Role of high mobility group box 1 in myocardial ischemia/reperfusion injury and the effect of ethyl pyruvate

Experimental and Therapeutic Medicine

Volumn 9, Issue 4, 2015, Pages 1537-1541

  Lin, Yunling ^a   Chen, Lianglong ^a   Li, Weiwei ^a   Fang, Jun ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Ethyl pyruvate; High mobility group box 1; Inflammation; Ischemia reperfusion injury

Indexed keywords

ETHYL PYRUVATE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 6; PYRUVIC ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMOLUMINESCENCE; CONTROLLED STUDY; HEART INFARCTION SIZE; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART RATE; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SYSTOLIC BLOOD PRESSURE; WESTERN BLOTTING;

EID: 84923065936     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2015.2290     Document Type: Article

References (22)

1. Yellon DM and Hausenloy DJ: Myocardial reperfusion injury. N Engl J Med 357: 1121-1135, 2007.
2. Dirksen MT, Laarman GJ, Simoons ML and Duncker DJ: Reperfusion injury in humans: a review of clinical trials on reperfusion injury inhibitory strategies. Cardiovasc Res 74: 343-355, 2007.
3. Klune JR, Dhupar R, Cardinal J, Billiar TR and Tsung A: HMGB1: endogenous danger signaling. Mol Med 14: 476-484, 2008.
4. Hu X, Xu W and Jiang H: HMGB1/IL-17A axis: an important mechanism for myocardial ischemia-reperfusion injury. Int J Cardiol 174: 447-448, 2014.
5. Ding HS, Yang J, Chen P, et al: The HMGB1-TLR4 axis contributes to myocardial ischemia/reperfusion injury via regulation of cardiomyocyte apoptosis. Gene 527: 389-393, 2013.
6. Andrassy M, Volz HC, Igwe JC, et al: High mobility group box 1 in ischemia reperfusion injury of the heart. Circulation 117: 3216-3226, 2008.
7. Tsung A, Kaizu T, Nakao A, et al: Ethyl pyruvate ameliorates liver ischemia reperfusion injury by decreasing hepatic necrosis and apoptosis. Transplantation 79: 196-204, 2005.
8. Ulloa L, Ochani M, Yang H, et al: Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc Natl Acad Sci USA 99: 12351-12356, 2002.
9. Rabadi MM, Ghaly T, Goligorksy MS and Ratliff BB: HMGB1 in renal ischemic injury. Am J Physiol Renal Physiol 303: F873-F885, 2012.
10. Shen M, Lu J, Dai W, et al: Ethyl pyruvate ameliorates hepatic ischemia reperfusion injury by inhibiting intrinsic pathway of apoptosis and autophagy. Mediators Inflamm 2013: 461536, 2013.
11. ATP channels. Circ Res 84: 846-851, 1999.
12. Rouhiainen A, Tumova S, Valmu L, Kalkkinen N and Rauvala H: Pivotal advance: analysis of proinflammatory activity of highly purified eukaryotic recombinant HMGB1 (amphoterin). J Leukoc Biol 81: 49-58, 2007.
13. Scaffidi P, Misteli T and Bianchi ME: Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418: 191-195, 2002.
14. Yang R, Gallo DJ, Baust JJ, et al: Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol 283: G212-G221, 2002.
15. O'Connor KA, Hansen MK, Rachal Pugh C, et al: Further characterization of high mobility group box 1 (HMGB1) as a proinflammatory cytokine: central nervous system effects. Cytokine 24: 254-265, 2003.
16. Tsung A, Sahai R, Tanaka H, et al: The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia reperfusion. J Exp Med 201: 1135-1143, 2005.
17. Chung KY, Park JJ and Kim YS: The role of high mobility group box 1 in renal ischemia and reperfusion injury and the effect of ethyl pyruvate. Transplant Proc 40: 2136-2138, 2008.
18. Yu YM, Kim JB, Lee KW, Kim SY, Han PL and Lee JK: Inhibition of the cerebral ischemic injury by ethyl pyruvate with a wide therapeutic window. Stroke 36: 2238-2243, 2005.
19. Woo YJ, Taylor MD, Cohen JE, et al: Ethyl pyruvate preserves cardiac function and attenuates oxidative injury after prolonged myocardial ischemia. J Thorac Cardiovasc Surg 127: 1262-1269, 2004.
20. Guo J, Zhang K, Ji Y, Jiang X and Zuo S: Effects of ethyl pyruvate on myocardial apoptosis and expression of Bcl 2 and Bax proteins after ischemia reperfusion in rats. J Huazhong Univ Sci Technolog Med Sci 28: 281-283, 2008.
21. Wang Q, Ding Q, Zhou Y, et al: Ethyl pyruvate attenuates spinal cord ischemic injury with a wide therapeutic window through inhibiting high mobility group box 1 release in rabbits. Anesthesiology 110: 1279-1286, 2009.
22. Zhang M and Chen L: Status of cytokines in ischemia reperfusion induced heart injury. Cardiovasc Hematol Disord Drug Targets 8: 161-172, 2008.