Polymyxin combination therapy and the use of serum bactericidal titers in the management of KPC-producing Klebsiella pneumoniae infections: A report of 3 cases

Case Reports in Medicine

Volumn 2011, Issue , 2011, Pages

  Gomez, Eric ^a   Sanchez, Martha ^a   Gul, Zonaira ^a   Urban, Carl ^b   Mariano, Noriel ^b   Eng, Robert H K ^c   Huang, David B ^c   Chiang, Tom ^c  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b NEW YORK PRESBYTERIAN HOSPITAL   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; DORIPENEM; LEVOFLOXACIN; POLYMYXIN B; RIFAMPICIN; TIGECYCLINE;

ABSENCE OF SIDE EFFECTS; AGED; ANTIBIOTIC THERAPY; ARTICLE; ATELECTASIS; CASE REPORT; CHILL; CLOSTRIDIUM DIFFICILE INFECTION; CONFUSION; DISORIENTATION; DRUG SUBSTITUTION; DRUG WITHDRAWAL; DYSPNEA; ELECTROENCEPHALOGRAM; EPILEPTIC STATE; FEVER; HUMAN; HYPOTENSION; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; LETHARGY; MALE; PHARMACOLOGICAL PARAMETERS; PHYSICAL EXAMINATION; PNEUMONIA; PRIORITY JOURNAL; SEPTIC SHOCK; SERUM BACTERICIDAL TITER; THORAX RADIOGRAPHY; TONIC CLONIC SEIZURE; URINARY HESITANCY; URINARY TRACT INFECTION; VENTILATOR ASSOCIATED PNEUMONIA; WEAKNESS;

EID: 84923197502     PISSN: 16879627     EISSN: 16879635     Source Type: Journal    
DOI: 10.1155/2011/659769     Document Type: Article

References (31)

1. Rosenblatt J. E., Laboratory tests used to guide antimicrobial therapy Mayo Clinic Proceedings 1983 58 1 14 20 (Pubitemid 13177798)
2. Robinson A., Barlett R. C., Mazens M. F., Antimicrobial synergy testing based on antibiotic levels, minimal bactericidal concentration, and serum bactericidal activity American Journal of Clinical Pathology 1985 84 3 328 333 (Pubitemid 15235205)
3. Hirsch E. B., Tam V. H., Detection and treatment options for Klebsiella pneumoniae carbapenemases (KPCs): an emerging cause of multidrug-resistant infection Journal of Antimicrobial Chemotherapy 2010 65 6 1119 1125
4. Endimiani A., Patel G., Hujer K. M., Swaminathan M., Perez F., Rice L. B., Jacobs M. R., Bonomo R. A., In vitro activity of fosfomycin against blaKPC-containing Klebsiella pneumoniae isolates, including those nonsusceptible to tigecycline and/or colistin Antimicrobial Agents and Chemotherapy 2010 54 1 526 529
5. Rahal J. J., Novel antibiotic combinations against infections with almost completely resistant Pseudomonas aeruginosa and Acinetobacter species Clinical Infectious Diseases 2006 43 supplement 2 S95 S99
6. Institute CCaLS, Methodology for the Serum Bactericidal Test. Approved Guidelines 2009 Wayne, Pa, USA CLSI
7. Petrosillo N., Ioannidou E., Falagas M. E., Colistin monotherapy vs. combination therapy: evidence from microbiological, animal and clinical studies Clinical Microbiology and Infection 2008 14 9 816 827
8. Li J., Rayner C. R., Nation R. L., Owen R. J., Spelman D., Tan K. E., Liolios L., Heteroresistance to colistin in multidrug-resistant Acinetobacter baumannii Antimicrobial Agents and Chemotherapy 2006 50 9 2946 2950 (Pubitemid 44396396)
9. Yoon J., Urban C., Terzian C., Mariano N., Rahal J. J., In vitro double and triple synergistic activities of polymyxin B, imipenem, and rifampin against multidrug-resistant acinetobacter baumannii Antimicrobial Agents and Chemotherapy 2004 48 3 753 757 (Pubitemid 38280320)
10. Thiolas A., Bollet C., La Scola B., Raoult D., Pages J.-M., Successive emergence of Enterobacter aerogenes strains resistant to imipenem and colistin in a patient Antimicrobial Agents and Chemotherapy 2005 49 4 1354 1358 (Pubitemid 40463361)
11. Lee J., Patel G., Huprikar S., Calfee D. P., Jenkins S. G., Decreased susceptibility to polymyxin B during treatment for carbapenem-resistant Klebsiella pneumonia infection Journal of Clinical Microbiology 2009 47 5 1611 1612
12. Pournaras S., Vrioni G., Neou E., Dendrinos J., Dimitroulia E., Poulou A., Tsakris A., Activity of tigecycline alone and in combination with colistin and meropenem against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae strains by time-kill assay International Journal of Antimicrobial Agents 2011 37 3 244 247
13. Urban C., Mariano N., Rahal J. J., In vitro double and triple bactericidal activities of doripenem, polymyxin B, and rifampin against multidrug-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli Antimicrobial Agents and Chemotherapy 2010 54 6 2732 2734
14. Elemam A., Rahimian J., Doymaz M., In vitro evaluation of antibiotic synergy for polymyxin B-resistant carbapenemase-producing Klebsiella pneumoniae Journal of Clinical Microbiology 2010 48 10 3558 3562
15. Humphries R. M., Kelesidis T., Bard J. D., Ward K. W., Bhattacharya D., Lewinski M. A., Successful treatment of pan-resistant Klebsiella pneumoniae pneumonia and bacteraemia with a combination of high-dose tigecycline and colistin Journal of Medical Microbiology 2010 59, part 11 1383 1386
16. Bulik C. C., Nicolau D. P., In vivo efficacy of simulated human dosing regimens of prolonged-infusion doripenem against carbapenemase-producing Klebsiella pneumoniae Antimicrobial Agents and Chemotherapy 2010 54 10 4112 4115
17. Landman D., Georgescu C., Martin D. A., Quale J., Polymyxins revisited Clinical Microbiology Reviews 2008 21 3 449 465
18. Klastersky J., Daneau D., Swings G., Weerts D., Antibacterial activity in serum and urine as a therapeutic guide in bacterial infections The Journal of Infectious Diseases 1974 129 2 187 193
19. Stratton C. W., The role of the microbiology laboratory in the treatment of infective endocarditis Journal of Antimicrobial Chemotherapy 1987 20 supplement A 41 49 (Pubitemid 17158034)
20. Schwartz B. S., Ngo P. D., Guglielmo B. J., Daptomycin treatment failure for vancomycin-resistant Enterococcus faecium infective endocarditis: impact of protein binding? Annals of Pharmacotherapy 2008 42 2 289 290 (Pubitemid 351238581)
21. Viollier A. F., Standiford H. C., Drusano G. L., Comparative pharmacokinetics and serum bactericidal activity of mezlocillin, ticarcillin and piperacillin, with and without gentamicin Journal of Antimicrobial Chemotherapy 1985 15 5 597 606 (Pubitemid 15093202)
22. Van der Auwera P., Vandermies A., Lieppe S., Grenier P., Bourguignon A. M., Ernst F., Ceftazidime combined with mecillinam: serum bactericidal titres compared with in-vitro synergy against gram-negative bacilli Journal of Antimicrobial Chemotherapy 1988 21 6 745 753
23. Licht J. H., Penicillinase-resistant penicillin/gentamicin synergism. Effect in patients with Staphylococcus aureus bacteremia Archives of Internal Medicine 1979 139 10 1094 1098 (Pubitemid 10115916)
24. Martino P., Venditti M., Valente B., Serum bactericidal activity as a therapeutic guide in severely granulocytopenic patients with gram-negative septicemia European Journal of Cancer and Clinical Oncology 1985 21 4 439 445 (Pubitemid 15076948)
25. Weinstein M. P., Stratton C. W., Ackley A., Multicenter collaborative evaluation of a standardized serum bactericidal test as a prognostic indicator in infective endocarditis The American Journal of Medicine 1985 78 2 262 269 (Pubitemid 15162927)
26. Prober C. G., Yeager A. S., Use of the serum bactericidal titer to assess the adequacy of oral antibiotic therapy in the treatment of acute hematogenous osteomyelitis The Journal of Pediatrics 1979 95 1 131 135 (Pubitemid 9183698)
27. Cahen P., Le Bourgeois M., Delacourt C., Coustere C., Nicaise P., De Blic J., Veron M., Scheinmann P., Gaillard J. L., Serum bactericidal test as a prognostic indicator in acute pulmonary exacerbations of cystic fibrosis Pediatrics 1993 91 2 451 455 (Pubitemid 23042332)
28. Schlichter J. G., Mac L. H., Milzer A., Effective penicillin therapy in subacute bacterial endocarditis and other chronic infections The American Journal of the Medical Sciences 1949 217 6 600 608
29. Van der Auwera P., Klastersky J., Lagast H., Husson M., Serum bactericidal activity and killing rate for volunteers receiving imipenem, imipenem plus amikacin, and ceftazidime plus amikacin against Pseudomonas aeruginosa Antimicrobial Agents and Chemotherapy 1986 30 1 122 126 (Pubitemid 16097387)
30. Pien F. D., Vosti K. L., Variation in performance of the serum bactericidal test Antimicrobial Agents and Chemotherapy 1974 6 3 330 333
31. Coleman D. L., Horwitz R. I., Andriole V. T., Association between serum inhibitory and bactericidal concentrations and therapeutic outcome in bacterial endocarditis The American Journal of Medicine 1982 73 2 260 267 (Pubitemid 13203925)