.doi.org/10.1128/AAC.00436-09.PMid:19620323. PMCid:2764197.
41. Giakkoupi P, Maltezou H, Polemis M, Pappa O, Saroglou G, Vatopoulos A, et al. KPC-2-producing Klebsiella pneumoniae infections in Greek hospitals are mainly due to a hyperepidemic clone. Euro Surveill. 2009;14(21):pii=19218.Available from: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19218
42. Kitchel B, Rasheed JK, Patel JB, Srinivasan A, Navon-Venezia S, Carmeli Y, et al. Molecular epidemiology of KPC-producing Klebsiella pneumoniae isolates in the United States: clonal expansion of multilocus sequence type 258. Antimicrob Agents Chemother. 2009;53(8):3365-70.http://dx.doi.org/10.1128/AAC.00126-09.PMid:19506063. PMCid:2715580.
43. Navon-Venezia S, Leavitt A, Schwaber MJ, Rasheed JK, Srinivasan A, Patel JB, et al. First report on a hyperepidemic clone of KPC-3-producing Klebsiella pneumoniae in Israel genetically related to a strain causing outbreaks in the United States. Antimicrob Agents Chemother. 2009;53(2):818-20.http://dx.doi.org/10.1128/AAC.00987-08.PMid:19029323. PMCid:2630632.
44. Bogaerts P, Montesinos I, Rodriguez-Villalobos H, Blairon L, Deplano A, Glupczynski Y. Emergence of clonally related Klebsiella pneumoniae isolates of sequence type 258 producing KPC-2 carbapenemase in Belgium. J Antimicrob Chemother. 2010;65(2):361-2.http://dx.doi.org/10.1093/jac/dkp453.PMid:20008447.
45. Cuzon G, Naas T, Truong H, Villegas MV, Wisell KT, Carmeli Y, et al. Worldwide diversity of Klebsiella pneumoniae that produce beta-lactamase blaKPC-2 gene. Emerg Infect Dis. 2010;16(9):1349-56.http://dx.doi.org/10.3201/eid1609.091389.PMid:20735917. PMCid:3294963.
46. Andrade LN, Curiao T, Ferreira JC, Longo JM, Climaco EC, Martinez R, et al. Dissemination of blaKPC-2 by the spread of Klebsiella pneumoniae clonal complex 258 clones (ST258, ST11, ST437) and plasmids (IncFII, IncN, IncL/M) among Enterobacteriaceae species in Brazil. Antimicrob Agents Chemother. 2011;55(7):3579-83.http://dx.doi.org/10.1128/AAC.01783-10.PMid:21576442. PMCid:3122403.
47. Warburg G, Hidalgo-Grass C, Partridge SR, Tolmasky ME, Temper V, Moses AE, et al. A carbapenem-resistant Klebsiella pneumoniae epidemic clone in Jerusalem: sequence type 512 carrying a plasmid encoding aac(6')-Ib. J Antimicrob Chemother. 2012;67(4):898-901.http://dx.doi.org/10.1093/jac/dkr552.Mid:22287232.
48. Frasson I, Lavezzo E, Franchin E, Toppo S, Barzon L, Cavallaro A, et al. Antimicrobial treatment and containment measures for an extremely drug-resistant Klebsiella pneumoniae ST101 isolate carrying pKPN101-IT, a novel fully sequenced bla(KPC-2) plasmid. J Clin Microbiol. 2012;50(11):3768-72.http://dx.doi.org/10.1128/JCM.01892-12.PMid:22972824. PMCid:3486238.
49. Seki LM, Pereira PS, de Souza Mda P, Conceição S, Marques EA, Porto CO, et al. Molecular epidemiology of KPC-2- producing Klebsiella pneumoniae isolates in Brazil: the predominance of sequence type 437. Diagn Microbiol Infect Dis. 2011;70(2):274-7.http://dx.doi.org/10.1016/j.diagmicrobio.2011.01.006.PMid:21397425.
50. Österblad M, Kirveskari J, Hakanen AJ, Tissari P, Vaara M, Jalava J. Carbapenemase-producing Enterobacteriaceae in Finland: the first years (2008-11). J Antimicrob Chemother. 2012; 67(12):2860-4.http://dx.doi.org/10.1093/jac/dks299.PMid:22855858.
51. Pitart C, Solé M, Roca I, Fàbrega A, Vila J, Marco F. First outbreak of a plasmid-mediated carbapenem-hydrolyzing OXA-48 beta-lactamase in Klebsiella pneumoniae in Spain. Antimicrob Agents Chemother. 2011;55(9):4398-401.http://dx.doi.org/10.1128/AAC.00329-11.PMid:21746954. PMCid:3165339.
52. Ma L, Lu PL, Siu LK, Hsieh MH. Molecular typing and resistance mechanisms of imipenem-non-susceptible Klebsiella pneumoniae in Taiwan: results from the Taiwan surveillance of antibiotic resistance (TSAR) study, 2002-2009. J Med Microbiol. 2013;62(Pt 1):101-7.http://dx.doi.org/10.1099/jmm.0.050492-0.PMid:23002067.
53. Marcade G, Brisse S, Bialek S, Marcon E, Leflon-Guibout V, Passet V, et al. The emergence of multidrug-resistant Klebsiella pneumoniae of international clones ST13, ST16, ST35, ST48 and ST101 in a teaching hospital in the Paris region. Epidemiol Infect. 2012; 4:1-8.http://dx.doi.org/10.1017/S0950268812002099.PMid:23034125.
54. Carbonne A, Thiolet JM, Fournier S, Fortineau N, Kassis-Chikhani N, Boytchev I, et al. Control of a multi-hospital outbreak of KPC-producing Klebsiella pneumoniae type 2 in France, September to October 2009. Euro Surveill. 2010;15(48):pii=19734.Available from: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19734
55. Schwaber MJ, Lev B, Israeli A, Solter E, Smollan G, Rubinovitch B, et al. Containment of a country-wide outbreak of carbapenem-resistant Klebsiella pneumoniae in Israeli hospitals via a nationally implemented intervention. Clin Infect Dis. 2011;52(7):848-55.http://dx.doi.org/10.1093/cid/cir025.PMid:21317398.
56. Landman D, Babu E, Shah N, Kelly P, Olawole O, Backer M, et al. Transmission of carbapenem-resistant pathogens in New York City hospitals: progress and frustration. J Antimicrob Chemother. 2012;67(6):1427-31.http://dx.doi.org/10.1093/jac/dks063.PMid:22378678.
57. Agenzia Sanitaria e sociale regionale. Indicazioni pratiche e protocolli operativi per la diagnosi, la sorveglianza e il controllo degli enterobatteri produttori di carbapenemasi nelle strutture sanitarie e socio-sanitarie. [Practical guidance and operational protocols for the diagnosis, surveillance and control of carbapenemase-producing Enterobacteriaceae in health and social care settings]. Jan 2013. Italian.Available from: http://assr.regione.emilia-romagna.it/it/servizi/pubblicazioni/rapporti-documenti/copy_of_indicazioni-pratiche-e-protocolli-operativi-per-la-diagnosi-la-sorveglianza-e-il-controllo-degli-enterobatteri-produttori-di-carbapenemasi-nelle-strutture-sanitarie-e-socio-sanitarie