Effects of ethyl pyruvate on myocardial apoptosis and expression of Bcl-2 and Bax proteins after ischemia-reperfusion in rats

Journal of Huazhong University of Science and Technology - Medical Science

Volumn 28, Issue 3, 2008, Pages 281-283

  Guo, Jialong ^a,b   Zhang, Kailun ^a   Ji, Yanmei ^b   Jiang, Xionggang ^a   Zuo, Shunqing ^b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUBEI UNIVERSITY OF MEDICINE   (China)

Author keywords

Apoptosis; Bax protein; Bcl 2 protein; Ethyl pyruvate; Myocardial reperfusion injury

Indexed keywords

MALONALDEHYDE; PROTEIN BAX; PROTEIN BCL 2; PYRUVIC ACID DERIVATIVE; PYRUVIC ACID ETHYL ESTER;

ANIMAL; APOPTOSIS; ARTICLE; CYTOLOGY; HEART MUSCLE; HEART MUSCLE CELL; MALE; METABOLISM; NICK END LABELING; OXIDATIVE STRESS; PATHOLOGY; RAT; REPERFUSION INJURY; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; IN SITU NICK-END LABELING; MALE; MALONDIALDEHYDE; MYOCARDIUM; MYOCYTES, CARDIAC; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRUVATES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; TISSUE DISTRIBUTION;

EID: 45749120789     PISSN: 16720733     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11596-008-0311-6     Document Type: Article

References (8)

1. Zhao Z Q, Nakamura M, Wang N P et al. Reperfusion induces myocardial apoptotic cell death. Cardiovasc Res, 2000,45(4):651-660
2. Woo Y J, Taylor M D, Jeffrey E et al. Ethyl pyruvate preserves cardiac function and attenuates oxidative injury after prolonged myocardial ischemia. J Thorac Cardiovasc Surg, 2004,127(5):1262-1269
3. Taylor M D, Grand T J, Cohen J E et al. Ethyl pyruvate enhances ATP levels, reduces oxidative stress and preserves cardiac function in a rat model of off-pump coronary bypas. Heart Lung Circ, 2005,14(1):25-34
4. Sims C A, Somkiat W S. Ringer's ethyl pyruvate solution ameliorates ischemia/reperfusion induced intestinal mucosal injury in rats. J Crit Care Med, 2001,29(8):1513-1518
5. Fink M P. Ringer's ethyl pyruvate solution: a novel resuscitation fluid for the treatment of hemorrhagic shock and sepsis. J Trauma, 2003,54(5):141-143
6. Maulik N, Yoshida T, Das D K et al. Oxidative stress developed during the reperfusion of ischemic myocardium induces apoptosis. Free Radic Biol Med, 1998,24(5):869-875
7. Misao J, Kearney M, Bortman S et al. Expression of Bcl-2 protein, an inhibitor of apoptosis, and Bax, an accelerator of apoptosis, in ventricular myocytes of human hearts with myocardial infarction. Circulation, 1996,94(7):1506-1512
8. Basile D P, Liapis H, Hsmmerman M R et al. Expression of bcl-2 and bax in regenerating rat renal tubules following ischemic injury. Am J Physiol, 1997,272(2):640-647