메뉴 건너뛰기




Volumn 9, Issue 4, 2015, Pages 1091-1096

Role of the angiopoietin/Tie system in pregnancy (Review)

Author keywords

Angiopoietin 1; Angiopoietin 2; Angiopoietin Tie system; Intrauterine growth restriction; Placenta; Preeclampsia; Pregnancy; Vascular endothelium specific receptor tyrosine kinase tie 2

Indexed keywords

ANGIOPOIETIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TIE RECEPTOR; TRANSCRIPTION FACTOR FOXO; VASCULOTROPIN;

EID: 84922980432     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2015.2280     Document Type: Article
Times cited : (44)

References (65)
  • 2
    • 78751682439 scopus 로고    scopus 로고
    • Angiogenic factors and preeclampsia
    • Maynard SE and Karumanchi SA: Angiogenic factors and preeclampsia. Semin Nephrol 31: 33-46, 2011.
    • (2011) Semin Nephrol , vol.31 , pp. 33-46
    • Maynard, S.E.1    Karumanchi, S.A.2
  • 3
  • 4
    • 84875424639 scopus 로고    scopus 로고
    • Maternal plasma concentrations of angiogenic/antiangiogenic factors in the third trimester of pregnancy to identify the patient at risk for stillbirth at or near term and severe late preeclampsia
    • Chaiworapongsa T, Romero R, Korzeniewski SJ, et al: Maternal plasma concentrations of angiogenic/antiangiogenic factors in the third trimester of pregnancy to identify the patient at risk for stillbirth at or near term and severe late preeclampsia. Am J Obstet Gynecol 208: 287. e1-287. e15, 2013.
    • (2013) Am J Obstet Gynecol , vol.208 , pp. 287.e1-287.e15
    • Chaiworapongsa, T.1    Romero, R.2    Korzeniewski, S.J.3
  • 6
    • 84863501982 scopus 로고    scopus 로고
    • The vascular endothelial growth factor family in adverse pregnancy outcomes
    • Andraweera PH, Dekker GA and Roberts CT: The vascular endothelial growth factor family in adverse pregnancy outcomes. Hum Reprod Update 18: 436-457, 2012.
    • (2012) Hum Reprod Update , vol.18 , pp. 436-457
    • Andraweera, P.H.1    Dekker, G.A.2    Roberts, C.T.3
  • 7
    • 0036319339 scopus 로고    scopus 로고
    • Soluble flt 1 and the angiopoietins in the development and regulation of placental vasculature
    • Charnock Jones DS: Soluble flt 1 and the angiopoietins in the development and regulation of placental vasculature. J Anat 200: 607-615, 2002.
    • (2002) J Anat , vol.200 , pp. 607-615
    • Charnock Jones, D.S.1
  • 8
    • 84906675773 scopus 로고    scopus 로고
    • Angiopoietin 2 induces pericyte apoptosis via α3β1 integrin signaling in diabetic retinopathy
    • Park SW, Yun JH, Kim JH, Kim KW, Cho CH and Kim JH: Angiopoietin 2 induces pericyte apoptosis via α3β1 integrin signaling in diabetic retinopathy. Diabetes 63: 3057-3068, 2014.
    • (2014) Diabetes , vol.63 , pp. 3057-3068
    • Park, S.W.1    Yun, J.H.2    Kim, J.H.3    Kim, K.W.4    Cho, C.H.5    Kim, J.H.6
  • 9
    • 79960227968 scopus 로고    scopus 로고
    • VEGF and angiopoietin signaling in tumor angiogenesis and metastasis
    • Saharinen P, Eklund L, Pulkki K, Bono P and Alitalo K: VEGF and angiopoietin signaling in tumor angiogenesis and metastasis. Trends Mol Med 17: 347-362, 2011.
    • (2011) Trends Mol Med , vol.17 , pp. 347-362
    • Saharinen, P.1    Eklund, L.2    Pulkki, K.3    Bono, P.4    Alitalo, K.5
  • 10
    • 84884638451 scopus 로고    scopus 로고
    • In search of biomarkers for diagnosing and managing neonatal sepsis: The role of angiopoietins
    • Mussap M, Cibecchini F, Noto A and Fanos V: In search of biomarkers for diagnosing and managing neonatal sepsis: The role of angiopoietins. J Matern Fetal Neonatal Med 26 (Suppl 2): 24-26, 2013.
    • (2013) J Matern Fetal Neonatal Med , vol.26 , pp. 24-26
    • Mussap, M.1    Cibecchini, F.2    Noto, A.3    Fanos, V.4
  • 11
    • 0242405592 scopus 로고    scopus 로고
    • Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis
    • Thurston G: Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis. Cell Tissue Res 314: 61-68, 2003.
    • (2003) Cell Tissue Res , vol.314 , pp. 61-68
    • Thurston, G.1
  • 12
    • 67650753834 scopus 로고    scopus 로고
    • The role of the Angiopoietins in vascular morphogenesis
    • Thomas M and Augustin HG: The role of the Angiopoietins in vascular morphogenesis. Angiogenesis 12: 125-137, 2009.
    • (2009) Angiogenesis , vol.12 , pp. 125-137
    • Thomas, M.1    Augustin, H.G.2
  • 13
    • 15144358851 scopus 로고    scopus 로고
    • Angiopoietin 2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
    • Maisonpierre PC, Suri C, Jones PF, et al: Angiopoietin 2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277: 55-60, 1997.
    • (1997) Science , vol.277 , pp. 55-60
    • Maisonpierre, P.C.1    Suri, C.2    Jones, P.F.3
  • 14
    • 0030460424 scopus 로고    scopus 로고
    • Isolation of angiopoietin 1, a ligand for the TIE2 receptor, by secretion trap expression cloning
    • Davis S, Aldrich TH, Jones PF, et al: Isolation of angiopoietin 1, a ligand for the TIE2 receptor, by secretion trap expression cloning. Cell 87: 1161-1169, 1996.
    • (1996) Cell , vol.87 , pp. 1161-1169
    • Davis, S.1    Aldrich, T.H.2    Jones, P.F.3
  • 15
    • 84945138467 scopus 로고    scopus 로고
    • Signalling network map of endothelial TEK tyrosine kinase
    • Khan AA, Sandhya VK, Singh P, et al: Signalling network map of endothelial TEK tyrosine kinase. J Signal Transduct 2014: 173026, 2014.
    • (2014) J Signal Transduct , vol.2014
    • Khan, A.A.1    Sandhya, V.K.2    Singh, P.3
  • 16
    • 2442608732 scopus 로고    scopus 로고
    • Angiopoietin 1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1)
    • Daly C, Wong V, Burova E, et al: Angiopoietin 1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1). Genes Dev 18: 1060-1071, 2004.
    • (2004) Genes Dev , vol.18 , pp. 1060-1071
    • Daly, C.1    Wong, V.2    Burova, E.3
  • 17
    • 77954369555 scopus 로고    scopus 로고
    • Angiopoietin 2 regulates gene expression in TIE2 expressing monocytes and augments their inherent proangiogenic functions
    • Coffelt SB, Tal AO, Scholz A, et al: Angiopoietin 2 regulates gene expression in TIE2 expressing monocytes and augments their inherent proangiogenic functions. Cancer Res 70: 5270-5280, 2010.
    • (2010) Cancer Res , vol.70 , pp. 5270-5280
    • Coffelt, S.B.1    Tal, A.O.2    Scholz, A.3
  • 18
    • 35248867961 scopus 로고    scopus 로고
    • Activation of the orphan endothelial receptor Tie1 modifies Tie2 mediated intracellular signaling and cell survival
    • Yuan HT, Venkatesha S, Chan B, Deutsch U, Mammoto T, Sukhatme VP, Woolf AS and Karumanchi SA: Activation of the orphan endothelial receptor Tie1 modifies Tie2 mediated intracellular signaling and cell survival. FASEB J 21: 3171-3183, 2007.
    • (2007) FASEB J , vol.21 , pp. 3171-3183
    • Yuan, H.T.1    Venkatesha, S.2    Chan, B.3    Deutsch, U.4    Mammoto, T.5    Sukhatme, V.P.6    Woolf, A.S.7    Karumanchi, S.A.8
  • 19
    • 60749096085 scopus 로고    scopus 로고
    • Control of vascular morphogenesis and homeostasis through the angiopoietin Tie system
    • Augustin HG, Koh GY, Thurston G and Alitalo K: Control of vascular morphogenesis and homeostasis through the angiopoietin Tie system. Nat Rev Mol Cell Biol 10: 165-177, 2009.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 165-177
    • Augustin, H.G.1    Koh, G.Y.2    Thurston, G.3    Alitalo, K.4
  • 21
    • 14944377120 scopus 로고    scopus 로고
    • The Tie 2 ligand angiopoietin 2 destabilizes quiescent endothelium through an internal autocrine loop mechanism
    • Scharpfenecker M, Fiedler U, Reiss Y and Augustin HG: The Tie 2 ligand angiopoietin 2 destabilizes quiescent endothelium through an internal autocrine loop mechanism. J Cell Sci 118: 771-780, 2005.
    • (2005) J Cell Sci , vol.118 , pp. 771-780
    • Scharpfenecker, M.1    Fiedler, U.2    Reiss, Y.3    Augustin, H.G.4
  • 22
    • 84871989305 scopus 로고    scopus 로고
    • Angiopoietin 2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition
    • Daly C, Eichten A, Castanaro C, et al: Angiopoietin 2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition. Cancer Res 73: 108-118, 2013.
    • (2013) Cancer Res , vol.73 , pp. 108-118
    • Daly, C.1    Eichten, A.2    Castanaro, C.3
  • 24
  • 25
    • 84861820220 scopus 로고    scopus 로고
    • Angiopoietin 2 differentially regulates angiogenesis through TIE2 and integrin signaling
    • Felcht M, Luck R, Schering A, et al: Angiopoietin 2 differentially regulates angiogenesis through TIE2 and integrin signaling. J Clin Invest 122: 1991-2005, 2012.
    • (2012) J Clin Invest , vol.122 , pp. 1991-2005
    • Felcht, M.1    Luck, R.2    Schering, A.3
  • 26
    • 32244436305 scopus 로고    scopus 로고
    • Angiopoietin 2 sensitizes endothelial cells to TNF alpha and has a crucial role in the induction of inflammation
    • Fiedler U, Reiss Y, Scharpfenecker M, et al: Angiopoietin 2 sensitizes endothelial cells to TNF alpha and has a crucial role in the induction of inflammation. Nat Med 12: 235-239, 2006.
    • (2006) Nat Med , vol.12 , pp. 235-239
    • Fiedler, U.1    Reiss, Y.2    Scharpfenecker, M.3
  • 27
    • 0033870151 scopus 로고    scopus 로고
    • Angiopoietin 1 and angiopoietin 2 activate trophoblast Tie 2 to promote growth and migration during placental development
    • Dunk C, Shams M, Nijjar S, Rhaman M, Qiu Y, Bussolati B and Ahmed A: Angiopoietin 1 and angiopoietin 2 activate trophoblast Tie 2 to promote growth and migration during placental development. Am J Pathol 156: 2185-2199, 2000.
    • (2000) Am J Pathol , vol.156 , pp. 2185-2199
    • Dunk, C.1    Shams, M.2    Nijjar, S.3    Rhaman, M.4    Qiu, Y.5    Bussolati, B.6    Ahmed, A.7
  • 28
    • 34547103275 scopus 로고    scopus 로고
    • Angiopoietin: A TIE(d) balance in tumor angiogenesis
    • Shim WS, Ho IA and Wong PE: Angiopoietin: A TIE(d) balance in tumor angiogenesis. Mol Cancer Res 5: 655-665, 2007.
    • (2007) Mol Cancer Res , vol.5 , pp. 655-665
    • Shim, W.S.1    Ho, I.A.2    Wong, P.E.3
  • 29
    • 84904690619 scopus 로고    scopus 로고
    • Angiopoietins promote ovarian cancer progression by establishing a procancer microenvironment
    • Brunckhorst MK, Xu Y, Lu R and Yu Q: Angiopoietins promote ovarian cancer progression by establishing a procancer microenvironment. Am J Pathol 184: 2285-2296, 2014.
    • (2014) Am J Pathol , vol.184 , pp. 2285-2296
    • Brunckhorst, M.K.1    Xu, Y.2    Lu, R.3    Yu, Q.4
  • 30
    • 77954890371 scopus 로고    scopus 로고
    • Targeting the ANGPT TIE2 pathway in malignancy
    • Huang H, Bhat A, Woodnutt G and Lappe R: Targeting the ANGPT TIE2 pathway in malignancy. Nat Rev Cancer 10: 575-585, 2010.
    • (2010) Nat Rev Cancer , vol.10 , pp. 575-585
    • Huang, H.1    Bhat, A.2    Woodnutt, G.3    Lappe, R.4
  • 31
    • 84987678893 scopus 로고    scopus 로고
    • Targeting the Angiopoietin 2/Tie 2 axis in conjunction with VEGF signal interference
    • Oct 12, (Epub ahead of print)
    • Biel NM and Siemann DW: Targeting the Angiopoietin 2/Tie 2 axis in conjunction with VEGF signal interference. Cancer Lett: Oct 12, 2014 (Epub ahead of print).
    • (2014) Cancer Lett
    • Biel, N.M.1    Siemann, D.W.2
  • 32
    • 79953750307 scopus 로고    scopus 로고
    • Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells
    • Mazzieri R, Pucci F, Moi D, et al: Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells. Cancer Cell 19: 512-526, 2011.
    • (2011) Cancer Cell , vol.19 , pp. 512-526
    • Mazzieri, R.1    Pucci, F.2    Moi, D.3
  • 33
    • 78049268477 scopus 로고    scopus 로고
    • Identification of serum angiopoietin 2 as a biomarker for clinical outcome of colorectal cancer patients treated with bevacizumab containing therapy
    • Goede V, Coutelle O, Neuneier J, et al: Identification of serum angiopoietin 2 as a biomarker for clinical outcome of colorectal cancer patients treated with bevacizumab containing therapy. Br J Cancer 103: 1407-1414, 2010.
    • (2010) Br J Cancer , vol.103 , pp. 1407-1414
    • Goede, V.1    Coutelle, O.2    Neuneier, J.3
  • 34
    • 63149188174 scopus 로고    scopus 로고
    • Angiopoietin-2 levels are associated with disease progression in metastatic malignant melanoma
    • Helfrich I, Edler L, Sucker A, et al: Angiopoietin-2 levels are associated with disease progression in metastatic malignant melanoma. Clin Cancer Res 15: 1384-1392, 2009.
    • (2009) Clin Cancer Res , vol.15 , pp. 1384-1392
    • Helfrich, I.1    Edler, L.2    Sucker, A.3
  • 35
    • 0036739927 scopus 로고    scopus 로고
    • Human placental vascular development: Vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor A, angiopoietin 1, and angiopoietin 2
    • Geva E, Ginzinger DG, Zaloudek CJ, Moore DH, Byrne A and Jaffe RB: Human placental vascular development: Vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor A, angiopoietin 1, and angiopoietin 2. J Clin Endocrinol Metab 87: 4213-4224, 2002.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 4213-4224
    • Geva, E.1    Ginzinger, D.G.2    Zaloudek, C.J.3    Moore, D.H.4    Byrne, A.5    Jaffe, R.B.6
  • 36
    • 0035718941 scopus 로고    scopus 로고
    • The regulation and localization of angiopoietin 1, 2, and their receptor Tie2 in normal and pathologic human placentae
    • Zhang EG, Smith SK, Baker PN and Charnock Jones DS: The regulation and localization of angiopoietin 1, 2, and their receptor Tie2 in normal and pathologic human placentae. Mol Med 7: 624-635, 2001.
    • (2001) Mol Med , vol.7 , pp. 624-635
    • Zhang, E.G.1    Smith, S.K.2    Baker, P.N.3    Charnock Jones, D.S.4
  • 39
    • 50049107816 scopus 로고    scopus 로고
    • The distribution of angiopoietin 1, angiopoietin 2 and their receptors tie 1 and tie 2 in the very early human placenta
    • Seval Y, Sati L, Celik Ozenci C, Taskin O and Demir R: The distribution of angiopoietin 1, angiopoietin 2 and their receptors tie 1 and tie 2 in the very early human placenta. Placenta 29: 809-815, 2008.
    • (2008) Placenta , vol.29 , pp. 809-815
    • Seval, Y.1    Sati, L.2    Celik Ozenci, C.3    Taskin, O.4    Demir, R.5
  • 41
    • 18644376701 scopus 로고    scopus 로고
    • In utero angiopoietin 2 gene delivery remodels placental blood vessel phenotype: A murine model for studying placental angiogenesis
    • Geva E, Ginzinger DG, Moore DH, Ursell PC and Jaffe RB: In utero angiopoietin 2 gene delivery remodels placental blood vessel phenotype: A murine model for studying placental angiogenesis. Mol Hum Reprod 11: 253-260, 2005.
    • (2005) Mol Hum Reprod , vol.11 , pp. 253-260
    • Geva, E.1    Ginzinger, D.G.2    Moore, D.H.3    Ursell, P.C.4    Jaffe, R.B.5
  • 43
    • 0036184536 scopus 로고    scopus 로고
    • Hemochorial placentation in the primate: Expression of vascular endothelial growth factor, angiopoietins, and their receptors throughout pregnancy
    • Wulff C, Wilson H, Dickson SE, Wiegand SJ and Fraser HM: Hemochorial placentation in the primate: Expression of vascular endothelial growth factor, angiopoietins, and their receptors throughout pregnancy. Biol Reprod 66: 802-812, 2002.
    • (2002) Biol Reprod , vol.66 , pp. 802-812
    • Wulff, C.1    Wilson, H.2    Dickson, S.E.3    Wiegand, S.J.4    Fraser, H.M.5
  • 45
    • 84861094112 scopus 로고    scopus 로고
    • Accuracy of circulating placental growth factor, vascular endothelial growth factor, soluble fms like tyrosine kinase 1 and soluble endoglin in the prediction of pre eclampsia: A systematic review and meta analysis
    • Kleinrouweler CE, Wiegerinck MM, Ris Stalpers C, Bossuyt PM, van der Post JA, von Dadelszen P, Mol BW and Pajkrt E; EBM CONNECT Collaboration: Accuracy of circulating placental growth factor, vascular endothelial growth factor, soluble fms like tyrosine kinase 1 and soluble endoglin in the prediction of pre eclampsia: A systematic review and meta analysis. BJOG 119: 778-787, 2012.
    • (2012) BJOG , vol.119 , pp. 778-787
    • Kleinrouweler, C.E.1    Wiegerinck, M.M.2    Ris Stalpers, C.3    Bossuyt, P.M.4    van der Post, J.A.5    von Dadelszen, P.6    Mol, B.W.7    Pajkrt, E.8    EBM CONNECT Collaboration9
  • 46
    • 79960075254 scopus 로고    scopus 로고
    • Decreased circulating soluble Tie2 levels in preeclampsia may result from inhibition of vascular endothelial growth factor (VEGF) signaling
    • Sung JF, Fan X, Dhal S, Dwyer BK, Jafari A, El Sayed YY, Druzin ML and Nayak NR: Decreased circulating soluble Tie2 levels in preeclampsia may result from inhibition of vascular endothelial growth factor (VEGF) signaling. J Clin Endocrinol Metab 96: E1148-E1152, 2011.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. E1148-E1152
    • Sung, J.F.1    Fan, X.2    Dhal, S.3    Dwyer, B.K.4    Jafari, A.5    El Sayed, Y.Y.6    Druzin, M.L.7    Nayak, N.R.8
  • 47
    • 84455199803 scopus 로고    scopus 로고
    • Angiopoietin 2: A promising indicator for the occurrence of severe preeclampsia
    • Han SY, Jun JK, Lee CH, Park JS and Syn HC: Angiopoietin 2: A promising indicator for the occurrence of severe preeclampsia. Hypertens Pregnancy 31: 189-199, 2012.
    • (2012) Hypertens Pregnancy , vol.31 , pp. 189-199
    • Han, S.Y.1    Jun, J.K.2    Lee, C.H.3    Park, J.S.4    Syn, H.C.5
  • 48
    • 84906794212 scopus 로고    scopus 로고
    • Placental mRNA expression of angiopoietins (Ang) 1, Ang 2 and their receptor Tie 2 is altered in pregnancies complicated by preeclampsia
    • Kappou D, Sifakis S, Androutsopoulos V, Konstantinidou A, Spandidos DA and Papantoniou N: Placental mRNA expression of angiopoietins (Ang) 1, Ang 2 and their receptor Tie 2 is altered in pregnancies complicated by preeclampsia. Placenta 35: 718-723, 2014.
    • (2014) Placenta , vol.35 , pp. 718-723
    • Kappou, D.1    Sifakis, S.2    Androutsopoulos, V.3    Konstantinidou, A.4    Spandidos, D.A.5    Papantoniou, N.6
  • 50
    • 0032985888 scopus 로고    scopus 로고
    • Hypoxia and vascular endothelial growth factor selectively up regulate angiopoietin 2 in bovine microvascular endothelial cells
    • Oh H, Takagi H, Suzuma K, Otani A, Matsumura M and Honda Y: Hypoxia and vascular endothelial growth factor selectively up regulate angiopoietin 2 in bovine microvascular endothelial cells. J Biol Chem 274: 15732-15739, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 15732-15739
    • Oh, H.1    Takagi, H.2    Suzuma, K.3    Otani, A.4    Matsumura, M.5    Honda, Y.6
  • 53
    • 47349125691 scopus 로고    scopus 로고
    • Preeclampsia and small for gestational age are associated with decreased concentrations of a factor involved in angiogenesis: Soluble Tie 2
    • Gotsch F, Romero R, Kusanovic JP, et al: Preeclampsia and small for gestational age are associated with decreased concentrations of a factor involved in angiogenesis: Soluble Tie 2. J Matern Fetal Neonatal Med 21: 389-402, 2008.
    • (2008) J Matern Fetal Neonatal Med , vol.21 , pp. 389-402
    • Gotsch, F.1    Romero, R.2    Kusanovic, J.P.3
  • 55
    • 84888188476 scopus 로고    scopus 로고
    • The importance of repeated measurements of the sFlt 1/PlGF ratio for the prediction of preeclampsia and intrauterine growth restriction
    • Schoofs K, Grittner U, Engels T, Pape J, Denk B, Henrich W and Verlohren S: The importance of repeated measurements of the sFlt 1/PlGF ratio for the prediction of preeclampsia and intrauterine growth restriction. J Perinat Med 42: 61-68, 2014.
    • (2014) J Perinat Med , vol.42 , pp. 61-68
    • Schoofs, K.1    Grittner, U.2    Engels, T.3    Pape, J.4    Denk, B.5    Henrich, W.6    Verlohren, S.7
  • 57
    • 35348932127 scopus 로고    scopus 로고
    • Reduced maternal serum concentrations of angiopoietin 2 in the first trimester precede intrauterine growth restriction associated with placental insufficiency
    • Wang Y, Tasevski V, Wallace EM, Gallery ED and Morris JM: Reduced maternal serum concentrations of angiopoietin 2 in the first trimester precede intrauterine growth restriction associated with placental insufficiency. BJOG 114: 1427-1431, 2007.
    • (2007) BJOG , vol.114 , pp. 1427-1431
    • Wang, Y.1    Tasevski, V.2    Wallace, E.M.3    Gallery, E.D.4    Morris, J.M.5
  • 58
    • 69749092722 scopus 로고    scopus 로고
    • Maternal serum angiopoietin 2 at 11 to 13 weeks of gestation in hypertensive disorders of pregnancy
    • Akolekar R, Casagrandi D, Skyfta E, Ahmed AA and Nicolaides KH: Maternal serum angiopoietin 2 at 11 to 13 weeks of gestation in hypertensive disorders of pregnancy. Prenat Diagn 29: 847-851, 2009.
    • (2009) Prenat Diagn , vol.29 , pp. 847-851
    • Akolekar, R.1    Casagrandi, D.2    Skyfta, E.3    Ahmed, A.A.4    Nicolaides, K.H.5
  • 59
    • 84897373099 scopus 로고    scopus 로고
    • Angiopoietin 1 and 2 serum concentrations in first trimester of pregnancy as biomarkers of adverse pregnancy outcomes
    • Schneuer FJ, Roberts CL, Ashton AW, Guilbert C, Tasevski V, Morris JM and Nassar N: Angiopoietin 1 and 2 serum concentrations in first trimester of pregnancy as biomarkers of adverse pregnancy outcomes. Am J Obstet Gynecol 210: 345. e1 e9, 2014.
    • (2014) Am J Obstet Gynecol , vol.210 , Issue.345 , pp. e1-e9
    • Schneuer, F.J.1    Roberts, C.L.2    Ashton, A.W.3    Guilbert, C.4    Tasevski, V.5    Morris, J.M.6    Nassar, N.7
  • 60
    • 36348946298 scopus 로고    scopus 로고
    • VEGF induces Tie2 shedding via a phosphoinositide 3 kinase/Akt dependent pathway to modulate Tie2 signaling
    • Findley CM, Cudmore MJ, Ahmed A and Kontos CD: VEGF induces Tie2 shedding via a phosphoinositide 3 kinase/Akt dependent pathway to modulate Tie2 signaling. Arterioscler Thromb Vasc Biol 27: 2619-2626, 2007.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 2619-2626
    • Findley, C.M.1    Cudmore, M.J.2    Ahmed, A.3    Kontos, C.D.4
  • 61
    • 0012746562 scopus 로고    scopus 로고
    • Placental development in normal and compromised pregnancies a review
    • Regnault TR, Galan HL, Parker TA and Anthony RV: Placental development in normal and compromised pregnancies a review. Placenta 23 (Suppl A): S119-S129, 2002.
    • (2002) Placenta , vol.23 , pp. S119-S129
    • Regnault, T.R.1    Galan, H.L.2    Parker, T.A.3    Anthony, R.V.4
  • 62
    • 31844443470 scopus 로고    scopus 로고
    • Differential expression of angiopoietin 1, angiopoietin 2, and Tie receptors in placentas from pregnancies complicated by placenta accreta
    • Tseng JJ, Hsu SL, Ho ES, Hsieh YT, Wen MC and Chou MM: Differential expression of angiopoietin 1, angiopoietin 2, and Tie receptors in placentas from pregnancies complicated by placenta accreta. Am J Obstet Gynecol 194: 564-571, 2006.
    • (2006) Am J Obstet Gynecol , vol.194 , pp. 564-571
    • Tseng, J.J.1    Hsu, S.L.2    Ho, E.S.3    Hsieh, Y.T.4    Wen, M.C.5    Chou, M.M.6
  • 63
    • 0034005203 scopus 로고    scopus 로고
    • VEGF, its receptors and the tie receptors in recurrent miscarriage
    • Vuorela P, Carpén O, Tulppala M and Halmesmäki E: VEGF, its receptors and the tie receptors in recurrent miscarriage. Mol Hum Reprod 6: 276-282, 2000.
    • (2000) Mol Hum Reprod , vol.6 , pp. 276-282
    • Vuorela, P.1    Carpén, O.2    Tulppala, M.3    Halmesmäki, E.4
  • 65
    • 84875456598 scopus 로고    scopus 로고
    • Angiopoietin-2: An attractive target for improved antiangiogenic tumor therapy
    • Gerald D, Chintharlapalli S, Augustin HG and Benjamin LE: Angiopoietin-2: an attractive target for improved antiangiogenic tumor therapy. Cancer Res 73: 1649-1657, 2013.
    • (2013) Cancer Res , vol.73 , pp. 1649-1657
    • Gerald, D.1    Chintharlapalli, S.2    Augustin, H.G.3    Benjamin, L.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.