Decreased circulating soluble Tie2 levels in preeclampsia may result from inhibition of Vascular Endothelial Growth Factor (VEGF) signaling

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 7, 2011, Pages

  Sung, Joyce F ^a   Fan, Xiujun ^a   Dhal, Sabita ^a   Dwyer, Bonnie K ^b   Jafari, Anahita ^a   El Sayed, Yasser Y ^a   Druzin, Maurice L ^a   Nayak, Nihar R ^a  

^a STANFORD UNIVERSITY   (United States)

^b CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN 2; ANGIOPOIETIN RECEPTOR; MATRIX METALLOPROTEINASE INHIBITOR; MESSENGER RNA; VASCULOTROPIN;

ARTERY MEDIA; ARTICLE; BLOOD VESSEL REACTIVITY; CLINICAL ARTICLE; CONTROLLED STUDY; DELIVERY; ENDOMETRIUM CELL; FEMALE; GENE EXPRESSION; GESTATIONAL AGE; HUMAN; HUMAN CELL; HUMAN TISSUE; MICROVASCULAR ENDOTHELIAL CELL; PATHOPHYSIOLOGY; PLACENTA; PREECLAMPSIA; PREGNANT WOMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; VASCULAR DISEASE;

ADULT; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; ENDOTHELIAL CELLS; FEMALE; HUMANS; MATRIX METALLOPROTEINASES; PRE-ECLAMPSIA; PREGNANCY; RECEPTOR, TIE-2; SIGNAL TRANSDUCTION; UTERUS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79960075254     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-0063     Document Type: Article

References (20)

1. Brosens JJ, Pijnenborg R, Brosens IA 2002 The myometrial junctional zone spiral arteries in normal and abnormal pregnancies: a review of the literature. Am J Obstet Gynecol 187:1416-1423 (Pubitemid 35397496)
2. Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J 2000 Vascular-specific growth factors and blood vessel formation. Nature 407:242-248
3. Nayak NR, Kuo CJ, Desai TA, Wiegand SJ, Lasley BL, Giudice LC, Brenner RM 2005 Expression, localization and hormonal control of angiopoietin-1 in the rhesus macaque endometrium: potential role in spiral artery growth. Mol Hum Reprod 11:791-799 (Pubitemid 43205487)
4. Leinonen E, Wathén KA, Alfthan H, Ylikorkala O, Andersson S, Stenman UH, Vuorela P 2010 Maternal serum angiopoietin-1 and -2 and tie-2 in early pregnancy ending in preeclampsia or intrauterine growth retardation. J Clin Endocrinol Metab 95:126-133
5. Han SY, Jun JK, Lee CH, Park JS, Syn HC 23 September 2010 Angiopoietin-2: a promising indicator for the occurrence of severe preeclampsia. Hypertens Pregnancy 10.3109/10641955.2010.507844
6. Dwyer BK, Krieg S, Balise R, Carroll IR, Chueh J, Nayak N, Druzin M2010 Variable expression of soluble fms-like tyrosine kinase 1 in patients at high risk for preeclampsia. J Matern Fetal Neonatal Med 23:705-711
7. Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, Schisterman EF, Thadhani R, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA 2004 Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 350:672-683 (Pubitemid 38364626)
8. Roberts JM, Rajakumar A 2009 Preeclampsia and soluble fms-like tyrosine kinase 1. J Clin Endocrinol Metab 94:2252-2254
9. Zhou Y, Genbacev O, Damsky CH, Fisher SJ 1998 Oxygen regulates human cytotrophoblast differentiation and invasion: implications for endovascular invasion in normal pregnancy and in pre-eclampsia. J Reprod Immunol 39:197-213 (Pubitemid 28418423)
10. Yabkowitz R, Meyer S, Black T, Elliott G, Merewether LA, Yamane HK 1999 Inflammatory cytokines and vascular endothelial growth factor stimulate the release of soluble tie receptor from human endothelial cells via metalloprotease activation. Blood 93:1969-1979 (Pubitemid 29128499)
11. Findley CM, Cudmore MJ, Ahmed A, Kontos CD 2007 VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling. Arterioscler Thromb Vasc Biol 27:2619-2626 (Pubitemid 350158914)
12. Brenner RM, Nayak NR, Slayden OD, Critchley HO, Kelly RW 2002 Premenstrual and menstrual changes in the macaque and human endometrium: relevance to endometriosis. Ann NY Acad Sci 955:60-74; discussion 86-88:396-406
13. Salamonsen LA, Zhang J, Hampton A, Lathbury L 2000 Regulation of matrix metalloproteinases in human endometrium. Hum Reprod 15(Suppl 3):112-119
14. Unemori EN, Ferrara N, Bauer EA, Amento EP 1992 Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J Cell Physiol 153:557-562
15. Fan X, Krieg S, Kuo CJ, Wiegand SJ, Rabinovitch M, Druzin ML, Brenner RM, Giudice LC, Nayak NR 2008 VEGF blockade inhibits angiogenesis and reepithelialization of endometrium. FASEB J 22:3571-3580
16. Gotsch F, Romero R, Kusanovic JP, Chaiworapongsa T, Dombrowski M, Erez O, Than NG, Mazaki-Tovi S, Mittal P, Espinoza J, Hassan SS 2008 Preeclampsia and small-for-gestational age are associated with decreased concentrations of a factor involved in angiogenesis: soluble Tie-2. J Matern Fetal Neonatal Med 21:389-402 (Pubitemid 351999171)
17. Hirokoshi K, Maeshima Y, Kobayashi K, Matsuura E, Sugiyama H, Yamasaki Y, Masuyama H, Hiramatsu Y, Makino H 2005 Increase of serum angiopoietin-2 during pregnancy is suppressed in women with preeclampsia. Am J Hypertens 18:1181-1188 (Pubitemid 41337970)
18. Vuorela P, Matikainen MT, Kuusela P, Ylikorkala O, Alitalo K, Halmesmäki E 1998 Endothelial tie receptor antigen in maternal and cord blood of healthy and preeclamptic subjects. Obstet Gynecol 92:179-183 (Pubitemid 28350844)
19. Gallery ED, Campbell S, Arkell J, Nguyen M, Jackson CJ 1999 Preeclamptic decidual microvascular endothelial cells express lower levels of matrix metalloproteinase-1 than normals. Microvasc Res 57:340-346 (Pubitemid 29393279)
20. Galewska Z, Bańkowski E, Romanowicz L, Jaworski S 2003 Preeclampsia (EPH-gestosis)-induced decrease of MMP-scontent in the umbilical cord artery. Clin Chim Acta 335:109-115 (Pubitemid 37338315)