A novel PPARγ 2 modulator sLZIP controls the balance between adipogenesis and osteogenesis during mesenchymal stem cell differentiation

Cell Death and Differentiation

Volumn 21, Issue 10, 2014, Pages 1642-1655

  Kim, J ^a   Ko, J ^a  

^a Korea University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CREB3 PROTEIN, MOUSE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DNA BINDING PROTEIN; FABP4 PROTEIN, MOUSE; FATTY ACID BINDING PROTEIN; HISTONE DEACETYLASE; HISTONE DEACETYLASE 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RUNX2 PROTEIN, MOUSE; TRANSCRIPTION FACTOR RUNX2;

ADIPOCYTE; ADIPOGENESIS; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BONE DENSITY; BONE DEVELOPMENT; C3H MOUSE; C57BL MOUSE; CELL CULTURE; CHONDROGENESIS; CYTOLOGY; ENHANCER REGION; GENETICS; HUMAN; MESENCHYMAL STROMA CELL; METABOLISM; MOUSE; OSTEOBLAST; PHYSIOLOGY; TRANSCRIPTION INITIATION; TRANSGENIC MOUSE;

ADIPOCYTES; ADIPOGENESIS; ANIMALS; BONE DENSITY; CELLS, CULTURED; CHONDROGENESIS; CORE BINDING FACTOR ALPHA 1 SUBUNIT; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DNA-BINDING PROTEINS; ENHANCER ELEMENTS, GENETIC; FATTY ACID-BINDING PROTEINS; HISTONE DEACETYLASES; HUMANS; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, TRANSGENIC; OSTEOBLASTS; OSTEOGENESIS; PPAR GAMMA; TRANSCRIPTIONAL ACTIVATION;

EID: 84923019936     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2014.80     Document Type: Article

References (28)

1. Uccelli A, Moretta L, Pistoia V. Mesenchymal stem cells in health and disease. Nat Rev Immunol 2008; 8: 726-736.
2. Kawai M, Rosen CJ. PPARgamma: a circadian transcription factor in adipogenesis and osteogenesis. Nat Rev Endocrinol 2010; 6: 629-636.
3. Jeon MJ, Kim JA, Kwon SH, Kim SW, Park KS, Park SW et al. Activation of peroxisome proliferator-activated receptor-gamma inhibits the Runx2-mediated transcription of osteocalcin in osteoblasts. J Biol Chem 2003; 278: 23270-23277.
4. Chandra V, Huang P, Hamuro Y, Raghuram S, Wang Y, Burris TP et al. Structure of the intact PPAR-gamma-RXR-nuclear receptor complex on DNA. Nature 2008; 456: 350-356.
5. Tontonoz P, Hu E, Graves RA, Budavari AI, Spiegelman BM. mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev 1994; 8: 1224-1234.
6. Lehrke M, Lazar MA. The many faces of PPARgamma. Cell 2005; 123: 993-999.
7. Perissi V, Aggarwal A, Glass CK, Rose DW, Rosenfeld MG. A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell 2004; 116: 511-526.
8. Yu C, Markan K, Temple KA, Deplewski D, Brady MJ, Cohen RN. The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis. J Biol Chem 2005; 280: 13600-13605.
9. Rosen ED, Hsu CH, Wang X, Sakai S, Freeman MW, Gonzalez FJ et al. C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev 2002; 16: 22-26.
10. Fajas L, Egler V, Reiter R, Hansen J, Kristiansen K, Debril MB et al. The retinoblastomahistone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation. Dev Cell 2002; 3: 903-910.
11. Herzig S, Hedrick S, Morantte I, Koo SH, Galimi F, Montminy M. CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma. Nature 2003; 426: 190-193.
12. Hong JH, Hwang ES, McManus MT, Amsterdam A, Tian Y, Kalmukova R et al. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science 2005; 309: 1074-1078.
13. Chan CP, Kok KH, Jin DY. CREB3 subfamily transcription factors are not created equal: Recent insights from global analyses and animal models. Cell Biosci 2011; 1: 6.
14. Luciano RL, Wilson AC. N-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the host cell factor-1 binding motif. Proc Natl Acad SciUSA 2000; 97: 10757-10762.
15. Kang H, Kim YS, Ko J. A novel isoform of human LZIP negatively regulates the transactivation of the glucocorticoid receptor. Mol Endocrinol 2009; 23: 1746-1757.
16. Guan HP, Ishizuka T, Chui PC, Lehrke M, Lazar MA. Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. Genes Dev 2005; 19: 453-461.
17. Sinha KM, Zhou X. Genetic and molecular control of Osterix in skeletal formation. J Cell Biochem 2013; 114: 975-984.
18. Katagiri T, Takahashi N. Regulatory mechanisms of osteoblast and osteoclast differentiation. Oral Dis 2002; 8: 147-159.
19. Rauch A, Seitz S, Baschant U, Schilling AF, Illing A, Stride B et al. Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor. Cell Metab 2010; 11: 517-531.
20. Savkur RS, Burris TP. The coactivator LXXLL nuclear receptor recognition motif. J Pept Res 2004; 63: 207-212.
21. Burbelo PD, Gabriel GC, Kibbey MC, Yamada Y, Kleinman HK, Weeks BS. LZIP-1 and LZIP-2: two novel members of the bZIP family. Gene 1994; 139: 241-245.
22. Liu Y, Berendsen AD, Jia S, Lotinun S, Baron R, Ferrara N et al. Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation. JClin Invest 2012; 122: 3101-3113.
23. Ichida F, Nishimura R, Hata K, Matsubara T, Ikeda F, Hisada K et al. Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation. J Biol Chem 2004; 279: 34015-34022.
24. Wang YX. PPARs: diverse regulators in energy metabolism and metabolic diseases. Cell Res 2010; 20: 124-137.
25. Schwartz AV, Sellmeyer DE, Vittinghoff E, Palermo L, Lecka-Czernik B, Feingold KR et al. Thiazolidinedione use and bone loss in older diabetic adults. JClin Endocrinol Metab 2006; 91: 3349-3354.
26. Murakami T, Saito A, Hino S, Kondo S, Kanemoto S, Chihara K et al. Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation. Nat Cell Biol 2009; 11: 1205-1211.
27. Zhang JW, Klemm DJ, Vinson C, Lane MD. Role of CREB in transcriptional regulation of CCAAT/enhancer-binding protein beta gene during adipogenesis. J Biol Chem 2004; 279: 4471-4478.
28. Shillabeer G, Lau DC. Regulation of new fat cell formation in rats: the role of dietary fats. J Lipid Res 1994; 35: 592-600.