Muscle atrophy and preferential loss of myosin in prolonged critically ill Patients

Critical Care Medicine

Volumn 40, Issue 1, 2012, Pages 79-89

  Derde, Sarah ^a   Hermans, Greet ^a   Derese, Inge ^a   Güiza, Fabian ^a   Hedström, Yvette ^b   Wouters, Pieter J ^a   Bruyninckx, Frans ^a   D'Hoore, André ^a   Larsson, Lars ^b   Van Den Berghe, Greet ^a   Vanhorebeek, Ilse ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Critical illness polyneuropathy myopathy; Hypergly cemia; Insulin; Intensive care; Muscle catabolism

Indexed keywords

ACETYLCHOLINE RECEPTOR GAMMA; ACTIN; ATROGIN 1; CATHEPSIN L; CHOLINERGIC RECEPTOR; CORTICOSTEROID; GLUCOSE; HISTONE DEACETYLASE 4; INSULIN; MESSENGER RNA; MUSCLE PROTEIN; MUSCLE RING FINGER 1 PROTEIN; MYOSIN; MYOSIN HEAVY CHAIN; MYOSTATIN; NEUROMUSCULAR BLOCKING AGENT; PROTEASOME; PROTEINASE; TRANSCRIPTION FACTOR FKHRL1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ABDOMINAL WALL; ADULT; AGED; ARTICLE; BLOOD GLUCOSE MONITORING; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CRITICALLY ILL PATIENT; DISEASE SEVERITY; DOWN REGULATION; ELECTROMYOGRAPHY; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN TISSUE; INSULIN INFUSION; INSULIN TREATMENT; INTENSIVE CARE UNIT; LENGTH OF STAY; LIMB; MAJOR CLINICAL STUDY; MALE; MUSCLE ATROPHY; MUSCLE BIOPSY; MUSCLE CELL; MUSCLE DENERVATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN SYNTHESIS; RECTUS ABDOMINIS MUSCLE; SECONDARY ANALYSIS; SKELETAL MUSCLE; TREATMENT DURATION; VASTUS LATERALIS MUSCLE;

ACTINS; AGED; BLOOD GLUCOSE; CASE-CONTROL STUDIES; CRITICAL ILLNESS; ELECTROMYOGRAPHY; FEMALE; HUMANS; INSULIN; MALE; MIDDLE AGED; MUSCLE, SKELETAL; MUSCULAR ATROPHY; MYOSINS;

EID: 84055167215     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31822d7c18     Document Type: Article

References (55)

1. Bednarík J, Vondracek P, Dusek L, et al: Risk factors for critical illness polyneuromyopathy. J Neurol 2005; 252:343-351
2. De Jonghe B, Sharshar T, Lefaucheur JP, et al: Paresis acquired in the intensive care unit: A prospective multicenter study. JAMA 2002; 288:2859-2867
3. Garnacho-Montero J, Madrazo-Osuna J, García-Garmendia JL, et al: Critical illness polyneuropathy: Risk factors and clinical consequences. A cohort study in septic patients. Intensive Care Med 2001; 27: 1288-1296
4. Leijten FS, Harinck-de Weerd JE, Poortvliet DC, et al: The role of polyneuropathy in motor convalescence after prolonged mechanical ventilation. JAMA 1995; 274:1221-1225
5. van Mook WN, Hulsewé-Evers RP: Critical illness polyneuropathy. Curr Opin Crit Care 2002; 8:302-310
6. Bednarik J, Lukas Z, Vondracek P: Critical illness polyneuromyopathy: The electrophysiological components of a complex entity. Intensive Care Med 2003; 29:1505-1514
7. Bolton CF, Laverty DA, Brown JD, et al: Critically ill polyneuropathy: Electrophysiological studies and differentiation from Guillain- Barrésyndrome. J Neurol Neurosurg Psychiatry 1986; 49:563-573
8. Latronico N, Guarneri B: Critical illness myopathy and neuropathy. Minerva Anestesiol 2008; 74:319-323
9. Larsson L, Li X, Edström L, et al: Acute quadriplegia and loss of muscle myosin in patients treated with nondepolarizing neuromuscular blocking agents and corticosteroids: Mechanisms at the cellular and molecular levels. Crit Care Med 2000; 28:34-45
10. Matsumoto N, Nakamura T, Yasui Y, et al: Analysis of muscle proteins in acute quadriplegic myopathy. Muscle Nerve 2000; 23: 1270-1276
11. Stibler H, Edström L, Ahlbeck K, et al: Electrophoretic determination of the myosin/actin ratio in the diagnosis of critical illness myopathy. Intensive Care Med 2003; 29: 1515-1527
12. Thompson LV, Durand D, Fugere NA, et al: Myosin and actin expression and oxidation in aging muscle. J Appl Physiol 2006; 101: 1581-1587
13. Ochala J, Larsson L: Effects of a preferential myosin loss on Ca2 activation of force generation in single human skeletal muscle fibres. Exp Physiol 2008; 93:486-495
14. Banduseela V, Ochala J, Lamberg K, et al: Muscle paralysis and myosin loss in a patient with cancer cachexia. Acta Myol 2007; 26: 136-144
15. Prochniewicz E, Thompson LV, Thomas DD: Age-related decline in actomyosin structure and function. Exp Gerontol 2007; 42: 931-938
16. van den Berghe G, Wouters P, Weekers F, et al: Intensive insulin therapy in the critically ill patients. N Engl J Med 2001; 345: 1359-1367
17. Van den Berghe G, Wilmer A, Hermans G, et al: Intensive insulin therapy in the medical ICU. N Engl J Med 2006; 354:449-461
18. Gore DC, Wolf SE, Sanford AP, et al: Extremity hyperinsulinemia stimulates muscle protein synthesis in severely injured patients. Am J Physiol Endocrinol Metab 2004; 286: E529-E534
19. Thomas SJ, Morimoto K, Herndon DN, et al: The effect of prolonged euglycemic hyperinsulinemia on lean body mass after severe burn. Surgery 2002; 132:341-347
20. Biolo G, De Cicco M, Lorenzon S, et al: Treating hyperglycemia improves skeletal muscle protein metabolism in cancer patients after major surgery. Crit Care Med 2008; 36:1768-1775
21. Larsson L, Moss RL: Maximum velocity of shortening in relation to myosin isoform composition in single fibres from human skeletal muscles. J Physiol 1993; 472: 595-614
22. Norman H, Kandala K, Kolluri R, et al: A porcine model of acute quadriplegic myopathy: A feasibility study. Acta Anaesthesiol Scand 2006; 50:1058-1067
23. Van den Berghe G, Schoonheydt K, Becx P, et al: Insulin therapy protects the central and peripheral nervous system of intensive care patients. Neurology 2005; 64:1348-1353
24. Hermans G, Wilmer A, Meersseman W, et al: Impact of intensive insulin therapy on neuromuscular complications and ventilator dependency in the medical intensive care unit. Am J Respir Crit Care Med 2007; 175: 480-489
25. de Jonghe B, Lacherade JC, Sharshar T, et al: Intensive care unit-acquired weakness: Risk factors and prevention. Crit Care Med 2009; 37:S309-S315
26. Biolo G, Wolfe RR: Insulin action on protein metabolism. Bailliè res Clin Endocrinol Metab 1993; 7:989-1005
27. Cohen TJ, Waddell DS, Barrientos T, et al: The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming. J Biol Chem 2007; 282: 33752-33759
28. Mansoor O, Beaufrere B, Boirie Y, et al: Increased mRNA levels for components of the lysosomal, Ca2-activated, and ATP-ubiquitin-dependent proteolytic pathways in skeletal muscle from head trauma patients. Proc Natl Acad Sci U S A 1996; 93:2714-2718
29. Tiao G, Hobler S, Wang JJ, et al: Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle. J Clin Invest 1997; 99:163-168
30. Helliwell TR, Wilkinson A, Griffiths RD, et al: Muscle fibre atrophy in critically ill patients is associated with the loss of myosin filaments and the presence of lysosomal enzymes and ubiquitin. Neuropathol Appl Neurobiol 1998; 24:507-517
31. Lang CH, Huber D, Frost RA: Burn-induced increase in atrogin-1 and MuRF-1 in skeletal muscle is glucocorticoid independent but downregulated by IGF-I. Am J Physiol Regul Integr Comp Physiol 2007; 292:R328-R336
32. de Boer MD, Selby A, Atherton P, et al: The temporal responses of protein synthesis, gene expression and cell signalling in human quadriceps muscle and patellar tendon to disuse. J Physiol 2007; 585:241-251
33. Klaude M, Fredriksson K, Tjäder I, et al: Proteasome proteolytic activity in skeletal muscle is increased in patients with sepsis. Clin Sci 2007; 112:499-506
34. Schakman O, Gilson H, Thissen JP: Mechanisms of glucocorticoid-induced myopathy. J Endocrinol 2008; 197:1-10
35. Lang CH, Silvis C, Nystrom G, et al: Regulation of myostatin by glucocorticoids after thermal injury. FASEB J 2001; 15:1807-1809
36. Smith IJ, Aversa Z, Alamdari N, et al: Sepsis downregulates myostatin mRNA levels without altering myostatin protein levels in skeletal muscle. J Cell Biochem 2010; 111: 1059-1073
37. Hasselgren PO: Ubiquitination, phosphorylation, and acetylation-triple threat in muscle wasting. J Cell Physiol 2007; 213:679-689
38. Sandri M, Sandri C, Gilbert A, et al: Foxo transcription factors induce the atrophyrelated ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell 2004; 117: 399-412
39. Smith IJ, Alamdari N, O'Neal P, et al: Sepsis increases the expression and activity of the transcription factor Forkhead Box O 1 (FOXO1) in skeletal muscle by a glucocorticoid-dependent mechanism. Int J Biochem Cell Biol 2010; 42:701-711
40. Marzani B, Felzani G, Bellomo RG, et al: Human muscle aging: ROS-mediated alterations in rectus abdominis and vastus lateralis muscles. Exp Gerontol 2005; 40:959-965
41. Chambers MA, Moylan JS, Reid MB: Physical inactivity and muscle weakness in the critically ill. Crit Care Med 2009; 37: S337-S346
42. Borina E, Pellegrino MA, D'Antona G, et al: Myosin and actin content of human skeletal muscle fibers following 35 days bed rest. Scand J Med Sci Sports 2010; 20:65-73
43. Lanone S, Mebazaa A, Heymes C, et al: Muscular contractile failure in septic patients: Role of the inducible nitric oxide synthase pathway. Am J Respir Crit Care Med 2000; 162:2308-2315
44. Derde S, Vanhorebeek I, Ververs EJ, et al: Increasing intravenous glucose load in the presence of normoglycemia: Effect on outcome and metabolism in critically ill rabbits. Crit Care Med 2010; 38:602-611
45. Vanhorebeek I, Gunst J, Derde S, et al: Insufficient activation of autophagy allows cellular damage to accumulate in critically ill patients. J Clin Endocrinol Metab 2011; 96: E633-E645
46. Ibebunjo C, Martyn J: Disparate dysfunction of skeletal muscles located near and distant from burn site in the rat. Muscle Nerve 2001; 24:1283-1294
47. Larsson L: Acute quadriplegic myopathy: An acquired "myosinopathy. " Adv Exp Med Biol 2008; 642:92-98
48. Nordquist J, Höglund AS, Norman H, et al: Transcription factors in muscle atrophy caused by blocked neuromuscular transmission and muscle unloading in rats. Mol Med 2007; 13:461-470
49. Banduseela VC, Ochala J, Chen YW, et al: Gene expression and muscle fiber function in a porcine ICU model. Physiol Genomics 2009; 39:141-159
50. Rich MM, Bird SJ, Raps EC, et al: Direct muscle stimulation in acute quadriplegic myopathy. Muscle Nerve 1997; 20:665-673
51. Sharshar T, Bastuji-Garin S, De Jonghe B, et al: Hormonal status and ICU-acquired paresis in critically ill patients. Intensive Care Med 2010; 36:1318-1326
52. Herridge MS, Cheung AM, Tansey CM, et al: One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med 2003; 348:683-693
53. de Letter MA, Schmitz PI, Visser LH, et al: Risk factors for the development of polyneuropathy and myopathy in critically ill patients. Crit Care Med 2001; 29:2281-2286
54. Tiao G, Fagan J, Roegner V, et al: Energyubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids. J Clin Invest 1996; 97:339-348
55. Gilson H, Schakman O, Combaret L, et al: Myostatin gene deletion prevents glucocorticoid-induced muscle atrophy. Endocrinology 2007; 148:452-460