Soluble flt-1 and the angiopoietins in the development and regulation of placental vasculature

Journal of Anatomy

Volumn 200, Issue 6, 2002, Pages 607-615

  Charnock Jones, D Stephen ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Angiogenesis; Endothelial cells; Maturity; Oxygen tension; Vessel size

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN 2; MESSENGER RNA; VASCULOTROPIN RECEPTOR 1;

ADAPTATION; GENETIC CODE; GENETIC STABILITY; HUMAN; HUMAN CELL; OXYGEN TENSION; PLACENTA CIRCULATION; PRIORITY JOURNAL; REVIEW; RNA TRANSCRIPTION;

ADAPTATION, PHYSIOLOGICAL; ALTITUDE; ANGIOPOIETIN-1; ANGIOPOIETIN-2; ANIMALS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MEMBRANE GLYCOPROTEINS; NEOVASCULARIZATION, PHYSIOLOGIC; OXYGEN; PLACENTAL CIRCULATION; PREGNANCY; PREGNANCY TRIMESTERS; PROTEINS; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

MAMMALIA;

EID: 0036319339     PISSN: 00218782     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1469-7580.2002.00063.x     Document Type: Review

References (69)

1. Role of VEGF receptor-1 (Flt-1) in mediating calcium-dependent nitric oxide release and limiting DNA synthesis in human trophoblast cells
2. Does hypercapillarization influence the branching pattern of terminal villi in the human placenta at high altitude?
3. Role of placenta growth factor (PIGF) in human extravillous trophoblast proliferation, migration and invasiveness
4. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
5. A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF- B and VEGF
6. Expression of vascular endothelial growth factor and its receptors fit and KDR in ovarian carcinoma
7. Coordinate expression of vascular endothelial growth factor receptor-1 (flt-1) and its ligand suggests a paracrine regulation of murine vascular development
8. The formation of vasculo-syncytial membranes in the human placenta
9. Stereological evaluation of vascular adaptations in human placental villi to differing forms of hypoxic stress
10. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
11. Differential expression of vascular endothelial growth factor and its receptor mRNAs in the mouse uterus around the time of implantation
12. Placental vascular morphogenesis Baillieres Best
13. Human chorionic gonadotropin pattern in maternal circulation. Amniotic fluid and fetal circulation in late pregnancy
14. A vascular endothelial growth factor antagonist is produced by the human placenta and released into the maternal circulation
15. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
16. Study of thromboxane and prostacyclin metabolism in an in vitro model of first-trimester human trophoblast
17. Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo
18. Vascularization of the mouse embryo: A study of flk-1, tek, tie, and vascular endothelial growth factor expression during development
19. Placental villus morpholgy in relation to maternal hypoxia at high altitude
20. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
21. Colocalization of acidic and basic fibroblast growth factor (FGF) in human placenta and the cellular effects of bFGF in trophoblast cell line JEG-3
22. What is the evidence that tumors are angiogenesis dependent?
23. Angiogenesis in cancer, vascular, rheumatoid and other disease
24. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
25. Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice
26. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is upregulated by hypoxia
27. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
28. Alternative splicing of vascular endothelial growth factor (VEGF) - R1 (FLT-1) pre-mRNA is important for the regulation of VEGF activity
29. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice
30. Morphometric studies on villi in human term placentae and the effects of altitude, ethnic grouping and sex of newborn
31. On the factors which contribute to thinning of the villous membrane at high altitude. II. An increase in the degree of peripheralization of fetal capillaries
32. Quantitative description of the elaboration and maturation of villi from 10 weeks of gestation to term
33. Onset of maternal arterial bloodflow and placental oxidative stress; a possible factor in human early pregnancy failure
34. Evaluation of respiratory gases and acid-base gradients in fetal fluids and uteroplacental tissue between 7 and 16 weeks
35. The effect of high altitude and other risk factors on birthweight: Independent or interactive effects?
36. The fetal vascularisation of term placental villi. II. Intermediate and terminal villi
37. Anatomy and genesis of the placenta
38. Three-dimensional representation of the fetal vessel system in the human placenta
39. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor
40. Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR
41. Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants
42. Cell culture models of trophoblast II: Trophoblast cell lines - A workshop report
43. Oxygen and placental villous development: Origins of fetal hypoxia
44. Enhanced expression of the tie receptor tyrosine kinase in endothelial cells during neovascularization
45. Fetal biometry at 4300 m compared to sea level in Peru
46. Quantitative studies of human placenta. I. Morphometry
47. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
48. Regulation of angiopoietin-2 mRNA levels in bovine
49. Microscopical morphology of the human placenta and its effects on oxygen diffusion: A morphometric model
50. Changes in oxygen diffusive conductances of human placental during gestation (10-41 weeks) are commensurate with the gain in fetal weight
51. Altered blood pressure course during normal pregnancy and increased preeclampsia at high altitude (3100 meters) in Colorado
52. Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR
53. Effects of hypobaric hypoxia on the fetoplacental unit: The morphometric diffusing capacity of the villous membrane at high altitude
54. Mechanisms of angiogenesis
55. Oxygen measurements in endometrial and trophoblastic tissues during early pregnancy
56. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
57. Failure of blood-island formation and vasculogenesis in Flk-1 deficient mice
58. Expression of mRNA for vascular endothelial growth factor in human placenta
59. Maternal plasma levels of vascular endothelial growth factor in normotensive pregnancies and in pregnancies-complicated by pre-eclampsia
60. Effect of gestational age on fetal and intervillous blood gas and acid-base values in human pregnancy
61. Developmental expression and regulation of basic fibroblast growth factor and vascular endothelial growth factor in rat decidua and in a decidual cell line
62. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
63. Increased vascularization in mice overexpressing angiopoietin-1
64. Histomorphometry of the human placenta in Class C diabetes mellitus
65. Histomorphometry of the human placenta in pre-eclampsia associated with severe intrauterine growth retardation
66. Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2
67. The Regulation and Localization of Angiopoietin-1-2, and Their Receptor Tie2 in Normal and Pathological Human Placentae